Tpr (translocated promoter region, nuclear basket protein) - Rat Genome Database

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Gene: Tpr (translocated promoter region, nuclear basket protein) Rattus norvegicus
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Symbol: Tpr
Name: translocated promoter region, nuclear basket protein
RGD ID: 1310664
Description: Predicted to enable several functions, including dynein complex binding activity; mitogen-activated protein kinase binding activity; and protein homodimerization activity. Predicted to be a structural constituent of nuclear pore. Involved in positive regulation of protein export from nucleus and protein export from nucleus. Located in nuclear inclusion body; nuclear membrane; and nuclear periphery. Part of nuclear pore nuclear basket. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human TPR (translocated promoter region, nuclear basket protein); PARTICIPATES IN RNA transport pathway; thyroid cancer pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC304862; megator; NPC-associated intranuclear protein; nucleoprotein TPR; translocated promoter region; translocated promoter region (to activated MET oncogene)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81364,974,419 - 65,037,604 (+)NCBIGRCr8
mRatBN7.21362,424,312 - 62,487,502 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1362,424,312 - 62,487,496 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1365,070,740 - 65,133,881 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01366,341,843 - 66,405,114 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01363,603,135 - 63,666,355 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01367,611,685 - 67,672,833 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1367,611,708 - 67,672,827 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01372,576,506 - 72,637,654 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41364,688,585 - 64,753,555 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11364,702,435 - 64,767,635 (+)NCBI
Celera1362,384,785 - 62,447,122 (+)NCBICelera
Cytogenetic Map13q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
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Original Reference(s)
TprRatAutosomal Recessive Intellectual Developmental Disorder 79  ISOTPR (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual developmental disorder and autosomal recessive 79ClinVarPMID:34494102
TprRatcamptodactyly-arthropathy-coxa vara-pericarditis syndrome  ISOTPR (Homo sapiens)8554872ClinVar Annotator: match by term: Camptodactyly-arthropathy-coxa vara-pericarditis syndromeClinVarPMID:25741868 and PMID:29397575
TprRatgastrointestinal stromal tumor  ISOTPR (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
TprRatgenetic disease  ISOTPR (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
TprRatintellectual disability  ISOTPR (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
TprRatparathyroid carcinoma  ISOTPR (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
Object Symbol
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Original Reference(s)
TprRatThyroid Neoplasms  ISOTPR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23811263
Object Symbol
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Original Reference(s)
TprRatAutosomal Recessive Intellectual Developmental Disorder 79  ISOTPR (Homo sapiens)7240710 OMIM 

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Original Reference(s)
TprRat(+)-catechin multiple interactionsISOTPR (Homo sapiens)6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of TPR mRNACTDPMID:24763279
TprRat(1->4)-beta-D-glucan multiple interactionsISOTpr (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of TPR mRNACTDPMID:36331819
TprRat(S)-nicotine increases expressionISOTPR (Homo sapiens)6480464Nicotine results in increased expression of TPR mRNACTDPMID:16949557
TprRat1-chloro-2,4-dinitrobenzene affects bindingISOTPR (Homo sapiens)6480464Dinitrochlorobenzene binds to TPR proteinCTDPMID:32991956
TprRat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of TPR mRNACTDPMID:20068009
TprRat2,2',4,4'-Tetrabromodiphenyl ether increases expressionEXP 64804642 more ...CTDPMID:27291303
TprRat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOTPR (Homo sapiens)64804642 more ...CTDPMID:31675489
TprRat2,2',5,5'-tetrachlorobiphenyl decreases expressionEXP 64804642 more ...CTDPMID:23829299
TprRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOTpr (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of TPR mRNACTDPMID:18691609 and PMID:21570461
TprRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of TPR mRNACTDPMID:33387578
TprRat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of TPR mRNACTDPMID:34747641
TprRat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of TPR mRNACTDPMID:21346803
TprRat2,6-dimethoxyphenol multiple interactionsISOTPR (Homo sapiens)6480464[Sodium Chloride co-treated with pyrogallol 1 and 3-dimethyl ether] results in increased expression of and affects the localization of TPR proteinCTDPMID:38598786
TprRat2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester increases expressionISOTPR (Homo sapiens)6480464homosalate results in increased expression of TPR mRNACTDPMID:38381479
TprRat2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester multiple interactionsISOTPR (Homo sapiens)6480464Polystyrenes promotes the reaction [homosalate results in increased expression of TPR mRNA]CTDPMID:38381479
TprRat2-methylcholine affects expressionISOTPR (Homo sapiens)6480464beta-methylcholine affects the expression of TPR mRNACTDPMID:21179406
TprRat3,3',5,5'-tetrabromobisphenol A increases expressionISOTPR (Homo sapiens)6480464tetrabromobisphenol A results in increased expression of TPR proteinCTDPMID:31675489
TprRat3,4-methylenedioxymethamphetamine decreases expressionISOTpr (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of TPR mRNACTDPMID:26251327
TprRat3-chloropropane-1,2-diol increases expressionEXP 6480464alpha-Chlorohydrin results in increased expression of TPR proteinCTDPMID:34915118
TprRat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOTPR (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of TPR mRNACTDPMID:28628672

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Biological Process
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Original Reference(s)
TprRatcell division involved_inIEAUniProtKB-KW:KW-01321600115GO_REF:0000043UniProtGO_REF:0000043
TprRatcellular response to heat involved_inISSUniProtKB:P122701600115GO_REF:0000024UniProtGO_REF:0000024
TprRatcellular response to heat involved_inIEAUniProtKB:P12270 and ensembl:ENSP000003564481600115GO_REF:0000107EnsemblGO_REF:0000107
TprRatcellular response to heat involved_inISOTPR (Homo sapiens)1624291 PMID:17897941RGDPMID:17897941
TprRatcellular response to interferon-alpha involved_inISSUniProtKB:F6ZDS41600115GO_REF:0000024UniProtGO_REF:0000024
TprRatcellular response to interferon-alpha involved_inISOTpr (Mus musculus)1624291 PMID:12513910RGDPMID:12513910
TprRatmitotic spindle assembly checkpoint signaling involved_inISSUniProtKB:P122701600115GO_REF:0000024UniProtGO_REF:0000024
TprRatmitotic spindle assembly checkpoint signaling involved_inISOTPR (Homo sapiens)1624291 PMID:20133940RGDPMID:20133940
TprRatmitotic spindle assembly checkpoint signaling involved_inIEAUniProtKB:P12270 and ensembl:ENSP000003564481600115GO_REF:0000107EnsemblGO_REF:0000107
TprRatmRNA export from nucleus involved_inIBAPANTHER:PTN001052033 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
TprRatmRNA export from nucleus in response to heat stress involved_inIEAUniProtKB:P12270 and ensembl:ENSP000003564481600115GO_REF:0000107EnsemblGO_REF:0000107
TprRatmRNA export from nucleus in response to heat stress involved_inISOTPR (Homo sapiens)1624291 PMID:17897941RGDPMID:17897941
TprRatmRNA export from nucleus in response to heat stress involved_inISSUniProtKB:P122701600115GO_REF:0000024UniProtGO_REF:0000024
TprRatmRNA transport involved_inIEAUniProtKB-KW:KW-05091600115GO_REF:0000043UniProtGO_REF:0000043
TprRatnegative regulation of RNA export from nucleus involved_inISOTPR (Homo sapiens)1624291 PMID:21613532 and PMID:22253824RGDPMID:21613532 and PMID:22253824
TprRatnegative regulation of RNA export from nucleus involved_inIEAUniProtKB:P12270 and ensembl:ENSP000003564481600115GO_REF:0000107EnsemblGO_REF:0000107
TprRatnegative regulation of RNA export from nucleus involved_inISSUniProtKB:P122701600115GO_REF:0000024UniProtGO_REF:0000024
TprRatnegative regulation of transcription by RNA polymerase II involved_inISSUniProtKB:P122701600115GO_REF:0000024UniProtGO_REF:0000024
TprRatnegative regulation of transcription by RNA polymerase II involved_inISOTPR (Homo sapiens)1624291 PMID:21613532RGDPMID:21613532
TprRatnegative regulation of transcription by RNA polymerase II involved_inIEAUniProtKB:P12270 and ensembl:ENSP000003564481600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
TprRatchromosome located_inIEAUniProtKB-KW:KW-01581600115GO_REF:0000043UniProtGO_REF:0000043
TprRatchromosome, centromeric region located_inIEAUniProtKB-KW:KW-01371600115GO_REF:0000043UniProtGO_REF:0000043
TprRatcytoplasm located_inISOTPR (Homo sapiens)1624291 PMID:11952838 and PMID:12802065RGDPMID:11952838 and PMID:12802065
TprRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
TprRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
TprRatcytoplasm located_inISSUniProtKB:P122701600115GO_REF:0000024UniProtGO_REF:0000024
TprRatcytoplasm located_inIEAUniProtKB:P12270 and ensembl:ENSP000003564481600115GO_REF:0000107EnsemblGO_REF:0000107
TprRatcytoplasmic dynein complex part_ofISSUniProtKB:P122701600115GO_REF:0000024UniProtGO_REF:0000024
TprRatcytoplasmic dynein complex part_ofISOTPR (Homo sapiens)1624291 PMID:20133940RGDPMID:20133940
TprRatcytoplasmic dynein complex part_ofIEAUniProtKB:P12270 and ensembl:ENSP000003564481600115GO_REF:0000107EnsemblGO_REF:0000107
TprRatcytoskeleton located_inIEAUniProtKB-KW:KW-02061600115GO_REF:0000043UniProtGO_REF:0000043
TprRatkinetochore located_inISOTPR (Homo sapiens)1624291 PMID:20133940RGDPMID:20133940
TprRatkinetochore located_inIEAUniProtKB:P12270 and ensembl:ENSP000003564481600115GO_REF:0000107EnsemblGO_REF:0000107
TprRatkinetochore NOT|located_inISSUniProtKB:P122701600115GO_REF:0000024UniProtGO_REF:0000024
TprRatkinetochore NOT|located_inISOTPR (Homo sapiens)1624291 PMID:19273613RGDPMID:19273613
TprRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
TprRatmitotic spindle located_inISSUniProtKB:P122701600115GO_REF:0000024UniProtGO_REF:0000024
TprRatmitotic spindle located_inISOTPR (Homo sapiens)1624291 PMID:20133940RGDPMID:20133940
TprRatmitotic spindle located_inIEAUniProtKB:P12270 and ensembl:ENSP000003564481600115GO_REF:0000107EnsemblGO_REF:0000107
TprRatnuclear envelope located_inISSUniProtKB:F6ZDS41600115GO_REF:0000024UniProtGO_REF:0000024
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Molecular Function
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Original Reference(s)
TprRatchromatin binding enablesISOTPR (Homo sapiens)1624291 PMID:17897941RGDPMID:17897941
TprRatchromatin binding enablesIEAUniProtKB:P12270 and ensembl:ENSP000003564481600115GO_REF:0000107EnsemblGO_REF:0000107
TprRatchromatin binding enablesISSUniProtKB:P122701600115GO_REF:0000024UniProtGO_REF:0000024
TprRatdynein complex binding enablesIEAUniProtKB:P12270 and ensembl:ENSP000003564481600115GO_REF:0000107EnsemblGO_REF:0000107
TprRatdynein complex binding enablesISOTPR (Homo sapiens)1624291 PMID:20133940RGDPMID:20133940
TprRatheat shock protein binding enablesISOTPR (Homo sapiens)1624291 PMID:17897941RGDPMID:17897941
TprRatheat shock protein binding enablesIEAUniProtKB:P12270 and ensembl:ENSP000003564481600115GO_REF:0000107EnsemblGO_REF:0000107
TprRatheat shock protein binding enablesISSUniProtKB:P122701600115GO_REF:0000024UniProtGO_REF:0000024
TprRatmitogen-activated protein kinase binding enablesIEAUniProtKB:P12270 and ensembl:ENSP000003564481600115GO_REF:0000107EnsemblGO_REF:0000107
TprRatmitogen-activated protein kinase binding enablesISOTPR (Homo sapiens)1624291 PMID:18794356RGDPMID:18794356
TprRatmitogen-activated protein kinase binding enablesISSUniProtKB:P122701600115GO_REF:0000024UniProtGO_REF:0000024
TprRatmRNA binding enablesISSUniProtKB:P122701600115GO_REF:0000024UniProtGO_REF:0000024
TprRatmRNA binding enablesISOTPR (Homo sapiens)1624291 PMID:17897941RGDPMID:17897941
TprRatmRNA binding enablesIEAUniProtKB:P12270 and ensembl:ENSP000003564481600115GO_REF:0000107EnsemblGO_REF:0000107
TprRatprotein binding enablesISOTPR (Homo sapiens)1624291UniProtKB:P27361 more ...RGDPMID:12802065 more ...
TprRatprotein binding enablesISOTpr (Mus musculus)1624291UniProtKB:P0DOV2 more ...RGDPMID:12513910 and PMID:26094769
TprRatprotein homodimerization activity enablesISSUniProtKB:P122701600115GO_REF:0000024UniProtGO_REF:0000024
TprRatprotein homodimerization activity enablesISOTPR (Homo sapiens)1624291 PMID:11514627 and PMID:12802065RGDPMID:11514627 and PMID:12802065
TprRatprotein homodimerization activity enablesIEAUniProtKB:P12270 and ensembl:ENSP000003564481600115GO_REF:0000107EnsemblGO_REF:0000107
TprRatprotein-membrane adaptor activity NOT|enablesISSUniProtKB:P122701600115GO_REF:0000024UniProtGO_REF:0000024
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Imported Annotations - KEGG (archival)

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Original Reference(s)
TprRatRNA transport pathway  IEA 6907045 KEGGrno:03013
TprRatthyroid cancer pathway  IEA 6907045 KEGGrno:05216

#
Reference Title
Reference Citation
1. Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export. Frosst P, etal., J Cell Biol. 2002 Feb 18;156(4):617-30. Epub 2002 Feb 11.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:9024684   PMID:9828100   PMID:9864356   PMID:11514627   PMID:11952838   PMID:12424524   PMID:12477932   PMID:12513910   PMID:12802065   PMID:15229283   PMID:15654337   PMID:17098863  
PMID:17897941   PMID:18794356   PMID:18981471   PMID:19273613   PMID:20133940   PMID:20407419   PMID:21613532   PMID:22253824   PMID:22401879   PMID:22658674   PMID:24970816   PMID:31505169  



Tpr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81364,974,419 - 65,037,604 (+)NCBIGRCr8
mRatBN7.21362,424,312 - 62,487,502 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1362,424,312 - 62,487,496 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1365,070,740 - 65,133,881 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01366,341,843 - 66,405,114 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01363,603,135 - 63,666,355 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01367,611,685 - 67,672,833 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1367,611,708 - 67,672,827 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01372,576,506 - 72,637,654 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41364,688,585 - 64,753,555 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11364,702,435 - 64,767,635 (+)NCBI
Celera1362,384,785 - 62,447,122 (+)NCBICelera
Cytogenetic Map13q21NCBI
TPR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381186,311,652 - 186,375,253 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1186,311,652 - 186,375,693 (-)EnsemblGRCh38hg38GRCh38
GRCh371186,280,784 - 186,344,385 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361184,547,407 - 184,611,080 (-)NCBINCBI36Build 36hg18NCBI36
Build 341183,014,615 - 183,076,114NCBI
Celera1159,391,490 - 159,455,165 (-)NCBICelera
Cytogenetic Map1q31.1NCBI
HuRef1157,515,355 - 157,578,976 (-)NCBIHuRef
CHM1_11187,702,490 - 187,766,196 (-)NCBICHM1_1
T2T-CHM13v2.01185,666,310 - 185,729,984 (-)NCBIT2T-CHM13v2.0
Tpr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391150,268,544 - 150,325,686 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1150,268,589 - 150,325,686 (+)EnsemblGRCm39 Ensembl
GRCm381150,392,802 - 150,449,935 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,392,838 - 150,449,935 (+)EnsemblGRCm38mm10GRCm38
MGSCv371152,239,968 - 152,297,065 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361152,155,071 - 152,212,147 (+)NCBIMGSCv36mm8
Celera1152,832,018 - 152,889,087 (+)NCBICelera
Cytogenetic Map1G1NCBI
cM Map163.84NCBI
Tpr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540624,742,525 - 24,805,989 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540624,742,525 - 24,805,989 (-)NCBIChiLan1.0ChiLan1.0
TPR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2163,343,613 - 63,405,202 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1163,025,048 - 63,086,633 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01161,842,037 - 161,903,567 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11165,993,726 - 166,055,223 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1165,993,726 - 166,055,223 (-)Ensemblpanpan1.1panPan2
TPR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1719,376,951 - 19,442,368 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl719,376,975 - 19,442,303 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha718,898,638 - 18,964,055 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0719,112,960 - 19,178,509 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl719,112,979 - 19,179,044 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1719,019,776 - 19,085,277 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0719,129,102 - 19,194,530 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0719,259,646 - 19,325,389 (-)NCBIUU_Cfam_GSD_1.0
Tpr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934486,203,944 - 86,264,933 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364814,050,794 - 4,111,682 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364814,050,693 - 4,111,682 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9127,481,684 - 127,540,398 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19127,481,678 - 127,540,393 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29139,933,094 - 139,992,501 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TPR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12543,056,605 - 43,120,570 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2543,056,886 - 43,123,474 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605544,245,730 - 44,312,643 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248147,249,278 - 7,306,235 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248147,249,379 - 7,306,239 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Tpr
176 total Variants


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
13 62460855 62460856 G C snv ACI/N (2020) View more Information


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
13 67645783 67645784 G C snv ACI/N (2020), ACI/N (MCW) View more Information

Predicted Target Of
Summary Value
Count of predictions:14
Count of miRNA genes:12
Interacting mature miRNAs:14
Transcripts:ENSRNOT00000063833
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 30 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
2303028Bp329Blood pressure QTL 329arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135849787273485113Rat

1 to 10 of 30 rows
RH144043  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21362,476,622 - 62,476,792 (+)MAPPERmRatBN7.2
Rnor_6.01367,661,954 - 67,662,123NCBIRnor6.0
Rnor_5.01372,626,775 - 72,626,944UniSTSRnor5.0
RGSC_v3.41364,742,682 - 64,742,851UniSTSRGSC3.4
Celera1362,436,248 - 62,436,417UniSTS
Cytogenetic Map13q21UniSTS
RH133437  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81365,036,861 - 65,037,503 (+)Marker Load Pipeline
mRatBN7.21362,486,755 - 62,487,397 (+)MAPPERmRatBN7.2
Rnor_6.01367,672,087 - 67,672,728NCBIRnor6.0
Rnor_5.01372,636,908 - 72,637,549UniSTSRnor5.0
RGSC_v3.41364,752,815 - 64,753,456UniSTSRGSC3.4
Celera1362,446,382 - 62,447,023UniSTS
RH 3.4 Map13288.0UniSTS
Cytogenetic Map13q21UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000063833   ⟹   ENSRNOP00000062172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1362,424,312 - 62,487,496 (+)Ensembl
Rnor_6.0 Ensembl1367,611,708 - 67,672,827 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097761   ⟹   ENSRNOP00000094758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1362,424,312 - 62,487,496 (+)Ensembl
RefSeq Acc Id: NM_001107185   ⟹   NP_001100655
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81364,974,419 - 65,037,602 (+)NCBI
mRatBN7.21362,424,312 - 62,487,496 (+)NCBI
Rnor_6.01367,611,708 - 67,672,827 (+)NCBI
Rnor_5.01372,576,506 - 72,637,654 (+)NCBI
RGSC_v3.41364,688,585 - 64,753,555 (+)RGD
Celera1362,384,785 - 62,447,122 (+)RGD
Sequence:
RefSeq Acc Id: XM_017598809   ⟹   XP_017454298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81364,974,444 - 65,037,604 (+)NCBI
mRatBN7.21362,424,334 - 62,487,502 (+)NCBI
Rnor_6.01367,611,685 - 67,672,833 (+)NCBI
Sequence:
Protein RefSeqs NP_001100655 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454298 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI01884 (Get FASTA)   NCBI Sequence Viewer  
  EDM09583 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000062172
  ENSRNOP00000094758
GenBank Protein F1MA98 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001100655   ⟸   NM_001107185
- UniProtKB: Q3T1J7 (UniProtKB/Swiss-Prot),   F1MA98 (UniProtKB/Swiss-Prot),   A0A8L2UNA6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454298   ⟸   XM_017598809
- Peptide Label: isoform X1
- UniProtKB: Q3T1J7 (UniProtKB/Swiss-Prot),   F1MA98 (UniProtKB/Swiss-Prot),   A0A8I6ALQ6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062172   ⟸   ENSRNOT00000063833
Ensembl Acc Id: ENSRNOP00000094758   ⟸   ENSRNOT00000097761
Nucleoprotein TPR/MLP1

Name Modeler Protein Id AA Range Protein Structure
AF-F1MA98-F1-model_v2 AlphaFold F1MA98 1-2360 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698879
Promoter ID:EPDNEW_R9404
Type:initiation region
Name:Tpr_1
Description:translocated promoter region, nuclear basket protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01367,611,656 - 67,611,716EPDNEW


1 to 22 of 22 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-17944 BioCyc
Ensembl Genes ENSRNOG00000002394 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000063833 ENTREZGENE
  ENSRNOT00000097761 ENTREZGENE
Gene3D-CATH 1.10.287.1490 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7929511 IMAGE-MGC_LOAD
InterPro TPR/MLP1 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124665 IMAGE-MGC_LOAD
NCBI Gene 304862 ENTREZGENE
PANTHER NUCLEOPROTEIN TPR UniProtKB/Swiss-Prot
  NUCLEOPROTEIN TPR-RELATED UniProtKB/Swiss-Prot
Pfam TPR_MLP1_2 UniProtKB/Swiss-Prot
PhenoGen Tpr PhenoGen
RatGTEx ENSRNOG00000002394 RatGTEx
UniProt A0A8I6ALQ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UNA6 ENTREZGENE, UniProtKB/TrEMBL
  A6ICR4_RAT UniProtKB/TrEMBL
  F1MA98 ENTREZGENE
  Q3T1J7 ENTREZGENE
  Q80UF5_RAT UniProtKB/TrEMBL
  TPR_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q3T1J7 UniProtKB/Swiss-Prot
1 to 22 of 22 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-16 Tpr  translocated promoter region, nuclear basket protein  Tpr  translocated promoter region (to activated MET oncogene)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-02-02 Tpr  translocated promoter region (to activated MET oncogene)  Tpr  translocated promoter region  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Tpr  translocated promoter region  Tpr_predicted  translocated promoter region (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Tpr_predicted  translocated promoter region (predicted)      Symbol and Name status set to approved 70820 APPROVED