Nnmt (nicotinamide N-methyltransferase) - Rat Genome Database

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Gene: Nnmt (nicotinamide N-methyltransferase) Rattus norvegicus
Analyze
Symbol: Nnmt
Name: nicotinamide N-methyltransferase
RGD ID: 1309606
Description: Predicted to enable nicotinamide N-methyltransferase activity. Involved in animal organ regeneration and response to xenobiotic stimulus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm. Orthologous to human NNMT (nicotinamide N-methyltransferase); PARTICIPATES IN homocysteine metabolic pathway; methionine cycle/metabolic pathway; niacin metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC300691
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8857,820,156 - 57,851,301 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl857,825,464 - 57,843,174 (-)EnsemblGRCr8
mRatBN7.2848,928,663 - 48,947,734 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl848,933,598 - 48,946,655 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx854,440,605 - 54,452,823 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0852,719,450 - 52,731,668 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0850,583,713 - 50,595,931 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0852,918,437 - 52,938,172 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl852,925,175 - 52,937,972 (-)Ensemblrn6Rnor6.0
Rnor_5.0851,512,701 - 51,531,316 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4851,871,506 - 51,883,785 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera848,493,115 - 48,505,360 (-)NCBICelera
RGSC_v3.1851,890,559 - 51,902,839 (-)NCBI
Cytogenetic Map8q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
allopurinol  (EXP)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
atorvastatin calcium  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
chromium(6+)  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
diclofenac  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
fenofibrate  (EXP)
fenthion  (ISO)
flutamide  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
gemcitabine  (ISO)
gentamycin  (EXP)
glutathione  (ISO)
glutathione disulfide  (ISO)
Heliotrine  (ISO)
inulin  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
naled  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
resveratrol  (EXP)
SB 431542  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toxaphene  (EXP)
triadimefon  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
triticonazole  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Assessment of gene expression profiles in peripheral occlusive arterial disease. Bubenek S, etal., Can J Cardiol. 2012 Nov-Dec;28(6):712-20. doi: 10.1016/j.cjca.2012.03.013. Epub 2012 Jun 19.
2. Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems. Dostalek M, etal., J Biol Chem. 2008 Jun 20;283(25):17147-57. Epub 2008 Apr 28.
3. Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension. Fedorowicz A, etal., Respir Res. 2016 Aug 31;17(1):108. doi: 10.1186/s12931-016-0423-7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Potential involvement of nicotinamide N-methyltransferase in the pathogenesis of metabolic syndrome. Giuliante R, etal., Metab Syndr Relat Disord. 2015 May;13(4):165-70. doi: 10.1089/met.2014.0134. Epub 2015 Feb 26.
6. Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. Giusti B, etal., J Med Genet. 2008 Nov;45(11):721-30. doi: 10.1136/jmg.2008.057851. Epub 2008 Jul 17.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Methylation of nicotinamide in rat liver cytosol and its correlation with hepatocellular proliferation. Hoshino J, etal., Biochim Biophys Acta. 1982 Dec 17;719(3):518-26.
9. Serum N1-Methylnicotinamide is Associated With Coronary Artery Disease in Chinese Patients. Liu M, etal., J Am Heart Assoc. 2017 Feb 7;6(2):e004328. doi: 10.1161/JAHA.116.004328.
10. Serum N1-methylnicotinamide is Associated with Left Ventricular Systolic Dysfunction in Chinese. Liu M, etal., Sci Rep. 2018 Jun 5;8(1):8581. doi: 10.1038/s41598-018-26956-7.
11. Activation of nicotinamide N-methyltrasferase and increased formation of 1-methylnicotinamide (MNA) in atherosclerosis. Mateuszuk Ł, etal., Pharmacol Rep. 2009 Jan-Feb;61(1):76-85. doi: 10.1016/s1734-1140(09)70009-x.
12. Increase of nicotinamide methyltransferase and N1-methyl-nicotinamide oxidase activities in the livers of the rats administered alkylating agents. Ohkubo M, etal., Cancer Lett. 1983 Dec;21(2):175-81.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Identification of nicotinamide N-methyltransferase as a novel tumor marker for renal clear cell carcinoma. Sartini D, etal., J Urol. 2006 Nov;176(5):2248-54.
18. Nicotinamide methylation. Tissue distribution, developmental and neoplastic changes. Seifert R, etal., Biochim Biophys Acta. 1984 Sep 28;801(2):259-64.
19. Nicotinamide homeostasis: a xenobiotic pathway that is key to development and degenerative diseases. Williams AC and Ramsden DB, Med Hypotheses 2005;65(2):353-62.
20. Gene expression analysis of renal carcinoma: adipose differentiation-related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma. Yao M, etal., J Pathol. 2005 Feb;205(3):377-87. doi: 10.1002/path.1693.
Additional References at PubMed
PMID:8845860   PMID:20626002   PMID:23455543   PMID:26571212  


Genomics

Comparative Map Data
Nnmt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8857,820,156 - 57,851,301 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl857,825,464 - 57,843,174 (-)EnsemblGRCr8
mRatBN7.2848,928,663 - 48,947,734 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl848,933,598 - 48,946,655 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx854,440,605 - 54,452,823 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0852,719,450 - 52,731,668 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0850,583,713 - 50,595,931 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0852,918,437 - 52,938,172 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl852,925,175 - 52,937,972 (-)Ensemblrn6Rnor6.0
Rnor_5.0851,512,701 - 51,531,316 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4851,871,506 - 51,883,785 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera848,493,115 - 48,505,360 (-)NCBICelera
RGSC_v3.1851,890,559 - 51,902,839 (-)NCBI
Cytogenetic Map8q23NCBI
NNMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811114,257,806 - 114,313,536 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11114,257,765 - 114,314,329 (+)Ensemblhg38GRCh38
GRCh3711114,128,528 - 114,184,258 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611113,671,745 - 113,688,448 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3411113,672,381 - 113,688,448NCBI
Celera11111,319,440 - 111,336,148 (+)NCBICelera
Cytogenetic Map11q23.2NCBI
HuRef11110,095,320 - 110,112,028 (+)NCBIHuRef
CHM1_111114,050,619 - 114,067,325 (+)NCBICHM1_1
T2T-CHM13v2.011114,268,171 - 114,323,905 (+)NCBIT2T-CHM13v2.0
Nnmt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39948,448,905 - 48,518,958 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl948,503,177 - 48,516,453 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38948,538,002 - 48,607,655 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl948,591,877 - 48,605,153 (-)Ensemblmm10GRCm38
MGSCv37948,399,995 - 48,413,182 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36948,343,844 - 48,357,120 (-)NCBIMGSCv36mm8
Celera945,886,739 - 45,899,895 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map926.45NCBI
Nnmt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541215,892,906 - 15,916,166 (+)NCBIChiLan1.0ChiLan1.0
NNMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29115,037,906 - 115,051,467 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111116,130,899 - 116,145,347 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011109,174,490 - 109,186,758 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111113,016,613 - 113,029,581 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11113,016,613 - 113,029,581 (+)EnsemblpanPan2panpan1.1
NNMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1519,026,514 - 19,044,154 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl519,026,556 - 19,044,016 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha518,951,887 - 18,969,497 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0519,047,373 - 19,066,042 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl519,045,438 - 19,065,924 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1519,112,740 - 19,131,352 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0519,013,803 - 19,032,413 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0519,060,255 - 19,078,887 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nnmt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494796,354,163 - 96,372,216 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936612333,421 - 351,202 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936612333,421 - 351,202 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NNMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl941,870,980 - 41,882,756 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1941,871,072 - 41,882,415 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2946,628,722 - 46,630,881 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NNMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11105,650,178 - 105,708,441 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1105,690,085 - 105,713,010 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604320,327,613 - 20,378,651 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nnmt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247849,765,582 - 9,783,004 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247849,765,582 - 9,783,004 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nnmt
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1843,086,468 - 43,098,817 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nnmt
133 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:52
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000007789
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)85158969958991895Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat

Markers in Region
BF406313  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2848,939,074 - 48,939,233 (+)MAPPERmRatBN7.2
Rnor_6.0852,929,850 - 52,930,008NCBIRnor6.0
Rnor_5.0851,523,101 - 51,523,259UniSTSRnor5.0
RGSC_v3.4851,876,205 - 51,876,363UniSTSRGSC3.4
Celera848,497,780 - 48,497,938UniSTS
RH 3.4 Map8521.7UniSTS
Cytogenetic Map8q23UniSTS
AU049445  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2848,941,855 - 48,942,041 (+)MAPPERmRatBN7.2
Rnor_6.0852,932,631 - 52,932,816NCBIRnor6.0
Rnor_5.0851,525,882 - 51,526,067UniSTSRnor5.0
RGSC_v3.4851,878,986 - 51,879,171UniSTSRGSC3.4
Celera848,500,561 - 48,500,746UniSTS
Cytogenetic Map8q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 140 91 90 59 55 59 6 319 155 11 119 81 92 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000007789   ⟹   ENSRNOP00000007789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl848,933,598 - 48,946,494 (-)Ensembl
Rnor_6.0 Ensembl852,925,175 - 52,937,972 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117251   ⟹   ENSRNOP00000086644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl857,829,313 - 57,843,174 (-)Ensembl
mRatBN7.2 Ensembl848,934,653 - 48,946,655 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000161964   ⟹   ENSRNOP00000108036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl857,825,464 - 57,843,174 (-)Ensembl
RefSeq Acc Id: NM_001106819   ⟹   NP_001100289
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8857,830,929 - 57,843,174 (-)NCBI
mRatBN7.2848,934,410 - 48,946,655 (-)NCBI
Rnor_6.0852,925,197 - 52,937,964 (-)NCBI
Rnor_5.0851,512,701 - 51,531,316 (-)NCBI
RGSC_v3.4851,871,506 - 51,883,785 (-)RGD
Celera848,493,115 - 48,505,360 (-)RGD
Sequence:
RefSeq Acc Id: XM_039081062   ⟹   XP_038936990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8857,820,156 - 57,843,292 (-)NCBI
mRatBN7.2848,928,663 - 48,946,735 (-)NCBI
RefSeq Acc Id: XM_039081063   ⟹   XP_038936991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8857,831,425 - 57,843,375 (-)NCBI
mRatBN7.2848,934,906 - 48,946,859 (-)NCBI
RefSeq Acc Id: XM_039081065   ⟹   XP_038936993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8857,830,942 - 57,841,734 (-)NCBI
mRatBN7.2848,934,423 - 48,947,734 (-)NCBI
RefSeq Acc Id: XM_039081066   ⟹   XP_038936994
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8857,830,942 - 57,841,726 (-)NCBI
mRatBN7.2848,934,423 - 48,945,185 (-)NCBI
RefSeq Acc Id: XM_039081067   ⟹   XP_038936995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8857,831,280 - 57,843,351 (-)NCBI
mRatBN7.2848,934,847 - 48,946,823 (-)NCBI
RefSeq Acc Id: XM_063265113   ⟹   XP_063121183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8857,830,942 - 57,851,301 (-)NCBI
RefSeq Acc Id: NP_001100289   ⟸   NM_001106819
- UniProtKB: D4A605 (UniProtKB/TrEMBL),   A6J4A4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007789   ⟸   ENSRNOT00000007789
RefSeq Acc Id: XP_038936990   ⟸   XM_039081062
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038936993   ⟸   XM_039081065
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038936994   ⟸   XM_039081066
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038936995   ⟸   XM_039081067
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038936991   ⟸   XM_039081063
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000086644   ⟸   ENSRNOT00000117251
RefSeq Acc Id: XP_063121183   ⟸   XM_063265113
- Peptide Label: isoform X1
- UniProtKB: A6J4A4 (UniProtKB/TrEMBL),   D4A605 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000108036   ⟸   ENSRNOT00000161964

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A605-F1-model_v2 AlphaFold D4A605 1-264 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695936
Promoter ID:EPDNEW_R6461
Type:initiation region
Name:Nnmt_2
Description:nicotinamide N-methyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6462  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0852,937,825 - 52,937,885EPDNEW
RGD ID:13695937
Promoter ID:EPDNEW_R6462
Type:initiation region
Name:Nnmt_1
Description:nicotinamide N-methyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6461  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0852,937,964 - 52,938,024EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309606 AgrOrtholog
BioCyc Gene G2FUF-30600 BioCyc
Ensembl Genes ENSRNOG00000005930 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000117251 ENTREZGENE
  ENSRNOT00000117251.2 UniProtKB/TrEMBL
  ENSRNOT00000161964.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/TrEMBL
InterPro NNMT/PNMT/TEMT_CS UniProtKB/TrEMBL
  NNMT_TEMT_trans UniProtKB/TrEMBL
  SAM-dependent_MTases-like UniProtKB/TrEMBL
KEGG Report rno:300691 UniProtKB/TrEMBL
NCBI Gene 300691 ENTREZGENE
PANTHER NICOTINAMIDE N-METHYLTRANSFERASE UniProtKB/TrEMBL
  NNMT_TEMT_trans UniProtKB/TrEMBL
Pfam NNMT_PNMT_TEMT UniProtKB/TrEMBL
PhenoGen Nnmt PhenoGen
PIRSF PNMTase UniProtKB/TrEMBL
PROSITE NNMT_PNMT_TEMT UniProtKB/TrEMBL
  SAM_MT_NNMT_PNMT_TEMT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005930 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A0A8I6A6E7_RAT UniProtKB/TrEMBL
  A0ABK0M0V0_RAT UniProtKB/TrEMBL
  A6J4A4 ENTREZGENE, UniProtKB/TrEMBL
  D4A605 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Nnmt  nicotinamide N-methyltransferase   Nnmt_predicted  nicotinamide N-methyltransferase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Nnmt_predicted  nicotinamide N-methyltransferase (predicted)      Symbol and Name status set to approved 70820 APPROVED