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Gene: Tmem163 (transmembrane protein 163) Rattus norvegicus

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Symbol:

Tmem163

Name:

transmembrane protein 163

RGD ID:

1306212

Description:

Enables zinc ion binding activity. Involved in zinc ion import into synaptic vesicle. Located in early endosome membrane. Is active in synaptic vesicle membrane. Used to study proteinuria. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 25. Orthologous to human TMEM163 (transmembrane protein 163); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC360839; RGD1306212; similar to hypothetical protein DKFZp566N034; Sv31; synaptic vesicle membrane protein of 31 kDa; synaptic vesicle protein of 30 kD

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TMEM163 (transmembrane protein 163)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Tmem163 (transmembrane protein 163)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tmem163 (transmembrane protein 163)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TMEM163 (transmembrane protein 163)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TMEM163 (transmembrane protein 163)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tmem163 (transmembrane protein 163)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TMEM163 (transmembrane protein 163)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TMEM163 (transmembrane protein 163)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tmem163 (transmembrane protein 163)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Tmem163 (transmembrane protein 163)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Tmem163 (transmembrane protein 163)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TMEM163 (transmembrane protein 163)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tmem163b (transmembrane protein 163b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tmem163a (transmembrane protein 163a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tmem163a (transmembrane protein 163a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tmem163	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	tmem163	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Candidate Gene For:

Bp401

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	41,520,595 - 41,693,938 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	41,520,359 - 41,693,938 (-)	Ensembl				GRCr8
mRatBN7.2	13	38,967,913 - 39,141,664 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	38,968,101 - 39,141,452 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	41,550,247 - 41,724,197 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	42,838,349 - 43,012,290 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	40,104,163 - 40,278,089 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	44,166,306 - 44,345,735 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	44,166,306 - 44,345,735 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	49,258,672 - 49,433,018 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	40,144,073 - 40,327,947 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	39,345,427 - 39,519,218 (-)	NCBI		Celera
RGSC_v3.1	13	40,158,648 - 40,363,296 (-)	NCBI
Cytogenetic Map	13	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hypomyelinating leukodystrophy 25 (ISO)

proteinuria (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

(1->4)-beta-D-glucan (ISO)

(S)-nicotine (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,4'-trichlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (EXP,ISO)

amitrole (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

arsenous acid (ISO)

atrazine (EXP)

benzo[a]pyrene (EXP,ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bisphenol F (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

cefaloridine (EXP)

choline (ISO)

cisplatin (EXP)

cobalt dichloride (EXP)

cylindrospermopsin (ISO)

diarsenic trioxide (ISO)

dorsomorphin (ISO)

entinostat (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

furan (EXP)

genistein (ISO)

hexadecanoic acid (ISO)

indole-3-methanol (EXP)

L-methionine (ISO)

mercury dibromide (ISO)

methapyrilene (ISO)

methimazole (EXP)

morphine (ISO)

nicotine (ISO)

p-chloromercuribenzoic acid (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

PCB138 (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (EXP)

phenylmercury acetate (ISO)

potassium bromate (EXP)

progesterone (ISO)

SB 431542 (ISO)

sodium dichromate (EXP)

sulfadimethoxine (EXP)

sunitinib (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triclosan (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vincristine (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intracellular zinc ion homeostasis (IEA,ISO)

myelination (IEA,ISO,ISS)

zinc export across plasma membrane (IEA,ISO,ISS)

zinc ion import into synaptic vesicle (IDA,IMP)

Cellular Component

cytoplasmic vesicle (IEA)

early endosome membrane (IDA,IEA)

intracellular vesicle (IEA,ISO)

late endosome (IEA,ISO)

late endosome membrane (IEA)

lysosomal membrane (IEA)

lysosome (IEA,ISO)

plasma membrane (IEA,ISO)

synaptic vesicle membrane (IBA,IDA,IEA,IEP,ISO)

Molecular Function

protein binding (ISO)

zinc ion binding (IBA,IDA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

salt-sensitive hypertension (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	SV31 is a Zn2+-binding synaptic vesicle protein.	Barth J, etal., J Neurochem. 2011 Aug;118(4):558-70. doi: 10.1111/j.1471-4159.2011.07344.x. Epub 2011 Jul 1.
2.	Identification and characterization of SV31, a novel synaptic vesicle membrane protein and potential transporter.	Burre J, etal., J Neurochem. 2007 Oct;103(1):276-87. Epub 2007 Jul 10.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl SS-13BN congenic strains.	Moreno C, etal., Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5. doi: 10.1152/ajpheart.01026.2010. Epub 2011 Jan 21.
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	The synaptic vesicle protein SV31 assembles into a dimer and transports Zn2.	Waberer L, etal., J Neurochem. 2017 Jan;140(2):280-293. doi: 10.1111/jnc.13886. Epub 2016 Dec 5.

Additional References at PubMed

PMID:17080482	PMID:17110340	PMID:18064521	PMID:25130899

Genomics

Comparative Map Data

Tmem163
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	41,520,595 - 41,693,938 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	41,520,359 - 41,693,938 (-)	Ensembl				GRCr8
mRatBN7.2	13	38,967,913 - 39,141,664 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	38,968,101 - 39,141,452 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	41,550,247 - 41,724,197 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	42,838,349 - 43,012,290 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	40,104,163 - 40,278,089 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	44,166,306 - 44,345,735 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	44,166,306 - 44,345,735 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	49,258,672 - 49,433,018 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	40,144,073 - 40,327,947 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	39,345,427 - 39,519,218 (-)	NCBI		Celera
RGSC_v3.1	13	40,158,648 - 40,363,296 (-)	NCBI
Cytogenetic Map	13	q13	NCBI

TMEM163
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	134,455,759 - 134,719,000 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	134,455,759 - 134,719,100 (-)	Ensembl			hg38	GRCh38
GRCh37	2	135,213,330 - 135,476,570 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	134,930,030 - 135,193,040 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	2	128,926,002 - 129,189,469 (-)	NCBI		Celera
Cytogenetic Map	2	q21.3	NCBI
HuRef	2	127,206,130 - 127,468,192 (-)	NCBI		HuRef
CHM1_1	2	135,217,959 - 135,481,287 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	134,895,326 - 135,159,268 (-)	NCBI		T2T-CHM13v2.0

Tmem163
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	127,418,079 - 127,605,758 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	127,414,283 - 127,607,285 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	127,490,342 - 127,678,021 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	127,486,546 - 127,679,548 (-)	Ensembl			mm10	GRCm38
MGSCv37	1	129,386,919 - 129,574,598 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	129,314,097 - 129,505,567 (-)	NCBI		MGSCv36	mm8
Celera	1	130,139,903 - 130,318,056 (-)	NCBI		Celera
Cytogenetic Map	1	E3	NCBI
cM Map	1	55.77	NCBI

Tmem163
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955440	2,007,097 - 2,240,275 (-)	Ensembl
ChiLan1.0	NW_004955440	2,006,152 - 2,240,209 (-)	NCBI	ChiLan1.0	ChiLan1.0

TMEM163
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	40,207,253 - 40,464,519 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	40,222,232 - 40,479,489 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	25,138,333 - 25,393,295 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	138,545,761 - 138,793,811 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

TMEM163
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	37,335,608 - 37,744,291 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	37,336,598 - 37,562,509 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	37,576,037 - 37,799,910 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	38,780,404 - 39,005,058 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	38,780,415 - 39,039,513 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	37,423,032 - 37,647,603 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	37,583,925 - 37,808,428 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	38,812,101 - 39,036,892 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tmem163
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	83,520,586 - 83,735,621 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936469	57,882,130 - 58,097,965 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMEM163
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	17,262,138 - 17,543,398 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	15	17,260,885 - 17,548,920 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	19,811,516 - 20,021,754 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMEM163
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	18,692,742 - 18,950,099 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666061	3,553,990 - 3,812,202 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmem163
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624732	33,904,224 - 34,143,441 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624732	33,903,263 - 34,143,635 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tmem163
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	8,075,735 - 8,250,199 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tmem163
1256 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	235
Count of miRNA genes:	158
Interacting mature miRNAs:	171
Transcripts:	ENSRNOT00000005006
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37216241	90057603	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	11866254	56866254	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	24853925	69853925	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	39968211	83286298	Rat
1300163	Cardf1	Cardiac cell morphology QTL 1	4.18		aorta morphology trait (VT:0000272)	artery lesion measurement (CMO:0000975)	13	12448421	47969993	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	17468282	62468282	Rat
2303030	Bp327	Blood pressure QTL 327			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	43736554	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
61339	Bp24	Blood pressure QTL 24		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	6002008	47359539	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	24335432	55601132	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37087983	82087983	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	40983585	85983585	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	12448421	48744906	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	26244808	71244808	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	33794096	78794096	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	34834947	79834947	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
2301962	Cm72	Cardiac mass QTL 72	4.12		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	13	33794096	60914504	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879471	Bp398	Blood pressure QTL 398			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	3088755	48088755	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	39814726	84814726	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	39968211	84968211	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	26244808	71244808	Rat
11530006	Niddm72	Non-insulin dependent diabetes mellitus QTL 72		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	38286298	83286298	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	17711336	62711336	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	11866254	56866254	Rat

Markers in Region

D13Rat147

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	39,138,363 - 39,138,623 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	44,342,655 - 44,342,914	NCBI	Rnor6.0
Rnor_5.0	13	49,429,945 - 49,430,204	UniSTS	Rnor5.0
RGSC_v3.4	13	40,324,394 - 40,324,653	UniSTS	RGSC3.4
RGSC_v3.4	13	40,324,393 - 40,324,654	RGD	RGSC3.4
Celera	13	39,516,118 - 39,516,377	UniSTS
RGSC_v3.1	13	40,338,436 - 40,338,697	RGD
RH 3.4 Map	13	76.5	UniSTS
RH 3.4 Map	13	76.5	RGD
RH 2.0 Map	13	226.7	RGD
SHRSP x BN Map	13	6.8599	RGD
Cytogenetic Map	13	q12	UniSTS

RH139058

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	38,968,188 - 38,968,308 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	44,166,394 - 44,166,513	NCBI	Rnor6.0
Rnor_5.0	13	49,258,760 - 49,258,879	UniSTS	Rnor5.0
RGSC_v3.4	13	40,144,161 - 40,144,280	UniSTS	RGSC3.4
Celera	13	39,345,515 - 39,345,634	UniSTS
RH 3.4 Map	13	73.1	UniSTS
Cytogenetic Map	13	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
13	7	63	154	91	90	59	90	59	4	325	178	11	132	69	79	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001110763	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB294577	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB294578	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000005006 ⟹ ENSRNOP00000005006

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	41,520,359 - 41,693,938 (-)	Ensembl
mRatBN7.2 Ensembl	13	38,968,101 - 39,141,452 (-)	Ensembl
Rnor_6.0 Ensembl	13	44,166,306 - 44,345,735 (-)	Ensembl

RefSeq Acc Id:

NM_001110763 ⟹ NP_001104233

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	41,520,595 - 41,693,938 (-)	NCBI
mRatBN7.2	13	38,968,101 - 39,141,452 (-)	NCBI
Rnor_6.0	13	44,166,306 - 44,345,735 (-)	NCBI
Rnor_5.0	13	49,258,672 - 49,433,018 (-)	NCBI
RGSC_v3.4	13	40,144,073 - 40,327,947 (-)	RGD
Celera	13	39,345,427 - 39,519,218 (-)	RGD

Sequence:

show sequence

CGAGAAGTGAGTGGGGGGCGCGTCCTCCGTCACGCCCTCACCCAGCCCTGCGCAAGCCGCAGGC
TGGTCTCCACGCCCCCTAACAGTCCCTCAGCTTCCGCGGGCTTTGGACCTTCTGGGGCCCTCCC
TCTCCACCCGCCTGGGTGCATCGATCCCGGTGCCCGGGCTCAGCGCCTCGGGGCGGGTCCCTGC
CGCCCGCACCTGCCCCCGGGGGCGGAGCGCAGCGGCGACAGCGCGGCCCCAGCCTCCGCCACAC
GCTGAGCTAGCGGCGGACCTGCCGCTCACCGCGGTCCGGGTGAAGCTCTTTCTCCGCGCCCTCG
GTCCCTGGCACTTCGGACCCGTGTCTCCATCGTGGTCCGCTTCGCCTCGGGGAGGATCTGCAGC
CCCGGCACCATGGAGCGGGCCCCGGGCAGCGAGCGCCGCAGCCCCCCTGGCCCTGGAGTCCCGC
GGCCGCCACCGCGGGGCCACGCGCCCTCGACCGCCGCCCCCGCCCCCAACCCGGCTCCTCTGAG
CTCCTCTATGCAGCCGGACGAGGAGCGGCAGCCGCGGATCAGCGAGAGCGGCCAGTTCAGCGAC
GGGTTTGAGGACCGAGGTTTACTAGAAAGCAGCACCCGGCTGAAACCTCACGAAGCCCAGAACT
ACAGGAAGAAGGCATTGTGGGTATCCTGGCTGTCCATTATTGTCACCCTGGCCCTGGCAGTGGC
CGCCTTCACTGTCTCCGTCATGAGGTACAGCGCCTCTGCCTTCGGGTTTGCATTTGATGCCATC
CTGGATGTGCTGTCCTCGGCCATTGTCCTCTGGCGTTACAGCAACGCAGCCGCCGTGCACTCTG
CTCACAGGGAGTATATAGCCTGTGTCATCTTGGGGGTGATCTTTCTTCTGTCATCTATATGCAT
AGTGGTCAAAGCTATCCATGACCTCTCAACAAGGCTGCTTCCTGAAGTGGACGATTTCCTGTTC
AGCGTCTCCATTTTAAGTGGGATCCTTTGCAGCGTCCTGGCTGTGTTGAAGTTCATGCTGGGGA
AGGTCCTGACAAGCAGAGCTCTCATCACGGATGGGTTCAACTCCCTTGTTGGGGGAGTGATGGG
CTTCTCTATCCTTCTAAGTGCGGAAGTGTTCAAACACAATGCAGCAGTCTGGTACCTGGACGGC
AGCATCGGTGTCCTGATCGGTCTCACCATCTTTGCCTACGGGGTCAAGCTCCTCATCGACATGG
TGCCCAGAGTGAGACAGACGCGTCATTATGAAATGTTTGAGTGAAGGCAGCAGGAAGGGCGGCA
GGGACTGCCCCCTGGTGAAGAGCGTCACTTGACGAGGTTTCCACGCAGGCAGATGGTGCCAACA
TTCAACCGCACATCCAGTTTCATTTTGGGAAGTTTTCGTTCATAGAGTCTGTCATCACGGGATG
AGGTCTGCCTGGAGGCTGGACCTGCCCTACATTCTCACCCAGTCGTCCACCATCAAACACGTTA
GGATGATGTTGCCCATGGGAGGGGCCGCCACGCTTCCCAGTGTGGAGCCGGAAGTGGCTCCCAT
GCTTCCCAATCTTGAGCCGGAAATGACATTTTCATTTCTTGGAGTCAAACAGTTCTCGGAAGCA
GGCTAGGGTCTCTGCTTGACAGGAAGCCACCTATGGTGCTTGCTGTCAGACAAATATAGATTGT
AACTGACCGGGTCACCTCCTCCTGGCACATATGGCCGAGTCACCTCTAGATTCACACTCTAGCA
GATCTCATCAGTAAAGCACTTCCTAACTTCTACCAACCCGTTTCATACACTTTTACTAATCCCA
ACACTAAACAGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001104233	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	A9CMA6	(Get FASTA)	NCBI Sequence Viewer
	BAF94224	(Get FASTA)	NCBI Sequence Viewer
	BAF94244	(Get FASTA)	NCBI Sequence Viewer
	EDM09891	(Get FASTA)	NCBI Sequence Viewer
	EDM09892	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000005006
	ENSRNOP00000005006.4

RefSeq Acc Id:

NP_001104233 ⟸ NM_001110763

- UniProtKB:

A9CMA6 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MERAPGSERRSPPGPGVPRPPPRGHAPSTAAPAPNPAPLSSSMQPDEERQPRISESGQFSDGFE
DRGLLESSTRLKPHEAQNYRKKALWVSWLSIIVTLALAVAAFTVSVMRYSASAFGFAFDAILDV
LSSAIVLWRYSNAAAVHSAHREYIACVILGVIFLLSSICIVVKAIHDLSTRLLPEVDDFLFSVS
ILSGILCSVLAVLKFMLGKVLTSRALITDGFNSLVGGVMGFSILLSAEVFKHNAAVWYLDGSIG
VLIGLTIFAYGVKLLIDMVPRVRQTRHYEMFE

hide sequence

Ensembl Acc Id:

ENSRNOP00000005006 ⟸ ENSRNOT00000005006

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A9CMA6-F1-model_v2	AlphaFold	A9CMA6	1-288	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306212	AgrOrtholog
BioCyc Gene	G2FUF-18437	BioCyc
Ensembl Genes	ENSRNOG00000003769	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000005006	ENTREZGENE
	ENSRNOT00000005006.5	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.1510.10	UniProtKB/Swiss-Prot
InterPro	Cation_efflux_TMD_sf	UniProtKB/Swiss-Prot
	Tmem163	UniProtKB/Swiss-Prot
KEGG Report	rno:360839	UniProtKB/Swiss-Prot
NCBI Gene	360839	ENTREZGENE
PANTHER	PTHR31937	UniProtKB/Swiss-Prot
	TRANSMEMBRANE PROTEIN 163	UniProtKB/Swiss-Prot
PhenoGen	Tmem163	PhenoGen
RatGTEx	ENSRNOG00000003769	RatGTEx
Superfamily-SCOP	SSF161111	UniProtKB/Swiss-Prot
UniProt	A9CMA6	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-07	Tmem163	transmembrane protein 163	RGD1306212_predicted	similar to hypothetical protein DKFZp566N034 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	RGD1306212_predicted	similar to hypothetical protein DKFZp566N034 (predicted)	LOC360839_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC360839_predicted	similar to hypothetical protein DKFZp566N034 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

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Mammalian Phenotype