RGD Reference Report - Identification and characterization of SV31, a novel synaptic vesicle membrane protein and potential transporter. - Rat Genome Database

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Identification and characterization of SV31, a novel synaptic vesicle membrane protein and potential transporter.

Authors: Burre, J  Zimmermann, H  Volknandt, W 
Citation: Burre J, etal., J Neurochem. 2007 Oct;103(1):276-87. Epub 2007 Jul 10.
RGD ID: 8553964
Pubmed: PMID:17623043   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1471-4159.2007.04758.x   (Journal Full-text)

Synaptic vesicle proteins govern all relevant functions of the synaptic vesicle life cycle, including vesicle biogenesis, vesicle transport, uptake and storage of neurotransmitters, and regulated endocytosis and exocytosis. In spite of impressive progress made in the past years, not all known vesicular functions can be assigned to defined protein components, suggesting that the repertoire of synaptic vesicle proteins is still incomplete. We have identified and characterized a novel synaptic vesicle membrane protein of 31 kDa with six putative transmembrane helices that, according to its membrane topology and phylogenetic relation, may function as a vesicular transporter. The vesicular allocation is demonstrated by subcellular fractionation, heterologous expression, immunocytochemical analysis of brain sections and immunoelectron microscopy. The protein is expressed in select brain regions and contained in subpopulations of nerve terminals that immunostain for the vesicular glutamate transporter 1 and the vesicular GABA transporter VGaT (vesicular amino acid transporter) and may attribute specific and as yet undiscovered functions to subsets of glutamatergic and GABAergic synapses.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
synaptic vesicle membrane is_active_inIDA 8553964PMID:17623043SynGO 
synaptic vesicle membrane is_active_inIEP 8553964PMID:17623043SynGO 
synaptic vesicle membrane located_inIDA 8553964PMID:17623043UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Tmem163  (transmembrane protein 163)


Additional Information