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Gene: Prex1 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1) Rattus norvegicus

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Symbol:

Prex1

Name:

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1

RGD ID:

1306534

Description:

Predicted to enable GTPase regulator activity; phospholipid binding activity; and protein serine/threonine kinase inhibitor activity. Involved in positive regulation of cell migration; regulation of actin filament polymerization; and regulation of dendrite development. Located in dendritic shaft; growth cone; and perinuclear region of cytoplasm. Orthologous to human PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rho/Rac/Cdc42 mediated signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC311647; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; RGD1306534; similar to P-Rex1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

Prex1^em2Mcwi

Genetic Models:

SS-Prex1^em2Mcwi

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	175,724,939 - 175,875,764 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	175,726,012 - 175,875,764 (-)	Ensembl				GRCr8
mRatBN7.2	3	155,306,950 - 155,456,688 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	155,306,950 - 155,456,688 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	159,108,046 - 159,257,416 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	167,607,015 - 167,756,375 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	165,348,709 - 165,498,079 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	163,329,580 - 163,477,822 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	163,329,975 - 163,477,715 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	169,494,331 - 169,575,981 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	157,693,897 - 157,863,943 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	153,891,483 - 154,040,542 (-)	NCBI		Celera
RGSC_v3.1	3	157,599,463 - 157,770,600 (-)	NCBI
Cytogenetic Map	3	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISS)

Lymphatic Metastasis (ISO)

prostate cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,2-dimethylhydrazine (EXP,ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-palmitoylglycerol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-chloroethyl) sulfide (EXP)

bisphenol A (EXP,ISO)

Brodifacoum (EXP)

buta-1,3-diene (ISO)

butanal (ISO)

C60 fullerene (EXP)

carbon nanotube (ISO)

carmustine (ISO)

cerium trichloride (ISO)

chloroprene (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

D-glucose (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

dieldrin (ISO)

disodium selenite (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

Enterolactone (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

FR900359 (ISO)

genistein (ISO)

gentamycin (EXP)

glucose (ISO)

glyphosate (EXP)

indometacin (ISO)

lanthanum trichloride (ISO)

methapyrilene (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

microcystin-LR (ISO)

naled (ISO)

nickel atom (ISO)

nitrogen dioxide (ISO)

O-methyleugenol (ISO)

okadaic acid (ISO)

oxaliplatin (EXP)

ozone (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

permethrin (ISO)

phorbol 13-acetate 12-myristate (ISO)

SB 431542 (ISO)

serpentine asbestos (ISO)

silicon dioxide (EXP)

sodium arsenite (ISO)

Soman (EXP)

sotorasib (ISO)

temozolomide (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trametinib (ISO)

trichostatin A (ISO)

triclosan (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

tungsten (ISO)

valproic acid (EXP,ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

G protein-coupled receptor signaling pathway (IBA,ISO)

intracellular signal transduction (IEA)

leukocyte activation (IEA)

negative regulation of TOR signaling (IBA)

neutrophil chemotaxis (ISO)

positive regulation of cell adhesion (ISO)

positive regulation of cell migration (IMP)

positive regulation of GTPase activity (ISO)

positive regulation of substrate adhesion-dependent cell spreading (ISO)

reactive oxygen species metabolic process (IEA,ISO)

regulation of actin filament polymerization (IMP)

regulation of dendrite development (IMP)

T cell differentiation (ISO)

Cellular Component

cytosol (IEA,ISO)

dendritic shaft (IDA)

growth cone (IDA)

perinuclear region of cytoplasm (IDA)

plasma membrane (IBA,IEA)

Molecular Function

GTPase activator activity (IBA)

guanyl-nucleotide exchange factor activity (IBA,IEA)

phospholipid binding (IEA,ISO)

protein binding (ISO)

protein serine/threonine kinase inhibitor activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

chemokine mediated signaling pathway (IEA)

insulin responsive facilitative sugar transporter mediated glucose transport pathway (ISO)

Rho/Rac/Cdc42 mediated signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis.	Qin J, etal., Oncogene. 2009 Apr 23;28(16):1853-63. Epub 2009 Mar 23.
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation
7.	Rho GTPases in insulin-stimulated glucose uptake.	Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
8.	P-Rex1 - a multidomain protein that regulates neurite differentiation.	Waters JE, etal., J Cell Sci. 2008 Sep 1;121(Pt 17):2892-903. Epub 2008 Aug 12.
9.	Involvement of a Rac activator,P-Rex1, in neurotrophin-derived signaling and neuronal migration.	Yoshizawa M, etal., J Neurosci. 2005 Apr 27;25(17):4406-19.

Additional References at PubMed

PMID:11955434	PMID:21178006	PMID:21179475	PMID:26514267	PMID:33347743

Genomics

Comparative Map Data

Prex1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	175,724,939 - 175,875,764 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	175,726,012 - 175,875,764 (-)	Ensembl				GRCr8
mRatBN7.2	3	155,306,950 - 155,456,688 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	155,306,950 - 155,456,688 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	159,108,046 - 159,257,416 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	167,607,015 - 167,756,375 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	165,348,709 - 165,498,079 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	163,329,580 - 163,477,822 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	163,329,975 - 163,477,715 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	169,494,331 - 169,575,981 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	157,693,897 - 157,863,943 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	153,891,483 - 154,040,542 (-)	NCBI		Celera
RGSC_v3.1	3	157,599,463 - 157,770,600 (-)	NCBI
Cytogenetic Map	3	q42	NCBI

PREX1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	48,624,252 - 48,888,185 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	48,624,249 - 48,828,096 (-)	Ensembl			hg38	GRCh38
GRCh37	20	47,240,790 - 47,444,536 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	46,674,200 - 46,877,827 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	20	43,945,979 - 44,149,646 (-)	NCBI		Celera
Cytogenetic Map	20	q13.13	NCBI
HuRef	20	43,990,060 - 44,195,320 (-)	NCBI		HuRef
CHM1_1	20	47,145,458 - 47,349,091 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	50,394,065 - 50,597,825 (-)	NCBI		T2T-CHM13v2.0

Prex1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	166,408,265 - 166,555,752 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	166,408,262 - 166,555,752 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	166,566,345 - 166,713,832 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	166,566,342 - 166,713,832 (-)	Ensembl			mm10	GRCm38
MGSCv37	2	166,391,845 - 166,539,332 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	166,256,959 - 166,405,037 (-)	NCBI		MGSCv36	mm8
Celera	2	172,502,260 - 172,653,067 (-)	NCBI		Celera
Cytogenetic Map	2	H3	NCBI
cM Map	2	87.09	NCBI

Prex1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955445	9,229,793 - 9,398,662 (+)	Ensembl
ChiLan1.0	NW_004955445	9,229,775 - 9,401,277 (+)	NCBI	ChiLan1.0	ChiLan1.0

PREX1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	54,369,425 - 54,573,462 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	54,362,530 - 54,566,568 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	44,965,850 - 45,169,891 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	46,034,724 - 46,157,984 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	46,033,937 - 46,226,500 (-)	Ensembl			panPan2	panpan1.1

PREX1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	35,403,078 - 35,503,428 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	35,404,564 - 35,582,041 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	34,646,334 - 34,825,207 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	36,111,037 - 36,287,341 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	36,112,187 - 36,287,722 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	35,349,797 - 35,528,690 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	35,484,549 - 35,662,320 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	36,026,106 - 36,205,507 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Prex1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	189,903,846 - 189,990,356 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936514	5,368,629 - 5,444,003 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936514	5,291,473 - 5,443,999 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PREX1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	50,354,775 - 50,550,637 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	17	50,352,273 - 50,550,402 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

PREX1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	15,152,001 - 15,354,556 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	15,152,096 - 15,354,544 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666050	63,656,144 - 63,859,525 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Prex1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624790	6,453,066 - 6,637,597 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624790	6,453,085 - 6,622,179 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Prex1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	151,249,232 - 151,400,100 (+)	NCBI		Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	87
Count of miRNA genes:	67
Interacting mature miRNAs:	76
Transcripts:	ENSRNOT00000009517
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2301411	Bp320	Blood pressure QTL 320		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141555229	186555229	Rat
12879876	Bw182	Body weight QTL 182		0.003	body mass (VT:0001259)	body weight (CMO:0000012)	3	141555229	186555229	Rat
1582233	Insul10	Insulin level QTL 10	5.4	0.0015	blood insulin amount (VT:0001560)	serum insulin level times blood glucose level (CMO:0002040)	3	133259579	178259579	Rat
1300113	Bp176	Blood pressure QTL 176	3.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	166376089	177728348	Rat
12879872	Cm97	Cardiac mass QTL 97		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	141555229	186555229	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	151075912	189428310	Rat
12879873	Cm96	Cardiac mass QTL 96		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	141555229	186555229	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	129154923	182114333	Rat
12879874	Cm98	Cardiac mass QTL 98		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	141555229	186555229	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	161492708	189428310	Rat
12879875	Kidm64	Kidney mass QTL 64		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	141555229	186555229	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
8552791	Vie2	Viral induced encephalitis QTL 2	4.1		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	3	166376089	189428310	Rat
61335	Bp20	Blood pressure QTL 20	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	161799493	176036425	Rat
1331726	Bp208	Blood pressure QTL 208	3.129		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	161799270	187311134	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	133134628	178134628	Rat
1582213	Insul6	Insulin level QTL 6	3.7	0.0009	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	3	155759447	189428310	Rat
1598854	Memor10	Memory QTL 10	2		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	3	166376089	189428310	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	152055202	189428310	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	142898802	187898802	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	79649560	177741895	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	145335553	189428310	Rat
1582256	Insul9	Insulin level QTL 9	4.4	0.0016	blood insulin amount (VT:0001560)	absolute change in serum insulin level (CMO:0002038)	3	155759447	189428310	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	139299381	184299381	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	141508991	177728348	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	137114333	182114333	Rat
1582248	Insul7	Insulin level QTL 7	3.9	0.0041	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	3	155759447	189428310	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	131036586	176036586	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	131036586	176036586	Rat
1578666	Vnigr1	Vascular neointimal growth QTL 1	4.6		artery morphology trait (VT:0002191)	artery lumen area (CMO:0001409)	3	151075912	189428310	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	151075912	189428310	Rat
12879871	Am7	Aortic mass QTL 7		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	141555229	186555229	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	144575244	189428310	Rat

Markers in Region

D3Got151

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	155,414,056 - 155,414,238 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	163,435,007 - 163,435,188	NCBI	Rnor6.0
Rnor_5.0	3	169,599,540 - 169,599,721	UniSTS	Rnor5.0
RGSC_v3.4	3	157,820,472 - 157,820,654	RGD	RGSC3.4
RGSC_v3.4	3	157,820,473 - 157,820,654	UniSTS	RGSC3.4
Celera	3	153,998,020 - 153,998,201	UniSTS
RGSC_v3.1	3	157,726,509 - 157,726,690	RGD
RH 3.4 Map	3	1464.6	UniSTS
RH 3.4 Map	3	1464.6	RGD
RH 2.0 Map	3	1004.9	RGD
Cytogenetic Map	3	q42	UniSTS

D3Cebr5

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	155,367,549 - 155,367,700 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	163,388,554 - 163,388,704	NCBI	Rnor6.0
Rnor_5.0	3	169,553,087 - 169,553,237	UniSTS	Rnor5.0
RGSC_v3.4	3	157,773,968 - 157,774,118	UniSTS	RGSC3.4
Celera	3	153,951,467 - 153,951,617	UniSTS
Cytogenetic Map	3	q42	UniSTS

BB045044

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	155,425,628 - 155,425,707 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	163,446,579 - 163,446,657	NCBI	Rnor6.0
Rnor_5.0	3	169,611,112 - 169,611,190	UniSTS	Rnor5.0
RGSC_v3.4	3	157,832,426 - 157,832,504	UniSTS	RGSC3.4
Celera	3	154,009,618 - 154,009,696	UniSTS
Cytogenetic Map	3	q42	UniSTS

AU049770

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	155,434,203 - 155,434,379 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	163,455,154 - 163,455,329	NCBI	Rnor6.0
Rnor_6.0	3	163,051,700 - 163,051,875	NCBI	Rnor6.0
Rnor_5.0	3	169,221,539 - 169,221,714	UniSTS	Rnor5.0
Rnor_5.0	3	169,619,687 - 169,619,862	UniSTS	Rnor5.0
RGSC_v3.4	3	157,841,001 - 157,841,176	UniSTS	RGSC3.4
Celera	3	154,018,189 - 154,018,364	UniSTS
Cytogenetic Map	3	q42	UniSTS

STS-Z39767

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	155,337,564 - 155,338,153 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	163,359,583 - 163,360,171	NCBI	Rnor6.0
Rnor_5.0	3	169,524,116 - 169,524,704	UniSTS	Rnor5.0
RGSC_v3.4	3	157,724,858 - 157,725,446	UniSTS	RGSC3.4
Celera	3	153,922,123 - 153,922,711	UniSTS
Cytogenetic Map	3	q42	UniSTS

Genetic Models

This gene Prex1 is modified in the following models/strains:

SS-Prex1^em2Mcwi

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001135718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105138	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213594	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009517 ⟹ ENSRNOP00000009517

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	175,727,557 - 175,875,764 (-)	Ensembl
mRatBN7.2 Ensembl	3	155,308,495 - 155,456,688 (-)	Ensembl
Rnor_6.0 Ensembl	3	163,329,975 - 163,477,715 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108011 ⟹ ENSRNOP00000096783

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	175,726,012 - 175,875,764 (-)	Ensembl
mRatBN7.2 Ensembl	3	155,306,950 - 155,456,688 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000151804 ⟹ ENSRNOP00000102009

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	175,726,012 - 175,838,569 (-)	Ensembl

RefSeq Acc Id:

NM_001135718 ⟹ NP_001129190

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	175,726,012 - 175,875,764 (-)	NCBI
mRatBN7.2	3	155,306,950 - 155,456,688 (-)	NCBI
Rnor_6.0	3	163,329,580 - 163,477,822 (-)	NCBI
Rnor_5.0	3	169,494,331 - 169,575,981 (-)	NCBI
RGSC_v3.4	3	157,693,897 - 157,863,943 (-)	RGD
Celera	3	153,891,483 - 154,040,542 (-)	RGD

Sequence:

show sequence

TCCGCCTGCCCCGGGCCCGCTGAGCGGCGCCTGTCCGGGATGCGGAGCCCGGACGCCTGAGCCG
CGGCGCGACCTCGGCGCGGGGAGTTCGGGCGCCGCGCGGCGATGGAGGCGCCCGGCAGCGGTAG
TGGCGATGGCGGCGGGGACCCAGGCGGGGACGGTGCGCATCCCGATGCTCGCGGTCCCAGCTCC
GGGCCATGCGCGGCCGCCCGCGACTCGGAGCGCCAGCTGCGCCTCCGTCTGTGCGTACTCAACG
AGATCCTGGCCACCGAGCGCGACTACGTGGGCACCTTGCGTTTCCTGCAGTCGGCGTTCCTACA
GCGGATCCGGCAGAATGTGGCCGACTCTGTGGACAAGGGCCTCACGGAAGAGAATGTCAAGATC
CTCTTCTCCAACATTGAGGACATCTTGGAGGTCCATAAGGATTTTTTGGCTGCCCTGGAATACT
GCCTACATCCGGAGCCCCAGTCTCAGCACGAACTTGGGAATGTTTTCTTGAAATTTAAGGACAA
GTTCTGTGTGTATGAGGAGTACTGCAGTAACCACGAGAAGGCCCTGCGTCTGTTGGTGGAGCTC
AACAAGGTCCCTGCCGCTCGCGCCTTCCTCCTGAACTGCATGCTTCTGGGAGGCCGGAAGACCA
CGGACATCCCTCTGGAGGGCTACCTGCTGTCCCCCATCCAGAGGATCTGCAAGTACCCACTCCT
GCTCAAGGAGTTATCTAAGAGGACCCCGGGCAAACACCCTGACCATTCCGCGGTACAGAGCGCC
CTGCAAGCCATGAAGACCGTCTGCTCCAACATCAATGAGACCAAGAGGCAGATGGAGAAGCTGG
AGGCCCTGGAGCAGCTGCAGTCTCACATCGAAGGCTGGGAGGGCTCGAACCTCACAGACATCTG
CACCCAGCTTCTCCTTCAGGGCACTCTGCTGAAGATCTCTGCAGGCAACATCCAAGAGAGAGCC
TTCTTCCTCTTCGACAACTTGCTCGTCTACTGCAAGCGGAAATCTAGGGTCACTGGGAGCAAGA
AATCTACCAAGAGGACCAAGTCCATCAACGGCTCCCTGTACATCTTCAGGGGTCGGATCAACAC
TGAGGTCATGGAAGTGGAGAATGTGGAAGACGGGACAGCCGATTACCACAGCAATGGCTACACC
GTCACCAATGGCTGGAAGATCCACAATACAGCCAAAAACAAGTGGTTTGTGTGTATGGCCAAGA
CAGCAGAGGAGAAGCAGAAGTGGCTGGACGCCCTGATCCGAGAGCGGGAGCAGCGAGAGAGCCT
GAAGCTGGGCATGGAGCGCGACGCATACGTCATGATTGCGGAGAAGGGGGAGAAGCTGTATCAC
ATGATGATGAGCAAGAAGGTGAACTTGATCAAGGACCGCCGACGGAAGCTGAGCACCGTCCCCA
AGTGCTTCCTTGGCAATGAGTTTGTCGCCTGGCTCCTGGAAATTGGTGAGATCAGCAAGACAGA
AGAAGGGGTCAACTTGGGCCAGGCCCTGTTGGAGAATGGCATCATCCACCACGTCTCCGACAAG
CATCAGTTCAAGAACGAGCAGGTGATGTATCGCTTCCGCTACGACGATGGCACCTACAAAGCCC
GCAGCGAGCTGGAGGACATCATGTCCAAGGGCGTGAGACTCTATTGCCGGCTTCACAGCCTGTA
CGCCCCCGTGATCAAGGACCGTGATTACCACCTGAAGACCTACAAGTCCGTGGTCCCCGGGAGC
AAGCTGGTCGACTGGCTCCTGGCACAGGGGGACTGCCAGACACGGGAGGAGGCGGTGGCGCTGG
GTGTGGGCCTGTGCAACAACGGTTTCATGCACCATGTTCTGGAGAAGAGCGAATTCAAGGACGA
GTCTCAGTACTTCCGCTTCCATGCGGACGAGGAGATGGAAGGGACCAGCAGCAAGAACAAACAG
CTTCGCAACGACTTCAAGCTAGTGGAGAACATCCTGGCCAAGCGGCTGCTGATCCCGCCGCAGG
AGGATGACTATGGCTTCGATCTTGAGGAGAAGAACAAGGCAGTGGTGGTGAAGTCCGTGCAGAG
GGGTTCGCTGGCTGAGATGGCTGGCCTGCAGGCGGGGAGGAAGATTTACTCCATCAACGAGGAC
CTGGTGTTCCTACGGCCCTTCTCTGAGGTGGAGACCATCCTTAACCAGTCCTTCTGCTCCCGCC
GCCCGCTGCGCCTCCTGGTGGCCACCAAGGCCAAAGAGACCATCAAAATCCCTGACCACCCAGA
GGCCCTGTCCTTCCAGATTCGAGGAACAGCCCCGCCGTGTGTCTTTGCCGTGGGCAGAGGTTCT
GAGGCTGTGGCTGCCGGGCTCTGCGCAGGCCAATGCATCCTGAAAGTCAACGGCAACAGCGTGG
CAAATGATGGCGCCCTTGAAGTTCTGGAGCACTTCCAGGCTTTCCGCAGCCGCAGGGAGGAGGC
CCTGGGCCTTTACCAGTGGGTCTACCACAGCCACGAGGACGCCCAGCAGGCGAGAGCCAGCCAG
GGTGCCCCGGATGAGGACCCCCAGGAGGATGACTCAGTCCTGCCCCTGCTGTCCCTGGGTCCCC
AGCTGAGCCTGCACGAGGACAGCGCTGTGGTCAGCCTGACGCTGGACAATGTTCACTTGGAGCA
CGGTGTGGTTTATGAATACGTGAGCACAGCAGGAGCCAAGTGTCACGTGCTGGAAAAGATCGTG
GAGCCCCGAGGCTGTTTCCGCCTGGCTGCCAAGATCCTTGAGGCCTTTGCCGAGGACGACAGCC
TCTTCGTGCAGAACTGTGGGCGGCTCATGGCCATGGGCAGCGCTATCATCACCATGTCCCACTA
CGAGTTCCACAACATCTGTGACACCAAGCTGGAGAGCATTGGCCAGAGAATCGCCTGCTACCAG
GAGTTTGCAGCCCAGCTGAAGAGCAGGGTCAGCCCCCCCTTCAAGCAGGCACCCCTGGAGGACC
ACCCGCTGTGTGGCCTGGACTTCTGCCCTACCAACTGCCACATCAACTTCATGGAGGTGTCCTA
CCCCAAGACCACCCCTTCAGTGGGCAGGTCCTTCAGCATCCGCTTTGGGCGCAAACCCTCCCTC
ATCGGCCTTGACCCAGAACAAGGCCACCTGAACCCCATGGCTTACACCCAGCACTGTATCACCA
CCATGGCTGCCCCGTCCTGGAAGTGCGCGCCTGCTGTAGATGGGGACTCTCAAAGCCAAGGTCT
CATTGACAGTATCTTCGTGTCAGCCAGTGGTGCCCTGAGCCAGCAAGAACGGGGCCTGAGCTTT
CTGCTCAAGCAGGAGGACCGGGAGATCCAGGACGCGTATCTGCAGCTCTTCACTAAGCTGGATG
TGGCCCTCAAGGAGATGAAGCAGTATGTCACCCAGATCAACAGGCTGCTGTCAACCATCACAGA
GCCCACGTCAGCTGCACCCTGTGACCCACCCTTGGTGGAGGAGACCTCATCTTCCCCACCGGCC
AGTGAAGAGAGCGAAGTGGACAGGACTGACCATGGCGGCATCAAGAAGGTGTGCTTCAAGGTGT
CAGAGGACGAGCAGGAAGACTCGGGCCACGACACCATGAGCTACCGAGACTCCTATAGTGAGTG
TAACAGCAATCGTGACTCTGTCCTGTCCTACACCAGCGTGAGAAGCAACAGTTCGTACCTGGGC
AGTGATGAGACAGGCTCAGGGGATGAGCTGCCCTGTGACATACGCATCCCATCCGACAAGCAGG
ACAAACTTCACGGCTGCCTGGAACATCTCTTTAACCAGGTGGATTCCATCCATGCCCTGCTCAA
GGGGCCTGTGATGAGCAGGGCGTTTGAGGAGACCAGGCATTTCCCCATGGAGCACAGCTGGCAA
GAGTTCAAACAGAAAGAAGAATGCACAGTCCGAGGCCGGAACTTGATCCAGATCAGCATCCAGG
AGGACCCTTGGAACCTACCCAGCTCCATCAGGACCCTGGTAGACAACATCCAGCGATATGTGGA
AGATGGGAAGAACCAGCTGCTTCTGGCCCTGCTGAAATGCACAGACACGGAGCTGCAGCTGCGC
AGGGATGCTGTCTTCTGTCAGGCCCTGGTGGCCGCCGTGTGCACCTTCTCGGAGCAGCTGCTGG
CCGCCCTCGACTACCGCTACAACAACAACGGCGAGTATGAAGAGAGCAGCAGAGACGCCAGCCG
CAAGTGGCTGGAGCAGGTGGCAGCCACCGGTGTCCTGCTGCACTGGCAGTCCCTGCTGGCACCA
GCCACCGTGAAAGAGGAACGGACCATGCTGGAGGACATCTGGGTGACACTGTCGGAGCTGGACA
ATGTCACCTTCTCCTTTAAGCAGCTGGATGAGAATTCTGTGGCCAACACCAACGTCTTCTACCA
CATTGAGGGCAGCAGGCAGGCACTGAAGGTAGTCTTCTACCTCGATGGCTTCCACTTCTCCAGG
CTGCCCTCTCGCCTGGAGGGTGGGGCCAGCCTCAGGCTGCACACCGTGCTATTCACAAAAGCTC
TGGAGAATGTGGAAGGGCCGTCGCCCCCAGGAAGCCAGGCTGCAGAAGATCTGCAGCAGGAGAT
CAATGCGCAGTCCCTGGAGAAGGTTCAGCAGTACTATAGAAGGCTCAGGGCCTTCTACCTGGAG
CGGTCCAACCTCCCCACAGATGCTACCACCACAGCTGTGAAGATCGACCAGCTGATCCGTCCCA
TCAACGCCCTGGACGAGCTCTACCGCCTCATGAAGTCCTTCGTGCACCCGAAAGCTGGTGCTGG
TGGGAGCCTAGGTGCCGGCCTCGTCCCCGTCTCCTCTGAGCTCTGCTACCGTCTGGGGGCGTGT
CAGATCACCATGTGTGGCACCGGCATGCAGCGGAGCACCCTGAGCGTGTCCTTGGAACAAGCAG
CCATCTTGGCTCGGAGCCACGGGCTGCTGCCCAAGTGTGTTATGCAGGCCACAGACATCATGCG
CAAGCAGGGCCCCCGAGTGGAGATCCTGGCAAAAAACCTCCGCATCAAAGACCCAATGCCCCAA
GGTGCACCACGCCTCTACCGCCTCTGCCAGCCTCCGGTGGATGGAGACCTCTGAACACCGACCT
GCTCCATGCTCAGCCACTGCCTCTGCAGCTGCCATGTGGGAGGACACGGAGGGGCTGCAAGGTG
ACCCGAGGCTTCTGCCATAGCTGTGTCAAGACCTACCCAGCTGACCCTGCCGCCACCGTCCAGG
TCAAGCCTCTGCGAGCATACACTGTCTCTGGACCGGCAGATCACGGTTGGGCTGGCAGATTCTC
CATACTTAACGCCTGAAACCTGAGGGCTGCTTGGGGCCCCAGAGCTCATGAATGTAGCCCGGCC
TGGATGCCTGCACTCACCCAGGTCCCCTACACAGGGAAAGGTCACAGGGTCCGGCGGGTGAAGG
CCTGCAGACCCCGCTCCTCAGATGGCAAAGCTGCACTTTGAACCTGGGTTCCTCCCAGGGTC

hide sequence

RefSeq Acc Id:

XM_039105138 ⟹ XP_038961066

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	175,724,939 - 175,751,749 (-)	NCBI
mRatBN7.2	3	155,306,954 - 155,332,712 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001129190	(Get FASTA)	NCBI Sequence Viewer
	XP_038961066	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL96434	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009517.8
	ENSRNOP00000096783
	ENSRNOP00000096783.1
	ENSRNOP00000102009.1

RefSeq Acc Id:

NP_001129190 ⟸ NM_001135718

- UniProtKB:

A0A8I6GLR6 (UniProtKB/TrEMBL), D3ZS72 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEAPGSGSGDGGGDPGGDGAHPDARGPSSGPCAAARDSERQLRLRLCVLNEILATERDYVGTLR
FLQSAFLQRIRQNVADSVDKGLTEENVKILFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGN
VFLKFKDKFCVYEEYCSNHEKALRLLVELNKVPAARAFLLNCMLLGGRKTTDIPLEGYLLSPIQ
RICKYPLLLKELSKRTPGKHPDHSAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWE
GSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLY
IFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDALIR
EREQRESLKLGMERDAYVMIAEKGEKLYHMMMSKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLE
IGEISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRL
YCRLHSLYAPVIKDRDYHLKTYKSVVPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVL
EKSEFKDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLIPPQEDDYGFDLEEKNKA
VVVKSVQRGSLAEMAGLQAGRKIYSINEDLVFLRPFSEVETILNQSFCSRRPLRLLVATKAKET
IKIPDHPEALSFQIRGTAPPCVFAVGRGSEAVAAGLCAGQCILKVNGNSVANDGALEVLEHFQA
FRSRREEALGLYQWVYHSHEDAQQARASQGAPDEDPQEDDSVLPLLSLGPQLSLHEDSAVVSLT
LDNVHLEHGVVYEYVSTAGAKCHVLEKIVEPRGCFRLAAKILEAFAEDDSLFVQNCGRLMAMGS
AIITMSHYEFHNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEDHPLCGLDFCPTNCH
INFMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMAYTQHCITTMAAPSWKCAPAVD
GDSQSQGLIDSIFVSASGALSQQERGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQIN
RLLSTITEPTSAAPCDPPLVEETSSSPPASEESEVDRTDHGGIKKVCFKVSEDEQEDSGHDTMS
YRDSYSECNSNRDSVLSYTSVRSNSSYLGSDETGSGDELPCDIRIPSDKQDKLHGCLEHLFNQV
DSIHALLKGPVMSRAFEETRHFPMEHSWQEFKQKEECTVRGRNLIQISIQEDPWNLPSSIRTLV
DNIQRYVEDGKNQLLLALLKCTDTELQLRRDAVFCQALVAAVCTFSEQLLAALDYRYNNNGEYE
ESSRDASRKWLEQVAATGVLLHWQSLLAPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENSV
ANTNVFYHIEGSRQALKVVFYLDGFHFSRLPSRLEGGASLRLHTVLFTKALENVEGPSPPGSQA
AEDLQQEINAQSLEKVQQYYRRLRAFYLERSNLPTDATTTAVKIDQLIRPINALDELYRLMKSF
VHPKAGAGGSLGAGLVPVSSELCYRLGACQITMCGTGMQRSTLSVSLEQAAILARSHGLLPKCV
MQATDIMRKQGPRVEILAKNLRIKDPMPQGAPRLYRLCQPPVDGDL

hide sequence

Ensembl Acc Id:

ENSRNOP00000009517 ⟸ ENSRNOT00000009517

RefSeq Acc Id:	XP_038961066 ⟸ XM_039105138
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000096783 ⟸ ENSRNOT00000108011

Ensembl Acc Id:

ENSRNOP00000102009 ⟸ ENSRNOT00000151804

Protein Domains

DEP DH PDZ PH

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZS72-F1-model_v2	AlphaFold	D3ZS72	1-1643	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692684

Promoter ID:

EPDNEW_R3209

Type:

initiation region

Name:

Prex1_1

Description:

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchangefactor 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	163,477,800 - 163,477,860	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306534	AgrOrtholog
BioCyc Gene	G2FUF-46766	BioCyc
Ensembl Genes	ENSRNOG00000006952	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000009517.9	UniProtKB/TrEMBL
	ENSRNOT00000108011	ENTREZGENE
	ENSRNOT00000108011.2	UniProtKB/TrEMBL
	ENSRNOT00000151804.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
	1.20.900.10	UniProtKB/TrEMBL
	2.30.29.30	UniProtKB/TrEMBL
	2.30.42.10	UniProtKB/TrEMBL
InterPro	DBL_dom_sf	UniProtKB/TrEMBL
	DEP_dom	UniProtKB/TrEMBL
	DH-domain	UniProtKB/TrEMBL
	GDS_CDC24_CS	UniProtKB/TrEMBL
	mTOR-Rac_regulators	UniProtKB/TrEMBL
	PDZ/DHR/GLGF	UniProtKB/TrEMBL
	PDZ_sf	UniProtKB/TrEMBL
	PH_dom-like	UniProtKB/TrEMBL
	Pleckstrin_homology	UniProtKB/TrEMBL
	SOS1_NGEF_PH	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
KEGG Report	rno:311647	UniProtKB/TrEMBL
NCBI Gene	311647	ENTREZGENE
PANTHER	DEP DOMAIN PROTEIN	UniProtKB/TrEMBL
	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN	UniProtKB/TrEMBL
Pfam	DEP	UniProtKB/TrEMBL
	RhoGEF	UniProtKB/TrEMBL
	SOS1_NGEF_PH	UniProtKB/TrEMBL
PhenoGen	Prex1	PhenoGen
PROSITE	DEP	UniProtKB/TrEMBL
	DH_1	UniProtKB/TrEMBL
	DH_2	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
	PH_DOMAIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000006952	RatGTEx
SMART	DEP	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
	RhoGEF	UniProtKB/TrEMBL
	SM00233	UniProtKB/TrEMBL
Superfamily-SCOP	DH-domain	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
	PH domain-like	UniProtKB/TrEMBL
	SSF46785	UniProtKB/TrEMBL
UniProt	A0A8I6GLR6	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LF47_RAT	UniProtKB/TrEMBL
	D3ZS72	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-12-01	Prex1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	RGD1306534	similar to P-Rex1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1306534	similar to P-Rex1	RGD1306534_predicted	similar to P-Rex1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-20	RGD1306534_predicted	similar to P-Rex1 (predicted)	LOC311647_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC311647_predicted	similar to P-Rex1 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - KEGG (archival)