Sntb1 (syntrophin, beta 1) - Rat Genome Database

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Gene: Sntb1 (syntrophin, beta 1) Rattus norvegicus
Analyze
Symbol: Sntb1
Name: syntrophin, beta 1
RGD ID: 1307728
Description: Enables PDZ domain binding activity. Predicted to be located in several cellular components, including anchoring junction; cytoskeleton; and sarcolemma. Predicted to be part of dystrophin-associated glycoprotein complex. Predicted to be active in synapse. Orthologous to human SNTB1 (syntrophin beta 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: beta-1-syntrophin; LOC299940; syntrophin, basic 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8788,950,642 - 89,219,017 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl788,950,642 - 89,219,017 (-)EnsemblGRCr8
mRatBN7.2787,060,926 - 87,329,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl787,060,926 - 87,329,315 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx788,942,750 - 89,211,066 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0791,143,964 - 91,412,302 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0790,949,316 - 91,217,722 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0795,395,417 - 95,670,093 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl795,397,113 - 95,669,809 (-)Ensemblrn6Rnor6.0
Rnor_5.0796,019,799 - 96,286,153 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4792,156,715 - 92,426,444 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera783,854,036 - 84,122,727 (-)NCBICelera
RGSC_v3.1792,191,431 - 92,460,727 (-)NCBI
Cytogenetic Map7q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
leflunomide  (ISO)
melphalan  (ISO)
menadione  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
quercetin  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triazines  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
fosphenytoin pharmacokinetics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. Leonoudakis D, etal., J Biol Chem. 2004 May 21;279(21):22331-46. Epub 2004 Mar 15.
4. Mapping the in vitro interactome of cardiac sodium (Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1). Lubelwana Hafver T, etal., Proteomics. 2017 Sep;17(17-18). doi: 10.1002/pmic.201600417.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10995443   PMID:17728463   PMID:18468998   PMID:21423176   PMID:25931508  


Genomics

Comparative Map Data
Sntb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8788,950,642 - 89,219,017 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl788,950,642 - 89,219,017 (-)EnsemblGRCr8
mRatBN7.2787,060,926 - 87,329,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl787,060,926 - 87,329,315 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx788,942,750 - 89,211,066 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0791,143,964 - 91,412,302 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0790,949,316 - 91,217,722 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0795,395,417 - 95,670,093 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl795,397,113 - 95,669,809 (-)Ensemblrn6Rnor6.0
Rnor_5.0796,019,799 - 96,286,153 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4792,156,715 - 92,426,444 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera783,854,036 - 84,122,727 (-)NCBICelera
RGSC_v3.1792,191,431 - 92,460,727 (-)NCBI
Cytogenetic Map7q32NCBI
SNTB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388120,535,756 - 120,812,046 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8120,535,745 - 120,813,273 (-)Ensemblhg38GRCh38
GRCh378121,547,996 - 121,824,286 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368121,619,226 - 121,893,910 (-)NCBIBuild 36Build 36hg18NCBI36
Build 348121,619,225 - 121,893,910NCBI
Celera8117,736,336 - 118,012,396 (-)NCBICelera
Cytogenetic Map8q24.12NCBI
HuRef8116,868,352 - 117,146,047 (-)NCBIHuRef
CHM1_18121,588,485 - 121,864,687 (-)NCBICHM1_1
T2T-CHM13v2.08121,664,208 - 121,941,521 (-)NCBIT2T-CHM13v2.0
Sntb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391555,499,784 - 55,770,707 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1555,499,784 - 55,770,345 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381555,636,388 - 55,907,302 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1555,636,388 - 55,906,949 (-)Ensemblmm10GRCm38
MGSCv371555,470,709 - 55,738,504 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361555,469,237 - 55,737,032 (-)NCBIMGSCv36mm8
Celera1557,171,449 - 57,431,827 (-)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1522.14NCBI
Sntb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541725,904,654 - 26,128,134 (-)Ensembl
ChiLan1.0NW_00495541725,906,013 - 26,128,134 (-)NCBIChiLan1.0ChiLan1.0
SNTB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27137,960,263 - 138,236,492 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18113,472,368 - 113,748,920 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08117,225,128 - 117,501,899 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18119,993,019 - 120,269,695 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8119,996,149 - 120,268,188 (-)EnsemblpanPan2panpan1.1
SNTB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11319,394,608 - 19,627,278 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1319,397,509 - 19,627,403 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1319,407,106 - 19,639,472 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01319,720,168 - 19,953,167 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1319,720,329 - 19,953,343 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11319,450,834 - 19,689,839 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01319,550,680 - 19,782,989 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01319,783,841 - 20,016,508 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sntb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530318,647,963 - 18,875,715 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647026,073,520 - 26,303,113 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647026,074,175 - 26,301,076 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SNTB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl418,288,843 - 18,526,215 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1418,288,756 - 18,524,362 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2419,416,987 - 19,549,147 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SNTB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18115,117,224 - 115,391,475 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8115,117,756 - 115,391,537 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603924,883,597 - 25,162,844 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sntb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476318,309,172 - 18,529,151 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476318,310,253 - 18,528,845 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Sntb1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11230,036,655 - 230,298,719 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sntb1
1920 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:62
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000006423
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)771103011106126789Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
1641908Teswt1Testicular weight QTL 13.28testis mass (VT:1000644)both testes wet weight (CMO:0000175)78211124596700643Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
724537Niddm52Non-insulin dependent diabetes mellitus QTL 520.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)78211124595485241Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
D7Got65  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8789,191,765 - 89,191,926 (+)Marker Load Pipeline
Rnor_6.0795,642,328 - 95,642,476NCBIRnor6.0
Rnor_5.0796,259,336 - 96,259,484UniSTSRnor5.0
RH 3.4 Map7610.2UniSTS
RH 3.4 Map7610.2RGD
Cytogenetic Map7q32UniSTS
UniSTS:224712  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2787,301,777 - 87,301,932 (+)MAPPERmRatBN7.2
Rnor_6.0795,642,042 - 95,642,196NCBIRnor6.0
Rnor_5.0796,259,050 - 96,259,204UniSTSRnor5.0
Cytogenetic Map7q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 159 91 90 59 92 59 6 353 191 10 138 79 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000006423   ⟹   ENSRNOP00000006423
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl788,950,642 - 89,219,017 (-)Ensembl
mRatBN7.2 Ensembl787,060,926 - 87,329,315 (-)Ensembl
Rnor_6.0 Ensembl795,397,113 - 95,669,809 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100092   ⟹   ENSRNOP00000096588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl787,063,860 - 87,329,315 (-)Ensembl
RefSeq Acc Id: NM_001130542   ⟹   NP_001124014
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8788,950,642 - 89,219,017 (-)NCBI
mRatBN7.2787,060,926 - 87,329,315 (-)NCBI
Rnor_6.0795,397,776 - 95,669,775 (-)NCBI
Rnor_5.0796,019,799 - 96,286,153 (-)NCBI
RGSC_v3.4792,156,715 - 92,426,444 (-)RGD
Celera783,854,036 - 84,122,727 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001124014 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM16244 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006423
  ENSRNOP00000006423.4
RefSeq Acc Id: NP_001124014   ⟸   NM_001130542
- UniProtKB: D3ZWC6 (UniProtKB/TrEMBL),   A6HRH8 (UniProtKB/TrEMBL),   A0A8I6GLN6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006423   ⟸   ENSRNOT00000006423
Ensembl Acc Id: ENSRNOP00000096588   ⟸   ENSRNOT00000100092
Protein Domains
PDZ   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZWC6-F1-model_v2 AlphaFold D3ZWC6 1-539 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695338
Promoter ID:EPDNEW_R5862
Type:single initiation site
Name:Sntb1_1
Description:syntrophin, beta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0795,669,540 - 95,669,600EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307728 AgrOrtholog
BioCyc Gene G2FUF-33368 BioCyc
Ensembl Genes ENSRNOG00000004821 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006423 ENTREZGENE
  ENSRNOT00000006423.7 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
InterPro PDZ/DHR/GLGF UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  PHsplit_syntrophin UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Syntrophin UniProtKB/TrEMBL
  Syntrophin_4th UniProtKB/TrEMBL
KEGG Report rno:299940 UniProtKB/TrEMBL
NCBI Gene 299940 ENTREZGENE
PANTHER BETA-1-SYNTROPHIN UniProtKB/TrEMBL
  Syntrophin UniProtKB/TrEMBL
Pfam PDZ UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  PH_17 UniProtKB/TrEMBL
  Syntrophin_4th UniProtKB/TrEMBL
PhenoGen Sntb1 PhenoGen
PROSITE PDZ UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004821 RatGTEx
SMART PDZ UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PDZ UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
UniProt A0A8I6GLN6 ENTREZGENE
  A6HRH8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZWC6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-10-22 Sntb1  syntrophin, beta 1  Sntb1  syntrophin, basic 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Sntb1  syntrophin, basic 1   Sntb1_predicted  syntrophin, basic 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Sntb1_predicted  syntrophin, basic 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED