Rrm2b (ribonucleotide reductase regulatory TP53 inducible subunit M2B) - Rat Genome Database

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Gene: Rrm2b (ribonucleotide reductase regulatory TP53 inducible subunit M2B) Rattus norvegicus
Analyze
Symbol: Rrm2b
Name: ribonucleotide reductase regulatory TP53 inducible subunit M2B
RGD ID: 1306045
Description: Predicted to enable identical protein binding activity and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in response to amine. Predicted to be located in membrane; mitochondrion; and nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B); PARTICIPATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; gemcitabine pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC299976; ribonucleoside-diphosphate reductase subunit M2 B; ribonucleotide reductase M2 B (TP53 inducible)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8770,962,008 - 70,993,726 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl770,965,590 - 70,993,670 (-)EnsemblGRCr8
mRatBN7.2769,077,024 - 69,108,742 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl769,078,291 - 69,108,633 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx770,964,402 - 70,992,039 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0773,166,927 - 73,194,570 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0773,034,966 - 73,062,605 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0776,750,045 - 76,780,817 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl776,750,050 - 76,780,817 (-)Ensemblrn6Rnor6.0
Rnor_5.0776,865,854 - 76,898,097 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4773,432,161 - 73,459,541 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera766,144,175 - 66,172,166 (-)NCBICelera
RGSC_v3.1773,452,888 - 73,480,282 (-)NCBI
Cytogenetic Map7q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (EXP,ISO)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
carbamazepine  (ISO)
chloramphenicol  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dicrotophos  (ISO)
diethanolamine  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enniatin  (EXP)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (ISO)
hydroxyurea  (ISO)
ifosfamide  (ISO)
inulin  (ISO)
isobutyraldehyde  (ISO)
isoniazide  (ISO)
lead(0)  (ISO)
metformin  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
morphine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
pirinixic acid  (ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
triapine  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zebularine  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,IEA,ISO)
mitochondrion  (IEA)
nucleoplasm  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Strong induction of p73 protein in vivo coincides with the onset of apoptosis in rat liver after treatment with the hepatocarcinogen N-nitrosomorpholine (NNM). Tudzarova-Trajkovska S and Wesierska-Gadek J, J Cell Biochem. 2003 Nov 1;90(4):837-55.
Additional References at PubMed
PMID:11517226   PMID:12858174   PMID:17486094   PMID:23376485   PMID:25416956   PMID:25502805   PMID:31515488  


Genomics

Comparative Map Data
Rrm2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8770,962,008 - 70,993,726 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl770,965,590 - 70,993,670 (-)EnsemblGRCr8
mRatBN7.2769,077,024 - 69,108,742 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl769,078,291 - 69,108,633 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx770,964,402 - 70,992,039 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0773,166,927 - 73,194,570 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0773,034,966 - 73,062,605 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0776,750,045 - 76,780,817 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl776,750,050 - 76,780,817 (-)Ensemblrn6Rnor6.0
Rnor_5.0776,865,854 - 76,898,097 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4773,432,161 - 73,459,541 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera766,144,175 - 66,172,166 (-)NCBICelera
RGSC_v3.1773,452,888 - 73,480,282 (-)NCBI
Cytogenetic Map7q22NCBI
RRM2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388102,204,501 - 102,238,961 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8102,204,502 - 102,239,382 (-)Ensemblhg38GRCh38
GRCh378103,216,729 - 103,251,189 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368103,285,907 - 103,320,522 (-)NCBIBuild 36Build 36hg18NCBI36
Build 348103,285,907 - 103,320,522NCBI
Celera899,401,627 - 99,436,245 (-)NCBICelera
Cytogenetic Map8q22.3NCBI
HuRef898,415,432 - 98,450,050 (-)NCBIHuRef
CHM1_18103,257,019 - 103,291,637 (-)NCBICHM1_1
T2T-CHM13v2.08103,330,401 - 103,364,861 (-)NCBIT2T-CHM13v2.0
Rrm2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391537,924,196 - 37,961,562 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1537,924,196 - 37,961,562 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381537,923,952 - 37,961,119 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1537,923,952 - 37,961,318 (-)Ensemblmm10GRCm38
MGSCv371537,853,707 - 37,890,810 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361537,868,541 - 37,905,644 (-)NCBIMGSCv36mm8
Celera1538,542,769 - 38,579,866 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1515.1NCBI
Rrm2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541726,949,686 - 26,976,726 (-)Ensembl
ChiLan1.0NW_00495541726,949,686 - 26,976,976 (-)NCBIChiLan1.0ChiLan1.0
RRM2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27119,564,086 - 119,603,582 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1895,100,314 - 95,136,516 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0898,854,101 - 98,890,365 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18101,016,069 - 101,052,235 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8101,019,699 - 101,052,056 (-)EnsemblpanPan2panpan1.1
RRM2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1133,774,725 - 3,838,576 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl133,799,025 - 3,837,934 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha133,776,853 - 3,840,752 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0133,934,984 - 3,998,893 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl133,956,962 - 3,998,249 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1133,777,888 - 3,841,775 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0133,890,675 - 3,954,582 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0133,907,686 - 3,971,792 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rrm2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530333,928,024 - 33,975,215 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647041,354,287 - 41,401,317 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647041,354,387 - 41,401,308 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RRM2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl434,823,758 - 34,859,778 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1434,823,869 - 34,859,777 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2437,679,202 - 37,715,064 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RRM2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1897,055,111 - 97,091,980 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603943,559,489 - 43,596,372 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rrm2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476319,362,663 - 19,391,443 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476319,362,793 - 19,391,401 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rrm2b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11211,386,405 - 211,413,044 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rrm2b
211 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:120
Interacting mature miRNAs:129
Transcripts:ENSRNOT00000033704
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
D7Rat110  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8770,974,936 - 70,975,163 (+)Marker Load Pipeline
mRatBN7.2769,089,957 - 69,090,184 (+)MAPPERmRatBN7.2
Rnor_6.0776,759,399 - 76,759,625NCBIRnor6.0
Rnor_5.0776,875,208 - 76,875,434UniSTSRnor5.0
RGSC_v3.4773,441,514 - 73,441,741RGDRGSC3.4
RGSC_v3.4773,441,515 - 73,441,741UniSTSRGSC3.4
Celera766,153,529 - 66,153,755UniSTS
RGSC_v3.1773,462,169 - 73,462,477RGD
SHRSP x BN Map744.42UniSTS
SHRSP x BN Map744.42RGD
Cytogenetic Map7q22UniSTS
BF387246  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,110,281 - 69,110,469 (+)MAPPERmRatBN7.2
Rnor_6.0776,782,636 - 76,782,823NCBIRnor6.0
Rnor_5.0776,899,916 - 76,900,103UniSTSRnor5.0
RGSC_v3.4773,461,202 - 73,461,389UniSTSRGSC3.4
Celera766,173,827 - 66,174,014UniSTS
RH 3.4 Map7638.0UniSTS
Cytogenetic Map7q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000033704   ⟹   ENSRNOP00000038047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl770,965,590 - 70,993,602 (-)Ensembl
mRatBN7.2 Ensembl769,078,547 - 69,108,586 (-)Ensembl
Rnor_6.0 Ensembl776,750,050 - 76,780,817 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107052   ⟹   ENSRNOP00000090940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl770,965,590 - 70,993,670 (-)Ensembl
mRatBN7.2 Ensembl769,078,547 - 69,108,633 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114573   ⟹   ENSRNOP00000077843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl769,078,291 - 69,108,490 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000154267   ⟹   ENSRNOP00000104012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl770,965,590 - 70,993,471 (-)Ensembl
RefSeq Acc Id: NM_001130543   ⟹   NP_001124015
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8770,965,583 - 70,993,602 (-)NCBI
mRatBN7.2769,080,604 - 69,108,621 (-)NCBI
Rnor_6.0776,750,045 - 76,780,817 (-)NCBI
Rnor_5.0776,865,854 - 76,898,097 (-)NCBI
RGSC_v3.4773,432,161 - 73,459,541 (-)RGD
Celera766,144,175 - 66,172,166 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078801   ⟹   XP_038934729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8770,962,008 - 70,993,726 (-)NCBI
mRatBN7.2769,077,024 - 69,108,742 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001124015 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934729 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM16371 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000038047
  ENSRNOP00000038047.6
  ENSRNOP00000090940
  ENSRNOP00000090940.1
  ENSRNOP00000104012.1
RefSeq Acc Id: NP_001124015   ⟸   NM_001130543
- UniProtKB: D4ADQ1 (UniProtKB/TrEMBL),   A6HR51 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038047   ⟸   ENSRNOT00000033704
RefSeq Acc Id: XP_038934729   ⟸   XM_039078801
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ACU7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090940   ⟸   ENSRNOT00000107052
Ensembl Acc Id: ENSRNOP00000077843   ⟸   ENSRNOT00000114573
Ensembl Acc Id: ENSRNOP00000104012   ⟸   ENSRNOT00000154267

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADQ1-F1-model_v2 AlphaFold D4ADQ1 1-351 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695298
Promoter ID:EPDNEW_R5823
Type:initiation region
Name:Rrm2b_1
Description:ribonucleotide reductase regulatory TP53 inducible subunit M2B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0776,780,744 - 76,780,804EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306045 AgrOrtholog
BioCyc Gene G2FUF-33616 BioCyc
BioCyc Pathway PWY-7184 [pyrimidine deoxyribonucleotides de novo biosynthesis I] BioCyc
  PWY-7210 [pyrimidine deoxyribonucleotides biosynthesis from CTP] BioCyc
  PWY-7226 [guanosine deoxyribonucleotides de novo biosynthesis I] BioCyc
  PWY-7227 [adenosine deoxyribonucleotides de novo biosynthesis I] BioCyc
BioCyc Pathway Image PWY-7184 BioCyc
  PWY-7210 BioCyc
  PWY-7226 BioCyc
  PWY-7227 BioCyc
Ensembl Genes ENSRNOG00000025454 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033704 ENTREZGENE
  ENSRNOT00000033704.8 UniProtKB/TrEMBL
  ENSRNOT00000107052 ENTREZGENE
  ENSRNOT00000107052.2 UniProtKB/TrEMBL
  ENSRNOT00000154267.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.620.20 UniProtKB/TrEMBL
InterPro Ferritin-like_SF UniProtKB/TrEMBL
  RNR-like UniProtKB/TrEMBL
  RNR_small UniProtKB/TrEMBL
  RNR_small UniProtKB/TrEMBL
  RNR_small_AS UniProtKB/TrEMBL
KEGG Report rno:299976 UniProtKB/TrEMBL
NCBI Gene 299976 ENTREZGENE
PANTHER PTHR23409 UniProtKB/TrEMBL
  RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B UniProtKB/TrEMBL
Pfam Ribonuc_red_sm UniProtKB/TrEMBL
PhenoGen Rrm2b PhenoGen
PIRSF NrdB UniProtKB/TrEMBL
PROSITE RIBORED_SMALL UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025454 RatGTEx
Superfamily-SCOP SSF47240 UniProtKB/TrEMBL
UniProt A0A8I6ACU7 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LRX0_RAT UniProtKB/TrEMBL
  A6HR51 ENTREZGENE, UniProtKB/TrEMBL
  D4ADQ1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-21 Rrm2b  ribonucleotide reductase regulatory TP53 inducible subunit M2B  Rrm2b  ribonucleotide reductase M2 B (TP53 inducible)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Rrm2b  ribonucleotide reductase M2 B (TP53 inducible)   Rrm2b_predicted  ribonucleotide reductase M2 B (TP53 inducible) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Rrm2b_predicted  ribonucleotide reductase M2 B (TP53 inducible) (predicted)      Symbol and Name status set to approved 70820 APPROVED