SNTB1 (syntrophin beta 1) - Rat Genome Database

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Pathways
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Gene: SNTB1 (syntrophin beta 1) Canis lupus familiaris
Analyze
Symbol: SNTB1
Name: syntrophin beta 1
RGD ID: 12235949
Description: ENCODES a protein that exhibits PDZ domain binding (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH genetic disease (ortholog); head and neck squamous cell carcinoma (ortholog); trichorhinophalangeal syndrome type I (ortholog); FOUND IN cytoskeleton (inferred); dystrophin-associated glycoprotein complex (inferred); protein-containing complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: beta-1-syntrophin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11319,394,608 - 19,627,278 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1319,397,509 - 19,627,403 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1319,407,106 - 19,639,472 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01319,720,168 - 19,953,167 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1319,720,329 - 19,953,343 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11319,450,834 - 19,689,839 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01319,550,680 - 19,782,989 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01319,783,841 - 20,016,508 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
fosphenytoin pharmacokinetics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SNTB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11319,394,608 - 19,627,278 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1319,397,509 - 19,627,403 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1319,407,106 - 19,639,472 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01319,720,168 - 19,953,167 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1319,720,329 - 19,953,343 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11319,450,834 - 19,689,839 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01319,550,680 - 19,782,989 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01319,783,841 - 20,016,508 (-)NCBIUU_Cfam_GSD_1.0
SNTB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388120,535,756 - 120,812,046 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8120,535,745 - 120,813,273 (-)EnsemblGRCh38hg38GRCh38
GRCh378121,547,996 - 121,824,286 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368121,619,226 - 121,893,910 (-)NCBINCBI36Build 36hg18NCBI36
Build 348121,619,225 - 121,893,910NCBI
Celera8117,736,336 - 118,012,396 (-)NCBICelera
Cytogenetic Map8q24.12NCBI
HuRef8116,868,352 - 117,146,047 (-)NCBIHuRef
CHM1_18121,588,485 - 121,864,687 (-)NCBICHM1_1
T2T-CHM13v2.08121,664,208 - 121,941,521 (-)NCBIT2T-CHM13v2.0
Sntb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391555,499,784 - 55,770,707 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1555,499,784 - 55,770,345 (-)EnsemblGRCm39 Ensembl
GRCm381555,636,388 - 55,907,302 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1555,636,388 - 55,906,949 (-)EnsemblGRCm38mm10GRCm38
MGSCv371555,470,709 - 55,738,504 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361555,469,237 - 55,737,032 (-)NCBIMGSCv36mm8
Celera1557,171,449 - 57,431,827 (-)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1522.14NCBI
Sntb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8788,950,642 - 89,219,017 (-)NCBIGRCr8
mRatBN7.2787,060,926 - 87,329,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl787,060,926 - 87,329,315 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx788,942,750 - 89,211,066 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0791,143,964 - 91,412,302 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0790,949,316 - 91,217,722 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0795,395,417 - 95,670,093 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl795,397,113 - 95,669,809 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0796,019,799 - 96,286,153 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4792,156,715 - 92,426,444 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1792,191,431 - 92,460,727 (-)NCBI
Celera783,854,036 - 84,122,727 (-)NCBICelera
Cytogenetic Map7q32NCBI
Sntb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541725,904,654 - 26,128,134 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541725,906,013 - 26,128,134 (-)NCBIChiLan1.0ChiLan1.0
SNTB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27137,960,263 - 138,236,492 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18113,472,368 - 113,748,920 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08117,225,128 - 117,501,899 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18119,993,019 - 120,269,695 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8119,996,149 - 120,268,188 (-)Ensemblpanpan1.1panPan2
Sntb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530318,647,963 - 18,875,715 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647026,073,520 - 26,303,113 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647026,074,175 - 26,301,076 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SNTB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl418,288,843 - 18,526,215 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1418,288,756 - 18,524,362 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2419,416,987 - 19,549,147 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SNTB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18115,117,224 - 115,391,475 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8115,117,756 - 115,391,537 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603924,883,597 - 25,162,844 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sntb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476318,309,172 - 18,529,151 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476318,310,253 - 18,528,845 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SNTB1
2953 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 5 22 6 6 6 6 6 7 10 6
Low 2 5 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000001482   ⟹   ENSCAFP00000001366
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1319,397,509 - 19,627,403 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000060568   ⟹   ENSCAFP00000059463
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1319,397,679 - 19,627,403 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845014927   ⟹   ENSCAFP00845011570
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1319,720,329 - 19,953,343 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845014974   ⟹   ENSCAFP00845011613
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1319,723,239 - 19,953,343 (-)Ensembl
RefSeq Acc Id: XM_014118605   ⟹   XP_013974080
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11319,394,608 - 19,627,278 (-)NCBI
Dog10K_Boxer_Tasha1319,407,106 - 19,639,472 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038493152   ⟹   XP_038349080
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11319,450,834 - 19,689,839 (-)NCBI
RefSeq Acc Id: XM_038555424   ⟹   XP_038411352
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01319,783,841 - 20,016,508 (-)NCBI
RefSeq Acc Id: XM_038619318   ⟹   XP_038475246
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01319,550,680 - 19,782,989 (-)NCBI
RefSeq Acc Id: XM_038684930   ⟹   XP_038540858
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01319,720,168 - 19,953,167 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_013974080   ⟸   XM_014118605
- UniProtKB: A0A8C0SBM6 (UniProtKB/TrEMBL),   A0A8C0K0I3 (UniProtKB/TrEMBL),   A0A8I3N923 (UniProtKB/TrEMBL),   A0A8C0MJ16 (UniProtKB/TrEMBL),   A0A8I3N5Y8 (UniProtKB/TrEMBL),   A0A8P0P8I5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000001366   ⟸   ENSCAFT00000001482
RefSeq Acc Id: ENSCAFP00000059463   ⟸   ENSCAFT00000060568
RefSeq Acc Id: XP_038349080   ⟸   XM_038493152
RefSeq Acc Id: XP_038475246   ⟸   XM_038619318
RefSeq Acc Id: XP_038540858   ⟸   XM_038684930
- UniProtKB: A0A8C0SBM6 (UniProtKB/TrEMBL),   A0A8C0K0I3 (UniProtKB/TrEMBL),   A0A8I3N923 (UniProtKB/TrEMBL),   A0A8C0MJ16 (UniProtKB/TrEMBL),   A0A8I3N5Y8 (UniProtKB/TrEMBL),   A0A8P0P8I5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038411352   ⟸   XM_038555424
- UniProtKB: A0A8C0K0I3 (UniProtKB/TrEMBL),   A0A8C0MJ16 (UniProtKB/TrEMBL),   A0A8C0SBM6 (UniProtKB/TrEMBL),   A0A8I3N5Y8 (UniProtKB/TrEMBL),   A0A8I3N923 (UniProtKB/TrEMBL),   A0A8P0P8I5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845011570   ⟸   ENSCAFT00845014927
RefSeq Acc Id: ENSCAFP00845011613   ⟸   ENSCAFT00845014974
Protein Domains
PDZ   PH

Promoters
RGD ID:13685593
Promoter ID:EPDNEW_C3662
Type:initiation region
Name:SNTB1_1
Description:syntrophin beta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11319,627,445 - 19,627,505EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000957 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030006450 UniProtKB/TrEMBL
  ENSCAFG00040011722 UniProtKB/TrEMBL
  ENSCAFG00845008497 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001482.5 UniProtKB/TrEMBL
  ENSCAFT00000060568.2 UniProtKB/TrEMBL
  ENSCAFT00030011862.1 UniProtKB/TrEMBL
  ENSCAFT00030011891.1 UniProtKB/TrEMBL
  ENSCAFT00040021615.1 UniProtKB/TrEMBL
  ENSCAFT00040021661.1 UniProtKB/TrEMBL
  ENSCAFT00845014927 ENTREZGENE
  ENSCAFT00845014927.1 UniProtKB/TrEMBL
  ENSCAFT00845014974.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
InterPro PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PHsplit_syntrophin UniProtKB/TrEMBL
  Syntrophin UniProtKB/TrEMBL
KEGG Report cfa:482030 UniProtKB/TrEMBL
NCBI Gene SNTB1 ENTREZGENE
PANTHER BETA-1-SYNTROPHIN UniProtKB/TrEMBL
  PTHR10554 UniProtKB/TrEMBL
Pfam PDZ UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  PH_17 UniProtKB/TrEMBL
PROSITE PDZ UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART PDZ UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
UniProt A0A8C0K0I3 ENTREZGENE
  A0A8C0MJ16 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SBM6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N5Y8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N923 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0P8I5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:46613 ENTREZGENE