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Gene: Sema5a (semaphorin 5A) Rattus norvegicus

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Symbol:

Sema5a

Name:

semaphorin 5A

RGD ID:

1308650

Description:

Enables chondroitin sulfate proteoglycan binding activity; heparan sulfate proteoglycan binding activity; and syndecan binding activity. Involved in nervous system development; regulation of axon extension involved in axon guidance; and signal clustering. Located in membrane. Orthologous to human SEMA5A (semaphorin 5A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC310207; sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A; sema F; semaphorin-5A; semaphorin-F

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	85,020,724 - 85,451,938 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	85,020,724 - 85,451,938 (+)	Ensembl				GRCr8
mRatBN7.2	2	83,309,843 - 83,741,084 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	83,309,843 - 83,741,084 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	90,354,073 - 90,791,652 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	88,475,679 - 88,913,259 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	83,531,943 - 83,969,519 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	85,377,318 - 85,808,970 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	85,377,318 - 85,808,970 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	105,049,343 - 105,480,370 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	84,725,092 - 85,158,599 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	78,800,990 - 79,231,054 (+)	NCBI		Celera
RGSC_v3.1	2	84,835,136 - 85,097,066 (+)	NCBI
Cytogenetic Map	2	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Charcot-Marie-Tooth disease (ISO)

intellectual disability (ISO)

salt and pepper syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(R)-lipoic acid (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4-diaminotoluene (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acetohydrazide (ISO)

acrylamide (EXP,ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

antimycin A (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

bisphenol F (EXP,ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

choline (ISO)

cobalt dichloride (EXP)

cocaine (EXP)

copper atom (EXP)

copper(0) (EXP)

DDT (EXP)

dibutyl phthalate (EXP,ISO)

diethyl malate (ISO)

dimethylarsinic acid (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

esketamine (ISO)

ethanol (ISO)

fenvalerate (EXP)

folic acid (ISO)

formaldehyde (ISO)

fulvestrant (ISO)

glycidol (EXP)

glyphosate (ISO)

hypochlorous acid (ISO)

inulin (ISO)

isoprenaline (ISO)

L-methionine (ISO)

Licochalcone B (ISO)

lipoic acid (ISO)

lipopolysaccharide (ISO)

maneb (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methapyrilene (ISO)

methylmercury chloride (ISO)

methylseleninic acid (ISO)

N,N-diethyl-m-toluamide (EXP)

nickel atom (ISO)

nickel sulfate (ISO)

organophosphorus compound (EXP)

ozone (ISO)

panobinostat (ISO)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (ISO)

permethrin (EXP)

pirinixic acid (ISO)

potassium dichromate (ISO)

SB 431542 (ISO)

selenomethionine (ISO)

silicon dioxide (EXP,ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

succimer (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

temozolomide (ISO)

testosterone (ISO)

titanium dioxide (ISO)

toluene (ISO)

tricetin (ISO)

trichostatin A (ISO)

triclosan (ISO)

valproic acid (EXP,ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axon extension (IBA,ISO)

axon guidance (IBA,ISO)

axonal fasciculation (IDA)

blood vessel endothelial cell proliferation involved in sprouting angiogenesis (ISO,ISS)

branching involved in blood vessel morphogenesis (ISO)

branching morphogenesis of an epithelial tube (ISO)

cell chemotaxis (ISO,ISS)

cell differentiation (IEA)

detection of light stimulus involved in visual perception (ISO)

diencephalon development (IMP)

negative chemotaxis (IEA)

negative regulation of axon extension involved in axon guidance (IMP)

negative regulation of cell adhesion (ISO,ISS)

negative regulation of endothelial cell apoptotic process (ISO,ISS)

nervous system development (IEA)

neural crest cell migration (IBA)

neuron projection extension (ISO)

neuron projection guidance (ISO)

positive chemotaxis (ISO,ISS)

positive regulation of actin filament depolymerization (ISO,ISS)

positive regulation of angiogenesis (ISO,ISS)

positive regulation of axon extension involved in axon guidance (IMP)

positive regulation of canonical Wnt signaling pathway (ISO,ISS)

positive regulation of cell migration (IBA)

positive regulation of endothelial cell chemotaxis (ISO,ISS)

positive regulation of endothelial cell proliferation (ISO,ISS)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ISO,ISS)

regulation of plasma membrane bounded cell projection organization (IEA)

semaphorin-plexin signaling pathway (IBA,ISO,ISS)

signal clustering (IEA,IMP,ISO,ISS)

Cellular Component

membrane (IDA,IEA,ISO)

plasma membrane (IBA)

Molecular Function

axon guidance receptor activity (ISO)

chemorepellent activity (IBA)

chondroitin sulfate proteoglycan binding (IMP)

heparan sulfate proteoglycan binding (IMP)

semaphorin receptor binding (IBA,IEA,ISO,ISS)

syndecan binding (IPI)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans.	Kantor DB, etal., Neuron. 2004 Dec 16;44(6):961-75.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval.	Simmons AD, etal., Biochem Biophys Res Commun. 1998 Jan 26;242(3):685-91.

Additional References at PubMed

PMID:12506007	PMID:15218527	PMID:15743826	PMID:16144627	PMID:19850054	PMID:21835343	PMID:22871113	PMID:23376485	PMID:23533145	PMID:25931508

Genomics

Comparative Map Data

Sema5a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	85,020,724 - 85,451,938 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	85,020,724 - 85,451,938 (+)	Ensembl				GRCr8
mRatBN7.2	2	83,309,843 - 83,741,084 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	83,309,843 - 83,741,084 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	90,354,073 - 90,791,652 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	88,475,679 - 88,913,259 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	83,531,943 - 83,969,519 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	85,377,318 - 85,808,970 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	85,377,318 - 85,808,970 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	105,049,343 - 105,480,370 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	84,725,092 - 85,158,599 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	78,800,990 - 79,231,054 (+)	NCBI		Celera
RGSC_v3.1	2	84,835,136 - 85,097,066 (+)	NCBI
Cytogenetic Map	2	q23	NCBI

SEMA5A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	9,035,033 - 9,546,075 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	9,035,033 - 9,546,142 (-)	Ensembl			hg38	GRCh38
GRCh37	5	9,035,145 - 9,546,187 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	9,088,138 - 9,599,233 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	9,091,858 - 9,599,158	NCBI
Celera	5	9,075,672 - 9,586,506 (-)	NCBI		Celera
Cytogenetic Map	5	p15.31	NCBI
HuRef	5	9,020,618 - 9,529,962 (-)	NCBI		HuRef
CHM1_1	5	9,034,070 - 9,546,215 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	8,974,898 - 9,485,916 (-)	NCBI		T2T-CHM13v2.0

Sema5a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	32,244,959 - 32,696,487 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	32,244,956 - 32,696,487 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	15	32,244,813 - 32,696,341 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	32,244,810 - 32,696,341 (+)	Ensembl			mm10	GRCm38
MGSCv37	15	32,174,568 - 32,626,096 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	15	32,361,948 - 32,640,922 (+)	NCBI		MGSCv36	mm8
Celera	15	32,949,262 - 33,396,657 (+)	NCBI		Celera
Cytogenetic Map	15	B3.1	NCBI
cM Map	15	13.02	NCBI

Sema5a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955504	6,350,866 - 6,762,104 (-)	Ensembl
ChiLan1.0	NW_004955504	6,343,747 - 6,691,945 (-)	NCBI	ChiLan1.0	ChiLan1.0

SEMA5A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	9,272,092 - 9,780,658 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	7,425,701 - 7,935,102 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	9,349,473 - 9,852,183 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	9,168,549 - 9,672,779 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	9,168,549 - 9,564,356 (-)	Ensembl			panPan2	panpan1.1

SEMA5A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	34	4,612,202 - 5,089,071 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	34	4,612,142 - 5,082,280 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	34	9,122,860 - 9,593,613 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	34	4,522,038 - 4,992,481 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	34	4,521,503 - 4,998,657 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	34	4,573,215 - 5,048,444 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	34	4,553,933 - 5,029,831 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	34	4,776,835 - 5,250,400 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Sema5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	237,599,219 - 238,050,371 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936643	1,355,070 - 1,637,151 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936643	1,352,401 - 1,803,553 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SEMA5A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	72,756,383 - 73,328,981 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	16	72,796,453 - 73,335,974 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	78,742,131 - 79,220,468 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SEMA5A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	8,598,680 - 9,095,346 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	8,600,959 - 9,095,423 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666064	19,470,071 - 19,975,962 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sema5a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624751	6,436,854 - 6,738,216 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624751	6,429,814 - 6,913,673 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Sema5a
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	148,146,000 - 148,579,266 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Sema5a
16940 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	828
Count of miRNA genes:	313
Interacting mature miRNAs:	402
Transcripts:	ENSRNOT00000016506
Prediction methods:	Microtar, Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578777	Stresp15	Stress response QTL 15	2	0.05	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	2	61556902	106556902	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
1598865	Bp296	Blood pressure QTL 296	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	82947902	127947902	Rat
1578772	Stresp14	Stress response QTL 14	5	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	2	84056790	132859658	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845370	229470703	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83465462	229820014	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
1581576	Pur7	Proteinuria QTL 7		0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	80396178	220931218	Rat
152025242	Bw191	Body weight QTL 191	3.62		body mass (VT:0001259)		2	40306867	124537199	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	78269809	208420281	Rat
61465	Bp13	Blood pressure QTL 13	3.3		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	78269809	104744824	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	27148328	145807373	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	80396178	220931218	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	41801363	104744824	Rat
631208	Bw1	Body weight QTL1	5.09		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	2	44904355	85286097	Rat
2317058	Aia13	Adjuvant induced arthritis QTL 13	2.9		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	2	78269809	123269809	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1300155	Bp174	Blood pressure QTL 174	4.09		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	44537979	112567334	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
5684990	Bmd82	Bone mineral density QTL 82	2.8		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	2	61051541	105724065	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	7605533	104774005	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1359034	Bp274	Blood pressure QTL 274			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	51266859	96266859	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845182	205135428	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	83400752	223709938	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	28652666	139067443	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	80396034	220931416	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	78269809	205135428	Rat
631500	Bp99	Blood pressure QTL 99	2.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	61051883	104684275	Rat
61392	Bp6	Blood pressure QTL 6	7		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	82214549	127214549	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
5684996	Bmd85	Bone mineral density QTL 85	4.7	0.024	tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	2	61051541	105724065	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	159440891	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	83465462	225110681	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	47856345	205135428	Rat
1558648	Smcn1	Smooth muscle cell number QTL 1		0.039	blood vessel smooth muscle cell quantity (VT:0010525)	aorta smooth muscle cell count per unit vessel length (CMO:0001646)	2	60861391	105861391	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	184731399	Rat
2306903	Bp336	Blood pressure QTL 336		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	38426449	111295694	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	76328396	209350714	Rat
152025206	Hrtrt23	Heart rate QTL 23	5.98		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
152025204	Hrtrt22	Heart rate QTL 22	5.6		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	44904355	89904355	Rat
61438	Cia7	Collagen induced arthritis QTL 7	4.6	0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	2	61051541	143746880	Rat

Markers in Region

D2Mgh19

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	2	85,285,943 - 85,286,097 (+)	Marker Load Pipeline
mRatBN7.2	2	83,575,072 - 83,575,226 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	85,642,517 - 85,642,672	NCBI	Rnor6.0
Rnor_5.0	2	105,313,917 - 105,314,072	UniSTS	Rnor5.0
RGSC_v3.4	2	84,991,829 - 84,991,982	RGD	RGSC3.4
RGSC_v3.4	2	84,991,830 - 84,991,985	UniSTS	RGSC3.4
Celera	2	79,065,698 - 79,065,847	UniSTS
RGSC_v3.1	2	84,936,791 - 84,936,944	RGD
RH 3.4 Map	2	526.5	UniSTS
RH 3.4 Map	2	526.5	RGD
RH 2.0 Map	2	427.8	RGD
SHRSP x BN Map	2	35.4298	RGD
Cytogenetic Map	2	q23	UniSTS

D2Rat328

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	2	85,179,626 - 85,179,788 (+)	Marker Load Pipeline
mRatBN7.2	2	83,468,750 - 83,468,912 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	85,536,218 - 85,536,379	NCBI	Rnor6.0
Rnor_5.0	2	105,208,031 - 105,208,192	UniSTS	Rnor5.0
RGSC_v3.4	2	84,885,630 - 84,885,792	RGD	RGSC3.4
RGSC_v3.4	2	84,885,631 - 84,885,792	UniSTS	RGSC3.4
Celera	2	78,959,432 - 78,959,593	UniSTS
RGSC_v3.1	2	84,830,592 - 84,830,754	RGD
SHRSP x BN Map	2	35.4298	UniSTS
SHRSP x BN Map	2	35.4298	RGD
Cytogenetic Map	2	q23	UniSTS

RH141406

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	83,735,110 - 83,735,317 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	85,802,997 - 85,803,203	NCBI	Rnor6.0
Rnor_5.0	2	105,474,397 - 105,474,603	UniSTS	Rnor5.0
RGSC_v3.4	2	85,152,626 - 85,152,832	UniSTS	RGSC3.4
Celera	2	79,225,073 - 79,225,279	UniSTS
RH 3.4 Map	2	523.7	UniSTS
Cytogenetic Map	2	q23	UniSTS

UniSTS:496014

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	83,596,708 - 83,596,799 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	85,664,155 - 85,664,245	NCBI	Rnor6.0
Rnor_5.0	2	105,335,555 - 105,335,645	UniSTS	Rnor5.0
RGSC_v3.4	2	85,013,469 - 85,013,559	UniSTS	RGSC3.4
Celera	2	79,087,335 - 79,087,425	UniSTS
Cytogenetic Map	2	q23	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	160	91	90	59	62	59	6	326	162	11	139	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107659	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017590833	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281754	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281755	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473992	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000016506 ⟹ ENSRNOP00000016506

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	85,020,724 - 85,451,938 (+)	Ensembl
mRatBN7.2 Ensembl	2	83,309,843 - 83,741,084 (+)	Ensembl
Rnor_6.0 Ensembl	2	85,377,318 - 85,808,970 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000085094 ⟹ ENSRNOP00000074231

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	85,020,724 - 85,451,938 (+)	Ensembl
mRatBN7.2 Ensembl	2	83,309,843 - 83,736,489 (+)	Ensembl
Rnor_6.0 Ensembl	2	85,377,341 - 85,802,558 (+)	Ensembl

RefSeq Acc Id:

NM_001107659 ⟹ NP_001101129

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	85,020,724 - 85,451,938 (+)	NCBI
mRatBN7.2	2	83,309,843 - 83,741,084 (+)	NCBI
Rnor_6.0	2	85,377,318 - 85,808,970 (+)	NCBI
Rnor_5.0	2	105,049,343 - 105,480,370 (+)	NCBI
RGSC_v3.4	2	84,725,092 - 85,158,599 (+)	RGD
Celera	2	78,800,990 - 79,231,054 (+)	RGD

Sequence:

show sequence

ACCCAGCTCTGGTCTACTCGCTAGGAAGGCGGCGTCGGCAGCGGCTGCTCACGTTGTGCCCAAT
CCCGCGCGCGCTGCGCTCCCGCCGCGGGTGGGCTCCTCAGCCTTTGGCTGGAGGTGGCCCCAGC
CTTGCGGCGGCATCTGTATCCCACCTTCCCACTGCGGGGAGGTCCCGGCACGTGCAATCCTTCT
TTGGGGTGTTCTGGTTCGCACGCGCGGACCTAAACAGAGGGTACCCAACTTTGCCATCTCACCG
GTTGCCCTCTCTCGGCGCGAGCCTGTTCACTCAGCTGCACAACTGGAGACTCCAGCAGGCGAGC
TGGTCCCCAGCCTGGCGCGCTGCGAGTGGAGGATAGCTCTGGAGAAGTGGCCGGGTGTAGTGGT
TGTTGCTGCCTCGACTTTCCTCCTGGCGCACTGAAGAGGACCCTGGGAGCAGCTCCGGGCCCCG
GGGCGCTGGATGACTAGTAGGAGGAACGCGCCCCGCATCTGGGCTGGTGTGTGACAACTGGGCT
TGGGTACCCATGTGGCTGTGCAGTTCATTGTGATTCATGACGGAGGCCACACGTCTGTCTCTGC
CCTCTCTCTCTCCTGGGTACTTTTCACACATGAGGAGAAGGTGAGCTTCGTAGAAGACACGTTC
CCAGAGTCGGAGACCCCTTGCCCACCATGAAGGGAGCCTGCATCCTTGCATGGCTGTTCTCAAG
CCTGGGAGTGTGGAGACTTGCTCGGCCTGAGACCCAGGACCCTGCCAAGTGCCAGAGAGCTGAG
CACCCCGTCGTCTCCTACAAAGAAATTGGCCCCTGGTTACGGGAATTCAGAGCCGAGAATGCTG
TGGATTTCTCGAGGTTAACATTTGACCCAGGACAGAAAGAACTTGTCGTAGGAGCAAGAAACTA
TCTCTTCAGACTACAGCTCGAGGATCTGTCTCTCATCCAGGCTGTGCAGTGGGAGTGTGATGAA
GCCACGAAGAAGGCCTGTTACAGCAAGGGCAAATCGAAGGAGGAATGTCAGAACTACATACGAG
TGCTCTTAGTGGGCGGGGACCGGCTCTTCACCTGTGGGACCAATGCCTTCACACCCGTCTGTAC
CATCCGCTCCTTAAGTAACCTGACTGAGATCCATGATCAGATCAGTGGCATGGCTCGATGTCCC
TATAGTCCCCAGCACAATTCTACAGCTCTACTCACTGCCAGTGGCGAGCTCTATGCTGCAACAG
CCATGGATTTCCCAGGGCGCGATCCAGCCATTTATCGAAGTCTGGGCACTTTACCTCCTCTTCG
AACTGCACAGTACAACTCCAAATGGCTCAATGAACCAAACTTTGTGTCTTCCTACGACATCGGG
AACTTCACCTACTTCTTCTTCCGAGAAAATGCCGTGGAACACGACTGTGGGAAGACTGTGTTCT
CCAGGGCAGCCAGGGTCTGCAAGAATGACATTGGAGGACGATTTCTTCTGGAGGATACCTGGAC
TACCTTCATGAAGGCTCGCCTCAACTGCTCTCGGCCTGGTGAGGTGCCGTTCTACTACAACGAG
CTTCAAAGCACCTTCTTCCTGCCGGAGCTGGATCTGATCTACGGCATCTTCACCACCAATGTAA
ACAGCATTGCTGCCTCTGCTGTCTGTGTCTTCAACCTGAGCGCCATCTCACAGGCCTTCAATGG
ACCCTTCAAGTACCAAGAGAACTCTCGCTCAGCCTGGCTGCCTTATCCCAACCCCAACCCCAAT
TTTCAGTGCGGCACCATGGACCAGGGCCTGTATGTAAACCTGACGGAAAGAAACCTACAGGATG
CTCAGAAGTTCATCCTGATGCATGAAGTGGTGCAGCCAGTGACCACAGTGCCTTCCTTCATGGA
AGACAACAGCCGTTTCTCCCATGTGGCTGTCGATGTTGTGCAAGGCAGGGACACCCTTGTCCAT
ATCATCTATCTGGCCACAGATTATGGCACCATTAAAAAAGTGCGGGCTCCGCTGAGTCAGAGCT
CGGGCAGCTGTTTGCTAGAAGAGATTGAGCTTTTTCCAGAGAGGAAGAGTGAGCCCATCAGGAG
CCTAAAGATCCTCCACAGCCAGAGTGTCCTATTTGTGGGGCTACAGGAGCATGTGGTCAAGATC
CCCCTGAAGAGATGCCATTTTCATCAAACACGTGGTGCCTGCATTGGTGCTCAGGACCCTTACT
GTGGCTGGGATGCGGTGATGAAGAAGTGCACCAGCCTGGAGGAGAGCCTGAGCATGACCCAGTG
GGATCAGAGCGTCCCCACCTGTCCGACCAGAAATCTCACCGTAGATGGGAGCTTTGGCCCGTGG
TCTCCATGGACACCCTGTACTCACACTGATGGCACTGCTGTGGGATCCTGCCTCTGCCGGTCCC
GATCCTGTGACAGCCCAGCTCCACAGTGTGGCGGCTGGCAGTGTGAGGGCCCTAGAATGGAGAT
CACCAACTGTTCCAGGAATGGAGGCTGGACTCCCTGGACCTCCTGGTCTCCCTGCAGCACCACT
TGTGGCATTGGCTTCCAGGTGCGGCAGCGCTCCTGCAGCAACCCTACGCCCAGGCATGGAGGGC
GTGTGTGCGTGGGCCAGAACAGGGAGGAAAGATACTGCAATGAACATTTACTCTGCCCACCACA
CGTGTTCTGGACAGGCTGGGGACCTTGGGAACGCTGCACAGCCCAGTGCGGGGGTGGCATTCAA
GCTCGCCGTAGGACCTGTGAAAATGGGCCTGACTGTGCAGGATGCAATGTGGAATACCAGCCTT
GTAACACCAATGCATGCCCAGAGTTGAAGAAGACCACACCATGGACCCCCTGGACACCTGTCAA
CATCTCTGACAATGGGGGCCACTATGAGCAGCGGTTCCGCTACACCTGTAAAGCTCGCCTGCCA
GATCCAAACTTATTGGAAGTAGGAAGACAAAGGATAGAAATGCGGTACTGTTCTAGTGATGGGA
CCAGTGGCTGCTCCACAGATGGACTTTCTGGAGACTTTCTAAGAGCTGGGAGATACTCTGCCCA
TACAGTCAATGGGGCATGGTCAGCCTGGACTTCCTGGTCACAGTGCAGCAGAGACTGCAGCAGG
GGCATTCGAAACAGGAAGCGTGTTTGCAACAACCCAGAGCCCAAGTATGGAGGTATGCCATGCC
TTGGTCCATCACTGGAGTTCCAGGAATGCAACATTTTACCCTGTCCAGTGGATGGTGTGTGGTC
TTGCTGGTCATCCTGGTCTAAATGCTCAGCAACTTGTGGGGGTGGACACTACATGAGAACCCGT
TCGTGTACGAATCCAGCCCCAGCATACGGAGGGGACATCTGCCTGGGACTGCACACGGAAGAGG
CCCTCTGTAACACACAGACCTGCCCAGAGAACTGGTCAGAGTGGTCAGAGTGGTCTGTGTGTGA
TGCATCTGGTACCCAGGTCCGTACTCGGCAGTGCATCCTTCTGTTTCCTGTGGGCAGCCAGTGT
TCTGGAAATACTACAGAGAGCCGGCCTTGTGTATTTGACTCTAATTTCATCCCAGAAGTGTCTG
TGGCAAGATCCAGCAGCGTAGAAGAGAAAAGGTGTGGAGAGTTCAACATGTTCCACATGATGGC
TGTGGGACTTAGCAGTTCCATCCTCGGCTGCCTCCTTACACTGCTTGTCTACACCTACTGCCAG
CGGTACCAGCAGCAGTCCCATGATGCAACTGTCATCCATCCTGTTTCTCCCGCCGCCCTCAACA
GCAGCATAACTAACCACATCAACAAACTGGATAAATACGATTCCGTGGAGGCCATCAAGGCATT
TAACAAAAACAACTTGATCCTAGAGGAGAGAAACAAATACTTCAACCCACATCTCACTGGGAAG
ACCTACTCCAACGCCTACTTTACAGATCTCAACAATTATGATGAATACTAGCAGCTCTTACACT
TCTGGCTCCTTGTAAACTCTCTGTTCCTCAAAGCTGTACTCCATGACTGCCCATATTTCTGAGA
CTTCAGAGATGATGTGTGGATCCATTTCAAGTGCATTTCAAACCAGGACTTTCCCATCACTACC
AAAAAAAGCGCACACCCTTATACCTAAATGTGGTGTTGTGAAAATCTGGTCTGTAGAAAACATT
TGGTGTTGCGAAGTGAGCCATGATATGACATTTTGTGTTATGCTCATCCCAAACTCTAACTGGT
CTACTGTTTTCATGAGTGTCATTTCATAAATGTGCCAACCATGTTAGAAAGTGTGTTCAGAAGC
ATAGCGTTGTCATGCTTTTAAGTGCAGAGGGTCAGGATGTTTTAACTTGGAAACAAACAAACAA
ACAATTATAACCAGGCACTTTAATCTGAGAGATGTCTTCCCCACACACACAGGGTCCAGAGTAA
TTCACAGAATGAAGGTGTGGCTACTGCCAACTCCCTCAACCTGGGTGACTCTATAGGTTCTTGG
AAACAGCTTTGTTGCACTTGGAGTGATTCCTGCCCAGGGATTCCATCTGCCCTGGACCTGCCAA
GTCATGGTCTACTGAAACCCTCTGCTTTGGTCTGGAGCAGTGATTGTCATCCCTGTTTGGTGAA
CACATGAAACAGAGAACAGCCAATGAGACACACAGCAGTATTCTGCAGCTTGCAGTGAAACTAA
TCTTACTCTAACTTTTGGATTCTGTGTCATCCAAGGAAGTTCCTTGTCATGATGGGGGCCTGAA
GGCCACCTTCCTGGGTGCTGAAGAGCCAGTCTGAGCATTTGCATAGACTCCACACCCCTTCCTC
CCTCCCTCCATGAGGAGAAAATTCTTGATTTATGATGGAAAATATTGAAATACCAAACTGTAAT
TGAAAGCTACTTTTTAATTTTTTTGTATTATGCAGTGTTGAATTAACTGATGTAATTGAAAGCT
ACTTTTTTATTTTTTATTTTTTTGTGTTATGCTGTGTTGAATGAACTGATGTTAATGGCTTTTT
TGTTTTTTGTTTTTTGTTTTGTATTCAGCATCTTTGATGTGACTAATGTGTAGCAATGGCCCCT
ATCAAAAGCATTAAAGGTGTGTAAAGCTGTCCCTCTGGAGCTCAGTGCAATCCCACTGAAGCAA
CACTCCAGTACCATGGTCTCCTCATTTGTCCCCTGCTGCCCCAACACCAGAGGAGGGAATGGCT
CTGGTGTCTGTTACTAAGTTGCTGCCTCCCTGTCCTCCAGCTTACTGAGTCCCACTTCTGCTCC
AAGACAGTAGCAGTCAAGATGTACCATAAGCAGTAACGGATGAGAAGGTCAGGATTTTAGTGGC
CTCTCTCTCTCATCCCAATGGTTGACTGTTCTAAGGCTACTCTTAAGATCCTCAGACAAGTAAA
GAAGAGTGGTTAGCATCTGAAACATGGTGTAGAGGTACCGATCTAATGCATTTTAAAGGTGAAG
ACAAATGGTTTGTCTGGGCCACTGGTCACTATGATAAAGGCCTGAGTAGGCAGTCATATATGTT
AAGGGCATATAAACTTTCAGGTTCTATGCAAATGTATAGCATGAGGAGTGAAGATTACAGGGTT
TTTATGAGTATATGTTTTCCCCCATGGAATATAAAGAAGCAACCTCAGAAGACATTCCAAAAAA
TCTTATGATTAATCACAAATTATTCTCATATAAACACATTTTTCAGACATAACTCTGTGTTAAA
ATTGAAATTAAAACAGCAGATGGGCTCTGGGAGATGTGTCAGATTGTGAGGAAATGGCATATGG
GAATATTGCGATGGGACATTGTGTGGCATTTCACACACTTCTTCTACAGTGTATGTGGCCTCCA
TTACACACACATTTTTAAAATCCACACTCAGCAGACAGAACGTGTCAGATGATTTATTCATTGT
CTCTAGGGTGGAATTTTAGTGGATGCTTCAACTCATCTCATTGCTTTCTTTTAAGAAAAGAATA
AATCCTCCTGGTATAGCACTATTCTAGTGTTTTAAAAAGAATCTCCCCTTCTTGAATATTTCTA
GTTTAAAAGGTCACTTTCTTTCCCCTGGGAAGAAGAGTACAAATATTTCAAGAATTTATGGCTA
AACTTGATAGGAAATGCTTTCTAAATGACCTCTAATCTGGCCTTCATCAGTTTGATATAGTAAC
CCCACCCCAGAGTTCTCATTTTCAAAGACAGTTTTCTGATATTAGTATTGCTTTTTAAAAGTCT
CCTCCTTGTCTGCTTTGTTCTCCCTTCAAATCCCCACCTCCAGCCACCAGTCCTTTGCTCTTAT
TTAGCCAAACAATTGGAGCAATTTCTTAGGAGTGCCTTGAGCTGCATTCTGGTTTTCACTACCT
GCTGCATGACTTATTTTCTGCAGGTGTACAGCTGCAGCTCCTGGTGCAGTCTATACCACACTCC
AGACTTCTCATTAACACATCACACACACGTGCATAACACACACACACACACACACACACACACA
CACACACACACACACATGTTTGAGTTAGGTTGCACTCTACGGGTCCTGTTTTAAATTCTGCCCT
GACATTTTCATTTTTCCCCTACTTTCTCCCCACAACCCTTCTTCCTTTCCTTTATTGCTTCTTT
ATTTCATCTCTTTCTTCTTTTGCCTTTTGATGAAAGAAAAACAGAGTAGAATTAATACTTTAAG
TTGTATCTGGCTGAACCTGTTGTTAAATGACATTAATCAACTTATCTTCTGGAGTTAGGGTTCA
AGTCTGGTTTTCATTAGGAAACTGGCTTCAGTCACACTAACATTCATTGGAATTTGGTCCCGAT
GTTGTTTGGGGTCCTCTCACTGATAAGACTGTCATCGATCCTGCTAAGTGATGACATTCTGCAG
AAATAAAGAGTAAAATATTTTCACACTTCATAGCCAGAGGTATTTCCAAATACTCCGGGGACTT
TCTTGGAACTGTGGGCTCTGTCATACTGACTGAAGCTATCTTGGTGATCCTAAGGAATTCTTGG
ACACTGGGAGATGCTCTGCTTCACAGAAAATTCTCTGTCATCATAGTCCTAGACTTTTCCTTCA
AAACTTTCCAATGCAAGCTAAACACCTTTATGCCTCTGCCCCTTAAGACTTACTCATGACACTT
AAGCATCTTGGTCCTGTTGGATGAATGAAAATGCATATTAAAGTAAATTCTACCTAAAAACATG
TATGTTGATGGAAGAAAAGAGGGTTTCTTGAGTGCATGATCAAGTGATAGAGACACTGAAGGAA
CTGAAGAGAAGTCATAAACTGAATGTTTGTAAGGGCATCTGCTATGGAGATGTCTCTATCATTA
GGAAGGACAGGTCTTGCCTTCAATACTGTAGGCAATTTCTCATCAAGAGGAATCCATCTATGTA
CTATGCTATTATGTGGTTGAATAGCTCAAGAGATGTCATCCTAAAGATATCTGACTTGAACTAT
CAGTTTGCCTAAACACAGCCTACTGTGCATGTAACCACATGTTTCTTTTCTGAATTCTTTTTTC
CTTTTCGAATAAACCACAAATATTTCCCCAACAGATCAAGCCAAATTCCTCATCAATTATTCCC
CAGGGTCATCAACTTTTTTAACTTTTAAGTTTCCTAGACTTTTTGGTGGGCTGTTCATATTTTA
ACTCGCACTTTGGAGTACACTAGTGCTACTGTATCAAAAGACAATTTGGGAGCCCCAACTAGAA
ATAGCAGATGCCATGTACCAATGGGTGATACCGTATTAGATCAACTGTTGGCAGGTTATTTTCA
AGTCTACAGGCTCAAAAATATCATTTTCCATGGAGATGTCAAAACAGTAAACTTAGACTCCTTT
GAAATTCTCTGGTGTTTTTCTAGAGTCTAAAGATGGAACTGGTCATACCCAGTTTGTCCAATCA
TTCTTACACCTTTACTACTTCATGGGGCATCTAGAGACTTATGTTAATACACCATTGCCAATAT
TCCAAAGCCTATTATTACCCATGGGTTTGTGATAATATCTACTATCCATTACTAAAGAGCATTA
TGAAAAAATGCTTCTTTTTATCTAAGAGATGTACCACAGGGAATGCTATGTAAGAAGTTACTGT
CCAGAGCCCAGAGATTGTTTATCTCTGCAGCTTACCTTCCCAGTTGTTATCATTAATTAAAATG
ATGTAAAGAGATTTTCCAAGCTCTATAAATACTAATCTATGGCCTTGAGGTAGTCTCTCTGGAT
TATCTCATGGTACAAAGAAAATGTGTTGTTTTCCAGTTTGCTACTGTACCCTTCAGGGAACAAA
AACCCTGTGGATAATATACAACATTGAACTATTGACAGAAGTTGTGAACGTTACTCTTCTCTGT
GGGTTTCATATCATAATGTTGCATTATCAGAGATTTGATACAAATTGCAGAAGCAACTTGGAAA
CCTGTCTCTTAAAATAGTTCAGGCTGCAAAGACTGTGCAGTCTCCTGGATACCAAATTCAGAGC
CTCCTACAAATAGTATAGTTCATAATGAAGTCCCAGCCCTAGTACATGATCTCTTTGAAAGATG
ATGTCCTGCCCTTTACGCCTGTTGTCCATGACCAGAGCCTATACCAACTCTGTTCCCAGGTAGA
AGTGCTTTCCTGGGAAGACACTGTACCTGGAACTAAACTGATCAAGAAAAAGCAGTGATGGGGA
ATCACTAAAATGCAAATCAGGCAGGAAAATCTCCACCCCTTCATAATCCAGCAAGGACCTAAAA
CCAGTCAATTAGCCATAATCGTCATCTTTCTCTGCTTCTTGGGAATTGAATACCGACTGGTTCC
AATGTTAGACAAATGCAAGCAAAACGAAAAGCCTAGGCTCTGATAAACACAACTGCTCTTCCAT
CCAGACAATAAAGGACGCCTGTTATCTGTGGAAGATGTAGTACTGACTTCCCTGTACAAAGTTG
CTAGTGCCTTGTATAAGCTATGTGCTGTCACTTTTCCTGGTTATTGATTGTCCCAATTAGAAGC
CACTCGGTGGTTGTATACACTTTGAGGAAATCTACTCCGTGTGTCTCTTTGAACTCAGGAACAG
AAAATGAGAGAAATGTGTCATGTTCGAGTGTGGTTTTGCTCTCAGAACAGGATAAAGAGTGCGT
TGTGTCCAGATGAAGTGACCCTGTTTCAGCCTGCAAGAAACTGATGTTGCTTTAACTTTTACAT
CTTCATGGGAATGGAGTAGAGCCTTTCCTGGGGTAGGAGAGTCAGCTCTGTTTCTGTAGAAGTC
AGTGGGTGTTTCTGTTGCTCTTCATGCACATACATAGATATACCGAAAACAGATACAGGCTACT
TACAGCCACACAGGTTGTGAAATGAGAACCAACTGGAACATCATTTGGATTGTTTTATCATATT
CTGCAAATCCAATATCAGAACTGCTCAAAAGTTCACAAAATTACTATTTTTCGCTTGGGTTTAA
AACATTAGCAGTGTCTTCTATGCTGAAGTTGACCACTGATCTCTTACACTGTGACTGTGGACTC
GAATCAGCTTATAGATCTGCTTCCAAAGCATGCACAGTGGGAGCTTCCAACCACTGAATCACCA
TGATATTCACCTCATCTGCCAATAAGATGCACCAGCTTCTTCCAGTGTAAGATTCTGCAGAACC
TGTGACCACTTGACTTTACACCTGCTATGCCTCCTTGCCTGTTTTGTGATACAAAATAAAATTG
TTTGGGATTGCTCATTCATTGAAATTTCTTCTAGGCCAACTTCAGCCCTTGGTAAACTTGCGGA
CTGTTCCTGATGTTAAGATTAAAACTTCAAAGGCGCTATTTATTAGTCACACAGAGCCATTTCA
AGAGAAAGGAGCTCTGCCTTTCCCCATCAGTTTCCTTAGAGAAGAGACACTTGGCTCTGTGTGG
AGTTGCTGCTGGCTGCTGAGTGTTCTCTTCCTGGTACAATGGGCAACCCACACTATTAGGCCCT
TATGTTTGGCTGAAATCTTACTAGCCATGTGCACTGGTCTTTTCTACAGCTTTCATTTTTCTGT
TTCACTCATTAACCCACTGCATTGATATTCTTCCTGGGAGCTGGTCAGGCCCTTGCCTCAAATT
GTGCTTAATGACACCTGGCAGATAGCTTGTTTTCAGAAATCATTTTAAGACCCTAATTATGTCA
ACCCAGGCAGGGATAATTCTGTCTTTCATGGAACCAATTATGGAACTTCCAAAAAGGGGAGAGC
AGGGACACTTCCCAACCAATCAACCAAACCAAACTCACACCCATCTAACCAAACATTAATAAGA
TGAATCATTATTATGGTAAATGTCACCTTGTATCTGCCCTAGGCACATTCCAATATCAGCATCT
CCACCTTCTTCATTGCTTCTAACATTGAAGTTATAAAATGGTCCTGCCTTTTGCCAAGAGCACA
GCACTACTCCCTTCTGAGACCTCCCTCCCCACCCCGAGCATCACCTCTCTGCCAACATTTTGTG
GAAACTAAAAGAATCTTACTATGTACAGATAAATTGTATTATATTTTTTGTACTTAATGTTTTG
TGTAAATAGTTTGCCTTGTTCAGTTGTATGTGAGTATTCAAATAAACCCTGCCATTTAGGAGAC
AATTA

hide sequence

RefSeq Acc Id:

XM_063281754 ⟹ XP_063137824

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	85,021,080 - 85,451,935 (+)	NCBI

RefSeq Acc Id:

XM_063281755 ⟹ XP_063137825

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	85,021,390 - 85,451,935 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101129	(Get FASTA)	NCBI Sequence Viewer
	XP_063137824	(Get FASTA)	NCBI Sequence Viewer
	XP_063137825	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	D3ZTD8	(Get FASTA)	NCBI Sequence Viewer
	EDL82657	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000016506
	ENSRNOP00000016506.4

RefSeq Acc Id:	NP_001101129 ⟸ NM_001107659
- Peptide Label:	precursor
- UniProtKB:	D3ZTD8 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MKGACILAWLFSSLGVWRLARPETQDPAKCQRAEHPVVSYKEIGPWLREFRAENAVDFSRLTFD PGQKELVVGARNYLFRLQLEDLSLIQAVQWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRL FTCGTNAFTPVCTIRSLSNLTEIHDQISGMARCPYSPQHNSTALLTASGELYAATAMDFPGRDP AIYRSLGTLPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKN DIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPELDLIYGIFTTNVNSIAASAVC VFNLSAISQAFNGPFKYQENSRSAWLPYPNPNPNFQCGTMDQGLYVNLTERNLQDAQKFILMHE VVQPVTTVPSFMEDNSRFSHVAVDVVQGRDTLVHIIYLATDYGTIKKVRAPLSQSSGSCLLEEI ELFPERKSEPIRSLKILHSQSVLFVGLQEHVVKIPLKRCHFHQTRGACIGAQDPYCGWDAVMKK CTSLEESLSMTQWDQSVPTCPTRNLTVDGSFGPWSPWTPCTHTDGTAVGSCLCRSRSCDSPAPQ CGGWQCEGPRMEITNCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNRE ERYCNEHLLCPPHVFWTGWGPWERCTAQCGGGIQARRRTCENGPDCAGCNVEYQPCNTNACPEL KKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLPDPNLLEVGRQRIEMRYCSSDGTSGCSTDGL SGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEFQE CNILPCPVDGVWSCWSSWSKCSATCGGGHYMRTRSCTNPAPAYGGDICLGLHTEEALCNTQTCP ENWSEWSEWSVCDASGTQVRTRQCILLFPVGSQCSGNTTESRPCVFDSNFIPEVSVARSSSVEE KRCGEFNMFHMMAVGLSSSILGCLLTLLVYTYCQRYQQQSHDATVIHPVSPAALNSSITNHINK LDKYDSVEAIKAFNKNNLILEERNKYFNPHLTGKTYSNAYFTDLNNYDEY hide sequence

Ensembl Acc Id:

ENSRNOP00000074231 ⟸ ENSRNOT00000085094

Ensembl Acc Id:

ENSRNOP00000016506 ⟸ ENSRNOT00000016506

RefSeq Acc Id:	XP_063137824 ⟸ XM_063281754
- Peptide Label:	isoform X1
- UniProtKB:	D3ZTD8 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_063137825 ⟸ XM_063281755
- Peptide Label:	isoform X1
- UniProtKB:	D3ZTD8 (UniProtKB/Swiss-Prot)

Protein Domains

PSI Sema TSP type-1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZTD8-F1-model_v2	AlphaFold	D3ZTD8	1-1074	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691214

Promoter ID:

EPDNEW_R1739

Type:

multiple initiation site

Name:

Sema5a_1

Description:

semaphorin 5A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	85,377,333 - 85,377,393	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308650	AgrOrtholog
BioCyc Gene	G2FUF-53846	BioCyc
Ensembl Genes	ENSRNOG00000011977	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000016506	ENTREZGENE
	ENSRNOT00000016506.6	UniProtKB/Swiss-Prot
Gene3D-CATH	2.130.10.10	UniProtKB/Swiss-Prot
	2.20.100.10	UniProtKB/Swiss-Prot
	ligand-binding face of the semaphorins, domain 2	UniProtKB/Swiss-Prot
InterPro	Plexin_repeat	UniProtKB/Swiss-Prot
	PSI	UniProtKB/Swiss-Prot
	Sema5A_sema	UniProtKB/Swiss-Prot
	Semap_dom	UniProtKB/Swiss-Prot
	Semap_dom_sf	UniProtKB/Swiss-Prot
	Semaphorin	UniProtKB/Swiss-Prot
	TSP1_rpt	UniProtKB/Swiss-Prot
	TSP1_rpt_sf	UniProtKB/Swiss-Prot
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:310207	UniProtKB/Swiss-Prot
NCBI Gene	310207	ENTREZGENE
PANTHER	PTHR11036	UniProtKB/Swiss-Prot
	SEMAPHORIN-5A	UniProtKB/Swiss-Prot
Pfam	PSI	UniProtKB/Swiss-Prot
	Sema	UniProtKB/Swiss-Prot
	TSP1_2	UniProtKB/Swiss-Prot
	TSP_1	UniProtKB/Swiss-Prot
PhenoGen	Sema5a	PhenoGen
PRINTS	TSP1REPEAT	UniProtKB/Swiss-Prot
PROSITE	SEMA	UniProtKB/Swiss-Prot
	TSP1	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000011977	RatGTEx
SMART	PSI	UniProtKB/Swiss-Prot
	Sema	UniProtKB/Swiss-Prot
	TSP1	UniProtKB/Swiss-Prot
Superfamily-SCOP	Plexin repeat	UniProtKB/Swiss-Prot
	SSF101912	UniProtKB/Swiss-Prot
	SSF82895	UniProtKB/Swiss-Prot
UniProt	A0A0G2K7J5_RAT	UniProtKB/TrEMBL
	D3ZTD8	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-01-21	Sema5a	semaphorin 5A	Sema5a	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Sema5a	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	Sema5a_predicted	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Sema5a_predicted	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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