Pnpla2 (patatin like domain 2, triacylglycerol lipase) - Rat Genome Database

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Gene: Pnpla2 (patatin like domain 2, triacylglycerol lipase) Rattus norvegicus
Analyze
Symbol: Pnpla2
Name: patatin like domain 2, triacylglycerol lipase (Ensembl:patatin-like phospholipase domain containing 2)
RGD ID: 1309044
Description: Predicted to enable acylglycerol O-acyltransferase activity and carboxylic ester hydrolase activity. Predicted to be involved in several processes, including acylglycerol metabolic process; intracellular triglyceride homeostasis; and lipid droplet disassembly. Predicted to act upstream of with a negative effect on lipid droplet fusion. Predicted to act upstream of or within lipid catabolic process and lipid droplet organization. Predicted to be located in plasma membrane. Predicted to be active in cytosol; lipid droplet; and membrane. Orthologous to human PNPLA2 (patatin like phospholipase domain containing 2); INTERACTS WITH (+)-catechin; (-)-cotinine; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adipose triglyceride lipase; calcium-independent phospholipase A2-zeta; iPLA2-zeta; LOC100911615; LOC361676; patatin-like phospholipase domain containing 2; patatin-like phospholipase domain-containing protein 2; patatin-like phospholipase domain-containing protein 2-like; RGD1309044; similar to RIKEN cDNA 0610039C21
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,982,279 - 205,987,361 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1205,982,258 - 205,987,359 (+)EnsemblGRCr8
mRatBN7.21196,552,723 - 196,557,805 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,552,723 - 196,557,805 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1204,898,082 - 204,903,154 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,026,596 - 212,031,676 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,700,734 - 204,705,814 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,434,638 - 214,439,720 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,434,626 - 214,439,720 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1213,997,709 - 214,002,815 (+)Ensemblrn6Rnor6.0
Rnor_5.01220,914,961 - 220,920,043 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41201,641,939 - 201,647,021 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1194,186,305 - 194,191,301 (+)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(-)-cotinine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
alpha-Zearalanol  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Bufotalin  (ISO)
buspirone  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
canrenoic acid  (EXP)
carbon nanotube  (ISO)
carmustine  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
cortisol  (ISO)
cycloheximide  (ISO)
D-glucose  (ISO)
DDE  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
folic acid  (ISO)
FR900359  (ISO)
fructose  (EXP,ISO)
glucose  (ISO)
hexadecanoic acid  (EXP,ISO)
imidacloprid  (ISO)
indometacin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
leflunomide  (EXP)
Licarin A  (ISO)
Licochalcone B  (ISO)
liraglutide  (ISO)
methidathion  (ISO)
methotrexate  (EXP)
MK-2206  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nevirapine  (EXP)
nicotine  (EXP)
nimesulide  (EXP)
NMN zwitterion  (ISO)
olanzapine  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phosphatidylcholine  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
raspberry ketone  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
Salvianolic acid A  (ISO)
scopoletin  (EXP)
senecionine  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
tamoxifen  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
tioguanine  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
tributylstannane  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
cytosol  (IEA,ISO)
lipid droplet  (IBA,IEA,ISO,ISS)
membrane  (IBA)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Skeletal muscle PLIN proteins, ATGL and CGI-58, interactions at rest and following stimulated contraction. MacPherson RE, etal., Am J Physiol Regul Integr Comp Physiol. 2013 Apr 15;304(8):R644-50. doi: 10.1152/ajpregu.00418.2012. Epub 2013 Feb 13.
3. Skeletal muscle PLIN3 and PLIN5 are serine phosphorylated at rest and following lipolysis during adrenergic or contractile stimulation. Macpherson RE, etal., Physiol Rep. 2013 Sep;1(4):e00084. doi: 10.1002/phy2.84. Epub 2013 Sep 17.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16679289   PMID:17074755   PMID:17603008   PMID:19389712   PMID:21148142   PMID:21498505   PMID:21944063   PMID:22183409   PMID:23297223   PMID:25436917   PMID:25890298   PMID:26141235  
PMID:26277390   PMID:26427354   PMID:26511521   PMID:27179362   PMID:27590244   PMID:27658392  


Genomics

Comparative Map Data
Pnpla2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,982,279 - 205,987,361 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1205,982,258 - 205,987,359 (+)EnsemblGRCr8
mRatBN7.21196,552,723 - 196,557,805 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,552,723 - 196,557,805 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1204,898,082 - 204,903,154 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,026,596 - 212,031,676 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,700,734 - 204,705,814 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,434,638 - 214,439,720 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,434,626 - 214,439,720 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1213,997,709 - 214,002,815 (+)Ensemblrn6Rnor6.0
Rnor_5.01220,914,961 - 220,920,043 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41201,641,939 - 201,647,021 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1194,186,305 - 194,191,301 (+)NCBICelera
Cytogenetic Map1q41NCBI
PNPLA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811818,914 - 825,573 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11818,914 - 825,573 (+)Ensemblhg38GRCh38
GRCh3711818,914 - 825,573 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611808,902 - 815,217 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3411808,901 - 815,216NCBI
Celera11885,450 - 892,225 (+)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef11634,726 - 640,840 (+)NCBIHuRef
CHM1_111817,799 - 824,534 (+)NCBICHM1_1
T2T-CHM13v2.011870,350 - 877,008 (+)NCBIT2T-CHM13v2.0
Pnpla2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,035,101 - 141,040,656 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,035,111 - 141,040,656 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387141,455,188 - 141,460,743 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,455,198 - 141,460,743 (+)Ensemblmm10GRCm38
MGSCv377148,641,087 - 148,646,642 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367141,306,527 - 141,311,414 (+)NCBIMGSCv36mm8
Celera7141,248,977 - 141,254,535 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.81NCBI
Pnpla2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,303,843 - 11,309,181 (-)Ensembl
ChiLan1.0NW_00495547611,304,660 - 11,309,755 (-)NCBIChiLan1.0ChiLan1.0
PNPLA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,217,710 - 3,224,177 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,428,305 - 2,434,123 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011838,339 - 844,035 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111883,279 - 887,258 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11881,934 - 886,896 (+)EnsemblpanPan2panpan1.1
PNPLA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11845,182,569 - 45,187,937 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1845,182,566 - 45,187,268 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1843,849,713 - 43,854,935 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01845,847,672 - 45,852,617 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1845,847,350 - 45,852,887 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11845,312,419 - 45,317,644 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01844,877,261 - 44,882,484 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01845,615,387 - 45,620,610 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pnpla2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947580,773 - 585,949 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936888580,767 - 587,083 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936888580,773 - 585,949 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNPLA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2513,077 - 518,182 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12513,065 - 517,962 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22156,833 - 161,266 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PNPLA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11626,060 - 631,556 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603897,715,973 - 97,721,418 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pnpla2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476621,690,873 - 21,697,009 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476621,692,023 - 21,697,018 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pnpla2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v128,027,496 - 8,032,573 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pnpla2
36 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:177
Count of miRNA genes:119
Interacting mature miRNAs:143
Transcripts:ENSRNOT00000025319, ENSRNOT00000025826
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1194786607207590403Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1201915593208479939Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512213659238Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
RH133487  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,557,567 - 196,557,761 (+)MAPPERmRatBN7.2
Rnor_6.01214,439,483 - 214,439,676NCBIRnor6.0
Rnor_6.01214,002,577 - 214,002,770NCBIRnor6.0
Rnor_5.01220,919,806 - 220,919,999UniSTSRnor5.0
Rnor_5.01221,356,595 - 221,356,788UniSTSRnor5.0
RGSC_v3.41201,646,784 - 201,646,977UniSTSRGSC3.4
Celera1194,191,064 - 194,191,257UniSTS
Cytogenetic Map1q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
19 2 30 113 68 61 36 79 36 12 255 144 11 88 56 75 25 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000025319   ⟹   ENSRNOP00000025319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1196,552,723 - 196,557,805 (+)Ensembl
Rnor_6.0 Ensembl1214,434,626 - 214,439,720 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000025826   ⟹   ENSRNOP00000025826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1205,982,258 - 205,987,359 (+)Ensembl
mRatBN7.2 Ensembl1196,552,723 - 196,557,805 (+)Ensembl
Rnor_6.0 Ensembl1213,997,709 - 214,002,815 (+)Ensembl
RefSeq Acc Id: NM_001108509   ⟹   NP_001101979
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,982,279 - 205,987,361 (+)NCBI
mRatBN7.21196,552,723 - 196,557,805 (+)NCBI
Rnor_6.01214,434,638 - 214,439,720 (+)NCBI
Rnor_5.01220,914,961 - 220,920,043 (+)NCBI
RGSC_v3.41201,641,939 - 201,647,021 (+)RGD
Celera1194,186,305 - 194,191,301 (+)RGD
Sequence:
RefSeq Acc Id: NP_001101979   ⟸   NM_001108509
- UniProtKB: P0C548 (UniProtKB/Swiss-Prot),   A6HXY0 (UniProtKB/TrEMBL),   A0A8L2QDK4 (UniProtKB/TrEMBL),   A6HXY1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025319   ⟸   ENSRNOT00000025319
Ensembl Acc Id: ENSRNOP00000025826   ⟸   ENSRNOT00000025826
Protein Domains
PNPLA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C548-F1-model_v2 AlphaFold P0C548 1-478 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690546
Promoter ID:EPDNEW_R1070
Type:initiation region
Name:Pnpla2_1
Description:patatin-like phospholipase domain containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01214,434,677 - 214,434,737EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309044 AgrOrtholog
BioCyc Gene G2FUF-56949 BioCyc
Ensembl Genes ENSRNOG00000018736 Ensembl
  ENSRNOG00000047551 Ensembl
  ENSRNOG00000069673 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025319.7 UniProtKB/Swiss-Prot
  ENSRNOT00000025826 ENTREZGENE
Gene3D-CATH Cytosolic phospholipase A2 catalytic domain UniProtKB/Swiss-Prot
InterPro Acyl_Trfase/lysoPLipase UniProtKB/Swiss-Prot
  PLPL UniProtKB/Swiss-Prot
  PNPLA2 UniProtKB/Swiss-Prot
  PNPLA_dom UniProtKB/Swiss-Prot
KEGG Report rno:361676 UniProtKB/Swiss-Prot
NCBI Gene 361676 ENTREZGENE
PANTHER PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 2 UniProtKB/Swiss-Prot
  PTHR12406 UniProtKB/Swiss-Prot
Pfam Patatin UniProtKB/Swiss-Prot
PhenoGen Pnpla2 PhenoGen
PROSITE PNPLA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018736 RatGTEx
  ENSRNOG00000047551 RatGTEx
  ENSRNOG00000069673 RatGTEx
Superfamily-SCOP SSF52151 UniProtKB/Swiss-Prot
UniProt A0A8L2QDK4 ENTREZGENE, UniProtKB/TrEMBL
  A6HXY0 ENTREZGENE, UniProtKB/TrEMBL
  A6HXY1 ENTREZGENE, UniProtKB/TrEMBL
  P0C548 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-11-13 Pnpla2  patatin like domain 2, triacylglycerol lipase  Pnpla2  patatin-like phospholipase domain containing 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-03-09 Pnpla2  patatin-like phospholipase domain containing 2  LOC100911615  patatin-like phospholipase domain-containing protein 2-like  Data merged from RGD:6492173 737654 PROVISIONAL
2012-07-05 LOC100911615  patatin-like phospholipase domain-containing protein 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Pnpla2  patatin-like phospholipase domain containing 2   Pnpla2_predicted  patatin-like phospholipase domain containing 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Pnpla2_predicted  patatin-like phospholipase domain containing 2 (predicted)  RGD1309044_predicted  similar to RIKEN cDNA 0610039C21 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1309044_predicted  similar to RIKEN cDNA 0610039C21 (predicted)  LOC361676_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC361676_predicted  similar to RIKEN cDNA 0610039C21 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL