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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306534
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prex1
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prex1affects expressionISOPREX1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the expression of PREX1 mRNAPMID:22316170
Prex1affects methylationISOPREX1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of PREX1 exon; Benzo(a)pyrene affects the methylation of PREX1 intronPMID:30157460
Prex1decreases expressionISOPREX1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of PREX1 mRNAPMID:20064835
Prex1decreases methylationISOPrex1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased methylation of PREX1 intronPMID:27901495
Prex1decreases methylationISOPREX1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of PREX1 promoterPMID:27901495
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