Rac2 (Rac family small GTPase 2) - Rat Genome Database

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Gene: Rac2 (Rac family small GTPase 2) Rattus norvegicus
Analyze
Symbol: Rac2
Name: Rac family small GTPase 2
RGD ID: 1307568
Description: Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including cytoskeleton organization; positive regulation of lamellipodium assembly; and regulation of neutrophil migration. Predicted to be active in several cellular components, including cytoplasmic vesicle; cytoskeleton; and plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis; immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia; and immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia. Orthologous to human RAC2 (Rac family small GTPase 2); PARTICIPATES IN B cell receptor signaling pathway; ceramide signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC366957; MGC105983; RAS-related C3 botulinum substrate 2; ras-related C3 botulinum toxin substrate 2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87111,981,825 - 112,009,201 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7111,996,742 - 112,009,267 (-)EnsemblGRCr8
mRatBN7.27110,101,344 - 110,128,718 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7110,116,260 - 110,128,720 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7111,866,531 - 111,878,841 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07114,090,071 - 114,102,381 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07114,057,780 - 114,070,175 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07119,769,708 - 119,797,111 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7119,783,849 - 119,797,098 (-)Ensemblrn6Rnor6.0
Rnor_5.07119,772,951 - 119,786,184 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47116,520,066 - 116,532,482 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7106,454,216 - 106,466,547 (-)NCBICelera
RGSC_v3.17116,554,295 - 116,566,712 (-)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-amanitin  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
antirheumatic drug  (ISO)
apilimod  (ISO)
aristolochic acids  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
berberine  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyproconazole  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
N-acetyl-L-cysteine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
NSC 23766  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
oxycodone  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
Soman  (EXP)
sotorasib  (ISO)
streptozocin  (EXP)
sulindac  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
triadimefon  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin filament  (IEA,ISO)
cell projection  (IBA)
cytoplasm  (IEA,ISO)
cytoplasmic vesicle  (IBA)
cytoskeleton  (IBA)
cytosol  (IEA,ISO)
lamellipodium  (IEA,ISO)
membrane  (IEA,ISO)
NADPH oxidase complex  (IEA,ISO)
nuclear envelope  (IEA,ISO)
plasma membrane  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues. Abe D, etal., J Periodontal Res. 2011 Jun;46(3):345-53. doi: 10.1111/j.1600-0765.2011.01349.x. Epub 2011 Mar 7.
2. Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation. Ambruso DR, etal., Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4654-9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. Rac-GTPase, osteoclast cytoskeleton and bone resorption. Razzouk S, etal., Eur J Cell Biol. 1999 Apr;78(4):249-55.
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10843388   PMID:11435472   PMID:11581314   PMID:12176888   PMID:12477932   PMID:15249579   PMID:16636067   PMID:16987989   PMID:19625648   PMID:20458337   PMID:21167572   PMID:21178006  
PMID:21423176   PMID:23533145   PMID:24270810   PMID:28033741  


Genomics

Comparative Map Data
Rac2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87111,981,825 - 112,009,201 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7111,996,742 - 112,009,267 (-)EnsemblGRCr8
mRatBN7.27110,101,344 - 110,128,718 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7110,116,260 - 110,128,720 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7111,866,531 - 111,878,841 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07114,090,071 - 114,102,381 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07114,057,780 - 114,070,175 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07119,769,708 - 119,797,111 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7119,783,849 - 119,797,098 (-)Ensemblrn6Rnor6.0
Rnor_5.07119,772,951 - 119,786,184 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47116,520,066 - 116,532,482 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7106,454,216 - 106,466,547 (-)NCBICelera
RGSC_v3.17116,554,295 - 116,566,712 (-)NCBI
Cytogenetic Map7q34NCBI
RAC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382237,225,270 - 37,244,269 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2237,225,270 - 37,259,594 (-)Ensemblhg38GRCh38
GRCh372237,621,310 - 37,640,309 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362235,951,256 - 35,970,251 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342235,945,811 - 35,964,805NCBI
Celera2221,422,402 - 21,441,189 (-)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2220,586,313 - 20,605,449 (-)NCBIHuRef
CHM1_12237,580,533 - 37,599,298 (-)NCBICHM1_1
T2T-CHM13v2.02237,685,220 - 37,704,752 (-)NCBIT2T-CHM13v2.0
Rac2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391578,443,369 - 78,456,983 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1578,443,367 - 78,456,983 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381578,559,169 - 78,572,783 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1578,559,167 - 78,572,783 (-)Ensemblmm10GRCm38
MGSCv371578,389,599 - 78,403,213 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361578,386,424 - 78,400,038 (-)NCBIMGSCv36mm8
Celera1580,021,772 - 80,035,664 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.57NCBI
Rac2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541323,693,669 - 23,710,704 (-)Ensembl
ChiLan1.0NW_00495541323,697,504 - 23,710,668 (-)NCBIChiLan1.0ChiLan1.0
RAC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22347,081,028 - 47,101,554 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12249,769,608 - 49,790,116 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02218,138,517 - 18,159,023 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12235,973,229 - 35,992,026 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2235,973,229 - 35,992,026 (-)EnsemblpanPan2panpan1.1
RAC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11027,295,597 - 27,311,864 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1027,295,640 - 27,311,397 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1027,250,607 - 27,266,864 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01028,087,974 - 28,104,244 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1028,088,002 - 28,104,243 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11027,809,701 - 27,825,938 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01028,118,381 - 28,134,648 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01028,296,231 - 28,312,501 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rac2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494510,715,942 - 10,727,556 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364923,726,313 - 3,736,905 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364923,726,375 - 3,737,961 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl510,553,433 - 10,573,014 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1510,553,986 - 10,571,082 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.258,149,403 - 8,166,396 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11919,930,799 - 19,949,381 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1919,929,892 - 19,949,376 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045105,878,666 - 105,897,462 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rac2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475210,589,017 - 10,601,661 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475210,589,017 - 10,620,652 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Rac2
228 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:55
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000009994
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 158 91 90 59 92 59 6 356 192 11 135 81 92 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000009994   ⟹   ENSRNOP00000009994
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7111,996,742 - 112,009,267 (-)Ensembl
mRatBN7.2 Ensembl7110,116,260 - 110,128,708 (-)Ensembl
Rnor_6.0 Ensembl7119,783,849 - 119,797,098 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097718   ⟹   ENSRNOP00000082909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7110,119,912 - 110,128,720 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100644   ⟹   ENSRNOP00000084626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7111,996,742 - 112,007,381 (-)Ensembl
mRatBN7.2 Ensembl7110,116,260 - 110,126,899 (-)Ensembl
RefSeq Acc Id: NM_001008384   ⟹   NP_001008385
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,996,744 - 112,009,160 (-)NCBI
mRatBN7.27110,116,262 - 110,128,678 (-)NCBI
Rnor_6.07119,783,878 - 119,797,068 (-)NCBI
Rnor_5.07119,772,951 - 119,786,184 (-)NCBI
RGSC_v3.47116,520,066 - 116,532,482 (-)RGD
Celera7106,454,216 - 106,466,547 (-)RGD
Sequence:
RefSeq Acc Id: XM_006242028   ⟹   XP_006242090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,996,738 - 112,009,197 (-)NCBI
mRatBN7.27110,116,256 - 110,128,717 (-)NCBI
Rnor_6.07119,783,872 - 119,797,111 (-)NCBI
Rnor_5.07119,772,951 - 119,786,184 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595021   ⟹   XP_017450510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,981,825 - 112,009,198 (-)NCBI
mRatBN7.27110,101,344 - 110,128,718 (-)NCBI
Rnor_6.07119,769,708 - 119,797,111 (-)NCBI
Sequence:
RefSeq Acc Id: XR_010053023
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,998,969 - 112,009,201 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001008385 (Get FASTA)   NCBI Sequence Viewer  
  XP_006242090 (Get FASTA)   NCBI Sequence Viewer  
  XP_017450510 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86399 (Get FASTA)   NCBI Sequence Viewer  
  EDM15859 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009994
  ENSRNOP00000009994.5
  ENSRNOP00000084626.1
RefSeq Acc Id: NP_001008385   ⟸   NM_001008384
- UniProtKB: Q5U1Y2 (UniProtKB/TrEMBL),   F7EM94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242090   ⟸   XM_006242028
- Peptide Label: isoform X1
- UniProtKB: Q5U1Y2 (UniProtKB/TrEMBL),   F7EM94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450510   ⟸   XM_017595021
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G820 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009994   ⟸   ENSRNOT00000009994
Ensembl Acc Id: ENSRNOP00000084626   ⟸   ENSRNOT00000100644
Ensembl Acc Id: ENSRNOP00000082909   ⟸   ENSRNOT00000097718

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U1Y2-F1-model_v2 AlphaFold Q5U1Y2 1-192 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695466
Promoter ID:EPDNEW_R5990
Type:initiation region
Name:Rac2_1
Description:Rac family small GTPase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07119,797,092 - 119,797,152EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307568 AgrOrtholog
BioCyc Gene G2FUF-32806 BioCyc
Ensembl Genes ENSRNOG00000007350 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009994 ENTREZGENE
  ENSRNOT00000009994.7 UniProtKB/TrEMBL
  ENSRNOT00000100644.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7303112 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Ras_GTPase UniProtKB/TrEMBL
  Small_GTP_bd UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/TrEMBL
KEGG Report rno:366957 UniProtKB/TrEMBL
MGC_CLONE MGC:105983 IMAGE-MGC_LOAD
NCBI Gene 366957 ENTREZGENE
PANTHER PTHR24072 UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PhenoGen Rac2 PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007350 RatGTEx
SMART RAB UniProtKB/TrEMBL
  RAN UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6A1P8_RAT UniProtKB/TrEMBL
  A0A8I6G820 ENTREZGENE
  A6HSL3_RAT UniProtKB/TrEMBL
  F7EM94 ENTREZGENE, UniProtKB/TrEMBL
  Q5U1Y2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-22 Rac2  Rac family small GTPase 2  Rac2  ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Rac2  ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)  Rac2  RAS-related C3 botulinum substrate 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Rac2  RAS-related C3 botulinum substrate 2  Rac2_predicted  RAS-related C3 botulinum substrate 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Rac2_predicted  RAS-related C3 botulinum substrate 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED