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Gene: Notum (NOTUM, palmitoleoyl-protein carboxylesterase) Rattus norvegicus

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Symbol:

Notum

Name:

NOTUM, palmitoleoyl-protein carboxylesterase

RGD ID:

1307119

Description:

Predicted to enable lipase activity; palmitoleyl hydrolase activity; and protein-containing complex destabilizing activity. Acts upstream of or within bone development. Orthologous to human NOTUM (notum, palmitoleoyl-protein carboxylesterase); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

hypothetical LOC303743; LOC303743; MGC109547; notum pectinacetylesterase homolog; notum pectinacetylesterase homolog (Drosophila); palmitoleoyl-protein carboxylesterase NOTUM; RGD1307119

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	106,431,572 - 106,438,654 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	106,431,572 - 106,438,654 (-)	Ensembl				GRCr8
mRatBN7.2	10	105,933,245 - 105,940,327 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	105,933,249 - 105,940,315 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	111,036,811 - 111,043,850 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	110,499,852 - 110,506,891 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	105,853,700 - 105,860,766 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	109,832,977 - 109,840,661 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	109,832,981 - 109,840,047 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	109,425,669 - 109,432,739 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	110,047,040 - 110,054,106 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	104,476,752 - 104,483,846 (-)	NCBI		Celera
RGSC_v3.1	10	110,061,546 - 110,064,337 (-)	NCBI
Cytogenetic Map	10	q32.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1-naphthyl isothiocyanate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-palmitoylglycerol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

celastrol (ISO)

cisplatin (ISO)

copper atom (EXP)

copper(0) (EXP)

cyclosporin A (ISO)

dextran sulfate (ISO)

dibenzofurans (ISO)

diquat (ISO)

fenthion (ISO)

furan (EXP)

indole-3-methanol (EXP)

methamphetamine (EXP)

methidathion (ISO)

naled (ISO)

niclosamide (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

SCH 23390 (EXP)

serpentine asbestos (ISO)

sulforaphane (ISO)

sunitinib (ISO)

tetrachloromethane (EXP)

Theaflavin 3,3'-digallate (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bone development (IMP,ISO)

negative regulation of canonical Wnt signaling pathway (IBA,ISO)

negative regulation of Wnt signaling pathway (IEA,ISO)

protein depalmitoleylation (ISO)

regulation of bone mineralization (ISO)

Molecular Function

hydrolase activity (IEA)

lipase activity (ISO)

palmitoleyl hydrolase activity (ISO)

protein binding (ISO)

protein-containing complex destabilizing activity (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	NOTUM inhibition increases endocortical bone formation and bone strength.	Brommage R, etal., Bone Res. 2019 Jan 8;7:2. doi: 10.1038/s41413-018-0038-3. eCollection 2019.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:8889548	PMID:15326124	PMID:18429952	PMID:25731175	PMID:25771893

Genomics

Comparative Map Data

Notum
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	106,431,572 - 106,438,654 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	106,431,572 - 106,438,654 (-)	Ensembl				GRCr8
mRatBN7.2	10	105,933,245 - 105,940,327 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	105,933,249 - 105,940,315 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	111,036,811 - 111,043,850 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	110,499,852 - 110,506,891 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	105,853,700 - 105,860,766 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	109,832,977 - 109,840,661 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	109,832,981 - 109,840,047 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	109,425,669 - 109,432,739 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	110,047,040 - 110,054,106 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	104,476,752 - 104,483,846 (-)	NCBI		Celera
RGSC_v3.1	10	110,061,546 - 110,064,337 (-)	NCBI
Cytogenetic Map	10	q32.3	NCBI

NOTUM
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	81,952,507 - 81,961,187 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	81,952,507 - 81,963,328 (-)	Ensembl			hg38	GRCh38
GRCh37	17	79,910,383 - 79,919,063 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	77,503,678 - 77,512,353 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	17	76,514,308 - 76,540,092 (-)	NCBI		Celera
Cytogenetic Map	17	q25.3	NCBI
HuRef	17	75,311,107 - 75,319,589 (-)	NCBI		HuRef
CHM1_1	17	79,996,557 - 80,005,040 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	82,819,665 - 82,828,345 (-)	NCBI		T2T-CHM13v2.0

Notum
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	120,544,614 - 120,552,019 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	120,544,614 - 120,552,001 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	11	120,653,788 - 120,661,193 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	120,653,788 - 120,661,175 (-)	Ensembl			mm10	GRCm38
MGSCv37	11	120,515,102 - 120,522,151 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	11	120,475,247 - 120,477,905 (+)	NCBI		MGSCv36	mm8
Celera	11	132,389,181 - 132,396,231 (-)	NCBI		Celera
Cytogenetic Map	11	E2	NCBI
cM Map	11	84.38	NCBI

Notum
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955506	1,203,309 - 1,212,966 (+)	Ensembl
ChiLan1.0	NW_004955506	1,203,309 - 1,212,938 (+)	NCBI	ChiLan1.0	ChiLan1.0

NOTUM
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	98,486,375 - 98,496,502 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	103,387,419 - 103,395,942 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	76,353,528 - 76,364,634 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	82,057,344 - 82,074,874 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

NOTUM
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	344,648 - 350,676 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	344,020 - 350,368 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	946,787 - 952,790 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	938,019 - 944,016 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	937,352 - 947,429 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	963,161 - 969,164 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	1,089,807 - 1,095,804 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	1,168,436 - 1,174,439 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Notum
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	945,618 - 953,134 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936594	5,457,687 - 5,465,162 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936594	5,458,825 - 5,465,135 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NOTUM
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	1,036,488 - 1,044,397 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	12	1,033,814 - 1,044,412 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

NOTUM
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	73,826,835 - 73,835,453 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666077	45,300,039 - 45,308,423 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Notum
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624801	10,791,939 - 10,802,463 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624801	10,795,603 - 10,802,394 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Notum
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	9	63,362,387 - 63,368,920 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Notum
30 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	288
Count of miRNA genes:	170
Interacting mature miRNAs:	195
Transcripts:	ENSRNOT00000054947
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7387312	Bw125	Body weight QTL 125	3	0.0047	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight (CMO:0000356)	10	65390777	107713808	Rat
1354641	Bvd2	Brain ventricular dilatation QTL 2	6.36	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	10	93723381	107556066	Rat
8657410	Bp374	Blood pressure QTL 374			heart left ventricle size trait (VT:0002753)	heart left ventricle end-diastolic diameter (CMO:0000982)	10	67476608	107713808	Rat
61449	Ciaa2	CIA Autoantibody QTL 2	7.1		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	10	63719161	107713808	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	52269185	107713808	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42546145	107713808	Rat
12903252	Cm113	Cardiac mass QTL 113		0.047	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	66817119	107713808	Rat
61396	Bp9	Blood pressure QTL 9	4.8	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68920187	107713808	Rat
2298548	Neuinf7	Neuroinflammation QTL 7	3.4		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	10	64939013	107713808	Rat
1302404	Cia27	Collagen induced arthritis QTL 27	2.6	0.0045	joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	10	76951790	107713808	Rat
1358915	Stresp7	Stress response QTL 7	3.52		blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	65307813	107713808	Rat
70168	Eae12	Experimental allergic encephalomyelitis QTL 12		0.0009	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	73599825	107713808	Rat
634320	Niddm49	Non-insulin dependent diabetes mellitus QTL 49	4.41		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	10	89039175	107713808	Rat
70363	Bp71	Blood pressure QTL 71		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	61843496	106843496	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	54296227	107713808	Rat
6893366	Bw106	Body weight QTL 106	0.3	0.47	body mass (VT:0001259)	body weight (CMO:0000012)	10	70698731	107713808	Rat
1576313	Pia25	Pristane induced arthritis QTL 25			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	96620293	107713808	Rat
12903269	Am15	Aortic mass QTL 15		0.042	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	66817119	107713808	Rat
12903266	Cm114	Cardiac mass QTL 114		0.02	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	10	66817119	107713808	Rat
1578672	Bmd16	Bone mineral density QTL 16	6.2		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	10	97202388	107556066	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
1576307	Cia28	Collagen induced arthritis QTL 28			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	96620293	107713808	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40535708	107713808	Rat
2313103	Bss80	Bone structure and strength QTL 80	2	0.0001	tibia strength trait (VT:1000284)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	10	62556066	107556066	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14991535	107713808	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
1581559	Eae18	Experimental allergic encephalomyelitis QTL 18		0.00002	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	10	66108888	107555881	Rat
70193	Mcs7	Mammary carcinoma susceptibility QTL 7	2.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72724423	107713808	Rat
12880372	Am12	Aortic mass QTL 12		0.003	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	66817119	107713808	Rat
2313105	Bss79	Bone structure and strength QTL 79	1.8	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	62556066	107556066	Rat
61363	Oia3	Oil induced arthritis QTL 3		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	87807758	107713808	Rat
12880375	Kidm66	Kidney mass QTL 66		0.009	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	66817119	107713808	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14991535	107556066	Rat
12880370	Cm105	Cardiac mass QTL 105		0.008	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	10	66817119	107713808	Rat
1600367	Mcs15	Mammary carcinoma susceptibility QTL 15	4.5		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72724423	107713808	Rat
12880371	Cm106	Cardiac mass QTL 106		0.007	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	66817119	107713808	Rat
631537	Oia4	Oil induced arthritis QTL 4			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	76128947	107713808	Rat
1300137	Bp186	Blood pressure QTL 186	3.57		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	10	91127270	107556066	Rat
634354	Rends3	Renal damage susceptibility QTL 3		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	10	61997479	106997479	Rat
61436	Cia5	Collagen induced arthritis QTL 5	4.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	91727883	107713808	Rat
11565453	Kidm58	Kidney mass QTL 58		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	66817119	107713808	Rat
2301405	Cm69	Cardiac mass QTL 69		0.031	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	10	66817119	107713808	Rat
1578663	Bss18	Bone structure and strength QTL 18	3.6		femur width (VT:1000666)	femoral neck width (CMO:0001695)	10	97202388	107556066	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
15	12	58	146	89	88	57	29	57	6	248	120	10	121	48	92	31	7	7

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001013975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001415777	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006247887	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006247888	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597348	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039086224	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC131537	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC090016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC158802	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BQ204914	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB768482	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO562343	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DV215880	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EX493402	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000054947 ⟹ ENSRNOP00000051830

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	106,431,572 - 106,438,654 (-)	Ensembl
mRatBN7.2 Ensembl	10	105,933,249 - 105,940,315 (-)	Ensembl
Rnor_6.0 Ensembl	10	109,832,981 - 109,840,047 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000125509 ⟹ ENSRNOP00000111783

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	106,431,572 - 106,438,528 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000131615 ⟹ ENSRNOP00000101238

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	106,431,572 - 106,438,654 (-)	Ensembl

RefSeq Acc Id:

NM_001013975 ⟹ NP_001013997

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	106,431,572 - 106,438,654 (-)	NCBI
mRatBN7.2	10	105,933,245 - 105,940,327 (-)	NCBI
Rnor_6.0	10	109,832,981 - 109,840,047 (-)	NCBI
Rnor_5.0	10	109,425,669 - 109,432,739 (-)	NCBI
RGSC_v3.4	10	110,047,040 - 110,054,106 (-)	RGD
Celera	10	104,476,752 - 104,483,846 (-)	RGD

Sequence:

show sequence

GCGCAGCGCAGTCGGGCGCACCAGCGGGATAGCGCAGCTCCAGCAACTACGAGGACTACGGTGG
CCACAGGCCGGAGTGACATTGCCATGGGCGGAGAGGTGCGCGTGCTGCTACTGCTGGGCCTGCT
GCACTGGGTTGGGGGCAGCGAGGGCAGGAAGACCTGGAGGCGCCGTGGCCAGCAGCCACCCCAG
CCGCCGCCCCCGCCGCCGCCCCCGCAGCGGGCTGAGGTGGCGCCGGGAGCCGGGCAGCCGGTGG
AGAGCTTCCCGCTGGACTTCACGGCAGTGGAGGGCAACATGGACAGCTTTATGGCGCAAGTCAA
GAGCCTGGCACAGTCCCTGTATCCCTGCTCTGCGCAGCAGCTCAACGAGGACCTGCGCCTTCAC
CTCCTGCTGAACACGTCGGTGACCTGCAATGACGGCAGCCCCGCCGGCTACTATTTGAAGGAGT
CCAAGGGCAGTCGGCGGTGGTTACTCTTTCTGGAAGGCGGCTGGTATTGCTTCAACCGGGAGAA
CTGTGACTCCAGATACAGCACCATGCGGCGCCTCATGAGCTCCAAAGACTGGCCACACACGCGC
ACAGGTACTGGTATTCTATCCTCCCAGCCAGAGGAGAACCCACACTGGTGGAATGCCAATATGG
TCTTCATCCCCTACTGCTCCAGTGACGTTTGGAGTGGGGCTTCACCCAAGTCTGAGAAGAATGA
GTATGCCTTCATGGGCTCCCTCATCATCCAGGAAGTGGTACGGGAGCTCCTGGTCAAAGGGCTG
AGTGGGGCAAAGGTGTTGCTGCTGGCTGGGAGCAGTGCTGGGGGCACCGGGGTGCTGTTGAATG
TAGACCGCGTGGCTGAGCTGTTGGAGGAGTTGGGCTACCCATCTATCCAGGTGCGGGGCCTGGC
TGACTCAGGTTGGTTCCTGGACAACAAGCAGTACCGACGGTCAGACTGCATCGATACCATCAAC
TGTGCACCCACGGAGGCCATCCGCCGAGGCATCAGGTACTGGAGTGGAATGGTCCCAGAGCGCT
GCCAGCGCCAGTTCAAGGAAGGAGAGGAATGGAATTGCTTCTTTGGCTACAAAATATATCCCAC
TCTGCGCTGTCCAGTGTTCGTAGTTCAGTGGCTTTTCGATGAGGCTCAGCTGACCGTGGATAAC
GTGCATCTCACTGGGCAGCCGGTTCAGGAGGGCCAGTGGCTGTACATCCAGAATCTGGGCCGAG
AACTGCGTGGCACACTCAAGGATGTGCAGGCCAGCTTTGCCCCCGCCTGCCTGTCCCATGAGAT
CATCATACGGAGCTATTGGACAGATGTCCAGGTGAAGGGGACCTCACTGCCCCGGGCACTGCAC
TGCTGGGACCGGAGCTTCCATGACAGCCATAAGGCCAGCAAAACGCCCATGAAGGGCTGCCCTT
TCCACCTGGTAGACAGCTGTCCCTGGCCCCACTGCAATCCCTCATGCCCTACCATCCGGGACCA
GTTCACAGGCCAAGAGATGAACGTGGCACAGTTCCTTATGCACATGGGCTTCGATGTGCAGACG
GTGGCCCAACAGCAGGGGATGGAGCCCAGCAAACTGCTAGGGATACTGAGTAGCGGAAACTAGA
TGTCTGCCTGCAGAGGAGGTAGTAATGAAGGGGCCGGTCCACCTACTGTCCCAGGGTGACTCAC
CTCTACTTCTAGGCTCTTCTGCTCTCCCAGGACCCACCTGAGTATGGATGCCTGACTGTCTATA
CCCTCCCTCTGCCCAGCTAGAAGAGTGGTCTGCCCTGAGCCCAGGGACCCTTCCTACCCCGTAT
CTGTTTCCCTAGCCCCCAGGCCAGCTTAGGGGCAAGCCGGAAGCAAAGCCAAGCACTGGATTCC
TGAGCCTATCAGCTCAGACAGTCCCTCCTAGCCCCCAACTGATCCTGTTCTTTTGTATTATTTT
ATAAAGTGACTTTTTTTATTACTTTAATTTTTAAAAGAAATCGAAATTAAGAAATATATGATGG
ATGATATTGTTTTGTAACATATTTTTTCTTAATAATTAAAAAAAAAGATAACAGACG

hide sequence

RefSeq Acc Id:

NM_001415777 ⟹ NP_001402706

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	106,431,572 - 106,438,040 (-)	NCBI
mRatBN7.2	10	105,933,245 - 105,939,713 (-)	NCBI

RefSeq Acc Id:

XM_006247887 ⟹ XP_006247949

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	106,431,572 - 106,438,486 (-)	NCBI
mRatBN7.2	10	105,933,245 - 105,940,055 (-)	NCBI
Rnor_6.0	10	109,832,977 - 109,839,945 (-)	NCBI
Rnor_5.0	10	109,425,669 - 109,432,739 (-)	NCBI

Sequence:

show sequence

CCGAGTGCGAGTCTCCCACGAATGCACTGGGCTCGGGCGCGGGAGGGAAGGCCCCAACTGTTCC
AGGTGAACCCTCGCACCCTGCGCCCTGACCCGTCGGGCAGAGCAGCTGCGCAATCGGCAGGGCG
CCCCCGTTGCGGAAAGGCCTCTTCCTCCCGGCCCCCGGGGCGCTCCGAGGGCGGGGGTAGCGGC
GCCGAGCTGGCCGCGGAGAATGAAGCTGCCGGGGGCCAGCCCGGCCGCGCTGCCCCCCACGGAG
CCGGGCCGGGAGCGCCTCCGGCGGCCGCAACGGGTGGCCACAGGCCGGAGTGACATTGCCATGG
GCGGAGAGGTGCGCGTGCTGCTACTGCTGGGCCTGCTGCACTGGGTTGGGGGCAGCGAGGGCAG
GAAGACCTGGAGGCGCCGTGGCCAGCAGCCACCCCAGCCGCCGCCCCCGCCGCCGCCCCCGCAG
CGGGCTGAGGTGGCGCCGGGAGCCGGGCAGCCGGTGGAGAGCTTCCCGCTGGACTTCACGGCAG
TGGAGGGCAACATGGACAGCTTTATGGCGCAAGTCAAGAGCCTGGCACAGTCCCTGTATCCCTG
CTCTGCGCAGCAGCTCAACGAGGACCTGCGCCTTCACCTCCTGCTGAACACGTCGGTGACCTGC
AATGACGGCAGCCCCGCCGGCTACTATTTGAAGGAGTCCAAGGGCAGTCGGCGGTGGTTACTCT
TTCTGGAAGGCGGCTGGTATTGCTTCAACCGGGAGAACTGTGACTCCAGATACAGCACCATGCG
GCGCCTCATGAGCTCCAAAGACTGGCCACACACGCGCACAGGTACTGGTATTCTATCCTCCCAG
CCAGAGGAGAACCCACACTGGTGGAATGCCAATATGGTCTTCATCCCCTACTGCTCCAGTGACG
TTTGGAGTGGGGCTTCACCCAAGTCTGAGAAGAATGAGTATGCCTTCATGGGCTCCCTCATCAT
CCAGGAAGTGGTACGGGAGCTCCTGGTCAAAGGGCTGAGTGGGGCAAAGGTGTTGCTGCTGGCT
GGGAGCAGTGCTGGGGGCACCGGGGTGCTGTTGAATGTAGACCGCGTGGCTGAGCTGTTGGAGG
AGTTGGGCTACCCATCTATCCAGGTGCGGGGCCTGGCTGACTCAGGTTGGTTCCTGGACAACAA
GCAGTACCGACGGTCAGACTGCATCGATACCATCAACTGTGCACCCACGGAGGCCATCCGCCGA
GGCATCAGGTACTGGAGTGGAATGGTCCCAGAGCGCTGCCAGCGCCAGTTCAAGGAAGGAGAGG
AATGGAATTGCTTCTTTGGCTACAAAATATATCCCACTCTGCGCTGTCCAGTGTTCGTAGTTCA
GTGGCTTTTCGATGAGGCTCAGCTGACCGTGGATAACGTGCATCTCACTGGGCAGCCGGTTCAG
GAGGGCCAGTGGCTGTACATCCAGAATCTGGGCCGAGAACTGCGTGGCACACTCAAGGATGTGC
AGGCCAGCTTTGCCCCCGCCTGCCTGTCCCATGAGATCATCATACGGAGCTATTGGACAGATGT
CCAGGTGAAGGGGACCTCACTGCCCCGGGCACTGCACTGCTGGGACCGGAGCTTCCATGACAGC
CATAAGGCCAGCAAAACGCCCATGAAGGGCTGCCCTTTCCACCTGGTAGACAGCTGTCCCTGGC
CCCACTGCAATCCCTCATGCCCTACCATCCGGGACCAGTTCACAGGCCAAGAGATGAACGTGGC
ACAGTTCCTTATGCACATGGGCTTCGATGTGCAGACGGTGGCCCAACAGCAGGGGATGGAGCCC
AGCAAACTGCTAGGGATACTGAGTAGCGGAAACTAGATGTCTGCCTGCAGAGGAGGTAGTAATG
AAGGGGCCGGTCCACCTACTGTCCCAGGGTGACTCACCTCTACTTCTAGGCTCTTCTGCTCTCC
CAGGACCCACCTGAGTATGGATGCCTGACTGTCTATACCCTCCCTCTGCCCAGCTAGAAGAGTG
GTCTGCCCTGAGCCCAGGGACCCTTCCTACCCCGTATCTGTTTCCCTAGCCCCCAGGCCAGCTT
AGGGGCAAGCCGGAAGCAAAGCCAAGCACTGGATTCCTGAGCCTATCAGCTCAGACAGTCCCTC
CTAGCCCCCAACTGATCCTGTTCTTTTGTATTATTTTATAAAGTGACTTTTTTTATTACTTTAA
TTTTTAAAAGAAATCGAAATTAAGAAATATATGATGGATGATATTGTTTTGTAACATATTTTTT
CTTAATAATTAAAAAAAAAGATAACAGACGCTCA

hide sequence

RefSeq Acc Id:

XM_006247888 ⟹ XP_006247950

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	106,431,572 - 106,437,450 (-)	NCBI
mRatBN7.2	10	105,933,245 - 105,939,105 (-)	NCBI
Rnor_6.0	10	109,832,977 - 109,838,944 (-)	NCBI
Rnor_5.0	10	109,425,669 - 109,432,739 (-)	NCBI

Sequence:

show sequence

TCTGCGCAGCAGCTCAACGAGGACCTGCGCCTTCACCTCCTGCTGAACACGTCGGTGACCTGCA
ATGACGGCAGCCCCGCCGGGTAAGGCCGGTGCTGGGCAGGACCCCGGGAGGCCGTCAACCTGGC
TTGGCTGGCTCCACCGGTGCTCCGCTCCTGGCTCGCCGTCGTCCCATCACTGGTGGCTCTCGCA
TCCTCTGCCTCCCCGCGCGCGCACAAACGCGGAGACTGCACTGGACCCTTCCTATTTTCAATGG
CTGATCTGGTCCCTAGAAGAAAGGGTTCCACTCGGGCGTCTATTGCTGCTAGCCCTGGGGAAAG
CCTGGCTTGGAGCCTCCCAAAGCGGGGGAGGGGGCAGCTCTTGAAGCTCTGGTCCGAGGCCAAC
TCGGGTGCTGACCTCTTGGCCACCGTGCACCCGCCTTTGAAAGTTCAGGTCCTCGGACAGGAAA
AGAGACTGCAGTCCCAGAGTGGCTATGTCTCCAGTAGAAAGAGGCAACATTGAAGGACAGGAGG
TTTCTGTCTCAGGGCTCCCCTGTGCGTAACAGATTGGTTCGGGACAGTCAGGAATCCGAACACG
GGAGCAAGGAGGGGGCACAAGAGGGACCGAAGGCTCCAGGTGCAGCATTCACACACGCACTCAA
CTTTGAAGTAGATAGAGGACACTGGGAGGTCAGAAGGGTCTCTGGATGCCCACGCGCTCAGTCT
GGGCCTTGATAGAAAGGCTGTAACACCGCTTCGGTGTCTCCTGCATCTCCTCGCTGCGCTCCTT
ACCACTACCGTTTTCTGGGCCTCTAGCCCTAGCATATTTCTCATTATTCAAGTGCCACTGCGTG
CTCGAGAGTGCAGCTCTTCGACAGACATCGGCGCCAGGGTTAACGCGGGTCTCATGCGGGGCGG
GCTGTGGGAATTTTCCACGGACCGCAGGACCCTTCATCCACCCACCCGCTGTCGCCACCTCTGG
GGAATCAGTGGGGTTTCACCAGCTTGTGCGTTCAGTTTGCGATTGGCTGCGGGCGCCCTCGCGC
GGCTGTGCTACTATTTGAAGGAGTCCAAGGGCAGTCGGCGGTGGTTACTCTTTCTGGAAGGCGG
CTGGTATTGCTTCAACCGGGAGAACTGTGACTCCAGATACAGCACCATGCGGCGCCTCATGAGC
TCCAAAGACTGGCCACACACGCGCACAGGTACTGGTATTCTATCCTCCCAGCCAGAGGAGAACC
CACACTGGTGGAATGCCAATATGGTCTTCATCCCCTACTGCTCCAGTGACGTTTGGAGTGGGGC
TTCACCCAAGTCTGAGAAGAATGAGTATGCCTTCATGGGCTCCCTCATCATCCAGGAAGTGGTA
CGGGAGCTCCTGGTCAAAGGGCTGAGTGGGGCAAAGGTGTTGCTGCTGGCTGGGAGCAGTGCTG
GGGGCACCGGGGTGCTGTTGAATGTAGACCGCGTGGCTGAGCTGTTGGAGGAGTTGGGCTACCC
ATCTATCCAGGTGCGGGGCCTGGCTGACTCAGGTTGGTTCCTGGACAACAAGCAGTACCGACGG
TCAGACTGCATCGATACCATCAACTGTGCACCCACGGAGGCCATCCGCCGAGGCATCAGGTACT
GGAGTGGAATGGTCCCAGAGCGCTGCCAGCGCCAGTTCAAGGAAGGAGAGGAATGGAATTGCTT
CTTTGGCTACAAAATATATCCCACTCTGCGCTGTCCAGTGTTCGTAGTTCAGTGGCTTTTCGAT
GAGGCTCAGCTGACCGTGGATAACGTGCATCTCACTGGGCAGCCGGTTCAGGAGGGCCAGTGGC
TGTACATCCAGAATCTGGGCCGAGAACTGCGTGGCACACTCAAGGATGTGCAGGCCAGCTTTGC
CCCCGCCTGCCTGTCCCATGAGATCATCATACGGAGCTATTGGACAGATGTCCAGGTGAAGGGG
ACCTCACTGCCCCGGGCACTGCACTGCTGGGACCGGAGCTTCCATGACAGCCATAAGGCCAGCA
AAACGCCCATGAAGGGCTGCCCTTTCCACCTGGTAGACAGCTGTCCCTGGCCCCACTGCAATCC
CTCATGCCCTACCATCCGGGACCAGTTCACAGGCCAAGAGATGAACGTGGCACAGTTCCTTATG
CACATGGGCTTCGATGTGCAGACGGTGGCCCAACAGCAGGGGATGGAGCCCAGCAAACTGCTAG
GGATACTGAGTAGCGGAAACTAGATGTCTGCCTGCAGAGGAGGTAGTAATGAAGGGGCCGGTCC
ACCTACTGTCCCAGGGTGACTCACCTCTACTTCTAGGCTCTTCTGCTCTCCCAGGACCCACCTG
AGTATGGATGCCTGACTGTCTATACCCTCCCTCTGCCCAGCTAGAAGAGTGGTCTGCCCTGAGC
CCAGGGACCCTTCCTACCCCGTATCTGTTTCCCTAGCCCCCAGGCCAGCTTAGGGGCAAGCCGG
AAGCAAAGCCAAGCACTGGATTCCTGAGCCTATCAGCTCAGACAGTCCCTCCTAGCCCCCAACT
GATCCTGTTCTTTTGTATTATTTTATAAAGTGACTTTTTTTATTACTTTAATTTTTAAAAGAAA
TCGAAATTAAGAAATATATGATGGATGATATTGTTTTGTAACATATTTTTTCTTAATAATTAAA
AAAAAAGATAACAGACGCTCA

hide sequence

RefSeq Acc Id:

XM_039086224 ⟹ XP_038942152

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	106,433,201 - 106,438,511 (-)	NCBI
mRatBN7.2	10	105,934,879 - 105,940,055 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001013997	(Get FASTA)	NCBI Sequence Viewer
	NP_001402706	(Get FASTA)	NCBI Sequence Viewer
	XP_006247949	(Get FASTA)	NCBI Sequence Viewer
	XP_006247950	(Get FASTA)	NCBI Sequence Viewer
	XP_038942152	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM06880	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000051830
	ENSRNOP00000051830.2
	ENSRNOP00000101238.1
	ENSRNOP00000111783
	ENSRNOP00000111783.1

RefSeq Acc Id:	NP_001013997 ⟸ NM_001013975
- Peptide Label:	precursor
- UniProtKB:	D3ZXI3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGGEVRVLLLLGLLHWVGGSEGRKTWRRRGQQPPQPPPPPPPPQRAEVAPGAGQPVESFPLDFT AVEGNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKESKGSRRWL LFLEGGWYCFNRENCDSRYSTMRRLMSSKDWPHTRTGTGILSSQPEENPHWWNANMVFIPYCSS DVWSGASPKSEKNEYAFMGSLIIQEVVRELLVKGLSGAKVLLLAGSSAGGTGVLLNVDRVAELL EELGYPSIQVRGLADSGWFLDNKQYRRSDCIDTINCAPTEAIRRGIRYWSGMVPERCQRQFKEG EEWNCFFGYKIYPTLRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGQWLYIQNLGRELRGTLKD VQASFAPACLSHEIIIRSYWTDVQVKGTSLPRALHCWDRSFHDSHKASKTPMKGCPFHLVDSCP WPHCNPSCPTIRDQFTGQEMNVAQFLMHMGFDVQTVAQQQGMEPSKLLGILSSGN hide sequence

RefSeq Acc Id:	XP_006247949 ⟸ XM_006247887
- Peptide Label:	isoform X1
- UniProtKB:	A6HLH5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKLPGASPAALPPTEPGRERLRRPQRVATGRSDIAMGGEVRVLLLLGLLHWVGGSEGRKTWRRR GQQPPQPPPPPPPPQRAEVAPGAGQPVESFPLDFTAVEGNMDSFMAQVKSLAQSLYPCSAQQLN EDLRLHLLLNTSVTCNDGSPAGYYLKESKGSRRWLLFLEGGWYCFNRENCDSRYSTMRRLMSSK DWPHTRTGTGILSSQPEENPHWWNANMVFIPYCSSDVWSGASPKSEKNEYAFMGSLIIQEVVRE LLVKGLSGAKVLLLAGSSAGGTGVLLNVDRVAELLEELGYPSIQVRGLADSGWFLDNKQYRRSD CIDTINCAPTEAIRRGIRYWSGMVPERCQRQFKEGEEWNCFFGYKIYPTLRCPVFVVQWLFDEA QLTVDNVHLTGQPVQEGQWLYIQNLGRELRGTLKDVQASFAPACLSHEIIIRSYWTDVQVKGTS LPRALHCWDRSFHDSHKASKTPMKGCPFHLVDSCPWPHCNPSCPTIRDQFTGQEMNVAQFLMHM GFDVQTVAQQQGMEPSKLLGILSSGN hide sequence

RefSeq Acc Id:

XP_006247950 ⟸ XM_006247888

- Peptide Label:

isoform X2

- Sequence:

show sequence

MRGGLWEFSTDRRTLHPPTRCRHLWGISGVSPACAFSLRLAAGALARLCYYLKESKGSRRWLLF
LEGGWYCFNRENCDSRYSTMRRLMSSKDWPHTRTGTGILSSQPEENPHWWNANMVFIPYCSSDV
WSGASPKSEKNEYAFMGSLIIQEVVRELLVKGLSGAKVLLLAGSSAGGTGVLLNVDRVAELLEE
LGYPSIQVRGLADSGWFLDNKQYRRSDCIDTINCAPTEAIRRGIRYWSGMVPERCQRQFKEGEE
WNCFFGYKIYPTLRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGQWLYIQNLGRELRGTLKDVQ
ASFAPACLSHEIIIRSYWTDVQVKGTSLPRALHCWDRSFHDSHKASKTPMKGCPFHLVDSCPWP
HCNPSCPTIRDQFTGQEMNVAQFLMHMGFDVQTVAQQQGMEPSKLLGILSSGN

hide sequence

Ensembl Acc Id:

ENSRNOP00000051830 ⟸ ENSRNOT00000054947

RefSeq Acc Id:	XP_038942152 ⟸ XM_039086224
- Peptide Label:	isoform X3

RefSeq Acc Id:	NP_001402706 ⟸ NM_001415777
- Peptide Label:	precursor
- UniProtKB:	D3ZXI3 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000101238 ⟸ ENSRNOT00000131615

Ensembl Acc Id:

ENSRNOP00000111783 ⟸ ENSRNOT00000125509

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZXI3-F1-model_v2	AlphaFold	D3ZXI3	1-503	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697973

Promoter ID:

EPDNEW_R8497

Type:

single initiation site

Name:

Notum_1

Description:

NOTUM, palmitoleoyl-protein carboxylesterase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	109,840,059 - 109,840,119	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307119	AgrOrtholog
BioCyc Gene	G2FUF-22398	BioCyc
Ensembl Genes	ENSRNOG00000036680	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000054947	ENTREZGENE
	ENSRNOT00000054947.4	UniProtKB/TrEMBL
	ENSRNOT00000125509	ENTREZGENE
	ENSRNOT00000125509.1	UniProtKB/TrEMBL
	ENSRNOT00000131615.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7321508	IMAGE-MGC_LOAD
	IMAGE:7325212	IMAGE-MGC_LOAD
InterPro	Pec_acetylest	UniProtKB/TrEMBL
KEGG Report	rno:303743	UniProtKB/TrEMBL
MGC_CLONE	MGC:109547	IMAGE-MGC_LOAD
	MGC:188212	IMAGE-MGC_LOAD
NCBI Gene	303743	ENTREZGENE
PANTHER	PALMITOLEOYL-PROTEIN CARBOXYLESTERASE NOTUM	UniProtKB/TrEMBL
	PTHR21562	UniProtKB/TrEMBL
Pfam	PAE	UniProtKB/TrEMBL
PhenoGen	Notum	PhenoGen
RatGTEx	ENSRNOG00000036680	RatGTEx
UniProt	A0ABK0L027_RAT	UniProtKB/TrEMBL
	A0ABK0M3Q7_RAT	UniProtKB/TrEMBL
	A6HLH5	ENTREZGENE, UniProtKB/TrEMBL
	D3ZXI3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-04-14	Notum	NOTUM, palmitoleoyl-protein carboxylesterase	Notum	notum pectinacetylesterase homolog (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-10-10	Notum	notum pectinacetylesterase homolog (Drosophila)	RGD1307119	hypothetical LOC303743	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1307119	hypothetical LOC303743	RGD1307119_predicted	hypothetical LOC303743 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1307119_predicted	hypothetical LOC303743 (predicted)	LOC303743_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC303743_predicted	hypothetical LOC303743 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD