Trdmt1 (tRNA aspartic acid methyltransferase 1)

Gene: Trdmt1 (tRNA aspartic acid methyltransferase 1) Rattus norvegicus

Analyze

Symbol:

Trdmt1

Name:

tRNA aspartic acid methyltransferase 1

RGD ID:

1306292

Description:

Predicted to enable tRNA (cytidine-5-)-methyltransferase activity. Involved in response to amphetamine. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human TRDMT1 (tRNA aspartic acid methyltransferase 1); PARTICIPATES IN homocysteine metabolic pathway; methionine cycle/metabolic pathway; cysteine and methionine metabolic pathway; INTERACTS WITH aflatoxin B1; allethrin; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

DNA (cytosine-5)-methyltransferase-like protein 2; DNA methyltransferase 2; Dnmt2; LOC291324; MGC112666; tRNA (cytosine(38)-C(5))-methyltransferase; tRNA (cytosine-5-)-methyltransferase

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	81,510,740 - 81,554,036 (-)	NCBI		GRCr8
mRatBN7.2	17	76,601,966 - 76,646,104 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	76,610,543 - 76,645,439 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	80,085,168 - 80,118,000 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	83,920,574 - 83,953,406 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	77,968,474 - 78,001,306 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	80,824,652 - 80,859,585 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	80,826,846 - 80,860,195 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	82,445,133 - 82,478,017 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	87,791,647 - 87,824,484 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	87,802,488 - 87,835,316 (-)	NCBI
Celera	17	75,981,585 - 76,014,443 (-)	NCBI		Celera
Cytogenetic Map	17	q12.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

hypoparathyroidism-deafness-renal disease syndrome (ISO)

Imerslund-Grasbeck Syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

acrylamide (ISO)

aflatoxin B1 (EXP,ISO)

allethrin (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

chromium(6+) (ISO)

curcumin (ISO)

cyclosporin A (ISO)

cyhalothrin (EXP)

cypermethrin (EXP)

DDT (EXP)

dibutyl phthalate (ISO)

diethyl maleate (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

ethyl methanesulfonate (ISO)

fenarimol (EXP)

fenvalerate (EXP)

flusilazole (EXP)

folic acid (ISO)

irinotecan (ISO)

L-methionine (ISO)

levetiracetam (EXP)

mercury dichloride (ISO)

methapyrilene (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

Monobutylphthalate (EXP)

morphine (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenylmercury acetate (ISO)

potassium chromate (ISO)

propiconazole (EXP)

pyrethrins (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP)

thimerosal (ISO)

trichostatin A (ISO)

tungsten (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

methylation (IEA)

response to amphetamine (IEP)

tRNA methylation (ISO,ISS)

tRNA stabilization (ISO,ISS)

Cellular Component

cytoplasm (ISO)

nucleus (IBA,IEA)

Molecular Function

methyltransferase activity (IEA)

RNA binding (IEA)

tRNA (cytidine-5-)-methyltransferase activity (ISO,ISS)

tRNA methyltransferase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

cysteine and methionine metabolic pathway (IEA)

homocysteine metabolic pathway (ISO)

methionine cycle/metabolic pathway (ISO)

External Pathway Database Links

KEGG Pathway

Cysteine and methionine metabolism

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	The human Dnmt2 has residual DNA-(cytosine-C5) methyltransferase activity.	Hermann A, etal., J Biol Chem 2003 Aug 22;278(34):31717-21. Epub 2003 Jun 6.
4.	Psychostimulant alters expression of DNA methyltransferase mRNA in the rat brain.	Numachi Y, etal., Ann N Y Acad Sci. 2004 Oct;1025:102-9.
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:16424344	PMID:18567810	PMID:22885326	PMID:35474613

Genomics

Comparative Map Data

Trdmt1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	81,510,740 - 81,554,036 (-)	NCBI		GRCr8
mRatBN7.2	17	76,601,966 - 76,646,104 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	76,610,543 - 76,645,439 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	80,085,168 - 80,118,000 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	83,920,574 - 83,953,406 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	77,968,474 - 78,001,306 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	80,824,652 - 80,859,585 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	80,826,846 - 80,860,195 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	82,445,133 - 82,478,017 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	87,791,647 - 87,824,484 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	87,802,488 - 87,835,316 (-)	NCBI
Celera	17	75,981,585 - 76,014,443 (-)	NCBI		Celera
Cytogenetic Map	17	q12.3	NCBI

TRDMT1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	17,137,336 - 17,201,672 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	17,137,336 - 17,202,054 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	17,179,335 - 17,243,671 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	17,224,988 - 17,283,687 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	10	17,118,228 - 17,177,333 (-)	NCBI		Celera
Cytogenetic Map	10	p13	NCBI
HuRef	10	17,098,163 - 17,157,293 (-)	NCBI		HuRef
CHM1_1	10	17,185,114 - 17,244,194 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	17,155,855 - 17,220,211 (-)	NCBI		T2T-CHM13v2.0

Trdmt1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	13,509,690 - 13,549,475 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	13,513,825 - 13,549,479 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	13,504,879 - 13,544,797 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	13,509,014 - 13,544,668 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	13,431,788 - 13,466,291 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	13,428,017 - 13,462,517 (-)	NCBI		MGSCv36	mm8
Celera	2	13,420,290 - 13,454,789 (-)	NCBI		Celera
Cytogenetic Map	2	A1	NCBI
cM Map	2	10.0	NCBI

Trdmt1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955429	10,742,097 - 10,771,877 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955429	10,741,512 - 10,774,268 (+)	NCBI	ChiLan1.0	ChiLan1.0

TRDMT1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	29,989,412 - 30,044,694 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	29,985,157 - 30,050,016 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	17,460,091 - 17,518,855 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	17,726,701 - 17,791,345 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	17,738,374 - 17,791,345 (-)	Ensembl	panpan1.1		panPan2

TRDMT1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	19,702,561 - 19,763,744 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	19,677,444 - 19,763,741 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	16,806,079 - 16,867,665 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	19,994,579 - 20,056,169 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	19,999,196 - 20,057,521 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	17,196,915 - 17,258,530 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	18,035,155 - 18,097,023 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	18,653,004 - 18,714,640 (+)	NCBI		UU_Cfam_GSD_1.0

Trdmt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	17,839,758 - 17,856,427 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936520	10,104,050 - 10,122,057 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRDMT1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	43,434,444 - 43,493,892 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	43,434,148 - 43,494,924 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	48,148,992 - 48,157,057 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TRDMT1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	17,098,086 - 17,166,267 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	17,100,491 - 17,155,826 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666051	22,733,372 - 22,794,872 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Trdmt1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624796	10,656,432 - 10,710,124 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624796	10,630,982 - 10,712,689 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Trdmt1
289 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	274
Count of miRNA genes:	170
Interacting mature miRNAs:	192
Transcripts:	ENSRNOT00000038651
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724549	Niddm56	Non-insulin dependent diabetes mellitus QTL 56		0.03	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	31990784	76990784	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	31990784	81292925	Rat
2301412	Kidm40	Kidney mass QTL 40		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	37479847	82479847	Rat
2317054	Aia12	Adjuvant induced arthritis QTL 12	4.24		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	38281509	83281509	Rat
2317060	Aia26	Adjuvant induced arthritis QTL 26	3.22		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	17	38281509	83281509	Rat
1598871	Memor5	Memory QTL 5	5.3		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	17	40540041	80387013	Rat
1358295	Aocep1	Aortic cell protein QTL 1	6.1	0.00000071	thoracic aorta cellular protein amount (VT:0010598)	aortic cell percentage	17	40990005	85990005	Rat
7411575	Bw140	Body weight QTL 140	30.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	48560935	86533673	Rat
8694181	Bw151	Body weight QTL 151	4.36	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	48560935	86533673	Rat
2317038	Ginf3	Gastrointestinal inflammation QTL 3	2.89	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	17	49920154	86533673	Rat
2303580	Gluco49	Glucose level QTL 49	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	50040271	86533673	Rat
4889894	Eae33	Experimental allergic encephalomyelitis QTL 33	5.2	0.0001	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	50909099	86022412	Rat
1354588	Bvd4	Brain ventricular dilatation QTL 4	5.31	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	53498828	82479847	Rat
2302365	Gluco40	Glucose level QTL 40	4.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	57246843	82046127	Rat
7488963	Bp369	Blood pressure QTL 369		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	59005649	77910000	Rat
2317045	Aia11	Adjuvant induced arthritis QTL 11	4.06		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	60781426	86533673	Rat
7411577	Bw141	Body weight QTL 141		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	62619516	86533673	Rat
631502	Cm26	Cardiac mass QTL 26	3.71		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	65703580	81153923	Rat
1300129	Rf25	Renal function QTL 25	3.03		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	17	71003325	81153923	Rat
12904736	Cm121	Cardiac mass QTL 121		0.043	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	71774621	82479847	Rat

Markers in Region

RH128044

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	76,612,780 - 76,612,970 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	80,826,895 - 80,827,084	NCBI	Rnor6.0
Rnor_5.0	17	82,445,279 - 82,445,468	UniSTS	Rnor5.0
RGSC_v3.4	17	87,791,793 - 87,791,982	UniSTS	RGSC3.4
Celera	17	75,981,731 - 75,981,920	UniSTS
RH 3.4 Map	17	773.0	UniSTS
Cytogenetic Map	17	q12.3	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			9	2	16	2			71	20	32	10
Low	3	43	48	39	3	39	8	11	3	15	9	1	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001031643	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017600497	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276249	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276250	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276251	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276252	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC096804	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000038651 ⟹ ENSRNOP00000038279

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	76,610,543 - 76,645,439 (-)	Ensembl
Rnor_6.0 Ensembl	17	80,826,846 - 80,860,195 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000112273 ⟹ ENSRNOP00000077582

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	76,610,543 - 76,645,439 (-)	Ensembl

RefSeq Acc Id:

NM_001031643 ⟹ NP_001026813

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	81,521,200 - 81,554,036 (-)	NCBI
mRatBN7.2	17	76,612,635 - 76,645,471 (-)	NCBI
Rnor_6.0	17	80,826,749 - 80,859,585 (-)	NCBI
Rnor_5.0	17	82,445,133 - 82,478,017 (-)	NCBI
RGSC_v3.4	17	87,791,647 - 87,824,484 (-)	RGD
Celera	17	75,981,585 - 76,014,443 (-)	RGD

Sequence:

show sequence

CTAGTTTCCAGGCCGCGGTCGCGGTTGCGAGAGGATGGAACCTCTGCGTGTCCTGGAGCTGTAC
AGTGGCATTGGGGGCATGCACCACGCGCTGCGAGAAAGCCGTGTCCCTGCACATGTGGTGGCTG
CTATTGACGTGAGCACTGTTGCTAACGAAGTATACAAGCATAACTTCCCTCATACACACTTACT
GGCAAAGACAATCGAAGGTATTTCACTGGAAGAGTTTGACAAGCTATCTTTCAATATGATTTTA
ATGAGCCCTCCATGTCAGCCATTCACAAGAATTGGCCTACAGGGGGACATGAGTGATCGAAGGA
CAAATAGCTTCTTGTATATTCTAGATATTCTCCCAAGGTTACAGAAGTTACCCAAGTATATTCT
TTTAGAAAATGTCAAAGGGTTTGAAGTTTCTTCTACAAGAGGGCTGCTGATACAAACAATGGAA
GCCTGCGGCTTTCAGTATCAAGAGTTTCTGTTGTCTCCGTCCTCTCTAGGCATTCCAAACTCAA
GGCTACGGTATTTTCTCATTGCGAAGCTTCAGTCAGAGCCTCTCTGTTTCCAGGCCCCTGGCCA
GATACTGATGGAGTTTCCTAATAGTGGAACAGTTCAGCCACAAGAATATGCAGTAGTTGAAGAA
GGCAAGCTGAGAGTGAGGACAAGGGAGCCAGATGTCTGCCTTGATAGCAGCAGCACCCAGTGCT
CTGGACAAGATAGCATTCTTTTTAAGCACGAGACTGCAGCAGACATTGACAGGAAGCGCCAACA
GGACAGTGACCTCTCTGTGCAGATGCTGAAAGGTTTCCTTGAAGATGGTGACACAGCTCAGTAC
CTTCTGCCAGCGAAGTCGCTGCTGCGCTACGCTCTCCTCCTCGACATCGTTAAGCCCACCTCCA
GGAGGTCCATGTGCTTCACTAAAGGGTATGGAAGCTACATAGAAGGGACAGGCTCTGTGTTACA
GACTGCAGAGGATGTGCAGATTGAGAATATCTACAAATCTCTTCCTGATTTGCCACCAGAAGAG
AAGATAGCTAAATTGTCAATGCTTAAACTGCGATATTTCACACCTAAAGAAATTGCAAATCTCC
TGGGATTTCCTCCAGAATTTGGGTTTCCTGAGAAGACAACGGTGAAGCAGCGTTACCGGCTGCT
CGGCAACAGCCTCAACGTGCATGTCGTCTCAAAGCTCCTTACAGTCCTGTGTGAGTGAGAGACG
TGGGAGAGCCGCTGAGGCGTCAGAGTATGCCTCTAATTCTAGACAGTCATCCCAAAATTCTATC
TTGAATTAATTCTTATAAAACTCAACTAAATTATTTTAGTTGCGTTTTAGCGGGTAATTCAGAG
GGAACTTAAATGTGCATATCTTATTGTTTCCTTAAATTTATATTACTGTATCTGACAAACTTCA
CATTGCTGTTTTTGCTTTATGGGCAAATATTTTTTATAAAGCTTTAAACATGTACATTAAATAT
TTTATATTTTGCTATAAACAAATTTAAGAATGTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063276249 ⟹ XP_063132319

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	81,519,103 - 81,547,417 (-)	NCBI

RefSeq Acc Id:

XM_063276250 ⟹ XP_063132320

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	81,510,740 - 81,547,419 (-)	NCBI

RefSeq Acc Id:

XM_063276251 ⟹ XP_063132321

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	81,519,103 - 81,553,915 (-)	NCBI

RefSeq Acc Id:

XM_063276252 ⟹ XP_063132322

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	81,519,103 - 81,531,324 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001026813	(Get FASTA)	NCBI Sequence Viewer
	XP_063132319	(Get FASTA)	NCBI Sequence Viewer
	XP_063132320	(Get FASTA)	NCBI Sequence Viewer
	XP_063132321	(Get FASTA)	NCBI Sequence Viewer
	XP_063132322	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98700	(Get FASTA)	NCBI Sequence Viewer
	EDL78719	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000038279
	ENSRNOP00000038279.4
	ENSRNOP00000077582.1
GenBank Protein	Q4G073	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001026813 ⟸ NM_001031643

- UniProtKB:

Q4G073 (UniProtKB/Swiss-Prot), A6JM42 (UniProtKB/TrEMBL), A0A8I5YBX0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEPLRVLELYSGIGGMHHALRESRVPAHVVAAIDVSTVANEVYKHNFPHTHLLAKTIEGISLEE
FDKLSFNMILMSPPCQPFTRIGLQGDMSDRRTNSFLYILDILPRLQKLPKYILLENVKGFEVSS
TRGLLIQTMEACGFQYQEFLLSPSSLGIPNSRLRYFLIAKLQSEPLCFQAPGQILMEFPNSGTV
QPQEYAVVEEGKLRVRTREPDVCLDSSSTQCSGQDSILFKHETAADIDRKRQQDSDLSVQMLKG
FLEDGDTAQYLLPAKSLLRYALLLDIVKPTSRRSMCFTKGYGSYIEGTGSVLQTAEDVQIENIY
KSLPDLPPEEKIAKLSMLKLRYFTPKEIANLLGFPPEFGFPEKTTVKQRYRLLGNSLNVHVVSK
LLTVLCE

hide sequence

RefSeq Acc Id:

ENSRNOP00000038279 ⟸ ENSRNOT00000038651

RefSeq Acc Id:

ENSRNOP00000077582 ⟸ ENSRNOT00000112273

RefSeq Acc Id:	XP_063132320 ⟸ XM_063276250
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063132321 ⟸ XM_063276251
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063132319 ⟸ XM_063276249
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063132322 ⟸ XM_063276252
- Peptide Label:	isoform X4

Protein Domains

SAM-dependent MTase C5-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4G073-F1-model_v2	AlphaFold	Q4G073	1-391	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700595

Promoter ID:

EPDNEW_R11119

Type:

single initiation site

Name:

Trdmt1_1

Description:

tRNA aspartic acid methyltransferase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	80,859,582 - 80,859,642	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306292	AgrOrtholog
BioCyc Gene	G2FUF-8608	BioCyc
Ensembl Genes	ENSRNOG00000026132	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000038651	ENTREZGENE
	ENSRNOT00000038651.6	UniProtKB/Swiss-Prot
	ENSRNOT00000112273.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.150	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DNA Methylase, subunit A, domain 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7387075	IMAGE-MGC_LOAD
InterPro	C5_MeTfrase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	C5_meth_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SAM-dependent_MTases	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:291324	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:112666	IMAGE-MGC_LOAD
NCBI Gene	291324	ENTREZGENE
PANTHER	TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE	UniProtKB/Swiss-Prot
	TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE	UniProtKB/Swiss-Prot
	TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE	UniProtKB/TrEMBL
	TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE	UniProtKB/TrEMBL
Pfam	DNA_methylase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Trdmt1	PhenoGen
PRINTS	C5METTRFRASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	C5_MTASE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SAM_MT_C5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000026132	RatGTEx
Superfamily-SCOP	SSF53335	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5YBX0	ENTREZGENE, UniProtKB/TrEMBL
	A6JM42	ENTREZGENE, UniProtKB/TrEMBL
	Q4G073	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-04	Trdmt1	tRNA aspartic acid methyltransferase 1	Dnmt2	DNA methyltransferase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Dnmt2	DNA methyltransferase 2	Dnmt2_predicted	DNA methyltransferase 2 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Dnmt2_predicted	DNA methyltransferase 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

External Pathway Database Links

External Pathway Database Links

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

External Pathway Database Links

External Pathway Database Links