PNPLA2 (patatin like phospholipase domain containing 2) - Rat Genome Database

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Gene: PNPLA2 (patatin like phospholipase domain containing 2) Canis lupus familiaris
Analyze
Symbol: PNPLA2
Name: patatin like phospholipase domain containing 2
RGD ID: 12051324
Description: ENCODES a protein that exhibits retinyl-palmitate esterase activity (ortholog); INVOLVED IN cellular lipid catabolic process (ortholog); intracellular triglyceride homeostasis (ortholog); lipid droplet fusion (ortholog); ASSOCIATED WITH Chanarin-Dorfman syndrome (ortholog); congestive heart failure (ortholog); delta beta-thalassemia (ortholog); FOUND IN lipid droplet (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: patatin-like phospholipase domain-containing protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11845,182,569 - 45,187,937 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1845,182,566 - 45,187,268 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1843,849,713 - 43,854,935 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01845,847,672 - 45,852,617 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1845,847,350 - 45,852,887 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11845,312,419 - 45,317,644 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01844,877,261 - 44,882,484 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01845,615,387 - 45,620,610 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
lipid droplet  (IEA,ISO)
membrane  (IEA)
nucleoplasm  (IEA)
plasma membrane  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PNPLA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11845,182,569 - 45,187,937 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1845,182,566 - 45,187,268 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1843,849,713 - 43,854,935 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01845,847,672 - 45,852,617 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1845,847,350 - 45,852,887 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11845,312,419 - 45,317,644 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01844,877,261 - 44,882,484 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01845,615,387 - 45,620,610 (+)NCBIUU_Cfam_GSD_1.0
PNPLA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811818,914 - 825,573 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11818,914 - 825,573 (+)EnsemblGRCh38hg38GRCh38
GRCh3711818,914 - 825,573 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611808,902 - 815,217 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411808,901 - 815,216NCBI
Celera11885,450 - 892,225 (+)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef11634,726 - 640,840 (+)NCBIHuRef
CHM1_111817,799 - 824,534 (+)NCBICHM1_1
T2T-CHM13v2.011870,350 - 877,008 (+)NCBIT2T-CHM13v2.0
Pnpla2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,035,101 - 141,040,656 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,035,111 - 141,040,656 (+)EnsemblGRCm39 Ensembl
GRCm387141,455,188 - 141,460,743 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,455,198 - 141,460,743 (+)EnsemblGRCm38mm10GRCm38
MGSCv377148,641,087 - 148,646,642 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,306,527 - 141,311,414 (+)NCBIMGSCv36mm8
Celera7141,248,977 - 141,254,535 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.81NCBI
Pnpla2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,982,279 - 205,987,361 (+)NCBIGRCr8
mRatBN7.21196,552,723 - 196,557,805 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,552,723 - 196,557,805 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,898,082 - 204,903,154 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,026,596 - 212,031,676 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,700,734 - 204,705,814 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,434,638 - 214,439,720 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,434,626 - 214,439,720 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,997,709 - 214,002,815 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01220,914,961 - 220,920,043 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,641,939 - 201,647,021 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1194,186,305 - 194,191,301 (+)NCBICelera
Cytogenetic Map1q41NCBI
Pnpla2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,303,843 - 11,309,181 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,304,660 - 11,309,755 (-)NCBIChiLan1.0ChiLan1.0
PNPLA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,217,710 - 3,224,177 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,428,305 - 2,434,123 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011838,339 - 844,035 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111883,279 - 887,258 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11881,934 - 886,896 (+)Ensemblpanpan1.1panPan2
Pnpla2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947580,773 - 585,949 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936888580,767 - 587,083 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936888580,773 - 585,949 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNPLA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2513,077 - 518,182 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12513,065 - 517,962 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22156,833 - 161,266 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PNPLA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11626,060 - 631,556 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603897,715,973 - 97,721,418 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pnpla2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476621,690,873 - 21,697,009 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476621,692,023 - 21,697,018 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PNPLA2
88 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 6
Medium 5 5 22 6 6 6 6 6 12 8 10
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000015162   ⟹   ENSCAFP00000014031
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1845,182,566 - 45,187,268 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845011669   ⟹   ENSCAFP00845009109
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1845,847,350 - 45,852,887 (+)Ensembl
RefSeq Acc Id: XM_038424591   ⟹   XP_038280519
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01845,847,672 - 45,852,617 (+)NCBI
RefSeq Acc Id: XM_038454113   ⟹   XP_038310041
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1843,849,713 - 43,854,935 (+)NCBI
RefSeq Acc Id: XM_038500863   ⟹   XP_038356791
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11845,312,419 - 45,317,644 (+)NCBI
RefSeq Acc Id: XM_038563520   ⟹   XP_038419448
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01845,615,387 - 45,620,610 (+)NCBI
RefSeq Acc Id: XM_038627641   ⟹   XP_038483569
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01844,877,261 - 44,882,484 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000014031   ⟸   ENSCAFT00000015162
RefSeq Acc Id: XP_038356791   ⟸   XM_038500863
RefSeq Acc Id: XP_038483569   ⟸   XM_038627641
RefSeq Acc Id: XP_038280519   ⟸   XM_038424591
- UniProtKB: A0A8C0KUN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038310041   ⟸   XM_038454113
- UniProtKB: A0A8C0KUN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038419448   ⟸   XM_038563520
- UniProtKB: A0A8C0KUN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845009109   ⟸   ENSCAFT00845011669
Protein Domains
PNPLA

Promoters
RGD ID:13686526
Promoter ID:EPDNEW_C4594
Type:single initiation site
Name:PNPLA2_1
Description:patatin like phospholipase domain containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11845,182,565 - 45,182,625EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009547 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845006576 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000015162.6 UniProtKB/TrEMBL
  ENSCAFT00845011669.1 UniProtKB/TrEMBL
Gene3D-CATH Cytosolic phospholipase A2 catalytic domain UniProtKB/TrEMBL
InterPro Acyl_Trfase/lysoPLipase UniProtKB/TrEMBL
  PLPL UniProtKB/TrEMBL
  PNPLA2 UniProtKB/TrEMBL
  PNPLA_dom UniProtKB/TrEMBL
NCBI Gene PNPLA2 ENTREZGENE
PANTHER PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
  PTHR12406 UniProtKB/TrEMBL
Pfam Patatin UniProtKB/TrEMBL
PROSITE PNPLA UniProtKB/TrEMBL
Superfamily-SCOP SSF52151 UniProtKB/TrEMBL
UniProt A0A8C0KUN0 ENTREZGENE
  A0A8I3MZB7_CANLF UniProtKB/TrEMBL
  A0A8P0NBX3_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:44753 ENTREZGENE