Tiparp (TCDD-inducible poly(ADP-ribose) polymerase) - Rat Genome Database

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Gene: Tiparp (TCDD-inducible poly(ADP-ribose) polymerase) Rattus norvegicus
Analyze
Symbol: Tiparp
Name: TCDD-inducible poly(ADP-ribose) polymerase
RGD ID: 1306171
Description: Predicted to enable NAD+ poly-ADP-ribosyltransferase activity; NAD+-protein-cysteine ADP-ribosyltransferase activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in response to 2,3,7,8-tetrachlorodibenzodioxine. Predicted to be active in nucleus. Orthologous to human TIPARP (TCDD inducible poly(ADP-ribose) polymerase); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; INTERACTS WITH (+)-schisandrin B; 1,2,3,7,8-Pentachlorodibenzodioxin; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC310467; RM1; TCDD-inducible poly [ADP-ribose] polymerase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82152,063,769 - 152,090,414 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2152,063,751 - 152,090,406 (+)EnsemblGRCr8
mRatBN7.22149,753,682 - 149,780,327 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2149,753,682 - 149,780,327 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2156,856,323 - 156,882,972 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02154,906,806 - 154,933,457 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02149,539,488 - 149,566,139 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02157,316,293 - 157,342,979 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2157,316,266 - 157,341,469 (+)Ensemblrn6Rnor6.0
Rnor_5.02176,685,223 - 176,711,918 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42155,312,341 - 155,339,357 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2144,165,974 - 144,192,615 (+)NCBICelera
RGSC_v3.12155,264,128 - 155,288,955 (+)NCBI
Cytogenetic Map2q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-nicotine  (ISO)
1,2,3,7,8-Pentachlorodibenzodioxin  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1,8-Dinitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,3',4,4',5-Hexachlorobiphenyl  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
4-vinylcyclohexene dioxide  (ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-naphthoflavone  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorpromazine  (EXP)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibenzofuran  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
diuron  (EXP,ISO)
entinostat  (ISO)
ethanol  (ISO)
fenofibrate  (EXP)
fluoranthene  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (EXP)
inulin  (ISO)
iron dichloride  (ISO)
isobutanol  (ISO)
lactacystin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lucanthone  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
metformin  (EXP)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
Pf-06840003  (ISO)
phenobarbital  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
poly(vinylpyrrolidone)  (EXP)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
puromycin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
tryptophan  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation. Barkauskaite E, etal., Mol Cell. 2015 Jun 18;58(6):935-46. doi: 10.1016/j.molcel.2015.05.007.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Maternal Tryptophan Supplementation Protects Adult Rat Offspring against Hypertension Programmed by Maternal Chronic Kidney Disease: Implication of Tryptophan-Metabolizing Microbiome and Aryl Hydrocarbon Receptor. Hsu CN, etal., Int J Mol Sci. 2020 Jun 26;21(12):4552. doi: 10.3390/ijms21124552.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. TCDD dysregulation of 13 AHR-target genes in rat liver. Watson JD, etal., Toxicol Appl Pharmacol. 2014 Feb 1;274(3):445-54. doi: 10.1016/j.taap.2013.12.004. Epub 2013 Dec 16.
Additional References at PubMed
PMID:8889548   PMID:10820183   PMID:11716501   PMID:17143286   PMID:19056881   PMID:23275542   PMID:25043379   PMID:30373764  


Genomics

Comparative Map Data
Tiparp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82152,063,769 - 152,090,414 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2152,063,751 - 152,090,406 (+)EnsemblGRCr8
mRatBN7.22149,753,682 - 149,780,327 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2149,753,682 - 149,780,327 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2156,856,323 - 156,882,972 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02154,906,806 - 154,933,457 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02149,539,488 - 149,566,139 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02157,316,293 - 157,342,979 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2157,316,266 - 157,341,469 (+)Ensemblrn6Rnor6.0
Rnor_5.02176,685,223 - 176,711,918 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42155,312,341 - 155,339,357 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2144,165,974 - 144,192,615 (+)NCBICelera
RGSC_v3.12155,264,128 - 155,288,955 (+)NCBI
Cytogenetic Map2q31NCBI
TIPARP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383156,674,590 - 156,706,770 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3156,673,235 - 156,706,770 (+)Ensemblhg38GRCh38
GRCh373156,392,379 - 156,424,559 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363157,875,073 - 157,907,228 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343157,875,080 - 157,907,236NCBI
Celera3154,815,555 - 154,847,904 (+)NCBICelera
Cytogenetic Map3q25.31NCBI
HuRef3153,788,071 - 153,820,428 (+)NCBIHuRef
CHM1_13156,353,862 - 156,386,212 (+)NCBICHM1_1
T2T-CHM13v2.03159,449,273 - 159,481,452 (+)NCBIT2T-CHM13v2.0
Tiparp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39365,435,868 - 65,462,939 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl365,435,831 - 65,462,939 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38365,528,447 - 65,555,518 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl365,528,410 - 65,555,518 (+)Ensemblmm10GRCm38
MGSCv37365,332,369 - 65,359,440 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36365,616,376 - 65,643,447 (+)NCBIMGSCv36mm8
Celera365,663,643 - 65,691,202 (+)NCBICelera
Cytogenetic Map3E1NCBI
cM Map330.2NCBI
Tiparp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554487,687,668 - 7,716,707 (+)Ensembl
ChiLan1.0NW_0049554487,687,668 - 7,716,481 (+)NCBIChiLan1.0ChiLan1.0
TIPARP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22154,590,906 - 154,624,445 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13154,595,679 - 154,629,176 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03153,730,307 - 153,762,442 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13161,784,004 - 161,816,525 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3161,783,999 - 161,816,525 (+)EnsemblpanPan2panpan1.1
TIPARP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12350,253,645 - 50,279,615 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2350,249,327 - 50,280,144 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2350,124,312 - 50,154,046 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02350,883,652 - 50,913,363 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2350,883,621 - 50,913,330 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12350,467,974 - 50,497,675 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02350,518,863 - 50,548,568 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02350,805,561 - 50,835,202 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tiparp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560286,021,871 - 86,049,211 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365193,684,515 - 3,712,081 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365193,683,972 - 3,712,081 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIPARP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1396,496,439 - 96,525,777 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11396,496,386 - 96,524,879 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213104,603,588 - 104,630,839 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TIPARP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11534,041,208 - 34,073,428 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1534,039,657 - 34,073,319 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660416,662,900 - 6,694,976 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tiparp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473034,262,468 - 34,293,087 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473034,262,630 - 34,293,034 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tiparp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1390,168,701 - 90,195,002 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tiparp
178 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:130
Count of miRNA genes:115
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000015387
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2124103798154505346Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2120039407159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149806826170653323Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2145807215173074435Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat

Markers in Region
RH133070  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22149,779,918 - 149,780,100 (+)MAPPERmRatBN7.2
Rnor_6.02157,342,571 - 157,342,752NCBIRnor6.0
Rnor_5.02176,711,510 - 176,711,691UniSTSRnor5.0
RGSC_v3.42155,338,588 - 155,338,769UniSTSRGSC3.4
Celera2144,192,207 - 144,192,388UniSTS
Cytogenetic Map2q31UniSTS
AI599420  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22149,779,559 - 149,779,722 (+)MAPPERmRatBN7.2
Rnor_6.02157,342,212 - 157,342,374NCBIRnor6.0
Rnor_5.02176,711,151 - 176,711,313UniSTSRnor5.0
RGSC_v3.42155,338,229 - 155,338,391UniSTSRGSC3.4
Celera2144,191,848 - 144,192,010UniSTS
RH 3.4 Map2967.2UniSTS
Cytogenetic Map2q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015387   ⟹   ENSRNOP00000015387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2152,063,751 - 152,090,406 (+)Ensembl
mRatBN7.2 Ensembl2149,753,682 - 149,780,327 (+)Ensembl
Rnor_6.0 Ensembl2157,316,266 - 157,341,469 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118365   ⟹   ENSRNOP00000084335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2149,756,307 - 149,780,327 (+)Ensembl
RefSeq Acc Id: NM_001107679   ⟹   NP_001101149
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82152,063,769 - 152,090,414 (+)NCBI
mRatBN7.22149,753,682 - 149,780,327 (+)NCBI
RefSeq Acc Id: XM_039102285   ⟹   XP_038958213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82152,064,017 - 152,090,410 (+)NCBI
mRatBN7.22149,753,931 - 149,780,205 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001101149 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958213 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM00942 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015387
  ENSRNOP00000015387.3
Ensembl Acc Id: ENSRNOP00000015387   ⟸   ENSRNOT00000015387
RefSeq Acc Id: NP_001101149   ⟸   NM_001107679
- UniProtKB: D3ZMH5 (UniProtKB/TrEMBL),   A6J5J7 (UniProtKB/TrEMBL),   A0A8I6GA83 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958213   ⟸   XM_039102285
- Peptide Label: isoform X1
- UniProtKB: D3ZMH5 (UniProtKB/TrEMBL),   A6J5J7 (UniProtKB/TrEMBL),   A0A8I6GA83 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084335   ⟸   ENSRNOT00000118365
Protein Domains
C3H1-type   PARP catalytic   WWE

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZMH5-F1-model_v2 AlphaFold D3ZMH5 1-657 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691373
Promoter ID:EPDNEW_R1884
Type:initiation region
Name:Tiparp_1
Description:TCDD-inducible poly(ADP-ribose) polymerase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02157,316,361 - 157,316,421EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306171 AgrOrtholog
BioCyc Gene G2FUF-52887 BioCyc
Ensembl Genes ENSRNOG00000011238 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015387 ENTREZGENE
  ENSRNOT00000015387.8 UniProtKB/TrEMBL
Gene3D-CATH 3.90.228.10 UniProtKB/TrEMBL
InterPro ARTD-AVP UniProtKB/TrEMBL
  Poly(ADP-ribose)pol_cat_dom UniProtKB/TrEMBL
  WWE-dom UniProtKB/TrEMBL
  WWE_dom_sf UniProtKB/TrEMBL
  Znf_CCCH UniProtKB/TrEMBL
NCBI Gene 310467 ENTREZGENE
PANTHER POLY [ADP-RIBOSE] POLYMERASE UniProtKB/TrEMBL
  PROTEIN MONO-ADP-RIBOSYLTRANSFERASE TIPARP UniProtKB/TrEMBL
Pfam PARP UniProtKB/TrEMBL
  WWE_4 UniProtKB/TrEMBL
PhenoGen Tiparp PhenoGen
PROSITE PARP_CATALYTIC UniProtKB/TrEMBL
  WWE UniProtKB/TrEMBL
  ZF_C3H1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011238 RatGTEx
Superfamily-SCOP ADP-ribosylation UniProtKB/TrEMBL
  SSF117839 UniProtKB/TrEMBL
UniProt A0A8I6GA83 ENTREZGENE
  A6J5J7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZMH5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Tiparp  TCDD-inducible poly(ADP-ribose) polymerase   Tiparp_predicted  TCDD-inducible poly(ADP-ribose) polymerase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tiparp_predicted  TCDD-inducible poly(ADP-ribose) polymerase (predicted)      Symbol and Name status set to approved 70820 APPROVED