Csk (C-terminal Src kinase) - Rat Genome Database

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Gene: Csk (C-terminal Src kinase) Rattus norvegicus
Analyze
Symbol: Csk
Name: C-terminal Src kinase
RGD ID: 1308800
Description: Enables enzyme binding activity; proline-rich region binding activity; and protein tyrosine kinase activity. Involved in several processes, including negative regulation of bone resorption; negative regulation of interleukin-6 production; and regulation of signal transduction. Located in cytoplasm. Biomarker of hepatocellular carcinoma. Orthologous to human CSK (C-terminal Src kinase); PARTICIPATES IN platelet-derived growth factor signaling pathway; chemokine mediated signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-SRC kinase; c-src tyrosine kinase; CSK, non-receptor tyrosine kinase; LOC315707; MGC112926; protein-tyrosine kinase (CSK); tyrosine-protein kinase CSK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8866,925,650 - 66,944,861 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl866,925,651 - 66,930,274 (-)EnsemblGRCr8
mRatBN7.2858,029,748 - 58,048,742 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl858,029,749 - 58,048,292 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx863,562,597 - 63,567,220 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,840,172 - 61,844,795 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0859,704,719 - 59,709,342 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,405,714 - 62,424,707 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,405,715 - 62,424,303 (-)Ensemblrn6Rnor6.0
Rnor_5.0862,183,286 - 62,208,785 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4861,381,336 - 61,386,013 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera857,495,667 - 57,500,290 (-)NCBICelera
RGSC_v3.1861,400,389 - 61,405,067 (-)NCBI
Cytogenetic Map8q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
atrazine  (ISO)
Azoxymethane  (EXP)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bosutinib  (EXP)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
chlorpyrifos  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
cyclophosphamide  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
formaldehyde  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
isobutanol  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
leflunomide  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (EXP)
nitrates  (ISO)
nitrofen  (EXP)
ozone  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (EXP)
phosgene  (ISO)
ponatinib  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
pyrazoles  (ISO)
pyrimidines  (ISO)
rac-lactic acid  (ISO)
saracatinib  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
sulindac  (EXP,ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
terbutaline  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell-cell junction  (IEA,ISO)
cytoplasm  (IDA,IEA)
cytosol  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Recombinant Csk expressed in Escherichia coli is autophosphorylated on tyrosine residue(s). Bougeret C, etal., Oncogene. 1993 May;8(5):1241-7.
2. Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study. Chen YM, etal., Biol Reprod. 2003 Aug;69(2):656-72. Epub 2003 Apr 16.
3. Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells. Cloutier JF and Veillette A, EMBO J. 1996 Sep 16;15(18):4909-18.
4. Integrins direct Src family kinases to regulate distinct phases of oligodendrocyte development. Colognato H, etal., J Cell Biol. 2004 Oct 25;167(2):365-75.
5. CSK negatively regulates nerve growth factor induced neural differentiation and augments AKT kinase activity. Dey N, etal., Exp Cell Res. 2005 Jul 1;307(1):1-14.
6. Functional modification of a murine macrophage cell line, J744A.1, transfected with rat csk genes. Dondog EA Hokkaido Igaku Zasshi. 2000 May;75(3):197-208.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Roles of C-terminal Src kinase in the initiation and the termination of the high affinity IgE receptor-mediated signaling. Honda Z, etal., J Biol Chem. 1997 Oct 10;272(41):25753-60.
10. Regulation of Src family kinases in the developing rat brain: correlation with their regulator kinase, Csk. Inomata M, etal., J Biochem. 1994 Aug;116(2):386-92.
11. Down-regulation of the tumor suppressor gene C-terminal Src kinase: an early event during premalignant colonic epithelial hyperproliferation. Kunte DP, etal., FEBS Lett. 2005 Jul 4;579(17):3497-502.
12. Protein kinases and adherens junction dynamics in the seminiferous epithelium of the rat testis. Lee NP and Cheng CY, J Cell Physiol. 2005 Feb;202(2):344-60.
13. Adrenomedullin inhibits angiotensin II-induced oxidative stress via Csk-mediated inhibition of Src activity. Liu J, etal., Am J Physiol Heart Circ Physiol. 2007 Apr;292(4):H1714-21. Epub 2006 Oct 27.
14. Reduced C-terminal Src kinase (Csk) activities in hepatocellular carcinoma. Masaki T, etal., Hepatology. 1999 Feb;29(2):379-84.
15. Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin. Melendez J, etal., J Biol Chem. 2004 Dec 17;279(51):53516-23. Epub 2004 Aug 22.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Mammalian Pragmin regulates Src family kinases via the Glu-Pro-Ile-Tyr-Ala (EPIYA) motif that is exploited by bacterial effectors. Safari F, etal., Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14938-43. doi: 10.1073/pnas.1107740108. Epub 2011 Aug 22.
23. A functional polymorphism of Ptpn22 is associated with type 1 diabetes in the BioBreeding rat. Sarmiento J, etal., J Immunol. 2015 Jan 15;194(2):615-29. doi: 10.4049/jimmunol.1302689. Epub 2014 Dec 12.
24. C-terminal Src kinase-mediated EPIYA phosphorylation of Pragmin creates a feed-forward C-terminal Src kinase activation loop that promotes cell motility. Senda Y, etal., Cancer Sci. 2016 Jul;107(7):972-80. doi: 10.1111/cas.12962. Epub 2016 Jun 13.
25. Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts. Takayanagi H, etal., J Clin Invest. 1999 Jul;104(2):137-46.
26. C-terminal SRC kinase controls acute inflammation and granulocyte adhesion. Thomas RM, etal., Immunity. 2004 Feb;20(2):181-91.
27. SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF. Wang B, etal., Mol Cell Biol. 2001 Feb;21(4):1077-88.
Additional References at PubMed
PMID:1709258   PMID:1722201   PMID:10790433   PMID:10801129   PMID:11884384   PMID:12477932   PMID:14613929   PMID:15861137   PMID:16203139   PMID:16511561   PMID:16982692   PMID:17911601  
PMID:18086565   PMID:18258597   PMID:19056867   PMID:19888460   PMID:20605918   PMID:21699177   PMID:23548896   PMID:27225249   PMID:27391443  


Genomics

Comparative Map Data
Csk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8866,925,650 - 66,944,861 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl866,925,651 - 66,930,274 (-)EnsemblGRCr8
mRatBN7.2858,029,748 - 58,048,742 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl858,029,749 - 58,048,292 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx863,562,597 - 63,567,220 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,840,172 - 61,844,795 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0859,704,719 - 59,709,342 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,405,714 - 62,424,707 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,405,715 - 62,424,303 (-)Ensemblrn6Rnor6.0
Rnor_5.0862,183,286 - 62,208,785 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4861,381,336 - 61,386,013 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera857,495,667 - 57,500,290 (-)NCBICelera
RGSC_v3.1861,400,389 - 61,405,067 (-)NCBI
Cytogenetic Map8q24NCBI
CSK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381574,782,080 - 74,803,197 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1574,782,055 - 74,803,198 (+)Ensemblhg38GRCh38
GRCh371575,074,421 - 75,095,538 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361572,861,768 - 72,882,558 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341572,861,767 - 72,882,557NCBI
Celera1552,024,458 - 52,045,568 (+)NCBICelera
Cytogenetic Map15q24.1NCBI
HuRef1551,872,089 - 51,892,744 (+)NCBIHuRef
CHM1_11575,192,927 - 75,214,023 (+)NCBICHM1_1
T2T-CHM13v2.01572,651,992 - 72,673,091 (+)NCBIT2T-CHM13v2.0
Csk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39957,533,929 - 57,560,758 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl957,533,929 - 57,560,914 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38957,626,646 - 57,653,631 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl957,626,646 - 57,653,631 (-)Ensemblmm10GRCm38
MGSCv37957,474,453 - 57,492,987 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36957,424,783 - 57,443,317 (-)NCBIMGSCv36mm8
Celera954,862,569 - 54,881,336 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map931.18NCBI
Csk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554503,127,561 - 3,144,550 (-)Ensembl
ChiLan1.0NW_0049554503,127,561 - 3,144,550 (-)NCBIChiLan1.0ChiLan1.0
CSK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21664,010,025 - 64,030,936 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11568,173,681 - 68,194,308 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01553,724,814 - 53,745,710 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11573,342,703 - 73,363,476 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1573,342,703 - 73,363,476 (+)EnsemblpanPan2panpan1.1
CSK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13037,851,269 - 37,870,382 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3037,852,046 - 37,870,378 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3037,784,125 - 37,802,413 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03038,056,541 - 38,074,206 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3038,056,497 - 38,074,435 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13038,009,325 - 38,027,610 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03038,055,644 - 38,073,934 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03038,291,119 - 38,309,429 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Csk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640115,909,712 - 115,929,808 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647133,757,772 - 33,778,933 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647133,757,778 - 33,777,871 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl758,736,531 - 58,755,260 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1758,736,473 - 58,755,034 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2763,425,071 - 63,443,632 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CSK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1268,667,657 - 8,688,850 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl268,667,655 - 8,688,824 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048132,942,200 - 132,963,400 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Csk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462489424,203 - 29,668 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462489412,621 - 29,400 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Csk
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1851,515,694 - 51,534,945 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Csk
82 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:94
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000026358
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat

Markers in Region
AW212630  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2858,029,812 - 58,029,924 (+)MAPPERmRatBN7.2
Rnor_6.0862,405,779 - 62,405,890NCBIRnor6.0
Rnor_5.0862,183,351 - 62,183,462UniSTSRnor5.0
RGSC_v3.4861,381,401 - 61,381,512UniSTSRGSC3.4
Celera857,495,732 - 57,495,843UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000026358   ⟹   ENSRNOP00000026358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl866,925,651 - 66,930,274 (-)Ensembl
mRatBN7.2 Ensembl858,029,749 - 58,034,372 (-)Ensembl
Rnor_6.0 Ensembl862,405,715 - 62,410,338 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091223   ⟹   ENSRNOP00000068638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl858,029,754 - 58,048,292 (-)Ensembl
Rnor_6.0 Ensembl862,405,984 - 62,424,303 (-)Ensembl
RefSeq Acc Id: NM_001030039   ⟹   NP_001025210
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,925,650 - 66,930,274 (-)NCBI
mRatBN7.2858,029,748 - 58,034,372 (-)NCBI
Rnor_6.0862,405,714 - 62,410,338 (-)NCBI
Rnor_5.0862,183,286 - 62,208,785 (-)NCBI
RGSC_v3.4861,381,336 - 61,386,013 (-)RGD
Celera857,495,667 - 57,500,290 (-)RGD
Sequence:
RefSeq Acc Id: XM_006243163   ⟹   XP_006243225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,925,650 - 66,944,861 (-)NCBI
mRatBN7.2858,029,748 - 58,048,742 (-)NCBI
Rnor_6.0862,405,714 - 62,424,707 (-)NCBI
Rnor_5.0862,183,286 - 62,208,785 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006243164   ⟹   XP_006243226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,925,650 - 66,943,854 (-)NCBI
mRatBN7.2858,029,748 - 58,047,954 (-)NCBI
Rnor_6.0862,405,714 - 62,423,964 (-)NCBI
Rnor_5.0862,183,286 - 62,208,785 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001025210   ⟸   NM_001030039
- UniProtKB: Q4G003 (UniProtKB/Swiss-Prot),   P32577 (UniProtKB/Swiss-Prot),   A6J4X1 (UniProtKB/TrEMBL),   A0A8L2QZY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243225   ⟸   XM_006243163
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006243226   ⟸   XM_006243164
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000026358   ⟸   ENSRNOT00000026358
Ensembl Acc Id: ENSRNOP00000068638   ⟸   ENSRNOT00000091223
Protein Domains
Protein kinase   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P32577-F1-model_v2 AlphaFold P32577 1-450 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696021
Promoter ID:EPDNEW_R6541
Type:initiation region
Name:Csk_1
Description:C-terminal Src kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0862,424,254 - 62,424,314EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308800 AgrOrtholog
BioCyc Gene G2FUF-30300 BioCyc
Ensembl Genes ENSRNOG00000019374 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026358 ENTREZGENE
  ENSRNOT00000026358.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7380519 IMAGE-MGC_LOAD
InterPro Csk-like_SH2 UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Non-receptor_tyrosine_kinases UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
KEGG Report rno:315707 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112926 IMAGE-MGC_LOAD
NCBI Gene 315707 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam Pkinase_Tyr UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
PhenoGen Csk PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
  TYRKINASE UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019374 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8L2QZY0 ENTREZGENE
  A6J4X1 ENTREZGENE, UniProtKB/TrEMBL
  CSK_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4G003 ENTREZGENE
UniProt Secondary Q4G003 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-18 Csk  C-terminal Src kinase  Csk  CSK, non-receptor tyrosine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-03-02 Csk  CSK, non-receptor tyrosine kinase  Csk  c-src tyrosine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Csk  c-src tyrosine kinase  Csk_predicted  c-src tyrosine kinase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Csk_predicted  c-src tyrosine kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED