Arhgap35 (Rho GTPase activating protein 35) - Rat Genome Database

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Gene: Arhgap35 (Rho GTPase activating protein 35) Rattus norvegicus
Analyze
Symbol: Arhgap35
Name: Rho GTPase activating protein 35
RGD ID: 1308738
Description: Enables GTPase activating protein binding activity and GTPase activator activity. Involved in positive regulation of GTPase activity. Predicted to be located in actin cytoskeleton; ciliary basal body; and cytoplasm. Predicted to be active in cytosol. Orthologous to human ARHGAP35 (Rho GTPase activating protein 35); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; platelet-derived growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GAP-associated protein p190; glucocorticoid receptor DNA binding factor 1; glucocorticoid receptor DNA-binding factor 1; Grlf1; LOC306400; p190RhoGAP; rho GTPase-activating protein 35
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Grlf1-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,330,566 - 86,447,414 (-)NCBIGRCr8
mRatBN7.2177,202,436 - 77,319,298 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,202,436 - 77,319,298 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx182,576,527 - 82,693,394 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,140,568 - 91,257,426 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,331,623 - 84,448,478 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,456,409 - 78,573,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,456,409 - 78,573,374 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0179,703,650 - 79,820,568 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,757,031 - 76,824,155 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11628,093,164 - 28,259,729 (+)NCBI
Celera171,687,713 - 71,804,603 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Arhgap35RatAnophthalmia  ISOARHGAP35 (Homo sapiens)8554872ClinVar Annotator: match by term: AnophthalmiaClinVarPMID:25741868 and PMID:36450800
Arhgap35RatMartsolf syndrome 1  ISOARHGAP35 (Homo sapiens)8554872ClinVar Annotator: match by term: Martsolf syndrome 1ClinVarPMID:25741868
Arhgap35Ratmicrophthalmia  ISOARHGAP35 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 and PMID:36450800
Arhgap35RatNeurodevelopmental Disorders  ISOARHGAP35 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868 and PMID:33057194
Arhgap35RatPeters anomaly  ISOARHGAP35 (Homo sapiens)8554872ClinVar Annotator: match by term: Irido-corneo-trabecular dysgenesisClinVarPMID:25741868 and PMID:36450800
Object Symbol
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Qualifier
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Reference
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Original Reference(s)
Arhgap35Ratlung adenocarcinoma  ISOARHGAP35 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27158780

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Object Symbol
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Original Reference(s)
Arhgap35Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of ARHGAP35 mRNA]CTDPMID:31150632
Arhgap35Rat(1->4)-beta-D-glucan multiple interactionsISOArhgap35 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of ARHGAP35 mRNACTDPMID:36331819
Arhgap35Rat1,2-dimethylhydrazine multiple interactionsISOArhgap35 (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of ARHGAP35 mRNA]CTDPMID:22206623
Arhgap35Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of ARHGAP35 mRNACTDPMID:29097150
Arhgap35Rat17beta-estradiol multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in increased expression of ARHGAP35 mRNACTDPMID:26496021
Arhgap35Rat17beta-estradiol increases expressionISOArhgap35 (Mus musculus)6480464Estradiol results in increased expression of ARHGAP35 mRNACTDPMID:39298647
Arhgap35Rat17beta-estradiol affects expressionEXP 6480464Estradiol affects the expression of ARHGAP35 mRNACTDPMID:32145629
Arhgap35Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOArhgap35 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of ARHGAP35 mRNACTDPMID:21570461
Arhgap35Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of ARHGAP35 mRNACTDPMID:33387578
Arhgap35Rat3-methylcholanthrene multiple interactionsISOARHGAP35 (Homo sapiens)6480464Methylcholanthrene promotes the reaction [AHR protein binds to ARHGAP35 promoter]CTDPMID:20348232
Arhgap35Rat4,4'-sulfonyldiphenol decreases expressionISOArhgap35 (Mus musculus)6480464bisphenol S results in decreased expression of ARHGAP35 mRNACTDPMID:39298647
Arhgap35Rat5-azacytidine increases expressionISOARHGAP35 (Homo sapiens)6480464Azacitidine results in increased expression of ARHGAP35 mRNACTDPMID:20823114
Arhgap35Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of ARHGAP35 mRNACTDPMID:30047161
Arhgap35Rataflatoxin B1 increases methylationISOARHGAP35 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of ARHGAP35 gene and Aflatoxin B1 results in increased methylation of ARHGAP35 intronCTDPMID:27153756 and PMID:30157460
Arhgap35Ratalachlor affects expressionEXP 6480464alachlor affects the expression of ARHGAP35 mRNACTDPMID:19425180
Arhgap35Ratamiodarone increases expressionISOARHGAP35 (Homo sapiens)6480464Amiodarone results in increased expression of ARHGAP35 mRNACTDPMID:19774075
Arhgap35Ratamphetamine decreases expressionEXP 6480464Amphetamine results in decreased expression of ARHGAP35 mRNACTDPMID:30779732
Arhgap35Ratantirheumatic drug increases expressionISOARHGAP35 (Homo sapiens)6480464Antirheumatic Agents results in increased expression of ARHGAP35 mRNACTDPMID:24449571
Arhgap35Rataristolochic acid A decreases expressionISOARHGAP35 (Homo sapiens)6480464aristolochic acid I results in decreased expression of ARHGAP35 mRNACTDPMID:33212167
Arhgap35Ratarsenite(3-) multiple interactionsISOARHGAP35 (Homo sapiens)6480464arsenite inhibits the reaction [G3BP1 protein binds to ARHGAP35 mRNA]CTDPMID:32406909

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Biological Process
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Original Reference(s)
Arhgap35Rataxon guidance involved_inISSUniProtKB:Q91YM21600115GO_REF:0000024UniProtGO_REF:0000024
Arhgap35Rataxon guidance involved_inIEAUniProtKB:Q91YM2 and ensembl:ENSMUSP000000752421600115GO_REF:0000107EnsemblGO_REF:0000107
Arhgap35Rataxon guidance involved_inISOArhgap35 (Mus musculus)1624291 PMID:11283609RGDPMID:11283609
Arhgap35Rataxonal fasciculation involved_inISSUniProtKB:Q91YM21600115GO_REF:0000024UniProtGO_REF:0000024
Arhgap35Rataxonal fasciculation involved_inIEAUniProtKB:Q91YM2 and ensembl:ENSMUSP000000752421600115GO_REF:0000107EnsemblGO_REF:0000107
Arhgap35Rataxonal fasciculation involved_inISOArhgap35 (Mus musculus)1624291 PMID:11283609RGDPMID:11283609
Arhgap35Ratcamera-type eye development acts_upstream_of_or_withinISOArhgap35 (Mus musculus)1624291MGI:2448591 PMID:11044403RGDPMID:11044403
Arhgap35Ratcamera-type eye development acts_upstream_of_or_withinIEAUniProtKB:Q91YM2 and ensembl:ENSMUSP000000752421600115GO_REF:0000107EnsemblGO_REF:0000107
Arhgap35Ratcell migration involved_inISOArhgap35 (Mus musculus)1624291 PMID:18502760RGDPMID:18502760
Arhgap35Ratcell migration involved_inIEAUniProtKB:Q91YM2 and ensembl:ENSMUSP000000752421600115GO_REF:0000107EnsemblGO_REF:0000107
Arhgap35Ratcell migration involved_inISSUniProtKB:Q91YM21600115GO_REF:0000024UniProtGO_REF:0000024
Arhgap35Ratcentral nervous system neuron axonogenesis involved_inISOArhgap35 (Mus musculus)1624291 PMID:11283609RGDPMID:11283609
Arhgap35Ratcentral nervous system neuron axonogenesis involved_inIEAUniProtKB:Q91YM2 and ensembl:ENSMUSP000000752421600115GO_REF:0000107EnsemblGO_REF:0000107
Arhgap35Ratcentral nervous system neuron axonogenesis involved_inISSUniProtKB:Q91YM21600115GO_REF:0000024UniProtGO_REF:0000024
Arhgap35Ratestablishment or maintenance of actin cytoskeleton polarity involved_inISSUniProtKB:Q91YM21600115GO_REF:0000024UniProtGO_REF:0000024
Arhgap35Ratestablishment or maintenance of actin cytoskeleton polarity involved_inISOArhgap35 (Mus musculus)1624291 PMID:18502760RGDPMID:18502760
Arhgap35Ratestablishment or maintenance of actin cytoskeleton polarity involved_inIEAUniProtKB:Q91YM2 and ensembl:ENSMUSP000000752421600115GO_REF:0000107EnsemblGO_REF:0000107
Arhgap35Ratforebrain development acts_upstream_of_or_withinIEAUniProtKB:Q91YM2 and ensembl:ENSMUSP000000752421600115GO_REF:0000107EnsemblGO_REF:0000107
Arhgap35Ratforebrain development acts_upstream_of_or_withinISOArhgap35 (Mus musculus)1624291MGI:2448591 PMID:11044403RGDPMID:11044403
Arhgap35Ratmammary gland development involved_inISSUniProtKB:Q91YM21600115GO_REF:0000024UniProtGO_REF:0000024
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Cellular Component
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Original Reference(s)
Arhgap35Ratactin cytoskeleton located_inISOArhgap35 (Mus musculus)1624291 PMID:11044403RGDPMID:11044403
Arhgap35Ratactin cytoskeleton located_inIEAUniProtKB:Q91YM2 and ensembl:ENSMUSP000000752421600115GO_REF:0000107EnsemblGO_REF:0000107
Arhgap35Ratcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Arhgap35Ratciliary basal body located_inISSUniProtKB:Q91YM21600115GO_REF:0000024UniProtGO_REF:0000024
Arhgap35Ratciliary basal body located_inIEAUniProtKB:Q91YM2 and ensembl:ENSMUSP000000752421600115GO_REF:0000107EnsemblGO_REF:0000107
Arhgap35Ratciliary basal body located_inISOArhgap35 (Mus musculus)1624291 PMID:26859289RGDPMID:26859289
Arhgap35Ratcytoplasm located_inISOArhgap35 (Mus musculus)1624291 PMID:11044403RGDPMID:11044403
Arhgap35Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Arhgap35Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Arhgap35Ratcytoplasm located_inIEAUniProtKB:Q91YM2 and ensembl:ENSMUSP000000752421600115GO_REF:0000107EnsemblGO_REF:0000107
Arhgap35Ratcytoskeleton located_inIEAUniProtKB-KW:KW-02061600115GO_REF:0000043UniProtGO_REF:0000043
Arhgap35Ratcytosol is_active_inIBAPANTHER:PTN002508977 and UniProtKB:Q130171600115GO_REF:0000033GO_CentralGO_REF:0000033
Arhgap35Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Arhgap35Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Arhgap35Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Arhgap35Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Arhgap35Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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Original Reference(s)
Arhgap35RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Arhgap35RatGTP binding enablesIEAUniProtKB-KW:KW-03421600115GO_REF:0000043UniProtGO_REF:0000043
Arhgap35RatGTP binding enablesIEAInterPro:IPR0018061600115GO_REF:0000002InterProGO_REF:0000002
Arhgap35RatGTPase activating protein binding  IPIRasa1 (Rattus norvegicus)10002731 RGD 
Arhgap35RatGTPase activator activity enablesISSUniProtKB:Q9NRY41600115GO_REF:0000024UniProtGO_REF:0000024
Arhgap35RatGTPase activator activity enablesIBAFB:FBgn0026375 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Arhgap35RatGTPase activator activity enablesIEAUniProtKB:Q91YM2 and ensembl:ENSMUSP000000752421600115GO_REF:0000107EnsemblGO_REF:0000107
Arhgap35RatGTPase activator activity enablesISOArhgap35 (Mus musculus)1624291 PMID:18502760RGDPMID:18502760
Arhgap35RatGTPase activator activity enablesIEAUniProtKB-KW:KW-03431600115GO_REF:0000043UniProtGO_REF:0000043
Arhgap35RatGTPase activator activity enablesISOARHGAP35 (Homo sapiens)1624291 PMID:19673492RGDPMID:19673492
Arhgap35RatGTPase activator activity enablesIDA 11535110PMID:9852136UniProt 
Arhgap35RatGTPase activity enablesIEAInterPro:IPR0018061600115GO_REF:0000002InterProGO_REF:0000002
Arhgap35Ratlipid binding enablesIEAUniProtKB-KW:KW-04461600115GO_REF:0000043UniProtGO_REF:0000043
Arhgap35Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Arhgap35Ratphospholipid binding enablesISSUniProtKB:Q9NRY41600115GO_REF:0000024UniProtGO_REF:0000024
Arhgap35Ratphospholipid binding enablesISOARHGAP35 (Homo sapiens)1624291 PMID:19673492RGDPMID:19673492
Arhgap35Ratprotein-containing complex binding  IDA 10002731 RGD 
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Imported Annotations - PID (archival)

Object Symbol
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Reference
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Source
Original Reference(s)
Arhgap35Ratephrin - ephrin receptor bidirectional signaling axis  ISOARHGAP35 (Homo sapiens)6484113 PIDPID:200216
Arhgap35Ratplatelet-derived growth factor signaling pathway  ISOARHGAP35 (Homo sapiens)6484113 PIDPID:200149

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein. Moran MF, etal., Mol Cell Biol. 1991 Apr;11(4):1804-12.
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. The function of the p190 Rho GTPase-activating protein is controlled by its N-terminal GTP binding domain. Tatsis N, etal., J Biol Chem. 1998 Dec 18;273(51):34631-8.
PMID:1581965   PMID:1894621   PMID:7503985   PMID:11044403   PMID:11283609   PMID:15084284   PMID:15280098   PMID:16188938   PMID:16971514   PMID:17562701   PMID:18267090   PMID:18502760  
PMID:19540230   PMID:19632305   PMID:19673492   PMID:20439493   PMID:21945077   PMID:22357865   PMID:23595732   PMID:26859289   PMID:27212270   PMID:27646271   PMID:30174148  



Arhgap35
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,330,566 - 86,447,414 (-)NCBIGRCr8
mRatBN7.2177,202,436 - 77,319,298 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,202,436 - 77,319,298 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx182,576,527 - 82,693,394 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,140,568 - 91,257,426 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,331,623 - 84,448,478 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,456,409 - 78,573,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,456,409 - 78,573,374 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0179,703,650 - 79,820,568 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,757,031 - 76,824,155 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11628,093,164 - 28,259,729 (+)NCBI
Celera171,687,713 - 71,804,603 (-)NCBICelera
Cytogenetic Map1q21NCBI
ARHGAP35
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381946,860,997 - 47,005,077 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1946,860,997 - 47,005,077 (+)EnsemblGRCh38hg38GRCh38
GRCh371947,364,254 - 47,508,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361952,113,773 - 52,200,174 (+)NCBINCBI36Build 36hg18NCBI36
Celera1944,226,291 - 44,312,689 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1943,846,727 - 43,932,756 (+)NCBIHuRef
CHM1_11947,423,799 - 47,510,216 (+)NCBICHM1_1
T2T-CHM13v2.01949,686,835 - 49,830,977 (+)NCBIT2T-CHM13v2.0
Arhgap35
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,228,398 - 16,349,313 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl716,227,644 - 16,348,918 (-)EnsemblGRCm39 Ensembl
GRCm38716,494,473 - 16,614,993 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,493,719 - 16,614,993 (-)EnsemblGRCm38mm10GRCm38
MGSCv37717,079,822 - 17,200,342 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36715,653,561 - 15,773,515 (-)NCBIMGSCv36mm8
Celera713,691,036 - 13,812,194 (-)NCBICelera
Cytogenetic Map7A2NCBI
cM Map79.15NCBI
Arhgap35
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574915,325 - 984,744 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955574915,604 - 984,744 (+)NCBIChiLan1.0ChiLan1.0
ARHGAP35
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22053,006,784 - 53,151,982 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11954,878,676 - 55,023,271 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01943,850,692 - 43,994,487 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11952,435,379 - 52,521,104 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1952,435,379 - 52,521,104 (+)Ensemblpanpan1.1panPan2
ARHGAP35
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11108,952,836 - 109,034,329 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1108,952,562 - 109,034,337 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1108,432,475 - 108,561,300 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01109,473,916 - 109,607,035 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1109,476,089 - 109,607,038 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11109,144,987 - 109,284,705 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01108,789,454 - 108,918,490 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01109,657,989 - 109,786,942 (-)NCBIUU_Cfam_GSD_1.0
Arhgap35
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934919,095,903 - 19,170,964 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936664713,984 - 789,344 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936664714,036 - 788,584 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP35
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,711,901 - 52,841,288 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1652,711,463 - 52,841,295 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2648,200,461 - 48,215,323 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGAP35
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1640,264,466 - 40,353,157 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl640,205,892 - 40,353,280 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607319,911,593 - 20,059,133 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgap35
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248326,650,383 - 6,719,786 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248326,650,383 - 6,773,828 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Arhgap35
416 total Variants

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:82
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000021223
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 46 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat

1 to 10 of 46 rows
BF405601  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21625,345,625 - 25,345,818 (+)MAPPERmRatBN7.2
Rnor_6.01627,233,388 - 27,233,580NCBIRnor6.0
Rnor_5.01627,104,254 - 27,104,446UniSTSRnor5.0
RGSC_v3.41628,259,238 - 28,259,430UniSTSRGSC3.4
Celera1625,424,195 - 25,424,387UniSTS
RH 3.4 Map16310.9UniSTS
Cytogenetic Map16p13UniSTS
Cytogenetic Map1q21UniSTS
RH139289  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,215,083 - 77,215,205 (+)MAPPERmRatBN7.2
Rnor_6.0178,469,056 - 78,469,177NCBIRnor6.0
Rnor_5.0179,716,297 - 79,716,418UniSTSRnor5.0
RGSC_v3.4176,769,659 - 76,769,780UniSTSRGSC3.4
Celera171,700,199 - 71,700,320UniSTS
RH 3.4 Map1789.5UniSTS
Cytogenetic Map1q21UniSTS
WI-9140  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21625,345,291 - 25,345,401 (+)MAPPERmRatBN7.2
mRatBN7.2177,251,899 - 77,251,999 (-)MAPPERmRatBN7.2
Rnor_6.01627,233,054 - 27,233,163NCBIRnor6.0
Rnor_5.01627,103,920 - 27,104,029UniSTSRnor5.0
RGSC_v3.41628,258,904 - 28,259,013UniSTSRGSC3.4
Celera1625,423,861 - 25,423,970UniSTS
Cytogenetic Map16p13UniSTS
Cytogenetic Map1q21UniSTS
RH132160  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,202,653 - 77,202,835 (+)MAPPERmRatBN7.2
Rnor_6.0178,456,627 - 78,456,808NCBIRnor6.0
Rnor_5.0179,703,868 - 79,704,049UniSTSRnor5.0
RGSC_v3.4176,754,454 - 76,754,635UniSTSRGSC3.4
Celera171,687,931 - 71,688,112UniSTS
RH 3.4 Map1769.8UniSTS
Cytogenetic Map1q21UniSTS
RH134350  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,203,095 - 77,203,276 (+)MAPPERmRatBN7.2
mRatBN7.21625,348,423 - 25,348,604 (+)MAPPERmRatBN7.2
Rnor_6.01627,236,186 - 27,236,366NCBIRnor6.0
Rnor_6.0178,457,069 - 78,457,249NCBIRnor6.0
Rnor_5.01627,107,052 - 27,107,232UniSTSRnor5.0
Rnor_5.0179,704,310 - 79,704,490UniSTSRnor5.0
RGSC_v3.4176,754,896 - 76,755,076UniSTSRGSC3.4
RGSC_v3.41628,262,036 - 28,262,216UniSTSRGSC3.4
Celera1625,426,994 - 25,427,174UniSTS
Celera171,688,373 - 71,688,553UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map16p13UniSTS
BE110269  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21625,346,773 - 25,346,947 (-)MAPPERmRatBN7.2
mRatBN7.21625,346,773 - 25,346,947 (+)MAPPERmRatBN7.2
mRatBN7.2177,204,783 - 77,204,957 (-)MAPPERmRatBN7.2
mRatBN7.2177,204,783 - 77,204,957 (+)MAPPERmRatBN7.2
Rnor_6.0178,458,757 - 78,458,930NCBIRnor6.0
Rnor_6.01627,234,536 - 27,234,709NCBIRnor6.0
Rnor_5.0179,705,998 - 79,706,171UniSTSRnor5.0
Rnor_5.01627,105,402 - 27,105,575UniSTSRnor5.0
RGSC_v3.4176,756,584 - 76,756,757UniSTSRGSC3.4
RGSC_v3.41628,260,386 - 28,260,559UniSTSRGSC3.4
Celera1625,425,343 - 25,425,516UniSTS
Celera171,690,061 - 71,690,234UniSTS
RH 3.4 Map16297.41UniSTS
Cytogenetic Map16p13UniSTS
Cytogenetic Map1q21UniSTS
RH135367  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,290,998 - 77,291,200 (+)MAPPERmRatBN7.2
Rnor_6.0178,544,961 - 78,545,162NCBIRnor6.0
Rnor_5.0179,792,202 - 79,792,403UniSTSRnor5.0
RGSC_v3.4176,847,422 - 76,847,623UniSTSRGSC3.4
Celera171,776,347 - 71,776,548UniSTS
RH 3.4 Map1790.7UniSTS
Cytogenetic Map1q21UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000021223   ⟹   ENSRNOP00000021223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl178,459,543 - 78,521,999 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090519   ⟹   ENSRNOP00000075649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,202,436 - 77,319,298 (-)Ensembl
Rnor_6.0 Ensembl178,456,409 - 78,573,374 (-)Ensembl
RefSeq Acc Id: NM_001271132   ⟹   NP_001258061
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,330,566 - 86,447,414 (-)NCBI
mRatBN7.2177,202,436 - 77,319,298 (-)NCBI
Rnor_6.0178,456,409 - 78,573,374 (-)NCBI
Rnor_5.0179,703,650 - 79,820,568 (-)NCBI
Celera171,687,713 - 71,804,603 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008758919   ⟹   XP_008757141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,331,094 - 86,447,051 (-)NCBI
mRatBN7.2177,202,452 - 77,292,695 (-)NCBI
Rnor_6.0178,456,637 - 78,546,651 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039110038   ⟹   XP_038965966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,331,094 - 86,447,050 (-)NCBI
mRatBN7.2177,202,506 - 77,318,980 (-)NCBI
RefSeq Acc Id: XM_063288062   ⟹   XP_063144132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,331,094 - 86,447,050 (-)NCBI
RefSeq Acc Id: XM_063288066   ⟹   XP_063144136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,331,094 - 86,447,050 (-)NCBI
Protein RefSeqs NP_001258061 (Get FASTA)   NCBI Sequence Viewer  
  XP_008757141 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965966 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144132 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144136 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075649
  ENSRNOP00000075649.1
GenBank Protein P81128 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001258061   ⟸   NM_001271132
- UniProtKB: A0A0G2KB46 (UniProtKB/Swiss-Prot),   P81128 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008757141   ⟸   XM_008758919
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KB46 (UniProtKB/Swiss-Prot),   P81128 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021223   ⟸   ENSRNOT00000021223
Ensembl Acc Id: ENSRNOP00000075649   ⟸   ENSRNOT00000090519
RefSeq Acc Id: XP_038965966   ⟸   XM_039110038
- Peptide Label: isoform X1
- UniProtKB: P81128 (UniProtKB/Swiss-Prot),   A0A0G2KB46 (UniProtKB/Swiss-Prot)
FF   pG1 pseudoGTPase   pG2 pseudoGTPase   Rho-GAP

Name Modeler Protein Id AA Range Protein Structure
AF-P81128-F1-model_v2 AlphaFold P81128 1-1499 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13689733
Promoter ID:EPDNEW_R258
Type:multiple initiation site
Name:Arhgap35_1
Description:Rho GTPase activating protein 35
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R259  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0178,572,988 - 78,573,048EPDNEW
RGD ID:13689734
Promoter ID:EPDNEW_R259
Type:multiple initiation site
Name:Arhgap35_2
Description:Rho GTPase activating protein 35
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R258  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0178,573,386 - 78,573,446EPDNEW


1 to 40 of 41 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-60607 BioCyc
Ensembl Genes ENSRNOG00000015852 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000090519 ENTREZGENE
  ENSRNOT00000090519.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.440 UniProtKB/Swiss-Prot
  1.10.555.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro FF_domain UniProtKB/Swiss-Prot
  FF_domain_sf UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  pG1 UniProtKB/Swiss-Prot
  Rho-GAP_domain UniProtKB/Swiss-Prot
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot
  RhoGAP-FF1 UniProtKB/Swiss-Prot
  RhoGAP_dom UniProtKB/Swiss-Prot
  RhoGAP_pG1_pG2 UniProtKB/Swiss-Prot
  RhoGAP_pG2 UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
KEGG Report rno:306400 UniProtKB/Swiss-Prot
NCBI Gene 306400 ENTREZGENE
PANTHER RHO GTPASE-ACTIVATING PROTEIN 190 UniProtKB/Swiss-Prot
  RHO GTPASE-ACTIVATING PROTEIN 35 UniProtKB/Swiss-Prot
Pfam Ras UniProtKB/Swiss-Prot
  RhoGAP UniProtKB/Swiss-Prot
  RhoGAP-FF1 UniProtKB/Swiss-Prot
  RhoGAP_pG1_pG2 UniProtKB/Swiss-Prot
PhenoGen Arhgap35 PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot
PROSITE PG1 UniProtKB/Swiss-Prot
  PG2 UniProtKB/Swiss-Prot
  PS51676 UniProtKB/Swiss-Prot
  RHOGAP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015852 RatGTEx
SMART RhoGAP UniProtKB/Swiss-Prot
  SM00441 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48350 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
  SSF81698 UniProtKB/Swiss-Prot
UniProt A0A0G2KB46 ENTREZGENE
  P81128 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 40 of 41 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Arhgap35  Rho GTPase activating protein 35  Grlf1  glucocorticoid receptor DNA binding factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-17 Grlf1  glucocorticoid receptor DNA binding factor 1   LOC686520  similar to Glucocorticoid receptor DNA-binding factor 1 (GAP-associated protein p190)  Data merged from RGD:1596377 1643240 APPROVED
2008-04-30 Grlf1  glucocorticoid receptor DNA binding factor 1   Grlf1_predicted  glucocorticoid receptor DNA binding factor 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC686520  similar to Glucocorticoid receptor DNA-binding factor 1 (GAP-associated protein p190)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Grlf1_predicted  glucocorticoid receptor DNA binding factor 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED