Rbbp8 (RB binding protein 8, endonuclease) - Rat Genome Database

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Gene: Rbbp8 (RB binding protein 8, endonuclease) Rattus norvegicus
Analyze
Symbol: Rbbp8
Name: RB binding protein 8, endonuclease
RGD ID: 1308872
Description: Predicted to enable several functions, including identical protein binding activity; single-stranded DNA endodeoxyribonuclease activity; and transcription corepressor activity. Involved in response to estradiol. Predicted to be located in nucleoplasm. Predicted to be part of BRCA1-C complex and transcription repressor complex. Predicted to be active in site of double-strand break. Human ortholog(s) of this gene implicated in Seckel syndrome 2. Orthologous to human RBBP8 (RB binding protein 8, endonuclease); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; non-homologous end joining pathway of double-strand break repair; INTERACTS WITH acetamide; bisphenol A; endosulfan.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ctBP-interacting protein; CtIP; DNA endonuclease RBBP8; LOC291787; RBBP-8; retinoblastoma binding protein 8; retinoblastoma-binding protein 8; retinoblastoma-interacting protein and myosin-like; RGD1308872; RIM; SAE2; similar to Retinoblastoma-binding protein 8 (RBBP-8) (CtBP interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM); sporulation in the absence of SPO11 protein 2 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8183,198,188 - 3,263,643 (+)NCBIGRCr8
mRatBN7.2182,922,985 - 2,988,851 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,921,286 - 2,988,846 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx183,162,687 - 3,227,671 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,950,375 - 4,015,359 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0183,177,120 - 3,242,324 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0183,134,630 - 3,227,702 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,162,543 - 3,227,688 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,173,428 - 3,239,961 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,266,565 - 3,333,153 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1183,269,885 - 3,333,117 (+)NCBI
Celera182,790,129 - 2,855,180 (+)NCBICelera
Cytogenetic Map18p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-methylcholine  (ISO)
acetamide  (EXP)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
Brevetoxin B  (ISO)
bromoacetate  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
ciguatoxin CTX1B  (ISO)
clomiphene  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
daidzein  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
epoxiconazole  (ISO)
estrone  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
hexestrol  (ISO)
ketamine  (EXP)
Lasiocarpine  (ISO)
lead(0)  (ISO)
mestranol  (ISO)
methoxychlor  (EXP)
mitoxantrone  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pinosylvin  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
topotecan  (EXP)
trans-pinosylvin  (ISO)
triadimefon  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. Double-strand break repair: 53BP1 comes into focus. Panier S and Boulton SJ, Nat Rev Mol Cell Biol. 2014 Jan;15(1):7-18. doi: 10.1038/nrm3719. Epub 2013 Dec 11.
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Rajendran P, etal., Epigenetics. 2013 Jun;8(6):612-23. doi: 10.4161/epi.24710. Epub 2013 Apr 26.
6. Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells. Rass E, etal., Nat Struct Mol Biol. 2009 Aug;16(8):819-24. doi: 10.1038/nsmb.1641. Epub 2009 Jul 26.
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Expressional regulation of neuronal and cancer-related genes by estrogen in adult female rats. Rho JY, etal., Endocr Res. 2004 May;30(2):257-67.
11. Prognosis value of RBBP8 expression in plasma cell myeloma. Zhang W, etal., Cancer Gene Ther. 2020 Feb;27(1-2):22-29. doi: 10.1038/s41417-018-0069-3. Epub 2019 Jan 9.
Additional References at PubMed
PMID:12477932   PMID:15632090   PMID:15831459   PMID:16287852   PMID:18716619   PMID:19202191   PMID:23144634   PMID:25558984   PMID:26721387  


Genomics

Comparative Map Data
Rbbp8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8183,198,188 - 3,263,643 (+)NCBIGRCr8
mRatBN7.2182,922,985 - 2,988,851 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,921,286 - 2,988,846 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx183,162,687 - 3,227,671 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,950,375 - 4,015,359 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0183,177,120 - 3,242,324 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0183,134,630 - 3,227,702 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,162,543 - 3,227,688 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,173,428 - 3,239,961 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,266,565 - 3,333,153 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1183,269,885 - 3,333,117 (+)NCBI
Celera182,790,129 - 2,855,180 (+)NCBICelera
Cytogenetic Map18p13NCBI
RBBP8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381822,914,139 - 23,026,486 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1822,798,261 - 23,026,488 (+)EnsemblGRCh38hg38GRCh38
GRCh371820,513,291 - 20,606,449 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361818,767,293 - 18,860,447 (+)NCBINCBI36Build 36hg18NCBI36
Build 341818,767,836 - 18,860,445NCBI
Celera1817,326,979 - 17,420,514 (+)NCBICelera
Cytogenetic Map18q11.2NCBI
HuRef1817,367,932 - 17,460,782 (+)NCBIHuRef
CHM1_11820,440,466 - 20,533,636 (+)NCBICHM1_1
T2T-CHM13v2.01822,991,142 - 23,219,842 (+)NCBIT2T-CHM13v2.0
Rbbp8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391811,766,333 - 11,876,264 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1811,766,333 - 11,878,278 (+)EnsemblGRCm39 Ensembl
GRCm381811,633,276 - 11,743,207 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1811,633,276 - 11,745,221 (+)EnsemblGRCm38mm10GRCm38
MGSCv371811,816,351 - 11,901,716 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361811,776,812 - 11,886,743 (+)NCBIMGSCv36mm8
Celera1811,932,048 - 11,982,146 (+)NCBICelera
Cytogenetic Map18A1NCBI
cM Map185.85NCBI
Rbbp8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540211,245,819 - 11,335,367 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540211,245,857 - 11,331,872 (+)NCBIChiLan1.0ChiLan1.0
RBBP8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21740,355,459 - 40,453,960 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11826,048,046 - 26,146,663 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01816,181,652 - 16,274,597 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11819,811,478 - 19,903,522 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1819,811,989 - 19,903,522 (+)Ensemblpanpan1.1panPan2
RBBP8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1765,218,288 - 65,319,696 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl765,218,297 - 65,297,099 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha764,671,375 - 64,772,805 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0765,281,737 - 65,383,259 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl765,279,668 - 65,364,585 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1764,950,000 - 65,050,453 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0764,971,408 - 65,071,512 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0765,270,573 - 65,371,708 (-)NCBIUU_Cfam_GSD_1.0
Rbbp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494461,262,082 - 61,350,225 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365502,485,769 - 2,539,548 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365502,482,915 - 2,554,077 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RBBP8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6107,924,002 - 108,022,669 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16107,923,921 - 108,020,067 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26100,453,140 - 100,534,616 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RBBP8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11857,501,070 - 57,617,301 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1857,501,271 - 57,597,670 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605032,258,206 - 32,355,889 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rbbp8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247709,023,392 - 9,119,183 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247709,026,592 - 9,100,818 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rbbp8
408 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:168
Count of miRNA genes:134
Interacting mature miRNAs:145
Transcripts:ENSRNOT00000017291
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor surface area measurement (CMO:0002078)18224947722066430Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18224947722066430Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 36 21 19 21 74 35 38 11
Low 17 21 20 20 8 10 3 8
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001134417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC162012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000017291   ⟹   ENSRNOP00000017291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl182,923,478 - 2,988,846 (+)Ensembl
Rnor_6.0 Ensembl183,163,214 - 3,227,688 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078615   ⟹   ENSRNOP00000069577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl182,923,478 - 2,988,846 (+)Ensembl
Rnor_6.0 Ensembl183,162,543 - 3,216,996 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111657   ⟹   ENSRNOP00000081826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl182,921,286 - 2,988,844 (+)Ensembl
RefSeq Acc Id: NM_001134417   ⟹   NP_001127889
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8183,198,485 - 3,263,643 (+)NCBI
mRatBN7.2182,923,687 - 2,988,851 (+)NCBI
Rnor_6.0183,163,214 - 3,227,702 (+)NCBI
Rnor_5.0183,173,428 - 3,239,961 (+)NCBI
RGSC_v3.4183,266,565 - 3,333,153 (+)RGD
Celera182,790,129 - 2,855,180 (+)RGD
Sequence:
RefSeq Acc Id: XM_039096747   ⟹   XP_038952675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8183,198,284 - 3,263,643 (+)NCBI
mRatBN7.2182,923,234 - 2,988,851 (+)NCBI
RefSeq Acc Id: XM_039096748   ⟹   XP_038952676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8183,198,284 - 3,263,643 (+)NCBI
mRatBN7.2182,923,233 - 2,988,851 (+)NCBI
RefSeq Acc Id: XM_039096752   ⟹   XP_038952680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8183,198,284 - 3,263,643 (+)NCBI
mRatBN7.2182,923,233 - 2,988,851 (+)NCBI
RefSeq Acc Id: XM_039096753   ⟹   XP_038952681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8183,198,188 - 3,263,643 (+)NCBI
mRatBN7.2182,923,232 - 2,988,851 (+)NCBI
RefSeq Acc Id: XM_063277268   ⟹   XP_063133338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8183,198,188 - 3,263,643 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001127889   ⟸   NM_001134417
- UniProtKB: B1WC58 (UniProtKB/Swiss-Prot),   A0A0G2JVQ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017291   ⟸   ENSRNOT00000017291
RefSeq Acc Id: ENSRNOP00000069577   ⟸   ENSRNOT00000078615
RefSeq Acc Id: XP_038952681   ⟸   XM_039096753
- Peptide Label: isoform X4
- UniProtKB: A0A0G2JVQ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952676   ⟸   XM_039096748
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JVQ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952680   ⟸   XM_039096752
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JVQ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952675   ⟸   XM_039096747
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVQ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000081826   ⟸   ENSRNOT00000111657
RefSeq Acc Id: XP_063133338   ⟸   XM_063277268
- Peptide Label: isoform X5
Protein Domains
DNA endonuclease activator Ctp1 C-terminal   DNA endonuclease Ctp1 N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1WC58-F1-model_v2 AlphaFold B1WC58 1-893 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700638
Promoter ID:EPDNEW_R11157
Type:initiation region
Name:Rbbp8_1
Description:RB binding protein 8, endonuclease
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0183,162,516 - 3,162,576EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308872 AgrOrtholog
BioCyc Gene G2FUF-8379 BioCyc
Ensembl Genes ENSRNOG00000012899 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017291 ENTREZGENE
  ENSRNOT00000017291.8 UniProtKB/Swiss-Prot
  ENSRNOT00000078615.2 UniProtKB/TrEMBL
  ENSRNOT00000111657.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9091712 IMAGE-MGC_LOAD
InterPro CtIP_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ctp1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBBP8-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:291787 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187882 IMAGE-MGC_LOAD
NCBI Gene 291787 ENTREZGENE
PANTHER PTHR15107 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15107:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CtIP_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAE2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB RBBP8 RGD
PhenoGen Rbbp8 PhenoGen
RatGTEx ENSRNOG00000012899 RatGTEx
UniProt A0A0G2JVQ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZSG9_RAT UniProtKB/TrEMBL
  A6KNF8_RAT UniProtKB/TrEMBL
  B1WC58 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-03 Rbbp8  RB binding protein 8, endonuclease  Rbbp8  retinoblastoma binding protein 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Rbbp8  retinoblastoma binding protein 8  RGD1308872  similar to Retinoblastoma-binding protein 8 (RBBP-8) (CtBP interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1308872  similar to Retinoblastoma-binding protein 8 (RBBP-8) (CtBP interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM)   RGD1308872_predicted  similar to Retinoblastoma-binding protein 8 (RBBP-8) (CtBP interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1308872_predicted  similar to Retinoblastoma-binding protein 8 (RBBP-8) (CtBP interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM) (predicted)  LOC291787_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC291787_predicted  similar to Retinoblastoma-binding protein 8 (RBBP-8) (CtBP interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL