Irf5 (interferon regulatory factor 5) - Rat Genome Database

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Gene: Irf5 (interferon regulatory factor 5) Rattus norvegicus
Analyze
Symbol: Irf5
Name: interferon regulatory factor 5
RGD ID: 1310447
Description: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and protein serine/threonine kinase binding activity. Predicted to be involved in several processes, including cellular response to muramyl dipeptide; positive regulation of macromolecule biosynthetic process; and response to virus. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Biomarker of obstructive jaundice and ureteral obstruction. Human ortholog(s) of this gene implicated in herpes simplex; inflammatory bowel disease 14; multiple sclerosis; rheumatoid arthritis; and systemic lupus erythematosus. Orthologous to human IRF5 (interferon regulatory factor 5); PARTICIPATES IN Toll-like receptor signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC296953
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8459,092,914 - 59,104,596 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl459,081,357 - 59,112,552 (+)EnsemblGRCr8
mRatBN7.2458,127,577 - 58,140,665 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl458,127,640 - 58,139,267 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx463,111,395 - 63,122,649 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0459,027,547 - 59,038,814 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0457,429,439 - 57,440,694 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0456,804,477 - 56,816,271 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl456,805,132 - 56,820,543 (+)Ensemblrn6Rnor6.0
Rnor_5.0456,571,823 - 56,583,434 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4456,407,560 - 56,418,694 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera453,236,000 - 53,247,024 (+)NCBICelera
RGSC_v3.1456,666,980 - 56,677,876 (+)NCBI
Cytogenetic Map4q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
actinomycin D  (ISO)
alpha-phellandrene  (ISO)
amitrole  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
corn oil  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
dexamethasone  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
dimethylarsinic acid  (ISO)
diquat  (ISO)
endosulfan  (EXP)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
menadione  (ISO)
metam  (ISO)
metformin  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
neohesperidin  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrates  (ISO)
Nutlin-3  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
protein kinase inhibitor  (ISO)
resiquimod  (ISO)
rimonabant  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
tamoxifen  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP,ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans. Alzaid F, etal., JCI Insight. 2016 Dec 8;1(20):e88689. doi: 10.1172/jci.insight.88689.
2. Interferon regulatory factor 5 is a potential target of autoimmune response triggered by Epstein-barr virus and Mycobacterium avium subsp. paratuberculosis in rheumatoid arthritis: investigating a mechanism of molecular mimicry. Bo M, etal., Clin Exp Rheumatol. 2018 May-Jun;36(3):376-381. Epub 2018 Jan 15.
3. Antibody response to homologous epitopes of Epstein-Barr virus, Mycobacterium avium subsp. paratuberculosis and IRF5 in patients with different connective tissue diseases and in mouse model of antigen-induced arthritis. Bo M, etal., J Transl Autoimmun. 2020 Mar 17;3:100048. doi: 10.1016/j.jtauto.2020.100048. eCollection 2020.
4. Rheumatoid arthritis patient antibodies highly recognize IL-2 in the immune response pathway involving IRF5 and EBV antigens. Bo M, etal., Sci Rep. 2018 Jan 29;8(1):1789. doi: 10.1038/s41598-018-19957-z.
5. MicroRNA-302a suppresses influenza A virus-stimulated interferon regulatory factor-5 expression and cytokine storm induction. Chen X, etal., J Biol Chem. 2017 Dec 29;292(52):21291-21303. doi: 10.1074/jbc.M117.805937. Epub 2017 Oct 18.
6. Human interferon regulatory factor 5 homologous epitopes of Epstein-Barr virus and Mycobacterium avium subsp. paratuberculosis induce a specific humoral and cellular immune response in multiple sclerosis patients. Cossu D, etal., Mult Scler. 2015 Jul;21(8):984-95. doi: 10.1177/1352458514557304. Epub 2014 Nov 12.
7. IRF-5 Promotes Cell Death in CD4 T Cells during Chronic Infection. Fabié A, etal., Cell Rep. 2018 Jul 31;24(5):1163-1175. doi: 10.1016/j.celrep.2018.06.107.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Glucocorticoid modulates high-mobility group box 1 expression and Toll-like receptor activation in obstructive jaundice. Huang YH, etal., J Surg Res. 2011 Sep;170(1):e47-55. doi: 10.1016/j.jss.2011.05.033. Epub 2011 Jun 15.
11. Sedum sarmentosum Bunge extract alleviates inflammation and kidney injury via inhibition of M1-macrophage polarization. Lu H, etal., Phytomedicine. 2019 Sep;62:152976. doi: 10.1016/j.phymed.2019.152976. Epub 2019 May 31.
12. IRF-5 Expression in Myeloid Cells Is Required for Splenomegaly in L. donovani Infected Mice. Mai LT, etal., Front Immunol. 2020 Jan 21;10:3071. doi: 10.3389/fimmu.2019.03071. eCollection 2019.
13. Microglial P2X4R-evoked pain hypersensitivity is sexually dimorphic in rats. Mapplebeck JCS, etal., Pain. 2018 Sep;159(9):1752-1763. doi: 10.1097/j.pain.0000000000001265.
14. The protective effect of interfering TLR9-IRF5 signaling pathway on the development of CVB3-induced myocarditis. Nie S, etal., Clin Immunol. 2019 Oct;207:24-35. doi: 10.1016/j.clim.2019.07.002. Epub 2019 Jul 4.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. Interferon-Regulatory Factor 5-Dependent Signaling Restricts Orthobunyavirus Dissemination to the Central Nervous System. Proenca-Modena JL, etal., J Virol. 2015 Oct 14;90(1):189-205. doi: 10.1128/JVI.02276-15.
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Interferon regulatory factor 5-dependent immune responses in the draining lymph node protect against West Nile virus infection. Thackray LB, etal., J Virol. 2014 Oct;88(19):11007-21. doi: 10.1128/JVI.01545-14. Epub 2014 Jul 16.
21. Human mesenchymal stem cells modulate inflammatory cytokines after spinal cord injury in rat. Urdzíková LM, etal., Int J Mol Sci. 2014 Jun 25;15(7):11275-93. doi: 10.3390/ijms150711275.
22. Validation of IRF5 as multiple sclerosis risk gene: putative role in interferon beta therapy and human herpes virus-6 infection. Vandenbroeck K, etal., Genes Immun. 2011 Jan;12(1):40-5. doi: 10.1038/gene.2010.46. Epub 2010 Sep 23.
23. Expression Levels of Interferon Regulatory Factor 5 (IRF5) and Related Inflammatory Cytokines Associated with Severity, Prognosis, and Causative Pathogen in Patients with Community-Acquired Pneumonia. Wang X, etal., Med Sci Monit. 2018 May 30;24:3620-3630. doi: 10.12659/MSM.910756.
24. An oligodeoxynucleotide with AAAG repeats significantly attenuates burn-induced systemic inflammatory responses via inhibiting interferon regulatory factor 5 pathway. Xiao Y, etal., Mol Med. 2017 Sep;23:166-176. doi: 10.2119/molmed.2016.00243. Epub 2017 Jun 14.
25. Differences in IP‑10, TLR4 and IRF5/3 between SVR and non‑SVR HCV‑1 patients treated with PEG‑IFN and ribavirin. Zhang M, etal., Mol Med Rep. 2017 Apr;15(4):2318-2324. doi: 10.3892/mmr.2017.6229. Epub 2017 Feb 22.
Additional References at PubMed
PMID:12600985   PMID:18836453   PMID:20451243   PMID:22412986   PMID:23332764   PMID:32406529   PMID:33609602   PMID:34260072   PMID:36088512   PMID:37622691  


Genomics

Comparative Map Data
Irf5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8459,092,914 - 59,104,596 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl459,081,357 - 59,112,552 (+)EnsemblGRCr8
mRatBN7.2458,127,577 - 58,140,665 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl458,127,640 - 58,139,267 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx463,111,395 - 63,122,649 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0459,027,547 - 59,038,814 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0457,429,439 - 57,440,694 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0456,804,477 - 56,816,271 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl456,805,132 - 56,820,543 (+)Ensemblrn6Rnor6.0
Rnor_5.0456,571,823 - 56,583,434 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4456,407,560 - 56,418,694 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera453,236,000 - 53,247,024 (+)NCBICelera
RGSC_v3.1456,666,980 - 56,677,876 (+)NCBI
Cytogenetic Map4q22NCBI
IRF5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387128,937,032 - 128,950,038 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7128,933,429 - 128,950,038 (+)Ensemblhg38GRCh38
GRCh377128,577,086 - 128,590,092 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367128,365,230 - 128,377,325 (+)NCBIBuild 36Build 36hg18NCBI36
Build 347128,172,221 - 128,184,037NCBI
Celera7123,374,509 - 123,386,585 (+)NCBICelera
Cytogenetic Map7q32.1NCBI
HuRef7122,939,186 - 122,951,277 (+)NCBIHuRef
CHM1_17128,511,266 - 128,523,397 (+)NCBICHM1_1
T2T-CHM13v2.07130,249,958 - 130,262,927 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27127,961,737 - 127,973,832 (+)NCBI
Irf5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39629,526,129 - 29,541,874 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl629,526,624 - 29,541,870 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38629,526,130 - 29,541,869 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl629,526,625 - 29,541,871 (+)Ensemblmm10GRCm38
MGSCv37629,476,733 - 29,487,319 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36629,476,743 - 29,487,329 (+)NCBIMGSCv36mm8
Celera629,535,579 - 29,546,163 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.36NCBI
IRF5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26165,742,532 - 165,754,167 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1717,752,862 - 17,764,413 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07120,889,752 - 120,902,096 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17133,415,170 - 133,426,356 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7133,415,170 - 133,426,356 (+)EnsemblpanPan2panpan1.1
IRF5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1147,724,168 - 7,734,976 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl147,724,780 - 7,742,795 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha147,411,116 - 7,421,966 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0147,490,116 - 7,500,966 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl147,489,132 - 7,500,059 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1147,695,157 - 7,706,007 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0147,437,183 - 7,448,035 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0147,582,360 - 7,592,901 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Irf5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511826,005,766 - 26,016,934 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365796,138,281 - 6,145,205 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365796,138,372 - 6,149,531 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRF5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1819,678,687 - 19,691,243 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11819,678,377 - 19,691,154 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21820,748,271 - 20,760,087 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IRF5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12197,536,803 - 97,549,576 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2197,537,790 - 97,549,945 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660425,852,040 - 5,864,687 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irf5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247837,260,005 - 7,274,433 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247837,267,680 - 7,275,918 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Irf5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16110,028,144 - 110,038,781 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Irf5
57 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:360
Count of miRNA genes:217
Interacting mature miRNAs:254
Transcripts:ENSRNOT00000010001
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41564430960644309Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)44049044275726188Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45808014680212111Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41890069763900697Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)44047145375939996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42228845363245191Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)41890069763900697Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41891315163913151Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42786220462997402Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42192515166925151Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat

Markers in Region
RH128447  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8459,108,456 - 59,108,665 (+)Marker Load Pipeline
mRatBN7.2458,143,127 - 58,143,336 (+)MAPPERmRatBN7.2
Rnor_6.0456,820,132 - 56,820,340NCBIRnor6.0
Rnor_5.0456,587,293 - 56,587,501UniSTSRnor5.0
RGSC_v3.4456,422,555 - 56,422,763UniSTSRGSC3.4
Celera453,250,885 - 53,251,093UniSTS
RH 3.4 Map4303.02UniSTS
Cytogenetic Map4q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC095491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW395567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000010001   ⟹   ENSRNOP00000010001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl459,096,336 - 59,104,609 (+)Ensembl
mRatBN7.2 Ensembl458,128,103 - 58,139,267 (+)Ensembl
Rnor_6.0 Ensembl456,805,132 - 56,816,271 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085483   ⟹   ENSRNOP00000069195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl459,085,702 - 59,104,609 (+)Ensembl
mRatBN7.2 Ensembl458,127,640 - 58,138,986 (+)Ensembl
Rnor_6.0 Ensembl456,805,158 - 56,820,543 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096658   ⟹   ENSRNOP00000076407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl459,081,357 - 59,104,609 (+)Ensembl
mRatBN7.2 Ensembl458,131,640 - 58,138,986 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000135232   ⟹   ENSRNOP00000109028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl459,092,952 - 59,105,533 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000168534   ⟹   ENSRNOP00000100832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl459,093,409 - 59,112,552 (+)Ensembl
RefSeq Acc Id: NM_001106586   ⟹   NP_001100056
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8459,093,455 - 59,104,596 (+)NCBI
mRatBN7.2458,128,103 - 58,139,267 (+)NCBI
Rnor_6.0456,805,132 - 56,816,271 (+)NCBI
Rnor_5.0456,571,823 - 56,583,434 (+)NCBI
RGSC_v3.4456,407,560 - 56,418,694 (+)RGD
Celera453,236,000 - 53,247,024 (+)RGD
Sequence:
RefSeq Acc Id: XM_006236184   ⟹   XP_006236246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8459,093,405 - 59,104,314 (+)NCBI
mRatBN7.2458,128,053 - 58,140,665 (+)NCBI
Rnor_6.0456,805,102 - 56,816,271 (+)NCBI
Rnor_5.0456,571,823 - 56,583,434 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236185   ⟹   XP_006236247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8459,094,552 - 59,104,314 (+)NCBI
mRatBN7.2458,128,956 - 58,140,665 (+)NCBI
Rnor_6.0456,805,218 - 56,816,271 (+)NCBI
Rnor_5.0456,571,823 - 56,583,434 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762765   ⟹   XP_008760987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8459,092,914 - 59,104,314 (+)NCBI
mRatBN7.2458,127,577 - 58,140,665 (+)NCBI
Rnor_6.0456,804,700 - 56,816,271 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107277   ⟹   XP_038963205
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8459,093,086 - 59,104,314 (+)NCBI
mRatBN7.2458,127,735 - 58,140,665 (+)NCBI
RefSeq Acc Id: XM_039107278   ⟹   XP_038963206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8459,095,901 - 59,104,314 (+)NCBI
mRatBN7.2458,130,552 - 58,140,665 (+)NCBI
RefSeq Acc Id: XM_063285738   ⟹   XP_063141808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8459,092,980 - 59,104,314 (+)NCBI
RefSeq Acc Id: NP_001100056   ⟸   NM_001106586
- UniProtKB: D3ZPU1 (UniProtKB/TrEMBL),   A6IEE2 (UniProtKB/TrEMBL),   A0A8I5YBA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236246   ⟸   XM_006236184
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006236247   ⟸   XM_006236185
- Peptide Label: isoform X4
- UniProtKB: A0A8I5YBA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760987   ⟸   XM_008762765
- Peptide Label: isoform X4
- UniProtKB: A0A8I5YBA0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010001   ⟸   ENSRNOT00000010001
Ensembl Acc Id: ENSRNOP00000069195   ⟸   ENSRNOT00000085483
RefSeq Acc Id: XP_038963205   ⟸   XM_039107277
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JUR2 (UniProtKB/TrEMBL),   A0A8I5YBA0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963206   ⟸   XM_039107278
- Peptide Label: isoform X2
- UniProtKB: A0A8I5YBA0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000076407   ⟸   ENSRNOT00000096658
RefSeq Acc Id: XP_063141808   ⟸   XM_063285738
- Peptide Label: isoform X3
- UniProtKB: A0A8I5YBA0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000100832   ⟸   ENSRNOT00000168534
Ensembl Acc Id: ENSRNOP00000109028   ⟸   ENSRNOT00000135232
Protein Domains
IRF tryptophan pentad repeat

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZPU1-F1-model_v2 AlphaFold D3ZPU1 1-497 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692926
Promoter ID:EPDNEW_R3451
Type:multiple initiation site
Name:Irf5_1
Description:interferon regulatory factor 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0456,805,134 - 56,805,194EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310447 AgrOrtholog
BioCyc Gene G2FUF-45390 BioCyc
Ensembl Genes ENSRNOG00000007437 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010001 ENTREZGENE
  ENSRNOT00000010001.8 UniProtKB/TrEMBL
  ENSRNOT00000085483 ENTREZGENE
  ENSRNOT00000085483.3 UniProtKB/TrEMBL
  ENSRNOT00000096658.2 UniProtKB/TrEMBL
  ENSRNOT00000135232 ENTREZGENE
  ENSRNOT00000135232.1 UniProtKB/TrEMBL
  ENSRNOT00000168534 ENTREZGENE
  ENSRNOT00000168534.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  2.60.200.10 UniProtKB/TrEMBL
InterPro Interferon_reg_fac_CS UniProtKB/TrEMBL
  Interferon_reg_factor UniProtKB/TrEMBL
  Interferon_reg_factor-3 UniProtKB/TrEMBL
  SMAD_dom-like UniProtKB/TrEMBL
  SMAD_FHA_domain UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:296953 UniProtKB/TrEMBL
NCBI Gene 296953 ENTREZGENE
PANTHER INTERFERON REGULATORY FACTOR UniProtKB/TrEMBL
  PTHR11949:SF10 UniProtKB/TrEMBL
Pfam IRF UniProtKB/TrEMBL
  IRF-3 UniProtKB/TrEMBL
PhenoGen Irf5 PhenoGen
PRINTS INTFRNREGFCT UniProtKB/TrEMBL
PROSITE IRF UniProtKB/TrEMBL
  IRF_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007437 RatGTEx
SMART IRF UniProtKB/TrEMBL
  IRF-3 UniProtKB/TrEMBL
Superfamily-SCOP SMAD_FHA UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
UniProt A0A0G2JUR2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8A1UD83_RAT UniProtKB/TrEMBL
  A0A8A1UFN5_RAT UniProtKB/TrEMBL
  A0A8A1UJ87_RAT UniProtKB/TrEMBL
  A0A8I5YBA0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LKP1_RAT UniProtKB/TrEMBL
  A0ABK0M553_RAT UniProtKB/TrEMBL
  A6IEE2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZPU1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Irf5  interferon regulatory factor 5   Irf5_predicted  interferon regulatory factor 5 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Irf5_predicted  interferon regulatory factor 5 (predicted)      Symbol and Name status set to approved 70820 APPROVED