Tpr (translocated promoter region, nuclear basket protein) - Rat Genome Database

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Gene: Tpr (translocated promoter region, nuclear basket protein) Rattus norvegicus
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Symbol: Tpr
Name: translocated promoter region, nuclear basket protein
RGD ID: 1310664
Description: Predicted to enable several functions, including dynein complex binding activity; mitogen-activated protein kinase binding activity; and protein homodimerization activity. Predicted to be a structural constituent of nuclear pore. Involved in positive regulation of protein export from nucleus and protein export from nucleus. Located in nuclear inclusion body; nuclear membrane; and nuclear periphery. Part of nuclear pore nuclear basket. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human TPR (translocated promoter region, nuclear basket protein); PARTICIPATES IN RNA transport pathway; thyroid cancer pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC304862; megator; NPC-associated intranuclear protein; nucleoprotein TPR; translocated promoter region; translocated promoter region (to activated MET oncogene)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81364,974,419 - 65,037,604 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1364,974,419 - 65,037,602 (+)EnsemblGRCr8
mRatBN7.21362,424,312 - 62,487,502 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1362,424,312 - 62,487,496 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1365,070,740 - 65,133,881 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01366,341,843 - 66,405,114 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01363,603,135 - 63,666,355 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01367,611,685 - 67,672,833 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1367,611,708 - 67,672,827 (+)Ensemblrn6Rnor6.0
Rnor_5.01372,576,506 - 72,637,654 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41364,688,585 - 64,753,555 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1362,384,785 - 62,447,122 (+)NCBICelera
RGSC_v3.11364,702,435 - 64,767,635 (+)NCBI
Cytogenetic Map13q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
biotin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
caffeine  (ISO)
carbonyl sulfide  (EXP)
chloroprene  (EXP)
chlorpyrifos  (ISO)
clobetasol  (ISO)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ferric oxide  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (ISO)
malathion  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
nicotine  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
paracetamol  (ISO)
penconazole  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pirinixic acid  (ISO)
poly(propylene imine) macromolecule  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (EXP)
thimerosal  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
torcetrapib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell division  (IEA)
cellular response to heat  (IEA,ISO,ISS)
cellular response to interferon-alpha  (ISO,ISS)
intracellular protein transport  (IEA)
mitotic spindle assembly checkpoint signaling  (IEA,ISO,ISS)
mRNA export from nucleus  (IBA)
mRNA export from nucleus in response to heat stress  (IEA,ISO,ISS)
mRNA transport  (IEA)
negative regulation of RNA export from nucleus  (IEA,ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
negative regulation of translational initiation  (IEA,ISO,ISS)
nuclear export  (IEA)
nuclear matrix organization  (ISO,ISS)
nuclear pore complex assembly  (IMP,ISO)
nuclear pore organization  (IEA,ISO,ISS)
positive regulation of heterochromatin formation  (IEA,ISO,ISS)
positive regulation of intracellular protein transport  (IEA,ISO,ISS)
positive regulation of mitotic cell cycle spindle assembly checkpoint  (IEA,ISO,ISS)
positive regulation of nucleocytoplasmic transport  (IEA)
positive regulation of protein export from nucleus  (IMP)
positive regulation of protein import into nucleus  (IEA,ISO,ISS)
protein export from nucleus  (IMP,ISO,ISS)
protein import into nucleus  (IEA,ISO,ISS)
protein transport  (IEA)
regulation of mitotic sister chromatid separation  (IEA,ISO,ISS)
regulation of mitotic spindle assembly  (IBA,IEA,ISO,ISS)
regulation of mRNA export from nucleus  (ISO)
regulation of protein export from nucleus  (ISO)
regulation of protein import into nucleus  (IMP,ISO)
regulation of protein localization  (IEA,ISO)
regulation of protein stability  (ISO,ISS)
response to epidermal growth factor  (IEA,ISO,ISS)
RNA export from nucleus  (IEA,ISO,ISS)
RNA import into nucleus  (IEA,ISO,ISS)

Cellular Component
cytoplasm  (IEA,ISO,ISS)
cytoplasmic dynein complex  (IEA,ISO,ISS)
kinetochore  (IEA,ISO,ISS)
mitotic spindle  (IEA,ISO,ISS)
nuclear envelope  (IEA,ISO,ISS)
nuclear inclusion body  (IDA,IEA,ISO)
nuclear membrane  (IDA,IEA,ISO)
nuclear periphery  (IDA,IEA,ISO)
nuclear pore  (IBA,IEA,ISO,ISS)
nuclear pore nuclear basket  (IDA,IEA,ISO)
nucleus  (IEA,ISO)
spindle  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export. Frosst P, etal., J Cell Biol. 2002 Feb 18;156(4):617-30. Epub 2002 Feb 11.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9024684   PMID:9828100   PMID:9864356   PMID:11514627   PMID:11952838   PMID:12424524   PMID:12477932   PMID:12513910   PMID:12802065   PMID:15229283   PMID:15654337   PMID:17098863  
PMID:17897941   PMID:18794356   PMID:18981471   PMID:19273613   PMID:20133940   PMID:20407419   PMID:21613532   PMID:22253824   PMID:22401879   PMID:22658674   PMID:24970816   PMID:31505169  


Genomics

Comparative Map Data
Tpr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81364,974,419 - 65,037,604 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1364,974,419 - 65,037,602 (+)EnsemblGRCr8
mRatBN7.21362,424,312 - 62,487,502 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1362,424,312 - 62,487,496 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1365,070,740 - 65,133,881 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01366,341,843 - 66,405,114 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01363,603,135 - 63,666,355 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01367,611,685 - 67,672,833 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1367,611,708 - 67,672,827 (+)Ensemblrn6Rnor6.0
Rnor_5.01372,576,506 - 72,637,654 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41364,688,585 - 64,753,555 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1362,384,785 - 62,447,122 (+)NCBICelera
RGSC_v3.11364,702,435 - 64,767,635 (+)NCBI
Cytogenetic Map13q21NCBI
TPR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381186,311,652 - 186,375,253 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1186,311,652 - 186,375,693 (-)Ensemblhg38GRCh38
GRCh371186,280,784 - 186,344,385 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361184,547,407 - 184,611,080 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341183,014,615 - 183,076,114NCBI
Celera1159,391,490 - 159,455,165 (-)NCBICelera
Cytogenetic Map1q31.1NCBI
HuRef1157,515,355 - 157,578,976 (-)NCBIHuRef
CHM1_11187,702,490 - 187,766,196 (-)NCBICHM1_1
T2T-CHM13v2.01185,666,310 - 185,729,984 (-)NCBIT2T-CHM13v2.0
Tpr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391150,268,544 - 150,325,686 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1150,268,589 - 150,325,686 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381150,392,802 - 150,449,935 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,392,838 - 150,449,935 (+)Ensemblmm10GRCm38
MGSCv371152,239,968 - 152,297,065 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361152,155,071 - 152,212,147 (+)NCBIMGSCv36mm8
Celera1152,832,018 - 152,889,087 (+)NCBICelera
Cytogenetic Map1G1NCBI
cM Map163.84NCBI
Tpr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540624,742,525 - 24,805,989 (-)Ensembl
ChiLan1.0NW_00495540624,742,525 - 24,805,989 (-)NCBIChiLan1.0ChiLan1.0
TPR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2163,343,613 - 63,405,202 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1163,025,048 - 63,086,633 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01161,842,037 - 161,903,567 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11165,993,726 - 166,055,223 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1165,993,726 - 166,055,223 (-)EnsemblpanPan2panpan1.1
TPR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1719,376,951 - 19,442,368 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl719,376,975 - 19,442,303 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha718,898,638 - 18,964,055 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0719,112,960 - 19,178,509 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl719,112,979 - 19,179,044 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1719,019,776 - 19,085,277 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0719,129,102 - 19,194,530 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0719,259,646 - 19,325,389 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tpr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934486,203,944 - 86,264,933 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364814,050,794 - 4,111,682 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364814,050,693 - 4,111,682 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9127,481,684 - 127,540,398 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19127,481,678 - 127,540,393 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29139,933,094 - 139,992,501 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TPR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12543,056,605 - 43,120,570 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2543,056,886 - 43,123,474 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605544,245,730 - 44,312,643 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248147,249,278 - 7,306,235 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248147,249,379 - 7,306,239 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tpr
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11029,838,063 - 29,894,614 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tpr
173 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:14
Count of miRNA genes:12
Interacting mature miRNAs:14
Transcripts:ENSRNOT00000063833
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat

Markers in Region
RH144043  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21362,476,622 - 62,476,792 (+)MAPPERmRatBN7.2
Rnor_6.01367,661,954 - 67,662,123NCBIRnor6.0
Rnor_5.01372,626,775 - 72,626,944UniSTSRnor5.0
RGSC_v3.41364,742,682 - 64,742,851UniSTSRGSC3.4
Celera1362,436,248 - 62,436,417UniSTS
Cytogenetic Map13q21UniSTS
RH133437  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81365,036,861 - 65,037,503 (+)Marker Load Pipeline
mRatBN7.21362,486,755 - 62,487,397 (+)MAPPERmRatBN7.2
Rnor_6.01367,672,087 - 67,672,728NCBIRnor6.0
Rnor_5.01372,636,908 - 72,637,549UniSTSRnor5.0
RGSC_v3.41364,752,815 - 64,753,456UniSTSRGSC3.4
Celera1362,446,382 - 62,447,023UniSTS
RH 3.4 Map13288.0UniSTS
Cytogenetic Map13q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000063833   ⟹   ENSRNOP00000062172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1364,974,419 - 65,037,602 (+)Ensembl
mRatBN7.2 Ensembl1362,424,312 - 62,487,496 (+)Ensembl
Rnor_6.0 Ensembl1367,611,708 - 67,672,827 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097761   ⟹   ENSRNOP00000094758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1364,974,419 - 65,037,602 (+)Ensembl
mRatBN7.2 Ensembl1362,424,312 - 62,487,496 (+)Ensembl
RefSeq Acc Id: NM_001107185   ⟹   NP_001100655
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81364,974,419 - 65,037,602 (+)NCBI
mRatBN7.21362,424,312 - 62,487,496 (+)NCBI
Rnor_6.01367,611,708 - 67,672,827 (+)NCBI
Rnor_5.01372,576,506 - 72,637,654 (+)NCBI
RGSC_v3.41364,688,585 - 64,753,555 (+)RGD
Celera1362,384,785 - 62,447,122 (+)RGD
Sequence:
RefSeq Acc Id: XM_017598809   ⟹   XP_017454298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81364,974,444 - 65,037,604 (+)NCBI
mRatBN7.21362,424,334 - 62,487,502 (+)NCBI
Rnor_6.01367,611,685 - 67,672,833 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001100655 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454298 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI01884 (Get FASTA)   NCBI Sequence Viewer  
  EDM09583 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000062172
  ENSRNOP00000094758
GenBank Protein F1MA98 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001100655   ⟸   NM_001107185
- UniProtKB: Q3T1J7 (UniProtKB/Swiss-Prot),   F1MA98 (UniProtKB/Swiss-Prot),   A0A8L2UNA6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454298   ⟸   XM_017598809
- Peptide Label: isoform X1
- UniProtKB: Q3T1J7 (UniProtKB/Swiss-Prot),   F1MA98 (UniProtKB/Swiss-Prot),   A0A8I6ALQ6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062172   ⟸   ENSRNOT00000063833
Ensembl Acc Id: ENSRNOP00000094758   ⟸   ENSRNOT00000097761
Protein Domains
Nucleoprotein TPR/MLP1-2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MA98-F1-model_v2 AlphaFold F1MA98 1-2360 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698879
Promoter ID:EPDNEW_R9404
Type:initiation region
Name:Tpr_1
Description:translocated promoter region, nuclear basket protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01367,611,656 - 67,611,716EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310664 AgrOrtholog
BioCyc Gene G2FUF-17944 BioCyc
Ensembl Genes ENSRNOG00000002394 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000063833 ENTREZGENE
  ENSRNOT00000097761 ENTREZGENE
Gene3D-CATH 1.10.287.1490 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7929511 IMAGE-MGC_LOAD
InterPro TPR/MLP1 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124665 IMAGE-MGC_LOAD
NCBI Gene 304862 ENTREZGENE
PANTHER NUCLEOPROTEIN TPR UniProtKB/Swiss-Prot
  NUCLEOPROTEIN TPR-RELATED UniProtKB/Swiss-Prot
Pfam Nucleoprot-TPR UniProtKB/Swiss-Prot
  TPR_MLP1_2 UniProtKB/Swiss-Prot
PhenoGen Tpr PhenoGen
RatGTEx ENSRNOG00000002394 RatGTEx
UniProt A0A8I6ALQ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UNA6 ENTREZGENE, UniProtKB/TrEMBL
  A6ICR4_RAT UniProtKB/TrEMBL
  F1MA98 ENTREZGENE
  Q3T1J7 ENTREZGENE
  Q80UF5_RAT UniProtKB/TrEMBL
  TPR_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q3T1J7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-16 Tpr  translocated promoter region, nuclear basket protein  Tpr  translocated promoter region (to activated MET oncogene)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-02-02 Tpr  translocated promoter region (to activated MET oncogene)  Tpr  translocated promoter region  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Tpr  translocated promoter region  Tpr_predicted  translocated promoter region (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Tpr_predicted  translocated promoter region (predicted)      Symbol and Name status set to approved 70820 APPROVED