Glrx5 (glutaredoxin 5) - Rat Genome Database

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Pathways
Gene: Glrx5 (glutaredoxin 5) Rattus norvegicus
Analyze
Symbol: Glrx5
Name: glutaredoxin 5
RGD ID: 1308383
Description: Predicted to enable 2 iron, 2 sulfur cluster binding activity and metal ion binding activity. Predicted to be involved in [2Fe-2S] cluster assembly and protein maturation. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in autosomal recessive pyridoxine-refractory sideroblastic anemia 3. Orthologous to human GLRX5 (glutaredoxin 5); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glutaredoxin 5 homolog; glutaredoxin 5 homolog (S. cerevisiae); glutaredoxin-related protein 5, mitochondrial; LOC362776; RGD1308383; similar to 2900070E19Rik protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86129,752,902 - 129,763,278 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6129,752,840 - 129,763,278 (+)EnsemblGRCr8
mRatBN7.26123,988,461 - 123,998,545 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6123,988,134 - 123,998,545 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6124,118,169 - 124,128,237 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06124,413,421 - 124,423,489 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06123,785,337 - 123,795,417 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06128,750,503 - 128,760,880 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6128,750,795 - 128,760,880 (+)Ensemblrn6Rnor6.0
Rnor_5.06137,947,583 - 137,957,960 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46129,233,209 - 129,243,293 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6121,459,083 - 121,469,162 (+)NCBICelera
RGSC_v3.16129,236,842 - 129,245,795 (+)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
dendrite  (IDA)
mitochondrial matrix  (IBA,IEA,ISO)
mitochondrion  (IEA,ISO)
neuronal cell body  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system. Aon-Bertolino ML, etal., Biochim Biophys Acta. 2011 Jan;1810(1):93-110. Epub 2010 Jul 8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N and Rouault TA, Biochim Biophys Acta. 2015 Jun;1853(6):1493-512. doi: 10.1016/j.bbamcr.2014.09.009. Epub 2014 Sep 19.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:14651853   PMID:18614015   PMID:20364084   PMID:24334290  


Genomics

Comparative Map Data
Glrx5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86129,752,902 - 129,763,278 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6129,752,840 - 129,763,278 (+)EnsemblGRCr8
mRatBN7.26123,988,461 - 123,998,545 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6123,988,134 - 123,998,545 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6124,118,169 - 124,128,237 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06124,413,421 - 124,423,489 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06123,785,337 - 123,795,417 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06128,750,503 - 128,760,880 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6128,750,795 - 128,760,880 (+)Ensemblrn6Rnor6.0
Rnor_5.06137,947,583 - 137,957,960 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46129,233,209 - 129,243,293 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6121,459,083 - 121,469,162 (+)NCBICelera
RGSC_v3.16129,236,842 - 129,245,795 (+)NCBI
Cytogenetic Map6q32NCBI
GLRX5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381495,535,050 - 95,544,714 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1495,533,503 - 95,544,724 (+)Ensemblhg38GRCh38
GRCh371496,001,387 - 96,011,051 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361495,071,076 - 95,080,808 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341495,071,075 - 95,080,808NCBI
Celera1476,057,010 - 76,066,743 (+)NCBICelera
Cytogenetic Map14q32.13NCBI
HuRef1476,186,979 - 76,196,711 (+)NCBIHuRef
CHM1_11495,939,246 - 95,948,981 (+)NCBICHM1_1
T2T-CHM13v2.01489,765,742 - 89,775,402 (+)NCBIT2T-CHM13v2.0
Glrx5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912104,998,877 - 105,007,170 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12104,998,947 - 105,009,165 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812105,032,618 - 105,040,911 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12105,032,688 - 105,042,906 (+)Ensemblmm10GRCm38
MGSCv3712106,270,899 - 106,279,120 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612105,433,739 - 105,441,960 (+)NCBIMGSCv36mm8
Celera12106,265,134 - 106,273,355 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1255.04NCBI
Glrx5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543817,066,955 - 17,075,789 (-)Ensembl
ChiLan1.0NW_00495543817,067,017 - 17,076,162 (-)NCBIChiLan1.0ChiLan1.0
GLRX5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21596,688,753 - 96,698,490 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11495,905,267 - 95,914,996 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01476,162,541 - 76,172,291 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11495,486,818 - 95,496,438 (+)NCBIPanPan1.1PanPan1.1panPan2
GLRX5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1864,383,203 - 64,392,886 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl864,383,227 - 64,383,841 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha863,961,948 - 63,972,042 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0864,651,949 - 64,662,047 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl864,652,309 - 64,662,049 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1864,326,648 - 64,336,722 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0864,385,664 - 64,395,761 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0864,710,831 - 64,720,934 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
GLRX5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7116,787,432 - 116,800,554 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.17116,787,346 - 116,797,477 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27124,001,745 - 124,011,835 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GLRX5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12473,387,941 - 73,398,208 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2473,387,641 - 73,398,233 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605360,564,346 - 60,574,102 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Glrx5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247347,987,116 - 7,995,220 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247347,986,999 - 7,995,604 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Glrx5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17116,129,641 - 116,138,712 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Glrx5
40 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:220
Count of miRNA genes:147
Interacting mature miRNAs:176
Transcripts:ENSRNOT00000005781
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
RH128046  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26123,996,866 - 123,997,076 (+)MAPPERmRatBN7.2
Rnor_6.06128,759,202 - 128,759,411NCBIRnor6.0
Rnor_5.06137,956,282 - 137,956,491UniSTSRnor5.0
RGSC_v3.46129,241,615 - 129,241,824UniSTSRGSC3.4
Celera6121,467,484 - 121,467,693UniSTS
RH 3.4 Map6820.0UniSTS
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000005781   ⟹   ENSRNOP00000005781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6129,752,840 - 129,763,278 (+)Ensembl
mRatBN7.2 Ensembl6123,988,134 - 123,998,545 (+)Ensembl
Rnor_6.0 Ensembl6128,750,795 - 128,760,880 (+)Ensembl
RefSeq Acc Id: NM_001108722   ⟹   NP_001102192
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86129,753,194 - 129,763,278 (+)NCBI
mRatBN7.26123,988,461 - 123,998,545 (+)NCBI
Rnor_6.06128,750,795 - 128,760,880 (+)NCBI
Rnor_5.06137,947,583 - 137,957,960 (+)NCBI
RGSC_v3.46129,233,209 - 129,243,293 (+)RGD
Celera6121,459,083 - 121,469,162 (+)RGD
Sequence:
RefSeq Acc Id: XM_063262127   ⟹   XP_063118197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86129,752,902 - 129,762,033 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001102192 (Get FASTA)   NCBI Sequence Viewer  
  NP_001416079 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118197 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL81815 (Get FASTA)   NCBI Sequence Viewer  
  EDL81816 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005781
  ENSRNOP00000005781.5
RefSeq Acc Id: NP_001102192   ⟸   NM_001108722
- UniProtKB: A6JES1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005781   ⟸   ENSRNOT00000005781
RefSeq Acc Id: XP_063118197   ⟸   XM_063262127
- Peptide Label: isoform X1
Protein Domains
Glutaredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADD7-F1-model_v2 AlphaFold D4ADD7 1-152 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694809
Promoter ID:EPDNEW_R5334
Type:multiple initiation site
Name:Glrx5_1
Description:glutaredoxin 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06128,750,802 - 128,750,862EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308383 AgrOrtholog
BioCyc Gene G2FUF-36351 BioCyc
Ensembl Genes ENSRNOG00000004206 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005781 ENTREZGENE
  ENSRNOT00000005781.7 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/TrEMBL
InterPro Glutaredoxin UniProtKB/TrEMBL
  GRX_PICOT_like UniProtKB/TrEMBL
  Monothiol_GRX_rel UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
KEGG Report rno:362776 UniProtKB/TrEMBL
NCBI Gene 362776 ENTREZGENE
PANTHER GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL UniProtKB/TrEMBL
  Glutredox-rel UniProtKB/TrEMBL
Pfam Glutaredoxin UniProtKB/TrEMBL
PhenoGen Glrx5 PhenoGen
PROSITE GLUTAREDOXIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004206 RatGTEx
Superfamily-SCOP Thiordxn-like_fd UniProtKB/TrEMBL
UniProt A6JES1 ENTREZGENE, UniProtKB/TrEMBL
  D4ADD7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-16 Glrx5  glutaredoxin 5  Glrx5  glutaredoxin 5 homolog (S. cerevisiae)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Glrx5  glutaredoxin 5 homolog (S. cerevisiae)   Glrx5_predicted  glutaredoxin 5 homolog (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Glrx5_predicted  glutaredoxin 5 homolog (S. cerevisiae) (predicted)  RGD1308383_predicted  similar to 2900070E19Rik protein (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1308383_predicted  similar to 2900070E19Rik protein (predicted)  LOC362776_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC362776_predicted  similar to 2900070E19Rik protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL