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Gene: Sec22b (SEC22 homolog B, vesicle trafficking protein) Rattus norvegicus

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Symbol:

Sec22b

Name:

SEC22 homolog B, vesicle trafficking protein

RGD ID:

1309988

Description:

Enables syntaxin binding activity. Predicted to be involved in Golgi vesicle transport; negative regulation of autophagosome assembly; and positive regulation of protein catabolic process. Predicted to act upstream of or within vesicle-mediated transport. Located in COPI-coated vesicle. Part of SNARE complex. Is active in synaptic vesicle. Orthologous to human SEC22B (SEC22 homolog B, vesicle trafficking protein); PARTICIPATES IN phagocytosis pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 3,4-methylenedioxymethamphetamine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

ER-Golgi SNARE of 24 kDa; ERS-24; ERS24; LOC310710; MGC112717; SEC22 vesicle trafficking protein homolog B; SEC22 vesicle trafficking protein homolog B (S. cerevisiae); SEC22 vesicle trafficking protein-like 1 (S. cerevisiae); SEC22 vesicle-trafficking protein homolog B; SEC22 vesicle-trafficking protein-like 1; Sec22l1; vesicle-trafficking protein SEC22b

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	188,188,783 - 188,209,565 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	188,188,751 - 188,211,600 (+)	Ensembl				GRCr8
mRatBN7.2	2	185,500,029 - 185,520,811 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	185,500,004 - 185,522,026 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	193,147,655 - 193,169,369 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	190,956,128 - 190,977,833 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	185,780,242 - 185,801,956 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	200,076,079 - 200,096,861 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	200,076,054 - 200,098,076 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	219,551,836 - 219,572,618 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	192,743,195 - 192,763,977 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	177,991,104 - 178,011,886 (+)	NCBI		Celera
RGSC_v3.1	2	192,705,948 - 192,726,731 (+)	NCBI
Cytogenetic Map	2	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

3,4-methylenedioxymethamphetamine (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (EXP)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

buspirone (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbon nanotube (ISO)

clofibrate (ISO)

cyclosporin A (ISO)

cyproconazole (ISO)

decabromodiphenyl ether (ISO)

dexamethasone (ISO)

dicrotophos (ISO)

diethylstilbestrol (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

glafenine (EXP)

hexadecanoic acid (ISO)

indometacin (ISO)

ivermectin (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methylmercury chloride (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodiethylamine (EXP)

nitrates (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pinosylvin (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

SB 431542 (ISO)

selenium atom (ISO)

sodium arsenate (ISO)

sodium arsenite (EXP,ISO)

Soman (EXP)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

trans-pinosylvin (ISO)

triticonazole (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

endoplasmic reticulum to Golgi vesicle-mediated transport (IBA,IEA)

negative regulation of autophagosome assembly (ISO)

positive regulation of protein catabolic process (ISO)

protein transport (IEA)

retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum (IBA,IEA)

vesicle fusion with Golgi apparatus (IBA)

vesicle-mediated transport (IEA,ISO)

Cellular Component

COPI-coated vesicle (IDA)

cytoplasm (IEA)

endomembrane system (IEA)

endoplasmic reticulum membrane (IBA,IEA,ISO)

endoplasmic reticulum-Golgi intermediate compartment (ISO)

endoplasmic reticulum-Golgi intermediate compartment membrane (IEA)

ER to Golgi transport vesicle membrane (IBA,ISO)

Golgi apparatus (IEA)

Golgi membrane (IBA,IEA,ISO)

melanosome (IEA)

membrane (IEA)

SNARE complex (IBA,IDA)

synaptic vesicle (EXP,IDA)

Molecular Function

protein binding (ISO)

SNAP receptor activity (IBA,IEA)

syntaxin binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

phagocytosis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Syntaxin 17 is abundant in steroidogenic cells and implicated in smooth endoplasmic reticulum membrane dynamics.	Steegmaier M, etal., Mol Biol Cell. 2000 Aug;11(8):2719-31.
8.	Molecular anatomy of a trafficking organelle.	Takamori S, etal., Cell. 2006 Nov 17;127(4):831-46.
9.	Members of a mammalian SNARE complex interact in the endoplasmic reticulum in vivo and are found in COPI vesicles.	Verrier SE, etal., Eur J Cell Biol. 2008 Nov;87(11):863-78. doi: 10.1016/j.ejcb.2008.07.003. Epub 2008 Oct 1.

Additional References at PubMed

PMID:9094723	PMID:11035026	PMID:11042173	PMID:12477932	PMID:14742712	PMID:15308636	PMID:15489334	PMID:17499046	PMID:18504258	PMID:21242315	PMID:21700703	PMID:24625528
PMID:33186631	PMID:33450132

Genomics

Comparative Map Data

Sec22b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	188,188,783 - 188,209,565 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	188,188,751 - 188,211,600 (+)	Ensembl				GRCr8
mRatBN7.2	2	185,500,029 - 185,520,811 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	185,500,004 - 185,522,026 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	193,147,655 - 193,169,369 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	190,956,128 - 190,977,833 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	185,780,242 - 185,801,956 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	200,076,079 - 200,096,861 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	200,076,054 - 200,098,076 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	219,551,836 - 219,572,618 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	192,743,195 - 192,763,977 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	177,991,104 - 178,011,886 (+)	NCBI		Celera
RGSC_v3.1	2	192,705,948 - 192,726,731 (+)	NCBI
Cytogenetic Map	2	q34	NCBI

SEC22B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	120,150,898 - 120,176,520 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	120,150,898 - 120,176,520 (-)	Ensembl			hg38	GRCh38
GRCh37	1	120,693,460 - 120,697,156 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	143,807,764 - 143,828,279 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	142,585,471 - 142,606,033	NCBI
Cytogenetic Map	1	p12	NCBI
CHM1_1	1	120,814,032 - 120,834,611 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	120,164,165 - 120,189,787 (-)	NCBI		T2T-CHM13v2.0

Sec22b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	97,808,543 - 97,829,634 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	97,808,506 - 97,830,592 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	97,901,227 - 97,922,318 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	97,901,190 - 97,923,276 (+)	Ensembl			mm10	GRCm38
MGSCv37	3	97,705,150 - 97,726,241 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	97,986,632 - 98,007,723 (+)	NCBI		MGSCv36	mm8
Celera	3	99,300,229 - 99,321,320 (+)	NCBI		Celera
Cytogenetic Map	3	F2.2	NCBI
cM Map	3	42.35	NCBI

Sec22b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955568	1,559,452 - 1,587,782 (+)	Ensembl
ChiLan1.0	NW_004955568	1,559,519 - 1,587,782 (+)	NCBI	ChiLan1.0	ChiLan1.0

SEC22B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	112,798,509 - 112,819,801 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	112,400,981 - 112,422,292 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	82,383,313 - 82,404,612 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

SEC22B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	57,094,038 - 57,115,891 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	57,053,218 - 57,115,886 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	56,732,928 - 56,754,271 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	57,974,306 - 57,996,180 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
UMICH_Zoey_3.1	17	56,998,099 - 57,020,005 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	57,034,820 - 57,056,678 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	57,682,634 - 57,704,489 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Sec22b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	2,791,486 - 2,844,458 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936872	294,066 - 313,293 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936872	294,116 - 313,893 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SEC22B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	100,880,937 - 100,905,993 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	100,880,843 - 100,900,942 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	110,848,659 - 110,868,687 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SEC22B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	13,602,852 - 13,624,483 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	13,602,870 - 13,622,650 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	16,237,498 - 16,259,142 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sec22b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624772	15,803,369 - 15,833,968 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624772	15,800,793 - 15,833,453 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Sec22b
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	59,388,779 - 59,410,930 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Sec22b
139 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	222
Count of miRNA genes:	139
Interacting mature miRNAs:	178
Transcripts:	ENSRNOT00000025327
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	163997722	225110681	Rat
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	169358774	214358774	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170656145	239614549	Rat
631566	Bp90	Blood pressure QTL 90		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	149957381	221199885	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845370	229470703	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83465462	229820014	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	138595962	205135428	Rat
1581576	Pur7	Proteinuria QTL 7		0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	80396178	220931218	Rat
152025245	Scl81	Serum cholesterol level QTL 81	3.49		blood cholesterol amount (VT:0000180)		2	124537199	209621565	Rat
1581578	Cm49	Cardiac mass QTL 49	4.9	0.01	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	145807215	220931416	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	78269809	208420281	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	122597372	215234002	Rat
12879836	Kidm61	Kidney mass QTL 61		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	154723085	199723085	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	80396178	220931218	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	145807215	190807215	Rat
12879837	Am2	Aortic mass QTL 2		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	154723085	199723085	Rat
10043139	Iddm55	Insulin dependent diabetes mellitus QTL 55	3.1	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	150313808	195313808	Rat
12879838	Cm86	Cardiac mass QTL 86		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	154723085	199723085	Rat
1302793	Bw16	Body weight QTL 16	5	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	2	159440891	205135267	Rat
12879839	Cm85	Cardiac mass QTL 85		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	154723085	199723085	Rat
1549833	Bp257	Blood pressure QTL 257		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170652929	215652929	Rat
1358900	Bw48	Body weight QTL 48	4.88		body mass (VT:0001259)	body weight (CMO:0000012)	2	159440891	220931218	Rat
4889834	Pur24	Proteinuria QTL 24	5.8	0.014	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	171994826	205135428	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	143565208	188565208	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
12879840	Bw179	Body weight QTL 179		0.005	body mass (VT:0001259)	body weight (CMO:0000012)	2	154723085	199723085	Rat
1581502	Esta3	Estrogen-induced thymic atrophy QTL 3			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	139067258	192287892	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	184856304	229856304	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	184856304	229856304	Rat
1359032	Hrtrt18	Heart rate QTL 18			heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	159440760	195313808	Rat
2301966	Bp322	Blood pressure QTL 322	3.58		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	144882354	205135428	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845182	205135428	Rat
1357991	Ael2	Aortic elastin QTL 2	4.2	0.000071	aorta elastin amount (VT:0003905)	aortic elastin	2	169227906	214227906	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	83400752	223709938	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	184856304	229856304	Rat
1578671	Bmd10	Bone mineral density QTL 10	5.4		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	2	175931416	220931416	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	251712708	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	80396034	220931416	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	78269809	205135428	Rat
2300189	Bmd48	Bone mineral density QTL 48	5.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	182024327	227024327	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	159440760	228950743	Rat
2301408	Kidm36	Kidney mass QTL 36		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	184482291	229482291	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	143344967	251712708	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	143746578	205135428	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	143344967	251712708	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	114384617	215381366	Rat
1598805	Memor8	Memory QTL 8	3		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	150096616	195096616	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
724568	Uae13	Urinary albumin excretion QTL 13	4.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	2	145306936	212705578	Rat
7488929	Bp366	Blood pressure QTL 366		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	187663373	195783351	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	113746222	205135428	Rat
738013	Alc15	Alcohol consumption QTL 15	4.1	0.00022	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	2	186850607	231850607	Rat
61401	Niddm2	Non-insulin dependent diabetes mellitus QTL 2	4.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	147287892	192287892	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	114384617	215381366	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	223841096	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	117415288	205135428	Rat
1598833	Bp295	Blood pressure QTL 295	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150096616	195096616	Rat
61417	Cia10	Collagen induced arthritis QTL 10	3.4		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	2	182635347	227635347	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	83465462	225110681	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	47856345	205135428	Rat
631522	Bp74	Blood pressure QTL 74		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	175008837	220008837	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	184856304	229856304	Rat
7488927	Bp365	Blood pressure QTL 365		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	165453811	210453811	Rat
7488925	Bp364	Blood pressure QTL 364		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	163253030	208253030	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	166372086	229820014	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	76328396	209350714	Rat

Markers in Region

RH127609

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	185,520,490 - 185,520,677 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	200,096,541 - 200,096,727	NCBI	Rnor6.0
Rnor_5.0	2	219,572,298 - 219,572,484	UniSTS	Rnor5.0
RGSC_v3.4	2	192,763,657 - 192,763,843	UniSTS	RGSC3.4
Celera	2	178,011,566 - 178,011,752	UniSTS
RH 3.4 Map	2	1251.8	UniSTS
Cytogenetic Map	2	q34	UniSTS

RH129053

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	185,521,828 - 185,522,014 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	200,097,879 - 200,098,064	NCBI	Rnor6.0
Rnor_5.0	2	219,573,636 - 219,573,821	UniSTS	Rnor5.0
RGSC_v3.4	2	192,764,995 - 192,765,180	UniSTS	RGSC3.4
Celera	2	178,012,904 - 178,013,089	UniSTS
RH 3.4 Map	2	1253.3	UniSTS
Cytogenetic Map	2	q34	UniSTS

RH142986

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	185,501,419 - 185,501,537 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	200,077,470 - 200,077,587	NCBI	Rnor6.0
Rnor_5.0	2	219,553,227 - 219,553,344	UniSTS	Rnor5.0
RGSC_v3.4	2	192,744,586 - 192,744,703	UniSTS	RGSC3.4
Celera	2	177,992,495 - 177,992,612	UniSTS
RH 3.4 Map	2	1255.3	UniSTS
Cytogenetic Map	2	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025686	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC129357	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098725	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211503	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000025327 ⟹ ENSRNOP00000025327

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	188,188,751 - 188,211,600 (+)	Ensembl
mRatBN7.2 Ensembl	2	185,500,004 - 185,522,026 (+)	Ensembl
Rnor_6.0 Ensembl	2	200,076,054 - 200,098,076 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000093465

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	2	200,082,201 - 200,090,038 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099730 ⟹ ENSRNOP00000087902

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	185,500,050 - 185,520,807 (+)	Ensembl

RefSeq Acc Id:

NM_001025686 ⟹ NP_001020857

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	188,188,783 - 188,209,565 (+)	NCBI
mRatBN7.2	2	185,500,029 - 185,520,811 (+)	NCBI
Rnor_6.0	2	200,076,079 - 200,096,861 (+)	NCBI
Rnor_5.0	2	219,551,836 - 219,572,618 (+)	NCBI
RGSC_v3.4	2	192,743,195 - 192,763,977 (+)	RGD
Celera	2	177,991,104 - 178,011,886 (+)	RGD

Sequence:

show sequence

GCGGCCAGCAGCTAGTTGTTGGAGACCTCAGCTGGAGGTGTAACTGGCCACCGCGGGAGAAGAA
GGGGCAGTGACTGAGGCGGCCGGGTCTCCGTAGCCAGGGAAGATGGTGCTGCTGACGATGATCG
CCCGCGTAGCGGACGGGCTTCCTCTGGCCGCCTCGATGCAGGAGGACGAGCAGTCAGGCCGGGA
CCTTCAGCAGTATCAGAGTCAGGCTAAGCAACTCTTTCGAAAGTTGAATGAACAGTCCCCTACC
AGATGTACCTTGGAAGCAGGAGCCATGACTTTTCACTACATTATTGAGCAGGGGGTGTGTTACT
TGGTTTTGTGTGAAGCTGCCTTCCCTAAGAAGTTGGCCTTTGCCTACCTAGAAGACTTGCACTC
GGAATTTGACGAGCAGCATGGGAAGAAGGTGCCCACTGTGTCTAGGCCCTATTCCTTCATCGAG
TTTGACACCTTCATTCAGAAGACCAAGAAACTCTACATTGATAGCCGTGCTCGGAGAAATCTCG
GCTCCATCAACACCGAATTGCAAGATGTGCAGAGGATCATGGTGGCGAATATTGAAGAAGTCCT
ACAGCGGGGAGAAGCACTCTCAGCATTGGATTCGAAGGCTAACAATTTGTCCAGTCTATCTAAG
AAATACCGCCAGGATGCGAAGTACCTGAACATGCGTTCCACCTACGCCAAGCTTGCAGCAGTAG
CCGTGTTCTTCATCATGCTGATAGTGTATGTGCGGTTTTGGTGGCTGTGAGATAGTGAAGCCTC
GTCACTAGTAAGGGAGAACCTAGAACCCAGCAGGTGTATGTTTTCAGGAAACTGAGCTCACAGG
GCTGTGTGTTAGAACCCAAGTGGAACTTCTGCCTCTAAAGACCTTGCAAGAAAAGACCTGTCCT
GAAATGAAAGATGGCGCCTCGTTTAAGGAAGCTTGACCCATGTGGATGTCTCCGGGGCAGAGAC
CTTCTCTGGGTGCTAAGCCATATGTATTAGGGAACAGTAGGTTGTCTGTTTTGTTTCTTCCCTC
CCCAGTACATTTGTGAGACAGCAGAGATGGGGCGGTCTCTCTGATGGAGCCATCAGTGAGATTT
AAGGTAGCCAACCCATTCTAGCAGCATCCTGAAATTCTGTCAGAGTTTCCCTTTGGGGAGTCCT
AACCTTAATCGACATTCCTTTGTTGGTTACATGTGTGATTAACTTTCAAGTAAGACTCAAAGTA
TGTGAAGGTTAATTGCTTCGGTGCACAGGTCCTGTGTGTTGGCCGCTGTAGGAAGTTAACTTTT
GTTTTTTGTTTTTTTTTCTTTTATATTTTGCTTATTGCACAGTTGCTTTGGAATTAAATCAATT
ATATTAATATGCCTTGAAATTATATAGTATTGCTTGACTAAAAGGATGAATTTTTTTCTGTCAT
TTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001020857	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98725	(Get FASTA)	NCBI Sequence Viewer
	EDL85575	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000025327
	ENSRNOP00000025327.4
GenBank Protein	Q4KM74	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001020857 ⟸ NM_001025686

- UniProtKB:

Q4KM74 (UniProtKB/Swiss-Prot), A6K3C5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVLLTMIARVADGLPLAASMQEDEQSGRDLQQYQSQAKQLFRKLNEQSPTRCTLEAGAMTFHYI
IEQGVCYLVLCEAAFPKKLAFAYLEDLHSEFDEQHGKKVPTVSRPYSFIEFDTFIQKTKKLYID
SRARRNLGSINTELQDVQRIMVANIEEVLQRGEALSALDSKANNLSSLSKKYRQDAKYLNMRST
YAKLAAVAVFFIMLIVYVRFWWL

hide sequence

Ensembl Acc Id:

ENSRNOP00000025327 ⟸ ENSRNOT00000025327

Ensembl Acc Id:

ENSRNOP00000087902 ⟸ ENSRNOT00000099730

Protein Domains

Longin v-SNARE coiled-coil homology

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4KM74-F1-model_v2	AlphaFold	Q4KM74	1-215	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691599

Promoter ID:

EPDNEW_R2124

Type:

initiation region

Name:

Sec22b_1

Description:

SEC22 homolog B, vesicle trafficking protein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	200,076,066 - 200,076,126	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309988	AgrOrtholog
BioCyc Gene	G2FUF-51926	BioCyc
Ensembl Genes	ENSRNOG00000018673	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000025327	ENTREZGENE
	ENSRNOT00000025327.9	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.5.110	UniProtKB/Swiss-Prot
	Longin domain	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7378284	IMAGE-MGC_LOAD
InterPro	Longin-like_dom_sf	UniProtKB/Swiss-Prot
	Longin_dom	UniProtKB/Swiss-Prot
	Sec22	UniProtKB/Swiss-Prot
	Synaptobrevin	UniProtKB/Swiss-Prot
	V_SNARE_CC	UniProtKB/Swiss-Prot
KEGG Report	rno:310710	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:112717	IMAGE-MGC_LOAD
NCBI Gene	310710	ENTREZGENE
PANTHER	PTHR45837	UniProtKB/Swiss-Prot
Pfam	Longin	UniProtKB/Swiss-Prot
	Synaptobrevin	UniProtKB/Swiss-Prot
PhenoGen	Sec22b	PhenoGen
PRINTS	SYNAPTOBREVN	UniProtKB/Swiss-Prot
PROSITE	LONGIN	UniProtKB/Swiss-Prot
	V_SNARE	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000018673	RatGTEx
SMART	Longin	UniProtKB/Swiss-Prot
Superfamily-SCOP	SNARE fusion complex	UniProtKB/Swiss-Prot
	SSF64356	UniProtKB/Swiss-Prot
UniProt	A6K3C5	ENTREZGENE, UniProtKB/TrEMBL
	Q4KM74	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-11-20	Sec22b	SEC22 homolog B, vesicle trafficking protein	Sec22b	SEC22 vesicle trafficking protein homolog B (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Sec22b	SEC22 vesicle trafficking protein homolog B (S. cerevisiae)	Sec22l1	SEC22 vesicle trafficking protein-like 1 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Sec22l1	SEC22 vesicle trafficking protein-like 1 (S. cerevisiae)	Sec22l1_predicted	SEC22 vesicle trafficking protein-like 1 (S. cerevisiae) (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Sec22l1_predicted	SEC22 vesicle trafficking protein-like 1 (S. cerevisiae) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)