Nfat5 (nuclear factor of activated T-cells 5) - Rat Genome Database

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Gene: Nfat5 (nuclear factor of activated T-cells 5) Rattus norvegicus
Analyze
Symbol: Nfat5
Name: nuclear factor of activated T-cells 5
RGD ID: 1309142
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in several processes, including R-loop processing; calcineurin-NFAT signaling cascade; and positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within positive regulation of gene expression and regulation of calcineurin-NFAT signaling cascade. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human NFAT5 (nuclear factor of activated T cells 5); PARTICIPATES IN B cell receptor signaling pathway; T cell receptor signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: NF-AT5; Nfat; nuclear factor of activated T-cells 5, tonicity-responsive; T-cell transcription factor NFAT5; TonEBP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81952,108,982 - 52,196,418 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1952,109,483 - 52,196,418 (+)EnsemblGRCr8
mRatBN7.21935,199,737 - 35,286,675 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1935,199,016 - 35,286,675 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1942,015,199 - 42,102,135 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01942,668,550 - 42,755,492 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01944,973,511 - 45,060,409 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01938,446,059 - 38,533,735 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1938,446,059 - 38,533,735 (-)Ensemblrn6Rnor6.0
Rnor_5.01949,320,570 - 49,403,625 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01950,363,699 - 50,398,311 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41937,154,326 - 37,242,191 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1934,621,583 - 34,708,117 (+)NCBICelera
RGSC_v3.11937,093,773 - 37,238,503 (+)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-demecolcine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azaorotic acid  (EXP)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP,ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
apigenin  (ISO)
Aroclor 1254  (ISO)
atrazine  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cantharidin  (ISO)
carmustine  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-mannitol  (EXP,ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichloromethane  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
elemental selenium  (ISO)
endosulfan  (EXP,ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
formaldehyde  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
indometacin  (ISO)
inulin  (ISO)
lipopolysaccharide  (ISO)
luteolin  (ISO)
maleic acid  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
myxothiazol  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
nickel subsulfide  (EXP)
o-xylene  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP)
pyridaben  (ISO)
quartz  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP,ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone enanthate  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
topotecan  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
transcription regulator complex  (IBA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. c-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBP. Gallazzini M, etal., FASEB J. 2010 Nov;24(11):4325-35. doi: 10.1096/fj.10-157362. Epub 2010 Jun 28.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10860829   PMID:11485737   PMID:11780147   PMID:11934689   PMID:12370307   PMID:12824075   PMID:15247427   PMID:15790681   PMID:16772300   PMID:17105721   PMID:17153592   PMID:17371162  
PMID:17533154   PMID:18502201   PMID:18945830   PMID:19008713   PMID:19052532   PMID:19138132   PMID:19147493   PMID:19188439   PMID:20142563   PMID:20368270   PMID:21209322   PMID:21357543  
PMID:21757659   PMID:22082260   PMID:22768306   PMID:23180003   PMID:25515214   PMID:25858778   PMID:27235345   PMID:27779669   PMID:27838821   PMID:28674405   PMID:28842479   PMID:30332317  
PMID:30664212   PMID:31883300   PMID:32239388   PMID:37380112  


Genomics

Comparative Map Data
Nfat5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81952,108,982 - 52,196,418 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1952,109,483 - 52,196,418 (+)EnsemblGRCr8
mRatBN7.21935,199,737 - 35,286,675 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1935,199,016 - 35,286,675 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1942,015,199 - 42,102,135 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01942,668,550 - 42,755,492 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01944,973,511 - 45,060,409 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01938,446,059 - 38,533,735 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1938,446,059 - 38,533,735 (-)Ensemblrn6Rnor6.0
Rnor_5.01949,320,570 - 49,403,625 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01950,363,699 - 50,398,311 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41937,154,326 - 37,242,191 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1934,621,583 - 34,708,117 (+)NCBICelera
RGSC_v3.11937,093,773 - 37,238,503 (+)NCBI
Cytogenetic Map19q12NCBI
NFAT5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381669,565,966 - 69,704,654 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1669,565,094 - 69,704,666 (+)Ensemblhg38GRCh38
GRCh371669,599,869 - 69,738,557 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361668,156,498 - 68,296,054 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1654,113,571 - 54,253,111 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1655,478,121 - 55,616,752 (+)NCBIHuRef
CHM1_11671,007,818 - 71,146,456 (+)NCBICHM1_1
T2T-CHM13v2.01675,368,170 - 75,506,838 (+)NCBIT2T-CHM13v2.0
Nfat5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398108,020,072 - 108,106,149 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8108,020,102 - 108,106,149 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388107,293,435 - 107,379,517 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8107,293,470 - 107,379,517 (+)Ensemblmm10GRCm38
MGSCv378109,817,370 - 109,903,417 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368110,182,991 - 110,268,646 (+)NCBIMGSCv36mm8
Celera8111,523,092 - 111,609,223 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.93NCBI
Nfat5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554847,034,799 - 7,142,883 (-)Ensembl
ChiLan1.0NW_0049554847,034,799 - 7,142,883 (-)NCBIChiLan1.0ChiLan1.0
NFAT5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21879,112,502 - 79,254,607 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11685,024,664 - 85,166,745 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01649,942,461 - 50,080,519 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11669,327,470 - 69,462,251 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1669,327,470 - 69,462,251 (+)EnsemblpanPan2panpan1.1
NFAT5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1579,995,292 - 80,115,116 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl580,003,587 - 80,115,096 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha579,984,111 - 80,105,721 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0580,425,837 - 80,547,558 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl580,432,528 - 80,548,712 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1580,253,618 - 80,375,936 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0579,943,167 - 80,064,783 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0580,576,081 - 80,698,426 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nfat5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934939,830,178 - 39,928,927 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647519,660,201 - 19,758,930 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647519,658,917 - 19,758,936 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFAT5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl617,313,413 - 17,434,940 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1617,313,511 - 17,434,951 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2616,252,167 - 16,381,341 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFAT5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1557,705,022 - 57,838,569 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl557,709,277 - 57,838,704 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604720,430,610 - 20,568,859 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfat5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474616,684,407 - 16,818,430 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474616,684,556 - 16,818,321 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Nfat5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11727,017,478 - 27,098,664 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nfat5
829 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1085
Count of miRNA genes:352
Interacting mature miRNAs:494
Transcripts:ENSRNOT00000017005
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat

Markers in Region
D19Got27  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81952,045,078 - 52,045,315 (+)Marker Load Pipeline
mRatBN7.21935,135,347 - 35,135,584 (+)MAPPERmRatBN7.2
Rnor_6.01939,430,434 - 39,430,670NCBIRnor6.0
Rnor_5.01950,294,454 - 50,294,690UniSTSRnor5.0
RGSC_v3.41937,089,324 - 37,089,567UniSTSRGSC3.4
RGSC_v3.41937,089,323 - 37,089,567RGDRGSC3.4
RGSC_v3.11937,094,205 - 37,094,448RGD
RH 3.4 Map19314.9RGD
RH 3.4 Map19314.9UniSTS
RH 2.0 Map19433.6RGD
Cytogenetic Map19q12UniSTS
D19Got110  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81952,137,675 - 52,137,814 (+)Marker Load Pipeline
mRatBN7.21935,227,931 - 35,228,070 (+)MAPPERmRatBN7.2
mRatBN7.21935,227,931 - 35,228,070 (-)MAPPERmRatBN7.2
Rnor_6.01939,529,896 - 39,530,034NCBIRnor6.0
Rnor_6.01938,504,660 - 38,504,798NCBIRnor6.0
Rnor_5.01950,391,893 - 50,392,031UniSTSRnor5.0
Rnor_5.01949,374,557 - 49,374,695UniSTSRnor5.0
RGSC_v3.41937,183,248 - 37,183,386UniSTSRGSC3.4
Celera1934,649,306 - 34,649,444UniSTS
Cytogenetic Map19q12UniSTS
RH133372  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81952,181,412 - 52,181,618 (+)Marker Load Pipeline
mRatBN7.21935,271,667 - 35,271,873 (-)MAPPERmRatBN7.2
Rnor_6.01938,460,859 - 38,461,064NCBIRnor6.0
Rnor_5.01949,330,552 - 49,330,757UniSTSRnor5.0
RGSC_v3.41937,227,186 - 37,227,391UniSTSRGSC3.4
Celera1934,693,121 - 34,693,326UniSTS
RH 3.4 Map19314.5UniSTS
Cytogenetic Map19q12UniSTS
RH142814  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21935,280,159 - 35,280,266 (-)MAPPERmRatBN7.2
Rnor_6.01938,452,466 - 38,452,572NCBIRnor6.0
Rnor_5.01949,322,159 - 49,322,265UniSTSRnor5.0
RGSC_v3.41937,235,678 - 37,235,784UniSTSRGSC3.4
Celera1934,701,613 - 34,701,719UniSTS
RH 3.4 Map19293.7UniSTS
Cytogenetic Map19q12UniSTS
UniSTS:224902  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21935,286,464 - 35,286,617 (-)MAPPERmRatBN7.2
Rnor_6.01938,446,117 - 38,446,269NCBIRnor6.0
Rnor_5.01949,315,810 - 49,315,962UniSTSRnor5.0
RGSC_v3.41937,241,981 - 37,242,133UniSTSRGSC3.4
Celera1934,707,907 - 34,708,059UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001107425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003751872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006255555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006255556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000017005   ⟹   ENSRNOP00000017005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1952,109,483 - 52,196,418 (+)Ensembl
mRatBN7.2 Ensembl1935,199,738 - 35,286,675 (+)Ensembl
Rnor_6.0 Ensembl1938,446,059 - 38,533,735 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077960   ⟹   ENSRNOP00000071907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1935,199,738 - 35,278,997 (+)Ensembl
Rnor_6.0 Ensembl1938,454,628 - 38,484,611 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094607   ⟹   ENSRNOP00000083454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1952,110,090 - 52,196,418 (+)Ensembl
mRatBN7.2 Ensembl1935,199,016 - 35,286,675 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102316   ⟹   ENSRNOP00000097702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1935,243,880 - 35,286,675 (+)Ensembl
RefSeq Acc Id: NM_001107425   ⟹   NP_001100895
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81952,109,483 - 52,196,418 (+)NCBI
mRatBN7.21935,199,738 - 35,286,675 (+)NCBI
Rnor_6.01938,446,059 - 38,533,735 (-)NCBI
Rnor_5.01950,363,699 - 50,398,311 (+)NCBI
RGSC_v3.41937,154,326 - 37,242,191 (+)RGD
Celera1934,621,583 - 34,708,117 (+)RGD
Sequence:
RefSeq Acc Id: XM_003751872   ⟹   XP_003751920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81952,108,982 - 52,196,411 (+)NCBI
mRatBN7.21935,199,737 - 35,286,671 (+)NCBI
Rnor_6.01938,451,557 - 38,533,720 (-)NCBI
Rnor_5.01949,320,570 - 49,403,625 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006255555   ⟹   XP_006255617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81952,143,988 - 52,196,411 (+)NCBI
mRatBN7.21935,234,218 - 35,286,671 (+)NCBI
Rnor_6.01938,451,557 - 38,531,186 (-)NCBI
Rnor_5.01949,320,570 - 49,403,625 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006255556   ⟹   XP_006255618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81952,143,964 - 52,196,411 (+)NCBI
mRatBN7.21935,234,216 - 35,286,671 (+)NCBI
Rnor_6.01938,451,557 - 38,531,186 (-)NCBI
Rnor_5.01949,320,570 - 49,403,625 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772503   ⟹   XP_008770725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81952,108,982 - 52,196,411 (+)NCBI
mRatBN7.21935,199,737 - 35,286,671 (+)NCBI
Rnor_6.01938,451,557 - 38,533,720 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772505   ⟹   XP_008770727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81952,157,140 - 52,196,411 (+)NCBI
mRatBN7.21935,247,398 - 35,286,671 (+)NCBI
Rnor_6.01938,451,557 - 38,531,186 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601291   ⟹   XP_017456780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81952,143,988 - 52,196,411 (+)NCBI
mRatBN7.21935,234,218 - 35,286,671 (+)NCBI
Rnor_6.01938,451,557 - 38,531,186 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097749   ⟹   XP_038953677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81952,143,962 - 52,196,411 (+)NCBI
mRatBN7.21935,234,218 - 35,286,671 (+)NCBI
RefSeq Acc Id: XM_039097751   ⟹   XP_038953679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81952,157,820 - 52,196,411 (+)NCBI
mRatBN7.21935,248,077 - 35,286,671 (+)NCBI
RefSeq Acc Id: XM_039097752   ⟹   XP_038953680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81952,158,318 - 52,196,411 (+)NCBI
mRatBN7.21935,248,433 - 35,286,671 (+)NCBI
RefSeq Acc Id: XM_063278043   ⟹   XP_063134113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81952,108,982 - 52,196,411 (+)NCBI
RefSeq Acc Id: XM_063278044   ⟹   XP_063134114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81952,112,049 - 52,196,411 (+)NCBI
RefSeq Acc Id: XM_063278045   ⟹   XP_063134115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81952,143,962 - 52,196,411 (+)NCBI
RefSeq Acc Id: XM_063278046   ⟹   XP_063134116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81952,143,988 - 52,196,411 (+)NCBI
RefSeq Acc Id: NP_001100895   ⟸   NM_001107425
- UniProtKB: D3ZGB1 (UniProtKB/Swiss-Prot),   A0A8I6ANN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003751920   ⟸   XM_003751872
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZWM0 (UniProtKB/TrEMBL),   A0A8I6ANN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255618   ⟸   XM_006255556
- Peptide Label: isoform X6
- UniProtKB: A0A8I6ANN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255617   ⟸   XM_006255555
- Peptide Label: isoform X6
- UniProtKB: A0A8I6ANN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770725   ⟸   XM_008772503
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ANN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770727   ⟸   XM_008772505
- Peptide Label: isoform X6
- UniProtKB: A0A8I6ANN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456780   ⟸   XM_017601291
- Peptide Label: isoform X5
- UniProtKB: A6IYZ9 (UniProtKB/TrEMBL),   A0A8I6ANN3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071907   ⟸   ENSRNOT00000077960
Ensembl Acc Id: ENSRNOP00000017005   ⟸   ENSRNOT00000017005
RefSeq Acc Id: XP_038953677   ⟸   XM_039097749
- Peptide Label: isoform X5
- UniProtKB: A6IYZ9 (UniProtKB/TrEMBL),   A0A8I6ANN3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953679   ⟸   XM_039097751
- Peptide Label: isoform X8
- UniProtKB: A0A8I6ANN3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953680   ⟸   XM_039097752
- Peptide Label: isoform X9
- UniProtKB: A0A8I6ANN3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083454   ⟸   ENSRNOT00000094607
Ensembl Acc Id: ENSRNOP00000097702   ⟸   ENSRNOT00000102316
RefSeq Acc Id: XP_063134113   ⟸   XM_063278043
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ANN3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134114   ⟸   XM_063278044
- Peptide Label: isoform X4
- UniProtKB: A0A8I6ANN3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134115   ⟸   XM_063278045
- Peptide Label: isoform X6
- UniProtKB: A0A8I6ANN3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134116   ⟸   XM_063278046
- Peptide Label: isoform X7
- UniProtKB: A0A8I6ANN3 (UniProtKB/TrEMBL)
Protein Domains
RHD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZGB1-F1-model_v2 AlphaFold D3ZGB1 1-1548 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309142 AgrOrtholog
BioCyc Gene G2FUF-5760 BioCyc
Ensembl Genes ENSRNOG00000011879 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017005 ENTREZGENE
  ENSRNOT00000017005.6 UniProtKB/Swiss-Prot
  ENSRNOT00000094607 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  2.60.40.340 UniProtKB/Swiss-Prot
InterPro Ig-like_fold UniProtKB/Swiss-Prot
  Ig_E-set UniProtKB/Swiss-Prot
  IPT_dom UniProtKB/Swiss-Prot
  NFAT UniProtKB/Swiss-Prot
  NFAT5 UniProtKB/Swiss-Prot
  p53-like_TF_DNA-bd UniProtKB/Swiss-Prot
  RHD_dimer UniProtKB/Swiss-Prot
  RHD_DNA_bind_dom UniProtKB/Swiss-Prot
  RHD_DNA_bind_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:307820 UniProtKB/Swiss-Prot
NCBI Gene 307820 ENTREZGENE
PANTHER PTHR12533 UniProtKB/Swiss-Prot
  PTHR12533:SF10 UniProtKB/Swiss-Prot
Pfam RHD_dimer UniProtKB/Swiss-Prot
  RHD_DNA_bind UniProtKB/Swiss-Prot
PhenoGen Nfat5 PhenoGen
PRINTS NUCFACTORATC UniProtKB/Swiss-Prot
PROSITE REL_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011879 RatGTEx
SMART IPT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49417 UniProtKB/Swiss-Prot
  SSF81296 UniProtKB/Swiss-Prot
UniProt A0A8I5ZWM0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ANN3 ENTREZGENE
  A6IYZ9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZGB1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-21 Nfat5  nuclear factor of activated T-cells 5  Nfat5  nuclear factor of activated T-cells 5, tonicity-responsive  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-22 Nfat5  nuclear factor of activated T-cells 5, tonicity-responsive  Nfat5  nuclear factor of activated T-cells 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Nfat5  nuclear factor of activated T-cells 5   Nfat5_predicted  nuclear factor of activated T-cells 5 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Nfat5_predicted  nuclear factor of activated T-cells 5 (predicted)      Symbol and Name status set to approved 70820 APPROVED