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Gene: Ccnl2 (cyclin L2) Rattus norvegicus

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Symbol:

Ccnl2

Name:

cyclin L2

RGD ID:

1309149

Description:

Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in regulation of RNA splicing. Predicted to be located in nuclear speck. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. Orthologous to human CCNL2 (cyclin L2); INTERACTS WITH 17beta-estradiol; 4,4'-diaminodiphenylmethane; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

cyclin-L2; LOC298686

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CCNL2 (cyclin L2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ccnl2 (cyclin L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ccnl2 (cyclin L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CCNL2 (cyclin L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CCNL2 (cyclin L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ccnl2 (cyclin L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CCNL2 (cyclin L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CCNL2 (cyclin L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ccnl2 (cyclin L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Ccnl2 (cyclin L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	AURKAIP1 (aurora kinase A interacting protein 1)	HGNC	EggNOG, Inparanoid, OrthoDB, PhylomeDB, Treefam
Alliance orthologs ³
Homo sapiens (human):	CCNL2 (cyclin L2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ccnl2 (cyclin L2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ccnl1b (cyclin L1b)	Alliance	DIOPT (OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG16903	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG16903	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyl-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyl-1	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ccnl2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	171,698,951 - 171,711,037 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	171,699,689 - 171,711,231 (+)	Ensembl				GRCr8
mRatBN7.2	5	166,416,940 - 166,428,997 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	166,417,508 - 166,436,882 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	169,122,392 - 169,133,662 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	170,943,811 - 170,955,083 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	170,906,342 - 170,917,614 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	173,256,301 - 173,268,279 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	173,256,637 - 173,276,169 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	176,731,925 - 176,743,703 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	172,666,512 - 172,673,024 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	164,618,287 - 164,624,788 (+)	NCBI		Celera
RGSC_v3.1	5	172,677,006 - 172,683,515 (+)	NCBI
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

choline (ISO)

chrysene (ISO)

ciguatoxin CTX1B (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dibutyl phthalate (EXP)

diuron (EXP)

doxorubicin (ISO)

enniatin (EXP)

folic acid (ISO)

FR900359 (ISO)

fulvestrant (ISO)

indometacin (ISO)

L-methionine (ISO)

lead diacetate (ISO)

leflunomide (EXP)

lipopolysaccharide (ISO)

methamphetamine (ISO)

methapyrilene (EXP)

methimazole (EXP)

miconazole (ISO)

nefazodone (EXP)

nicotine (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (ISO)

pirinixic acid (EXP,ISO)

potassium dichromate (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

propiconazole (ISO)

rotenone (EXP)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

testosterone (ISO)

tetraphene (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

tolcapone (EXP)

triphenyl phosphate (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA-templated transcription (IEA)

mRNA processing (IEA)

regulation of mRNA splicing, via spliceosome (IEA,ISO)

regulation of RNA splicing (IEA,ISO)

regulation of transcription by RNA polymerase II (IEA)

RNA splicing (IEA)

Cellular Component

cyclin L-CDK11 complex (IEA,ISO)

nuclear speck (IEA)

nucleoplasm (IEA,ISO)

nucleus (IBA,IEA,ISO)

Molecular Function

cyclin-dependent protein serine/threonine kinase regulator activity (IBA,IEA,ISO)

protein binding (IPI,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation.	Chen HH, etal., Mol Cell Biol. 2006 Apr;26(7):2736-45.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15057822	PMID:15489334	PMID:17494991

Genomics

Comparative Map Data

Ccnl2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	171,698,951 - 171,711,037 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	171,699,689 - 171,711,231 (+)	Ensembl				GRCr8
mRatBN7.2	5	166,416,940 - 166,428,997 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	166,417,508 - 166,436,882 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	169,122,392 - 169,133,662 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	170,943,811 - 170,955,083 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	170,906,342 - 170,917,614 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	173,256,301 - 173,268,279 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	173,256,637 - 173,276,169 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	176,731,925 - 176,743,703 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	172,666,512 - 172,673,024 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	164,618,287 - 164,624,788 (+)	NCBI		Celera
RGSC_v3.1	5	172,677,006 - 172,683,515 (+)	NCBI
Cytogenetic Map	5	q36	NCBI

CCNL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	1,385,711 - 1,399,335 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	1,385,711 - 1,399,339 (-)	Ensembl			hg38	GRCh38
GRCh37	1	1,321,091 - 1,334,715 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	1,310,954 - 1,324,553 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	1	1,246,539 - 1,260,165 (+)	NCBI		Celera
Cytogenetic Map	1	p36.33	NCBI
HuRef	1	593,397 - 606,925 (-)	NCBI		HuRef
CHM1_1	1	1,308,113 - 1,322,132 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	817,645 - 832,544 (-)	NCBI		T2T-CHM13v2.0

Ccnl2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	155,894,468 - 155,909,005 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	155,896,946 - 155,909,000 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	155,810,219 - 155,824,543 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	155,812,489 - 155,824,543 (+)	Ensembl			mm10	GRCm38
MGSCv37	4	155,186,598 - 155,198,652 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	154,656,289 - 154,668,343 (+)	NCBI		MGSCv36	mm8
Celera	4	158,083,766 - 158,095,796 (+)	NCBI		Celera
Cytogenetic Map	4	E2	NCBI
cM Map	4	87.47	NCBI

Ccnl2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	9,423,491 - 9,432,811 (+)	Ensembl
ChiLan1.0	NW_004955486	9,423,491 - 9,432,811 (+)	NCBI	ChiLan1.0	ChiLan1.0

CCNL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	226,826,053 - 226,839,037 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	225,523,620 - 225,536,617 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	142,530 - 155,377 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	1,343,608 - 1,355,392 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	1,344,346 - 1,355,361 (-)	Ensembl			panPan2	panpan1.1

CCNL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	56,542,358 - 56,550,701 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	56,542,566 - 56,550,691 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	56,618,538 - 56,626,881 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	56,744,445 - 56,752,791 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	56,744,452 - 56,752,793 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	56,735,164 - 56,743,507 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	56,627,430 - 56,635,773 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	57,017,713 - 57,026,057 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ccnl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	27,692,794 - 27,700,958 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936737	1,764,189 - 1,772,475 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936737	1,765,027 - 1,773,156 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CCNL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	63,659,054 - 63,668,047 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	63,659,053 - 63,668,077 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	58,269,483 - 58,271,859 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CCNL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	130,049,590 - 130,065,241 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	130,049,646 - 130,065,881 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666054	34,588,417 - 34,603,111 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ccnl2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624818	8,233,574 - 8,242,542 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624818	8,233,547 - 8,242,547 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ccnl2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	4,809,382 - 4,821,381 (-)	NCBI		Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	93
Count of miRNA genes:	71
Interacting mature miRNAs:	84
Transcripts:	ENSRNOT00000025531
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	130249266	172190305	Rat
1354583	Despr3	Despair related QTL3	4.98	0.0002	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	5	132930505	172190305	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	141212838	172190305	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	131708216	172190305	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	133789363	172190305	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	134369199	172190305	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	136631198	172190305	Rat
1354631	Swd2	Spike wave discharge measurement QTL 2	3.64	0.0002	brain electrophysiology trait (VT:0010557)	brain total spike-and-wave discharge duration (CMO:0001740)	5	156396728	172190305	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133081618	172190305	Rat
1581505	Rf54	Renal function QTL 54			kidney physiology trait (VT:0002136)	kidney 20-HETE level (CMO:0001854)	5	133270647	172190305	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	160071170	172129029	Rat
2317753	Glom24	Glomerulus QTL 24	3.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	5	141764300	172190305	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133081618	172190305	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	133789363	172190305	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	148093485	172129029	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	125969677	172190305	Rat

Markers in Region

RH144311

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	166,422,663 - 166,422,796 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	173,261,946 - 173,262,078	NCBI	Rnor6.0
Rnor_5.0	5	176,737,560 - 176,737,692	UniSTS	Rnor5.0
RGSC_v3.4	5	172,671,627 - 172,671,759	UniSTS	RGSC3.4
Celera	5	164,623,391 - 164,623,523	UniSTS
RH 3.4 Map	5	1164.4	UniSTS
Cytogenetic Map	5	q36	UniSTS

AA955673

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	5	171,703,000 - 171,703,135 (+)	Marker Load Pipeline
mRatBN7.2	5	166,420,765 - 166,420,900 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	173,260,048 - 173,260,182	NCBI	Rnor6.0
Rnor_5.0	5	176,735,662 - 176,735,796	UniSTS	Rnor5.0
RGSC_v3.4	5	172,669,727 - 172,669,861	UniSTS	RGSC3.4
Celera	5	164,621,493 - 164,621,627	UniSTS
RH 3.4 Map	5	1175.1	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001401305	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001401307	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006239544	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593316	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109721	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287498	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287499	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287500	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005504417	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_592798	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC106940	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC088316	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210439	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211043	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000025531 ⟹ ENSRNOP00000025531

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	171,699,689 - 171,705,946 (+)	Ensembl
mRatBN7.2 Ensembl	5	166,417,508 - 166,435,860 (+)	Ensembl
Rnor_6.0 Ensembl	5	173,256,637 - 173,275,340 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000025952 ⟹ ENSRNOP00000025952

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	166,435,194 - 166,436,882 (+)	Ensembl
Rnor_6.0 Ensembl	5	173,274,774 - 173,276,169 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000089936 ⟹ ENSRNOP00000068952

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	171,699,736 - 171,711,231 (+)	Ensembl
mRatBN7.2 Ensembl	5	166,417,540 - 166,428,800 (+)	Ensembl
Rnor_6.0 Ensembl	5	173,256,834 - 173,263,334 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096422 ⟹ ENSRNOP00000077305

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	171,699,769 - 171,711,033 (+)	Ensembl
mRatBN7.2 Ensembl	5	166,417,550 - 166,428,797 (+)	Ensembl

RefSeq Acc Id:

NM_001401305 ⟹ NP_001388234

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	171,699,775 - 171,711,037 (+)	NCBI
mRatBN7.2	5	166,417,540 - 166,428,802 (+)	NCBI

RefSeq Acc Id:

NM_001401307 ⟹ NP_001388236

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	171,699,775 - 171,707,417 (+)	NCBI
mRatBN7.2	5	166,417,540 - 166,425,182 (+)	NCBI

RefSeq Acc Id:

XM_006239544 ⟹ XP_006239606

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	171,698,951 - 171,711,035 (+)	NCBI
mRatBN7.2	5	166,416,954 - 166,428,997 (+)	NCBI
Rnor_6.0	5	173,256,306 - 173,268,279 (+)	NCBI
Rnor_5.0	5	176,731,925 - 176,743,703 (+)	NCBI

Sequence:

show sequence

GAGGTCCGCCTGCTTCTGCCTTCCAAGTGCTGGGATTAAAGGCACCACTGCCCCGCTTTCTTCT
GCACCTTTAATGCTGGCAGATCCACCCCACAGCCAGAGGACAGAAGAGGGTTGCGAACTAAAGA
CCCTGAACTAAATCGCGGTGTAATGTACACATGAGACTGTGGAGAAAAAGGGTTGTTCTGTCCC
GATCCCCGCGGAAAGACTCCCTTCTAGAACCCCAGTTTTCGAGGCAGAAGCACTGTAACCTCCG
GATTTCGAGACAGTAGCCTTGTAATCTCCTGGCTTTCTGGATTGACCACTTCCGGTTCGGGCCA
GGCCGCGGAGCCAAGTGGGTAACGAGCAGCCCCACCCGTGGGTACTTCCGGCGTCAGTGCCTGA
CGCGATACTGAAGGACTGGTCGTACGGCCAACGGCGTCGAGACAGCGGTGACGTTCAACCAATG
GAAGGGGGTGGGGCGGGGCGGCCATGATCGTCTCGAGCAGCCGCCCTGACGGGAAGGGCCCGAA
AAGAGTCGGCGGCACAAAATGGCGGCGGCGGCAGCCGGGGCTTCGGGGTTGATGGCTCCTGCGT
TGGCGGCCTGCTCTTCCGGCTCGGGGGGAGCAGCCCCAGGGTCTCAGGGGGTGCTGATCGGTGA
CAGGCTATACTCCGGAGTTCTCATCACCTTGGAAAACTGCCTGCTGCCCGACGACAAGCTCCGC
TTCACGCCATCCATGTCGAGCGGTCTCGACATCGATACAGAGACTGGACTCCGCGTAGTGGGCT
GCGAGCTCATCCAGGCAGCCGGCATCCTACTCCGCCTGCCGCAGGTGGCCATGGCTACAGGGCA
GGTGTTGTTCCAGCGCTTCTTTTACACTAAGTCCTTCGTGAAACATTCCATGGAGCATGTGTCC
ATGGCTTGTGTTCACCTGGCTTCCAAAATAGAAGAGGCTCCAAGACGAATCAGAGATGTCATCA
ACGTATTCCATCGCCTTCGGCATCTGCGAGAGAAAAAGAAACCTGTGCCTCTGGTGCTGGATCA
AGAGTATGTTAATCTGAAGAACCAGATTATAAAGGCAGAGAGACGGGTTCTCAAGGAATTGGGC
TTTTGTGTCCATGTGAAGCATCCTCACAAGATAATCGTTATGTACCTTCAGGTGTTAGAATGTG
AGCGTAATCAGCACCTGGTCCAGACTGCATGGAACTACATGAATGACAGCCTTCGCACAGATGT
CTTTGTGCGGTTCCAGCCTGAAAGCATTGCTTGTGCCTGTATCTACCTTGCTGCCCGGACACTG
GAGATCCCTTTACCTAATCGTCCACATTGGTTTCTTTTGTTTGGAGCAACTGAAGAGGAAATTC
AAGAAATTTGCTTTAAAATCTTGCAGCTTTATACACGGAAAAAGGTTGACTTGACGCATCTGGA
AAGTGAAGTGGAAAAGAGAAAGCACGCCATCGAAGAGGCAAAGGCACGAGCCAAGGGTCTGCTG
CCACCAGGGAGTGCGCCAGGCTTGGACAGTGCTACTGCAGGGTTCTCACCCGCTCCCAAGCCGG
TAGAATCCCCCAAAGAAGGTAAAGGAAGCAAGTCTTCCCCACTCTCTGTAAAGAATGCCAAACG
GAAAATGGAAGGCCCAAAGAAAGCCAAGGGCGACAGCCCTGTAAATGGCTTGCTAAAAGGGCAG
GAGAGTCGAAGTCAAAGCAGGAGTCGTGAGCAGAGCTACTCAAGGTCCCCATCACGGTCTGCTT
CTCCAAAGAGAAGGAAAAGTGATAGTGGCTCTACCTCAGGGGGGTCCAAGTCACAGAGTCGTTC
TCGGAGCCGCAGTGACTCTCCTCCAAGGCAAGTACACCGTGGTGCTCCCTACAAAGGCTCAGAA
GTGAGGGGCTCCCGGAAATCCAAGGACTGCAAGCACCTCACCCAGAAGCCACACAAGTCTCGTA
GCCGGAGCTCCTCCCGTTCCCGCAGCCGGTCACGAGAACGGACAGACAGTTCTGGAAAATACAA
GAAGAAAAGTCATTACTATAGAGATCAAAGACGGGAGCGCTCAAGGTCATATGAGCGCACAGGC
CATCGATATGAGAGGGACCACCCTGGACACAGCAGGCATCGGAGGTGAGATAGGTTCCCTGGTG
GCTGCCCTTGGTCCCTCCCTGTTGGGCACACCTTGGCTTCAGTGGCCTTGTCACATAATGTTTT
TTTAAAGTGTTTTTGATTGGACCTTGAGGTGAATTTGACAGTGGGCAAGGTGCCCTTCAGGCTG
GCCTGGGGAGTGCTGCACATCTGTCCTAGGTAATGGTCCACCTCAACTGCAGACCTTCAGGTAG
CTGGATGGAACAGCAAAGGCACACGCCTCCACTGGCGTGGCTTGGTGCTATTGACAAGCTGTCT
CTTCACTCCTAAACTGATACTCAATTACGTTAAGCCAAGAAAGATGATTTTTCAAATCTTTGCC
TATATTAGGTTGTACTTGTGTACATATTTTGCAGTGGTTCACAATGAGAAAATGGCCTTAATAG
CCCCCTTGTTCTCTATTCACGTTGTAAATAAACATGTTTAATACAAGTGAAAGCTATATATGAG
AACTCAGAATTTGATTCTGTTAGCTTAACACTTGTATAGAAAATTGAGATTTTTAAAATGTGAA
GGTATTTAGGTCTGTGTTGAAAGTCATATATTTTTATCTGTGCAATGCTGAGTGCAGGCCACCA
GCTCGAGAGAAATTTTACGTGGTTGAATAAACAATTCTCAGGACACTTGTTATGTAAGACTTTG
TGGGCTGTCATTTTGGTTTTTTTTTGTGTGTGTGTGTGCATGCCTGGGATTTGGCTGTGGGACT
CAGGCCTGGTGGGAGTATTTGTGTGCAACTGTGCACTGCCAGCTTAGCTATTCTAGGGGCTGTA
TGAGCTGTGTATTCCCTGGTCCTTCATCCCTCTTCTCATTAAAGTGTTGGATTTTGTACTGA

hide sequence

RefSeq Acc Id:

XM_039109721 ⟹ XP_038965649

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	171,698,951 - 171,711,035 (+)	NCBI
mRatBN7.2	5	166,416,952 - 166,428,997 (+)	NCBI

RefSeq Acc Id:

XM_063287498 ⟹ XP_063143568

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	171,698,951 - 171,711,035 (+)	NCBI

RefSeq Acc Id:

XM_063287499 ⟹ XP_063143569

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	171,705,820 - 171,711,035 (+)	NCBI

RefSeq Acc Id:

XM_063287500 ⟹ XP_063143570

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	171,698,951 - 171,708,404 (+)	NCBI

RefSeq Acc Id:

XR_005504417

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	171,698,951 - 171,707,633 (+)	NCBI
mRatBN7.2	5	166,416,944 - 166,425,479 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001388234	(Get FASTA)	NCBI Sequence Viewer
	NP_001388236	(Get FASTA)	NCBI Sequence Viewer
	XP_006239606	(Get FASTA)	NCBI Sequence Viewer
	XP_038965649	(Get FASTA)	NCBI Sequence Viewer
	XP_063143568	(Get FASTA)	NCBI Sequence Viewer
	XP_063143569	(Get FASTA)	NCBI Sequence Viewer
	XP_063143570	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH88316	(Get FASTA)	NCBI Sequence Viewer
	EDL81328	(Get FASTA)	NCBI Sequence Viewer
	EDL81329	(Get FASTA)	NCBI Sequence Viewer
	EDL81330	(Get FASTA)	NCBI Sequence Viewer
	EDL81331	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000025531
	ENSRNOP00000068952
	ENSRNOP00000077305
GenBank Protein	Q5I0H5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_006239606 ⟸ XM_006239544
- Peptide Label:	isoform X1
- UniProtKB:	A6IUS7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAAAAGASGLMAPALAACSSGSGGAAPGSQGVLIGDRLYSGVLITLENCLLPDDKLRFTPSMS SGLDIDTETGLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSMEHVSMACVHL ASKIEEAPRRIRDVINVFHRLRHLREKKKPVPLVLDQEYVNLKNQIIKAERRVLKELGFCVHVK HPHKIIVMYLQVLECERNQHLVQTAWNYMNDSLRTDVFVRFQPESIACACIYLAARTLEIPLPN RPHWFLLFGATEEEIQEICFKILQLYTRKKVDLTHLESEVEKRKHAIEEAKARAKGLLPPGSAP GLDSATAGFSPAPKPVESPKEGKGSKSSPLSVKNAKRKMEGPKKAKGDSPVNGLLKGQESRSQS RSREQSYSRSPSRSASPKRRKSDSGSTSGGSKSQSRSRSRSDSPPRQVHRGAPYKGSEVRGSRK SKDCKHLTQKPHKSRSRSSSRSRSRSRERTDSSGKYKKKSHYYRDQRRERSRSYERTGHRYERD HPGHSRHRR hide sequence

Ensembl Acc Id:

ENSRNOP00000068952 ⟸ ENSRNOT00000089936

Ensembl Acc Id:

ENSRNOP00000025531 ⟸ ENSRNOT00000025531

Ensembl Acc Id:

ENSRNOP00000025952 ⟸ ENSRNOT00000025952

RefSeq Acc Id:	XP_038965649 ⟸ XM_039109721
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I5Y5M3 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000077305 ⟸ ENSRNOT00000096422

RefSeq Acc Id:	NP_001388234 ⟸ NM_001401305
- Peptide Label:	isoform 1
- UniProtKB:	Q5I0H5 (UniProtKB/Swiss-Prot), A6IUS7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001388236 ⟸ NM_001401307
- Peptide Label:	isoform 2
- UniProtKB:	A6IUS8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063143568 ⟸ XM_063287498
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I5Y5M3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063143570 ⟸ XM_063287500
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_063143569 ⟸ XM_063287499
- Peptide Label:	isoform X4

Protein Domains

Cyclin C-terminal Cyclin-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5I0H5-F1-model_v2	AlphaFold	Q5I0H5	1-520	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309149	AgrOrtholog
BioCyc Gene	G2FUF-38896	BioCyc
Ensembl Genes	ENSRNOG00000018691	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000025531	ENTREZGENE
	ENSRNOT00000089936	ENTREZGENE
	ENSRNOT00000096422	ENTREZGENE
Gene3D-CATH	Cyclin-like	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7325177	IMAGE-MGC_LOAD
InterPro	Cyclin-like	UniProtKB/Swiss-Prot
	Cyclin-like_sf	UniProtKB/Swiss-Prot
	Cyclin/Ssn8	UniProtKB/Swiss-Prot
	Cyclin_C-dom	UniProtKB/Swiss-Prot
	Cyclin_N	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:109544	IMAGE-MGC_LOAD
NCBI Gene	298686	ENTREZGENE
PANTHER	PTHR10026	UniProtKB/Swiss-Prot
Pfam	Cyclin_C	UniProtKB/Swiss-Prot
	Cyclin_N	UniProtKB/Swiss-Prot
PhenoGen	Ccnl2	PhenoGen
PIRSF	Cyclin_L	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000018691	RatGTEx
SMART	CYCLIN	UniProtKB/Swiss-Prot
	Cyclin_C	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF47954	UniProtKB/Swiss-Prot
UniProt	A0A0H2UHQ5_RAT	UniProtKB/TrEMBL
	A0A8I5Y5M3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2QZY3_RAT	UniProtKB/TrEMBL
	A6IUS7	ENTREZGENE, UniProtKB/TrEMBL
	A6IUS8	ENTREZGENE, UniProtKB/TrEMBL
	A6IUS9_RAT	UniProtKB/TrEMBL
	A6IUT0_RAT	UniProtKB/TrEMBL
	CCNL2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Ccnl2	cyclin L2	Ccnl2_predicted	cyclin L2 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Ccnl2_predicted	cyclin L2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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