Nhp2 (NHP2 ribonucleoprotein) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Nhp2 (NHP2 ribonucleoprotein) Rattus norvegicus
Analyze
Symbol: Nhp2
Name: NHP2 ribonucleoprotein
RGD ID: 1309435
Description: Enables U3 snoRNA binding activity and mRNA 3'-UTR binding activity. Involved in snoRNA guided rRNA pseudouridine synthesis. Part of box H/ACA snoRNP complex. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 2. Orthologous to human NHP2 (NHP2 ribonucleoprotein); PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: H/ACA ribonucleoprotein complex subunit 2; H/ACA ribonucleoprotein complex subunit 2-like; LOC100910210; LOC103690013; LOC287273; NHP2 ribonucleoprotein homolog; NHP2 ribonucleoprotein homolog (yeast); Nola2; nucleolar protein family A, member 2
RGD Orthologs
Human
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,378,020 - 36,381,362 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1036,377,997 - 36,381,354 (+)EnsemblGRCr8
mRatBN7.21035,877,057 - 35,880,399 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1035,877,054 - 35,882,545 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx363,415,455 - 63,415,690 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0371,999,106 - 71,999,341 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
Rnor_6.01034,975,701 - 34,979,082 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,069,344 - 37,072,733 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1034,975,708 - 34,979,082 (+)Ensemblrn6Rnor6.0
Rnor_5.01036,841,672 - 36,845,050 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41037,137,277 - 37,140,651 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1035,233,774 - 35,237,148 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
alpha-phellandrene  (ISO)
amitrole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
buspirone  (EXP)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlormequat chloride  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
clobetasol  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
fenthion  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (EXP)
glafenine  (EXP)
inulin  (ISO)
ivermectin  (ISO)
maneb  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
miconazole  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
nitrates  (ISO)
Nivalenol  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
poly(I:C)  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulfadimethoxine  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
tungsten  (ISO)
valdecoxib  (EXP)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins. Wang C and Meier UT, EMBO J. 2004 Apr 21;23(8):1857-67. Epub 2004 Mar 25.
8. Immunopurified small nucleolar ribonucleoprotein particles pseudouridylate rRNA independently of their association with phosphorylated Nopp140. Wang C, etal., Mol Cell Biol 2002 Dec;22(24):8457-66.
9. The box C/D and H/ACA snoRNPs: key players in the modification, processing and the dynamic folding of ribosomal RNA. Watkins NJ and Bohnsack MT, Wiley Interdiscip Rev RNA. 2012 May-Jun;3(3):397-414. doi: 10.1002/wrna.117. Epub 2011 Nov 7.
Additional References at PubMed
PMID:12477932   PMID:18082603   PMID:19135898   PMID:20351177   PMID:22527283   PMID:22658674   PMID:25467444   PMID:29695869  


Genomics

Comparative Map Data
Nhp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,378,020 - 36,381,362 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1036,377,997 - 36,381,354 (+)EnsemblGRCr8
mRatBN7.21035,877,057 - 35,880,399 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1035,877,054 - 35,882,545 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx363,415,455 - 63,415,690 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0371,999,106 - 71,999,341 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
Rnor_6.01034,975,701 - 34,979,082 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,069,344 - 37,072,733 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1034,975,708 - 34,979,082 (+)Ensemblrn6Rnor6.0
Rnor_5.01036,841,672 - 36,845,050 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41037,137,277 - 37,140,651 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1035,233,774 - 35,237,148 (+)NCBICelera
Cytogenetic Map10q22NCBI
NHP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385178,149,463 - 178,153,885 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5178,149,459 - 178,153,961 (-)Ensemblhg38GRCh38
GRCh375177,576,464 - 177,580,886 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365177,509,070 - 177,513,567 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345177,509,073 - 177,513,567NCBI
Celera5173,203,446 - 173,207,943 (-)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5172,302,433 - 172,306,930 (-)NCBIHuRef
CHM1_15177,007,842 - 177,012,339 (-)NCBICHM1_1
T2T-CHM13v2.05178,699,722 - 178,704,144 (-)NCBIT2T-CHM13v2.0
Nhp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554082,090,772 - 2,094,453 (+)Ensembl
ChiLan1.0NW_0049554082,090,772 - 2,094,453 (+)NCBIChiLan1.0ChiLan1.0
NHP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24173,090,862 - 173,095,371 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15171,230,398 - 171,234,909 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05173,308,560 - 173,313,046 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15180,566,008 - 180,570,502 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5180,566,008 - 180,570,502 (-)EnsemblpanPan2panpan1.1
NHP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1113,389,549 - 3,393,010 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl113,389,591 - 3,395,313 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha113,532,480 - 3,535,984 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0113,365,217 - 3,368,723 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl113,365,309 - 3,368,720 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1113,335,883 - 3,337,251 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0113,413,347 - 3,416,848 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0113,654,898 - 3,659,015 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nhp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213113,517,778 - 113,522,464 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936647520,494 - 525,226 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936647520,542 - 525,226 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NHP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1280,223,439 - 80,227,614 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2281,839,915 - 81,844,092 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NHP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12379,842,690 - 79,847,138 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2379,842,948 - 79,846,984 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607511,143,336 - 11,147,779 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nhp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473341,371,897 - 41,375,363 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473341,371,897 - 41,375,360 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Nhp2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1934,208,138 - 34,211,773 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nhp2
31 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:237
Count of miRNA genes:108
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000005688, ENSRNOT00000064984, ENSRNOT00000073317
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
AA851865  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81036,380,581 - 36,381,191 (+)Marker Load Pipeline
mRatBN7.21035,879,618 - 35,880,228 (+)MAPPERmRatBN7.2
Rnor_6.01037,071,978 - 37,072,587NCBIRnor6.0
Rnor_6.01034,978,292 - 34,978,901NCBIRnor6.0
Rnor_5.01034,750,893 - 34,751,502UniSTSRnor5.0
Rnor_5.01036,844,260 - 36,844,869UniSTSRnor5.0
RGSC_v3.41037,139,861 - 37,140,470UniSTSRGSC3.4
Celera1035,236,358 - 35,236,967UniSTS
RH 3.4 Map5931.0UniSTS
Cytogenetic Map10q22UniSTS
RH141376  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21035,880,081 - 35,880,283 (+)MAPPERmRatBN7.2
Rnor_6.01037,072,441 - 37,072,642NCBIRnor6.0
Rnor_6.01034,978,755 - 34,978,956NCBIRnor6.0
Rnor_5.01034,751,356 - 34,751,557UniSTSRnor5.0
Rnor_5.01036,844,723 - 36,844,924UniSTSRnor5.0
RGSC_v3.41037,140,324 - 37,140,525UniSTSRGSC3.4
Celera1035,236,821 - 35,237,022UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000064984   ⟹   ENSRNOP00000063697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1034,975,708 - 34,979,082 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000073317   ⟹   ENSRNOP00000067439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1035,877,054 - 35,882,545 (+)Ensembl
Rnor_6.0 Ensembl1037,069,344 - 37,072,733 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090404   ⟹   ENSRNOP00000072941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1037,069,461 - 37,072,535 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000154891   ⟹   ENSRNOP00000099243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1036,377,997 - 36,381,354 (+)Ensembl
RefSeq Acc Id: NM_001414279   ⟹   NP_001401208
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,378,020 - 36,381,362 (+)NCBI
mRatBN7.21035,877,057 - 35,880,399 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001401208 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI62010 (Get FASTA)   NCBI Sequence Viewer  
  EDM04315 (Get FASTA)   NCBI Sequence Viewer  
  EDM04316 (Get FASTA)   NCBI Sequence Viewer  
  EDM04317 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000099243
  ENSRNOP00000099243.1
Ensembl Acc Id: ENSRNOP00000063697   ⟸   ENSRNOT00000064984
Ensembl Acc Id: ENSRNOP00000072941   ⟸   ENSRNOT00000090404
Ensembl Acc Id: ENSRNOP00000067439   ⟸   ENSRNOT00000073317
RefSeq Acc Id: NP_001401208   ⟸   NM_001414279
- UniProtKB: B1WC56 (UniProtKB/TrEMBL),   A6HE60 (UniProtKB/TrEMBL),   M0RCV4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099243   ⟸   ENSRNOT00000154891
Protein Domains
Ribosomal protein eL8/eL30/eS12/Gadd45

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1WC56-F1-model_v2 AlphaFold B1WC56 1-153 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309435 AgrOrtholog
BioCyc Gene G2FUF-25197 BioCyc
Ensembl Genes ENSRNOG00000004247 Ensembl
  ENSRNOG00000049622 Ensembl
  ENSRNOG00000063470 Ensembl
  ENSRNOG00000075550 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000154891 ENTREZGENE
  ENSRNOT00000154891.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1330.30 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9091322 IMAGE-MGC_LOAD
InterPro eL8_RNA-proc_assembly UniProtKB/TrEMBL
  H/ACA_rnp_Nhp2_euk UniProtKB/TrEMBL
  L30e-like UniProtKB/TrEMBL
  Ribosomal_L7Ae/L30e/S12e/Gad45 UniProtKB/TrEMBL
  Ribosomal_L7Ae/L8/Nhp2 UniProtKB/TrEMBL
MGC_CLONE MGC:187877 IMAGE-MGC_LOAD
NCBI Gene 287273 ENTREZGENE
PANTHER RIBOSOMAL PROTEIN L7AE FAMILY MEMBER UniProtKB/TrEMBL
Pfam Ribosomal_L7Ae UniProtKB/TrEMBL
PhenoGen Nhp2 PhenoGen
PRINTS L7ARS6FAMILY UniProtKB/TrEMBL
  NUCLEARHMG UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004247 RatGTEx
  ENSRNOG00000049622 RatGTEx
  ENSRNOG00000063470 RatGTEx
  ENSRNOG00000075550 RatGTEx
Superfamily-SCOP SSF55315 UniProtKB/TrEMBL
UniProt A6HE60 ENTREZGENE, UniProtKB/TrEMBL
  B1WC56 ENTREZGENE
  M0RCV4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B1WC56 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Nhp2  NHP2 ribonucleoprotein  LOC103690013  H/ACA ribonucleoprotein complex subunit 2  Data merged from RGD:9459675 737654 PROVISIONAL
2015-02-26 Nhp2  NHP2 ribonucleoprotein  LOC100910210  H/ACA ribonucleoprotein complex subunit 2-like  Data merged from RGD:6499385 737654 APPROVED
2014-08-25 LOC103690013  H/ACA ribonucleoprotein complex subunit 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-12-18 Nhp2  NHP2 ribonucleoprotein  Nhp2  NHP2 ribonucleoprotein homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910210  H/ACA ribonucleoprotein complex subunit 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-10-22 Nhp2  NHP2 ribonucleoprotein homolog (yeast)  Nola2  nucleolar protein family A, member 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Nola2  nucleolar protein family A, member 2   Nola2_predicted  nucleolar protein family A, member 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Nola2_predicted  nucleolar protein family A, member 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED