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Gene: Ehd1 (EH-domain containing 1) Rattus norvegicus

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Symbol:

Ehd1

Name:

EH-domain containing 1

RGD ID:

1309017

Description:

Predicted to enable identical protein binding activity; protein-macromolecule adaptor activity; and small GTPase binding activity. Involved in cellular response to nerve growth factor stimulus; neuron projection development; and positive regulation of neuron projection development. Located in endosome membrane. Is active in glutamatergic synapse and presynaptic active zone. Biomarker of obesity. Orthologous to human EHD1 (EH domain containing 1); PARTICIPATES IN retromer-mediated pathway; endocytosis pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

EH domain-containing protein 1; LOC293692; RGD1306960

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EHD1 (EH domain containing 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ehd1 (EH-domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ehd1 (EH domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EHD1 (EH domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EHD1 (EH domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ehd1 (EH domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EHD1 (EH domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EHD1 (EH domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ehd1 (EH domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Ehd1 (EH domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	EHD3 (EH domain containing 3)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	EHD1 (EH domain containing 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ehd1 (EH-domain containing 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ehd1b (EH-domain containing 1b)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Danio rerio (zebrafish):	ehd1b (EH-domain containing 1b)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	ehd1a (EH-domain containing 1a)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Danio rerio (zebrafish):	ehd1a (EH-domain containing 1a)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Past1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rme-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	IRS4	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	SLA1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	ehd1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	ehd1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	213,009,113 - 213,031,488 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	213,008,049 - 213,031,485 (+)	Ensembl				GRCr8
mRatBN7.2	1	203,579,850 - 203,602,226 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	203,579,869 - 203,602,212 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	211,928,608 - 211,950,969 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	219,025,181 - 219,047,556 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	211,716,238 - 211,738,613 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	221,644,867 - 221,667,242 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	221,644,867 - 221,667,239 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	228,632,629 - 228,655,004 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	209,055,234 - 209,077,609 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	201,113,342 - 201,135,717 (+)	NCBI		Celera
RGSC_v3.1	1	209,213,709 - 209,234,786 (+)	NCBI
Cytogenetic Map	1	q43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Disease Progression (ISO)

high grade glioma (ISO)

Neoplasm Recurrence, Local (ISO)

obesity (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

1,3-dinitrobenzene (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-amino-14,16-dimethyloctadecan-3-ol (ISO)

2-methylcholine (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

Benzo[k]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bleomycin A2 (EXP)

Butylbenzyl phthalate (ISO)

C60 fullerene (EXP)

cadmium dichloride (ISO)

caffeine (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

chrysene (ISO)

cobalt dichloride (ISO)

copper(II) chloride (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

deoxynivalenol (ISO)

dextran sulfate (ISO)

diazinon (ISO)

Dibutyl phosphate (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

epoxiconazole (EXP,ISO)

ethanol (ISO)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

gardiquimod (ISO)

gentamycin (EXP)

ivermectin (ISO)

leflunomide (ISO)

Licochalcone B (ISO)

lipopolysaccharide (ISO)

mercury dichloride (EXP)

Mesaconitine (EXP)

methimazole (EXP)

morphine (EXP)

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (ISO)

N-methyl-4-phenylpyridinium (ISO)

naphthalene (ISO)

nickel atom (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

peptidoglycan (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

progesterone (ISO)

propiconazole (EXP)

Propiverine (EXP)

protein kinase inhibitor (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

selenomethionine (ISO)

serpentine asbestos (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

succimer (ISO)

sulfadimethoxine (EXP)

temozolomide (ISO)

tetrachloromethane (ISO)

tetraphene (ISO)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc sulfate (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell projection organization (IEA)

cellular response to nerve growth factor stimulus (IDA)

cholesterol homeostasis (IEA,ISO)

cilium assembly (IBA,IEA,ISO,ISS)

endocytic recycling (IBA,IEA,ISO,ISS)

endocytosis (IBA,IEA,ISO,ISS)

endosomal transport (ISO)

intracellular protein transport (IEA,ISO,ISS)

low-density lipoprotein particle clearance (IEA,ISO)

neuron projection development (IMP)

positive regulation of cholesterol storage (IEA,ISO)

positive regulation of endocytic recycling (IEA,ISO,ISS)

positive regulation of myoblast fusion (IEA,ISO,ISS)

positive regulation of neuron projection development (IMP)

protein homooligomerization (IEA,ISO)

protein localization to cilium (IEA,ISO,ISS)

protein localization to plasma membrane (IBA)

protein transport (IEA)

Cellular Component

ciliary membrane (IEA)

ciliary pocket membrane (IEA,ISO,ISS)

ciliary transition zone (IEA,ISO)

cilium (IEA,ISO,ISS)

cytoplasm (IBA,IEA)

early endosome (IBA,IEA,ISO)

early endosome membrane (IEA,ISO,ISS)

endocytic vesicle (IBA,IEA,ISO)

endosome (IEA,ISO)

endosome membrane (IDA)

glutamatergic synapse (IDA)

lipid droplet (IEA,ISO)

perinuclear region of cytoplasm (IBA,IEA,ISO)

plasma membrane (IBA,IEA,ISO,ISS)

platelet dense tubular network membrane (IEA,ISO)

presynaptic active zone (IDA)

recycling endosome membrane (IBA,IEA,ISO,ISS)

Molecular Function

ATP binding (IEA)

calcium ion binding (IEA)

GTP binding (IEA)

identical protein binding (IEA,ISO)

metal ion binding (IEA)

nucleotide binding (IEA)

protein binding (IPI,ISO)

protein-macromolecule adaptor activity (IBA)

small GTPase binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

endocytosis pathway (IEA)

retromer-mediated pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Retromer and sorting nexins in endosomal sorting.	Gallon M and Cullen PJ, Biochem Soc Trans. 2015 Feb;43(1):33-47. doi: 10.1042/BST20140290.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Differential expression of adipose tissue proteins between obesity-susceptible and -resistant rats fed a high-fat diet.	Joo JI, etal., Proteomics. 2011 Apr;11(8):1429-48. doi: 10.1002/pmic.201000515. Epub 2011 Feb 25.
5.	Rab35 establishes the EHD1-association site by coordinating two distinct effectors during neurite outgrowth.	Kobayashi H and Fukuda M, J Cell Sci. 2013 Jun 1;126(Pt 11):2424-35. doi: 10.1242/jcs.117846. Epub 2013 Apr 9.
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29.	Rotem-Yehudar R, etal., J Biol Chem. 2001 Aug 31;276(35):33054-60. Epub 2001 Jun 21.
11.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12.	EHD1 is a synaptic protein that modulates exocytosis through binding to snapin.	Wei S, etal., Mol Cell Neurosci. 2010 Dec;45(4):418-29. doi: 10.1016/j.mcn.2010.07.014. Epub 2010 Aug 6.
13.	Mutually exclusive interactions of EHD1 with GS32 and syndapin II.	Xu Y, etal., Mol Membr Biol. 2004 Jul-Aug;21(4):269-77.

Additional References at PubMed

PMID:8889548	PMID:11389441	PMID:12121420	PMID:15020713	PMID:15247266	PMID:17233914	PMID:17451652	PMID:17634366	PMID:19056867	PMID:19199708	PMID:19864458	PMID:19946888
PMID:20458337	PMID:20463227	PMID:20489164	PMID:20801876	PMID:21147988	PMID:21177873	PMID:21957258	PMID:23376485	PMID:23533145	PMID:23596323	PMID:25468996	PMID:25686250
PMID:26316108	PMID:27211346	PMID:30053369	PMID:30320922	PMID:32138615

Genomics

Comparative Map Data

Ehd1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	213,009,113 - 213,031,488 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	213,008,049 - 213,031,485 (+)	Ensembl				GRCr8
mRatBN7.2	1	203,579,850 - 203,602,226 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	203,579,869 - 203,602,212 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	211,928,608 - 211,950,969 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	219,025,181 - 219,047,556 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	211,716,238 - 211,738,613 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	221,644,867 - 221,667,242 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	221,644,867 - 221,667,239 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	228,632,629 - 228,655,004 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	209,055,234 - 209,077,609 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	201,113,342 - 201,135,717 (+)	NCBI		Celera
RGSC_v3.1	1	209,213,709 - 209,234,786 (+)	NCBI
Cytogenetic Map	1	q43	NCBI

EHD1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	64,851,642 - 64,879,693 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	64,851,642 - 64,888,372 (-)	Ensembl			hg38	GRCh38
GRCh37	11	64,619,114 - 64,647,165 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	64,376,784 - 64,402,767 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	11	64,376,783 - 64,402,767	NCBI
Celera	11	61,946,373 - 61,972,260 (-)	NCBI		Celera
Cytogenetic Map	11	q13.1	NCBI
HuRef	11	60,947,278 - 60,973,225 (-)	NCBI		HuRef
CHM1_1	11	64,504,028 - 64,529,958 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	64,844,974 - 64,872,935 (-)	NCBI		T2T-CHM13v2.0

Ehd1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	6,326,926 - 6,350,126 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	6,326,755 - 6,350,126 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	19	6,276,896 - 6,300,096 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	6,276,725 - 6,300,096 (+)	Ensembl			mm10	GRCm38
MGSCv37	19	6,276,896 - 6,300,096 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	19	6,276,896 - 6,300,096 (+)	NCBI		MGSCv36	mm8
Celera	19	6,149,194 - 6,172,784 (+)	NCBI		Celera
Cytogenetic Map	19	A	NCBI
cM Map	19	4.4	NCBI

Ehd1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	20,302,655 - 20,324,591 (+)	Ensembl
ChiLan1.0	NW_004955422	20,302,409 - 20,324,591 (+)	NCBI	ChiLan1.0	ChiLan1.0

EHD1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	66,079,274 - 66,107,007 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	67,122,242 - 67,149,976 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	60,208,840 - 60,236,513 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	63,550,258 - 63,577,252 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	63,547,286 - 63,577,252 (-)	Ensembl			panPan2	panpan1.1

EHD1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	52,291,304 - 52,312,787 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	52,291,327 - 52,311,526 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	50,898,642 - 50,920,115 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	53,332,471 - 53,353,954 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	53,332,477 - 53,353,942 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	52,427,459 - 52,448,913 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	52,012,970 - 52,034,432 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	52,797,390 - 52,818,875 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ehd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	8,007,727 - 8,029,462 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936599	4,450,188 - 4,473,738 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936599	4,451,207 - 4,473,078 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EHD1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	7,298,208 - 7,321,576 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	7,299,295 - 7,321,580 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	6,430,635 - 6,454,134 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EHD1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	9,356,128 - 9,382,204 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	9,356,177 - 9,382,832 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	106,742,061 - 106,769,019 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ehd1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	21,522,750 - 21,544,133 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624767	21,522,871 - 21,543,925 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ehd1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	1,388,026 - 1,410,637 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ehd1
105 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	244
Count of miRNA genes:	150
Interacting mature miRNAs:	189
Transcripts:	ENSRNOT00000054830
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	160111531	262090437	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	160573753	266453731	Rat
1357335	Bw39	Body weight QTL 39	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	1	207243873	252243873	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	186658830	266453731	Rat
2293674	Bss39	Bone structure and strength QTL 39	7.1	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	1	210980612	255980612	Rat
1354653	Despr9	Despair related QTL 9		0.00019	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	177339686	222339686	Rat
2293673	Bss27	Bone structure and strength QTL 27	18.63	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	1	181059071	226059071	Rat
2293677	Bss41	Bone structure and strength QTL 41	9.38	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	1	181059071	226059071	Rat
1549830	Bss1	Bone structure and strength QTL 1	4.8		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	182039247	227039247	Rat
70163	Bw20	Body weight QTL 20	5.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	183564652	228564652	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	205233991	267096252	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	186658830	266453731	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	176288899	270518180	Rat
631838	Niddm36	Non-insulin dependent diabetes mellitus QTL 36		0.01	insulin secretion trait (VT:0003564)	calculated pancreatic islet insulin release measurement (CMO:0001217)	1	193964073	238964073	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	162548015	270518180	Rat
2293689	Bss47	Bone structure and strength QTL 47	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	1	181059071	226059071	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	132966869	252856240	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
2293694	Bss38	Bone structure and strength QTL 38	7.05	0.0001	femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	1	210980612	255980612	Rat
61341	Bp26	Blood pressure QTL 26			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	139442053	223964440	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	152919152	268496042	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	160111531	262090437	Rat
2293693	Bss22	Bone structure and strength QTL 22	33.52	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	1	181059071	226059071	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	99645382	221502378	Rat
2300161	Bmd43	Bone mineral density QTL 43	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	181059071	226059071	Rat
1300145	Rf7	Renal function QTL 7	2.96		urine creatinine amount (VT:0010540)	urine creatinine level (CMO:0000125)	1	194575422	239575422	Rat
61347	Bp197	Blood pressure QTL 197	4.2		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	1	168063662	213063662	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	193400541	238400541	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	200449456	256003563	Rat
631214	Bw61	Body weight QTL61	3.4	0.0001	intramuscular adipose amount (VT:0010044)	intramuscular fat area (CMO:0001162)	1	182535316	227535316	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	146080545	243492863	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	103779152	223964440	Rat
731175	Uae20	Urinary albumin excretion QTL 20	3.5	0.0018	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	207163993	269633915	Rat
2300175	Bmd40	Bone mineral density QTL 40	15.4	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	1	210980612	255980612	Rat
2300174	Bmd42	Bone mineral density QTL 42	8.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	1	181059071	226059071	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	153679879	232414077	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	160574007	235238518	Rat
2293654	Bss30	Bone structure and strength QTL 30	32.65	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	1	181059071	226059071	Rat
2293655	Bss36	Bone structure and strength QTL 36	10.66	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	210980612	255980612	Rat
1298084	Thym4	Thymus enlargement QTL 4	10.68		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	207243873	252243873	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	160111426	262090599	Rat
2300187	Bmd41	Bone mineral density QTL 41	8.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	181059071	226059071	Rat
2314011	Gluco56	Glucose level QTL 56			blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	209203273	254203273	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	202543537	247543537	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	154961463	266453731	Rat
1358292	Cm37	Cardiac mass QTL 37	6.2	8e-07	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	1	205674651	250674651	Rat
61376	Bp42	Blood pressure QTL 42	23.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	207243873	252243873	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	208479811	269633915	Rat
634312	Bp143	Blood pressure QTL 143	3	0.0002	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	203300512	229359342	Rat
1358294	Bw37	Body weight QTL 37	5	0.000011	body mass (VT:0001259)	body weight (CMO:0000012)	1	180739993	225739993	Rat
724559	Pancm1	Pancreatic morphology QTL 1	7.1		islet of Langerhans morphology trait (VT:0005215)	pancreatic islet damage composite score (CMO:0001156)	1	191190115	223964326	Rat
2312420	Pur17	Proteinuria QTL 17	7.1	0.0001	urine protein amount (VT:0005160)	urine total protein excretion rate (CMO:0000756)	1	172718770	228180370	Rat
10059600	Bp378	Blood pressure QTL 378	3.08	0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	186298393	231298393	Rat
1358916	Kidm22	Kidney mass QTL 22	3.32		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	212738576	257738576	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	194786607	262083703	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	188241285	250779312	Rat
2292218	Kidm35	Kidney mass QTL 35			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	208798288	253798288	Rat
724562	Rends1	Renal damage susceptibility QTL 1		0.05	kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	1	139442053	223964440	Rat
1300168	Bp170	Blood pressure QTL 170	2.76		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	192995199	237995199	Rat
61403	Niddm4	Non-insulin dependent diabetes mellitus QTL 4			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	201464383	246464383	Rat
2292222	Bp307	Blood pressure QTL 307	3.06	0.0014	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	186298393	231298393	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	186298393	231298393	Rat
1641926	Teswt2	Testicular weight QTL 2	2.82		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	1	203675682	248675682	Rat
631658	Cm7	Cardiac mass QTL 7	5.32	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	1	205674651	250674651	Rat
1600380	Niddm70	Non-insulin dependent diabetes mellitus QTL 70	3.1	0.0008	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	185979875	230979875	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
1582206	Kidm33	Kidney mass QTL 33	6.9		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	197807365	233480676	Rat
2293700	Bmd27	Bone mineral density QTL 27	6.6	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	210980612	255980612	Rat
2293701	Bmd34	Bone mineral density QTL 34	8.3	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	1	210980612	255980612	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	193400541	238400541	Rat
634338	Hcar4	Hepatocarcinoma resistance QTL 4	4.6		liver integrity trait (VT:0010547)	liver tumorous lesion number to liver area ratio (CMO:0001210)	1	202851915	223964440	Rat
6480783	Insul19	Insulin level QTL 19	4.33		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	203300512	213659238	Rat
6903303	Scl34	Serum cholesterol QTL 34	2.5	0.0033	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	173363824	227535316	Rat
1600374	Mcs17	Mammary carcinoma susceptibility QTL 17	3		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	207099883	252099883	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	210980612	255980612	Rat
2293083	Iddm25	Insulin dependent diabetes mellitus QTL 25	4.18		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	191260175	236260175	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	111949780	228180370	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	185857683	270518180	Rat
2325727	Pia41	Pristane induced arthritis QTL 41			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	188241285	233241285	Rat
7394701	Uae46	Urinary albumin excretion QTL 46	3.6	0.0056	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	210980612	255980612	Rat

Markers in Region

RH136882

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	203,601,954 - 203,602,153 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	221,666,971 - 221,667,169	NCBI	Rnor6.0
Rnor_5.0	1	228,654,733 - 228,654,931	UniSTS	Rnor5.0
RGSC_v3.4	1	209,077,338 - 209,077,536	UniSTS	RGSC3.4
Celera	1	201,135,446 - 201,135,644	UniSTS
RH 3.4 Map	1	1536.7	UniSTS
Cytogenetic Map	1	q43	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001011939	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC082030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC160908	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BQ192279	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO571196	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CV120970	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000054830 ⟹ ENSRNOP00000051714

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	213,008,049 - 213,031,485 (+)	Ensembl
mRatBN7.2 Ensembl	1	203,579,869 - 203,602,212 (+)	Ensembl
Rnor_6.0 Ensembl	1	221,644,867 - 221,667,239 (+)	Ensembl

RefSeq Acc Id:

NM_001011939 ⟹ NP_001011939

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	213,009,113 - 213,031,488 (+)	NCBI
mRatBN7.2	1	203,579,850 - 203,602,226 (+)	NCBI
Rnor_6.0	1	221,644,867 - 221,667,242 (+)	NCBI
Rnor_5.0	1	228,632,629 - 228,655,004 (+)	NCBI
RGSC_v3.4	1	209,055,234 - 209,077,609 (+)	RGD
Celera	1	201,113,342 - 201,135,717 (+)	RGD

Sequence:

show sequence

CTCCTCGGCCGCGCGCTCCAGTCCCGCTCAGCCGCCGCTCGGTCCTGTAGCAGCCAGCTCTGTC
TCCGGCAGCATGTTCAGCTGGGTGAGCAAGGATGCCCGCCGCAAGAAGGAGCCGGAGCTCTTCC
AGACGGTGGCCGAGGGGCTGCGGCAGCTGTACGCGCAGAAGCTGCTGCCGCTGGAGGAGCACTA
TCGCTTCCACGAGTTCCATTCGCCGGCTCTGGAGGACGCTGACTTCGACAACAAACCCATGGTG
CTCCTGGTCGGCCAGTACAGCACCGGCAAGACCACCTTCATCCGCCACTTGATCGAGCAGGACT
TCCCAGGGATGCGCATCGGGCCGGAGCCCACCACCGACTCCTTCATCGCAGTCATGCATGGCCC
CACCGAGGGCGTGGTGCCCGGCAACGCGCTCGTCGTGGACCCGCGGCGCCCCTTCCGCAAGCTT
AACGCCTTCGGCAACGCCTTCCTCAACAGGTTCATGTGTGCACAGCTGCCTAACCCAGTATTGG
ACAGCATTAGCATCATTGACACTCCTGGAATCCTGTCTGGAGAGAAGCAGCGCATCAGCCGAGG
TTATGACTTTGCGGCTGTCCTTGAGTGGTTCGCAGAGCGTGTGGACCGCATCATTCTGCTCTTT
GACGCCCACAAGCTAGACATCTCAGATGAATTTTCAGAAGTCATCAAGGCCCTCAAAAATCACG
AGGACAAGATCCGTGTGGTGCTGAACAAAGCTGACCAAATTGAGACACAGCAGCTGATGCGAGT
GTACGGAGCTCTCATGTGGTCGCTGGGGAAGATCATCAACACCCCTGAGGTGGTCCGTGTCTAC
ATTGGCTCCTTCTGGTCACACCCACTGCTCATCCCTGACAACCGGAAGCTCTTTGAGGCAGAGG
AGCAGGACCTCTTCAAAGACATCCAGTCTCTACCAAGAAATGCTGCCCTTAGGAAGCTCAATGA
CTTAATCAAGCGGGCCAGGCTGGCCAAGGTCCATGCCTACATCATCAGCTCCCTCAAGAAGGAG
ATGCCCAATGTCTTTGGGAAAGAGAGCAAGAAGAAAGAGCTGGTGAACAACTTGGGAGAGATCT
ACCAGAAAATTGAGCGGGAGCACCAGATCTCCTCCGGCGACTTCCCAAGCCTGCGTAAGATGCA
GGAACTTCTGCAGACGCAGGACTTCAGCAAGTTCCAGGCCTTGAAGCCCAAGCTGCTGGATACG
GTGGATGATATGCTGGCCAACGATATAGCTCGGCTGATGGTGATGGTGCGCCAGGAGGAGTCCC
TGATGCCCTCACAGGCTGTGAAGGGTGGTGCTTTTGATGGCACCATGAATGGGCCCTTTGGGCA
TGGGTATGGCGAGGGGGCTGGCGAGGGCATTGATGATGTTGAGTGGGTAGTTGGCAAGGACAAG
CCCACCTATGATGAGATCTTCTACACACTGTCTCCTGTCAATGGCAAGATCACGGGCGCTAATG
CCAAGAAGGAGATGGTGAAGTCCAAGCTGCCTAACACAGTGCTGGGGAAGATCTGGAAGCTGGC
TGATGTGGACAAGGATGGCCTGCTAGATGACGAGGAGTTTGCCCTGGCCAACCACCTTATCAAG
GTCAAGCTAGAGGGCCATGAGCTGCCCGCTGACCTTCCTCCACATCTCATCCCACCCTCCAAAC
GGAGGCATGAGTGACTTCTGTGCCTGAGATACCCCACACCTCCAGGGCTGCTGGCACTTTCTAC
CCGCCAGTTCTTTGTCTGCCCAGGTGGGCTGGGGCCTGGAGGGGCAGAGATTGGGGGAGGGAAG
GGGTCACCATTTTTCAAGGTCCATAAAGACTGAGCGGTGTTTCCTTAGCTCTTGAATAGGAAAA
CCACCATCTTTCTTTTAAAGCTGTTCTAGGGTTCAGAGGGGAGGCATGGGTGATGCTTGGATGT
GAACAGTGGGATTTTGTGCACAAGAACCATGATATTTTTAATATATAACGTTAGAGGCAGCTGC
CTTTCTTGCCTCTTCTGTCTGACACAGCCCCACACTCAGCCTCTCCCCTATCCCAGCTAGGCAG
GACAGTGACTCTGGGAACCACCTCTCCAACCCACCCTGGCACCCCCATGTCTGCTGCCCCAGGG
CTCTGTAAGCAGGAGGCCTCCAGCCCCTTTGGTTTGTTTTCAGACTGGGGCTTCCTTATGGGGC
AGCGGTTATTTCCTACTAGCTGTGTTCTGCACTTGGGTAAGCTGCTCCAGTCCTCTGCTGTGGT
CTGGAGTGCACACCTTCCTTTTTCCATATCCCCTGACACCCCAGCCAGCACAGCATCCACAGGT
AGAAGACCCAACCACTGCTAATGTTGTGGGGACTGGAGGAGAGAGACCGTGTCATATAGGGAAA
TGTATAAGCTAGTCAGTTCACTGTAAAGTGACACTTTATACTTGACCAAGGTTTTCAGTAGCTT
TTACATCACTTATTCAAAGCTGTGATTTTTTGTCTCCTCTTGCCTATACTCCAGGAGCTCCACC
CCAGAGCCAGCATAGAGCAGACCTCCTTGGGCTTGAGTTTGCTTTCTGTCTGAGGGGAGGTCGT
CCCAGCTTCTGCTCAGAGGGGTCCAAAATGTACCCCCTAAAGTCAGTCTTTATGGCAGCTTCCT
GGAGCCCTCTCTGCCTTGGGGCAGGCTGTGGGCCCTGTGACCTGGGGATGGTCTGGGGCTGCTA
AGAGGAAGCCTGTGTCTCTGGCCTGGGTTAGTGTCCATGCTGCAGGATAGGGGAAAACCCAGCC
CCTTCCCTCACCCTGTCATTTCCTTCCTCTCCTCCTCTGCTGAGCCAAGGAGGTCTGGGTGTCC
TGAGAGCCCCAGACTGAGCAGTAAGAAGCCAGAGCTAGCAAGTGACCACTTTAGCCATCCCACA
GTAGCCTGGGAGACCTGACCACACCCTCTGGCCAGTGGTTGGCTGCCAGGGTGGGCTTTATACT
GAGGTGGGCAGGGAAGTGCAGCTTGCTCATCTGGCACTACAGGTGGGCTTCAGGGAGCTGCCTG
CCATCCCCCAGCACTGTGCTGGGCCCTGCTGAGGGTGCGCTCCAGCCTGGCCTGTTACCTTCTG
CCTCAGCCCTCCACTCCTCCATTCCTGTCCTTGGCTGAGGGTGAGTGAGATGTCTTTCTCACAG
GTTCACTGCTTAAAGTCCAGCGAGCTCTGTCCTCACCTGTGGGGAGAGTGGCTGAGTGAGGACT
GTTTCTTGCATTAAAGAAAGTTTAATTGTGCCAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001011939	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH82030	(Get FASTA)	NCBI Sequence Viewer
	AAI60908	(Get FASTA)	NCBI Sequence Viewer
	EDM12590	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000051714
	ENSRNOP00000051714.2
GenBank Protein	Q641Z6	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001011939 ⟸ NM_001011939

- UniProtKB:

B1H289 (UniProtKB/Swiss-Prot), Q641Z6 (UniProtKB/Swiss-Prot), A6HZF9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFSWVSKDARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHEFHSPALEDADFDNKPMVLLV
GQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMHGPTEGVVPGNALVVDPRRPFRKLNAF
GNAFLNRFMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAH
KLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSLGKIINTPEVVRVYIGS
FWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPN
VFGKESKKKELVNNLGEIYQKIEREHQISSGDFPSLRKMQELLQTQDFSKFQALKPKLLDTVDD
MLANDIARLMVMVRQEESLMPSQAVKGGAFDGTMNGPFGHGYGEGAGEGIDDVEWVVGKDKPTY
DEIFYTLSPVNGKITGANAKKEMVKSKLPNTVLGKIWKLADVDKDGLLDDEEFALANHLIKVKL
EGHELPADLPPHLIPPSKRRHE

hide sequence

Ensembl Acc Id:

ENSRNOP00000051714 ⟸ ENSRNOT00000054830

Protein Domains

Dynamin-type G EF-hand EH

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q641Z6-F1-model_v2	AlphaFold	Q641Z6	1-534	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690696

Promoter ID:

EPDNEW_R1219

Type:

initiation region

Name:

Ehd1_1

Description:

EH-domain containing 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	221,644,886 - 221,644,946	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309017	AgrOrtholog
BioCyc Gene	G2FUF-56601	BioCyc
Ensembl Genes	ENSRNOG00000043503	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000054830	ENTREZGENE
	ENSRNOT00000054830.3	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.268.20	UniProtKB/Swiss-Prot
	3.40.50.300	UniProtKB/Swiss-Prot
	EF-hand	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7455505	IMAGE-MGC_LOAD
InterPro	DUF5600	UniProtKB/Swiss-Prot
	Dynamin_N	UniProtKB/Swiss-Prot
	EF-hand-dom_pair	UniProtKB/Swiss-Prot
	EF_Hand_1_Ca_BS	UniProtKB/Swiss-Prot
	EF_hand_dom	UniProtKB/Swiss-Prot
	EH_dom	UniProtKB/Swiss-Prot
	EHD_N	UniProtKB/Swiss-Prot
	G_DYNAMIN_dom	UniProtKB/Swiss-Prot
	P-loop_NTPase	UniProtKB/Swiss-Prot
KEGG Report	rno:293692	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:188641	IMAGE-MGC_LOAD
NCBI Gene	293692	ENTREZGENE
PANTHER	DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D	UniProtKB/Swiss-Prot
	EH DOMAIN	UniProtKB/Swiss-Prot
Pfam	DUF5600	UniProtKB/Swiss-Prot
	Dynamin_N	UniProtKB/Swiss-Prot
	EF-hand_4	UniProtKB/Swiss-Prot
	EHD_N	UniProtKB/Swiss-Prot
PhenoGen	Ehd1	PhenoGen
PROSITE	EF_HAND_1	UniProtKB/Swiss-Prot
	EF_HAND_2	UniProtKB/Swiss-Prot
	G_DYNAMIN_2	UniProtKB/Swiss-Prot
	PS50031	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000043503	RatGTEx
SMART	SM00027	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF47473	UniProtKB/Swiss-Prot
	SSF52540	UniProtKB/Swiss-Prot
UniProt	A6HZF9	ENTREZGENE, UniProtKB/TrEMBL
	B1H289	ENTREZGENE
	EHD1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	B1H289	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Ehd1	EH-domain containing 1	Ehd1_predicted	EH-domain containing 1 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Ehd1_predicted	EH-domain containing 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)