Fa2h (fatty acid 2-hydroxylase) - Rat Genome Database

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Gene: Fa2h (fatty acid 2-hydroxylase) Rattus norvegicus
Analyze
Symbol: Fa2h
Name: fatty acid 2-hydroxylase
RGD ID: 1310347
Description: Enables fatty acid 2-hydroxylase activity. Involved in galactosylceramide biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 35. Orthologous to human FA2H (fatty acid 2-hydroxylase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: fatty acid alpha-hydroxylase; LOC307855; RGD1310347; similar to RIKEN cDNA 5430401O09 gene; WD repeat domain 59; Wdr59
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81956,222,240 - 56,273,480 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1956,222,242 - 56,273,623 (-)EnsemblGRCr8
mRatBN7.21939,312,904 - 39,364,153 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1939,312,906 - 39,364,153 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1946,117,440 - 46,168,745 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01946,770,768 - 46,822,076 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01949,070,937 - 49,122,203 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01943,545,380 - 43,596,788 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1943,545,378 - 43,596,801 (-)Ensemblrn6Rnor6.0
Rnor_5.01954,355,770 - 54,407,097 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41941,268,120 - 41,319,682 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1938,700,320 - 38,749,569 (-)NCBICelera
RGSC_v3.11941,275,527 - 41,460,325 (-)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
choline  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dimethylarsinous acid  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
GW 4064  (ISO)
GW 7647  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
rac-lactic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
titanium dioxide  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. FA2H is responsible for the formation of 2-hydroxy galactolipids in peripheral nervous system myelin. Maldonado EN, etal., J Lipid Res. 2008 Jan;49(1):153-61. doi: 10.1194/jlr.M700400-JLR200. Epub 2007 Sep 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:15337768   PMID:15489334   PMID:15658937   PMID:15863841   PMID:16998236   PMID:17355976   PMID:18815260   PMID:21491498   PMID:21628453   PMID:22517924  


Genomics

Comparative Map Data
Fa2h
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81956,222,240 - 56,273,480 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1956,222,242 - 56,273,623 (-)EnsemblGRCr8
mRatBN7.21939,312,904 - 39,364,153 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1939,312,906 - 39,364,153 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1946,117,440 - 46,168,745 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01946,770,768 - 46,822,076 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01949,070,937 - 49,122,203 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01943,545,380 - 43,596,788 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1943,545,378 - 43,596,801 (-)Ensemblrn6Rnor6.0
Rnor_5.01954,355,770 - 54,407,097 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41941,268,120 - 41,319,682 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1938,700,320 - 38,749,569 (-)NCBICelera
RGSC_v3.11941,275,527 - 41,460,325 (-)NCBI
Cytogenetic Map19q12NCBI
FA2H
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381674,712,969 - 74,774,820 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1674,712,955 - 74,774,837 (-)Ensemblhg38GRCh38
GRCh371674,746,867 - 74,808,718 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361673,304,359 - 73,366,224 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341673,304,358 - 73,366,222NCBI
Celera1659,039,540 - 59,101,413 (-)NCBICelera
Cytogenetic Map16q23.1NCBI
HuRef1660,496,759 - 60,558,638 (-)NCBIHuRef
CHM1_11676,159,142 - 76,220,992 (-)NCBICHM1_1
T2T-CHM13v2.01680,759,709 - 80,821,550 (-)NCBIT2T-CHM13v2.0
Fa2h
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398112,071,770 - 112,120,453 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8112,071,767 - 112,120,456 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388111,345,138 - 111,393,821 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8111,345,135 - 111,393,824 (-)Ensemblmm10GRCm38
MGSCv378113,869,038 - 113,917,721 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368114,231,814 - 114,280,488 (-)NCBIMGSCv36mm8
Celera8115,571,613 - 115,620,271 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map857.98NCBI
Fa2h
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554842,726,362 - 2,775,903 (+)Ensembl
ChiLan1.0NW_0049554842,726,496 - 2,775,763 (+)NCBIChiLan1.0ChiLan1.0
FA2H
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21884,427,208 - 84,488,814 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11690,349,280 - 90,410,924 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01655,278,769 - 55,340,332 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11674,632,161 - 74,693,710 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1674,632,179 - 74,693,710 (-)EnsemblpanPan2panpan1.1
FA2H
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1575,878,539 - 75,923,886 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl575,878,243 - 75,948,094 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha575,854,248 - 75,930,177 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0576,234,701 - 76,310,974 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl576,234,701 - 76,304,198 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1576,137,818 - 76,213,734 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0575,960,777 - 76,036,528 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0576,452,798 - 76,528,826 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fa2h
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934935,913,903 - 35,964,152 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647523,624,969 - 23,675,235 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647523,625,023 - 23,675,211 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FA2H
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl612,855,421 - 12,910,818 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1612,855,330 - 12,910,821 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2612,797,906 - 12,853,541 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FA2H
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1552,930,289 - 52,993,751 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl552,930,833 - 52,992,499 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604715,810,775 - 15,873,476 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fa2h
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474612,125,506 - 12,186,671 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474612,125,709 - 12,186,254 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fa2h
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11731,043,207 - 31,093,673 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fa2h
194 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:511
Count of miRNA genes:244
Interacting mature miRNAs:290
Transcripts:ENSRNOT00000025625
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
D19Rat69  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81956,258,204 - 56,258,405 (+)Marker Load Pipeline
mRatBN7.21939,348,870 - 39,349,071 (+)MAPPERmRatBN7.2
Rnor_6.01943,581,528 - 43,581,728NCBIRnor6.0
Rnor_5.01954,391,918 - 54,392,118UniSTSRnor5.0
RGSC_v3.41941,304,084 - 41,304,284UniSTSRGSC3.4
RGSC_v3.41941,304,016 - 41,304,337RGDRGSC3.4
Celera1938,734,265 - 38,734,461UniSTS
RGSC_v3.11941,308,965 - 41,309,165RGD
RH 3.4 Map19483.9RGD
RH 3.4 Map19483.9UniSTS
RH 2.0 Map19540.3RGD
SHRSP x BN Map1928.8998RGD
Cytogenetic Map19q12UniSTS
RH144444  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21939,313,287 - 39,313,528 (+)MAPPERmRatBN7.2
Rnor_6.01943,545,764 - 43,546,004NCBIRnor6.0
Rnor_5.01954,356,154 - 54,356,394UniSTSRnor5.0
RGSC_v3.41941,268,504 - 41,268,744UniSTSRGSC3.4
Celera1938,700,704 - 38,700,944UniSTS
RH 3.4 Map19485.8UniSTS
Cytogenetic Map19q12UniSTS
BE110252  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21939,320,478 - 39,320,636 (+)MAPPERmRatBN7.2
Rnor_6.01943,552,955 - 43,553,112NCBIRnor6.0
Rnor_5.01954,363,345 - 54,363,502UniSTSRnor5.0
RGSC_v3.41941,275,695 - 41,275,852UniSTSRGSC3.4
Celera1938,706,365 - 38,706,522UniSTS
RH 3.4 Map19485.4UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 12 55 124 55 51 27 29 27 6 244 113 9 106 81 89 24 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000025625   ⟹   ENSRNOP00000025625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1956,222,242 - 56,273,623 (-)Ensembl
mRatBN7.2 Ensembl1939,312,906 - 39,364,153 (-)Ensembl
Rnor_6.0 Ensembl1943,545,378 - 43,596,801 (-)Ensembl
RefSeq Acc Id: NM_001135583   ⟹   NP_001129055
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81956,222,240 - 56,273,480 (-)NCBI
mRatBN7.21939,312,904 - 39,364,153 (-)NCBI
Rnor_6.01943,545,380 - 43,596,788 (-)NCBI
Rnor_5.01954,355,770 - 54,407,097 (-)NCBI
RGSC_v3.41941,268,120 - 41,319,682 (-)RGD
Celera1938,700,320 - 38,749,569 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001129055 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABC71132 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025625
  ENSRNOP00000025625.5
GenBank Protein Q2LAM0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001129055   ⟸   NM_001135583
- UniProtKB: Q2LAM0 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025625   ⟸   ENSRNOT00000025625
Protein Domains
Cytochrome b5 heme-binding   Fatty acid hydroxylase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2LAM0-F1-model_v2 AlphaFold Q2LAM0 1-372 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701147
Promoter ID:EPDNEW_R11671
Type:initiation region
Name:Fa2h_1
Description:fatty acid 2-hydroxylase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01943,596,785 - 43,596,845EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310347 AgrOrtholog
BioCyc Gene G2FUF-5653 BioCyc
BioCyc Pathway PWY66-388 [ceramide degradation by alpha-oxidation] BioCyc
BioCyc Pathway Image PWY66-388 BioCyc
Ensembl Genes ENSRNOG00000018950 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025625 ENTREZGENE
  ENSRNOT00000025625.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.120.10 UniProtKB/Swiss-Prot
InterPro Cyt_B5-like_heme/steroid-bd UniProtKB/Swiss-Prot
  Cyt_B5-like_heme/steroid_sf UniProtKB/Swiss-Prot
  Cyt_B5_heme-BS UniProtKB/Swiss-Prot
  Fatty_acid_hydroxylase UniProtKB/Swiss-Prot
  Scs7 UniProtKB/Swiss-Prot
KEGG Report rno:307855 UniProtKB/Swiss-Prot
NCBI Gene 307855 ENTREZGENE
PANTHER FATTY ACID 2-HYDROXYLASE UniProtKB/Swiss-Prot
  PTHR12863 UniProtKB/Swiss-Prot
Pfam Cyt-b5 UniProtKB/Swiss-Prot
  FA_hydroxylase UniProtKB/Swiss-Prot
PhenoGen Fa2h PhenoGen
PIRSF IPC-B_HD UniProtKB/Swiss-Prot
PRINTS CYTOCHROMEB5 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_B5_1 UniProtKB/Swiss-Prot
  CYTOCHROME_B5_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018950 RatGTEx
SMART Cyt-b5 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55856 UniProtKB/Swiss-Prot
UniProt FA2H_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Fa2h  fatty acid 2-hydroxylase  LOC688373  similar to fatty acid 2-hydroxylase  Data merged from RGD:1590002 1643240 APPROVED
2007-12-12 Fa2h  fatty acid 2-hydroxylase  Wdr59  WD repeat domain 59  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2006-11-20 LOC688373  similar to fatty acid 2-hydroxylase      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Wdr59  WD repeat domain 59  RGD1310347  similar to RIKEN cDNA 5430401O09 gene  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1310347  similar to RIKEN cDNA 5430401O09 gene  RGD1310347_predicted  similar to RIKEN cDNA 5430401O09 gene (predicted)  Symbol and Name status set to approved 1299863 APPROVED
2005-01-20 RGD1310347_predicted  similar to RIKEN cDNA 5430401O09 gene (predicted)  LOC307855_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC307855_predicted  similar to RIKEN cDNA 5430401O09 gene (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL