Cd68 (Cd68 molecule) - Rat Genome Database

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Gene: Cd68 (Cd68 molecule) Rattus norvegicus
Analyze
Symbol: Cd68
Name: Cd68 molecule
RGD ID: 1305970
Description: Involved in response to ethanol. Predicted to be located in lysosome. Predicted to be active in late endosome membrane; lysosomal membrane; and plasma membrane. Biomarker of metabolic dysfunction and alcohol associated liver disease and metabolic dysfunction-associated steatohepatitis. Orthologous to human CD68 (CD68 molecule); INTERACTS WITH (-)-cotinine; (S)-nicotine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD68 antigen; LOC287435; macrosialin; MGC114377
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,880,562 - 54,882,441 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1054,880,563 - 54,882,540 (-)EnsemblGRCr8
mRatBN7.21054,381,814 - 54,383,693 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,381,815 - 54,383,697 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1059,044,451 - 59,046,330 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,533,003 - 58,534,882 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,040,608 - 54,042,465 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,268,726 - 56,270,605 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,268,720 - 56,270,640 (-)Ensemblrn6Rnor6.0
Rnor_5.01056,014,364 - 56,016,243 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41056,481,701 - 56,483,580 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1053,536,351 - 53,538,212 (-)NCBICelera
RGSC_v3.11056,495,323 - 56,497,228 (-)NCBI
Cytogenetic Map10q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-cotinine  (EXP)
(1->4)-beta-D-glucan  (ISO)
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid  (ISO)
(S)-nicotine  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-bromohexadecanoic acid  (ISO)
2-butoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,7-dihydropurine-6-thione  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis,11-trans-octadecadienoic acid  (ISO)
acetamide  (EXP)
acetamiprid  (EXP)
adenine  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
alternariol  (ISO)
AM6545  (ISO)
amitrole  (EXP)
amlexanox  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
argatroban  (ISO)
aristolochic acid A  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
asbestos  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromodichloromethane  (ISO)
buspirone  (EXP)
butanal  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calcium dichloride  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
CHIR 99021  (ISO)
choline  (ISO)
chromium atom  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt dichloride  (EXP)
conjugated linoleic acid  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP,ISO)
cyclosporin A  (EXP,ISO)
Deoxycorticosterone acetate  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diethylstilbestrol  (ISO)
dimethyl fumarate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
Evodiamine  (ISO)
fenamidone  (ISO)
fenitrothion  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fragrance  (ISO)
fructose  (EXP,ISO)
gadolinium trichloride  (EXP,ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
Gingerenone A  (ISO)
glycyrrhizinic acid  (EXP)
GW 4064  (ISO)
hexadecanoic acid  (ISO)
HU-308  (EXP)
hydrogen peroxide  (ISO)
iron dichloride  (ISO)
kainic acid  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (EXP,ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mechlorethamine  (EXP)
mercaptopurine  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (EXP)
microcystin-LR  (ISO)
minocycline  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
N(4)-hydroxycytidine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP)
nifuroxazide  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
nonanedioic acid  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
paeoniflorin  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perindopril  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
pluronic P-123  (ISO)
Poloxamer  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
propanal  (ISO)
propionic acid  (EXP)
propofol  (ISO)
prostaglandin E2  (ISO)
purine-6-thiol  (EXP)
Pyridostigmine bromide  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
retinoic acid receptor antagonist  (ISO)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
rutin  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
Salvianolic acid A  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium nitrite  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trans-caffeic acid  (ISO)
tributylstannane  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valsartan  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Lack of association of tumor-associated macrophages with clinical outcome in patients with classical Hodgkin's lymphoma. Azambuja D, etal., Ann Oncol. 2012 Mar;23(3):736-742. doi: 10.1093/annonc/mdr157. Epub 2011 May 20.
2. Comparative quantitative analysis of macrophage populations defined by CD68 and carbohydrate antigens in normal and pathologically altered human liver tissue. Baldus SE, etal., Anal Cell Pathol. 1998;16(3):141-50. doi: 10.1155/1998/192975.
3. Impact of opiate addiction on neuroinflammation in HIV. Byrd D, etal., J Neurovirol. 2012 Oct;18(5):364-73. doi: 10.1007/s13365-012-0118-x. Epub 2012 Jul 14.
4. HIV-1 expression protects macrophages and microglia from apoptotic death. Cosenza MA, etal., Neuropathol Appl Neurobiol. 2004 Oct;30(5):478-90. doi: 10.1111/j.1365-2990.2004.00563.x.
5. The Number of Liver Galectin-3 Positive Cells Is Dually Correlated with NAFLD Severity in Children. de Oliveira FL, etal., Int J Mol Sci. 2019 Jul 14;20(14):3460. doi: 10.3390/ijms20143460.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Expression of FOXP3, CD68, and CD20 at diagnosis in the microenvironment of classical Hodgkin lymphoma is predictive of outcome. Greaves P, etal., J Clin Oncol. 2013 Jan 10;31(2):256-62. doi: 10.1200/JCO.2011.39.9881. Epub 2012 Oct 8.
9. All-trans retinoic acid attenuates experimental colitis through inhibition of NF-κB signaling. Hong K, etal., Immunol Lett. 2014 Nov;162(1 Pt A):34-40. doi: 10.1016/j.imlet.2014.06.011. Epub 2014 Jul 6.
10. Morphological and functional characterization of non-alcoholic fatty liver disease induced by a methionine-choline-deficient diet in C57BL/6 mice. Itagaki H, etal., Int J Clin Exp Pathol. 2013 Nov 15;6(12):2683-96. eCollection 2013.
11. Tumor-infiltrating macrophages correlate with adverse prognosis and Epstein-Barr virus status in classical Hodgkin's lymphoma. Kamper P, etal., Haematologica. 2011 Feb;96(2):269-76. doi: 10.3324/haematol.2010.031542. Epub 2010 Nov 11.
12. Clinical significance of CD163⁺ tumor-associated macrophages in patients with adult T-cell leukemia/lymphoma. Komohara Y, etal., Cancer Sci. 2013 Jul;104(7):945-51. doi: 10.1111/cas.12167. Epub 2013 May 9.
13. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. CD68 on rat macrophages binds tightly to S100A8 and S100A9 and helps to regulate the cells' immune functions. Okada K, etal., J Leukoc Biol. 2016 Nov;100(5):1093-1104. doi: 10.1189/jlb.2A0415-170RRR. Epub 2016 Jun 16.
16. Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression. Peng JH, etal., J Pharmacol Exp Ther. 2013 Mar;344(3):646-54. doi: 10.1124/jpet.112.201137. Epub 2012 Dec 31.
17. Intratumoral and peritumoral expression of CD68 and CD206 in hepatocellular carcinoma and their prognostic value. Ren CX, etal., Oncol Rep. 2017 Aug;38(2):886-898. doi: 10.3892/or.2017.5738. Epub 2017 Jun 21.
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Gene expression of cell surface antigens in the early phase of murine influenza pneumonia determined by a cDNA expression array technique. Sakai S, etal., Mediators Inflamm. 2002 Dec;11(6):359-61. doi: 10.1080/0962935021000051557.
21. Brain macrophage surface marker expression with HIV-1 infection and drug abuse: a preliminary study. Shapshak P, etal., J NeuroAIDS. 2002;2(3):37-50. doi: 10.1300/j128v02n03_03.
22. Microvesicular fat, inter cellular adhesion molecule-1 and regulatory T-lymphocytes are of importance for the inflammatory process in livers with non-alcoholic steatohepatitis. Söderberg C, etal., APMIS. 2011 Jul;119(7):412-20. doi: 10.1111/j.1600-0463.2011.02746.x. Epub 2011 Apr 25.
23. Macrophages and nerve fibres in peritoneal endometriosis. Tran LV, etal., Hum Reprod. 2009 Apr;24(4):835-41. doi: 10.1093/humrep/den483. Epub 2009 Jan 9.
24. Association of steroid use with complicated sigmoid diverticulitis: potential role of activated CD68+/CD163+ macrophages. von Rahden BH, etal., Langenbecks Arch Surg. 2011 Aug;396(6):759-68. doi: 10.1007/s00423-011-0797-4. Epub 2011 May 7.
25. Merkel cell carcinoma induces lymphatic microvessel formation. Werchau S, etal., J Am Acad Dermatol. 2012 Aug;67(2):215-25. doi: 10.1016/j.jaad.2011.09.002. Epub 2011 Nov 3.
26. Orchitis: a complication of severe acute respiratory syndrome (SARS). Xu J, etal., Biol Reprod. 2006 Feb;74(2):410-6. doi: 10.1095/biolreprod.105.044776. Epub 2005 Oct 19.
27. Altered biliary epithelial cell and monocyte responses to lipopolysaccharide as a TLR ligand in patients with primary biliary cirrhosis. Zhao J, etal., Scand J Gastroenterol. 2011 Apr;46(4):485-94. doi: 10.3109/00365521.2010.539624. Epub 2011 Jan 28.
28. Açaí (Euterpe oleracea Mart.) attenuates alcohol-induced liver injury in rats by alleviating oxidative stress and inflammatory response. Zhou J, etal., Exp Ther Med. 2018 Jan;15(1):166-172. doi: 10.3892/etm.2017.5427. Epub 2017 Nov 1.
29. Glucose regulated protein 78 is potentially an important player in the development of nonalcoholic steatohepatitis. Zhou X, etal., Gene. 2017 Dec 30;637:138-144. doi: 10.1016/j.gene.2017.09.051. Epub 2017 Sep 23.
Additional References at PubMed
PMID:12477932   PMID:16157452   PMID:18497889   PMID:18563318   PMID:19109740   PMID:19528371   PMID:21572087   PMID:23523271   PMID:24986327   PMID:26216124   PMID:26433032   PMID:27391866  
PMID:27551151   PMID:28338461   PMID:28601280   PMID:29619884  


Genomics

Comparative Map Data
Cd68
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,880,562 - 54,882,441 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1054,880,563 - 54,882,540 (-)EnsemblGRCr8
mRatBN7.21054,381,814 - 54,383,693 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,381,815 - 54,383,697 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1059,044,451 - 59,046,330 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,533,003 - 58,534,882 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,040,608 - 54,042,465 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,268,726 - 56,270,605 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,268,720 - 56,270,640 (-)Ensemblrn6Rnor6.0
Rnor_5.01056,014,364 - 56,016,243 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41056,481,701 - 56,483,580 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1053,536,351 - 53,538,212 (-)NCBICelera
RGSC_v3.11056,495,323 - 56,497,228 (-)NCBI
Cytogenetic Map10q24NCBI
CD68
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,579,638 - 7,582,111 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,579,380 - 7,582,112 (+)Ensemblhg38GRCh38
GRCh37177,482,956 - 7,485,429 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,423,529 - 7,426,153 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34177,423,707 - 7,426,150NCBI
Celera177,509,128 - 7,511,752 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,376,970 - 7,379,593 (+)NCBIHuRef
CHM1_1177,491,734 - 7,494,362 (+)NCBICHM1_1
T2T-CHM13v2.0177,483,886 - 7,486,361 (+)NCBIT2T-CHM13v2.0
Cd68
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,555,039 - 69,556,996 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,555,039 - 69,556,979 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381169,664,213 - 69,666,170 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,664,213 - 69,666,153 (-)Ensemblmm10GRCm38
MGSCv371169,477,873 - 69,479,564 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361170,248,478 - 70,250,169 (-)NCBIMGSCv36mm8
MGSCv361169,480,566 - 69,482,257 (-)NCBIMGSCv36mm8
Cytogenetic Map11B3NCBI
cM Map1142.86NCBI
Cd68
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,341,364 - 9,343,836 (-)Ensembl
ChiLan1.0NW_0049554679,340,490 - 9,343,912 (-)NCBIChiLan1.0ChiLan1.0
CD68
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21915,174,231 - 15,176,798 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11717,140,359 - 17,142,865 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,610,725 - 7,613,696 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,596,995 - 7,599,981 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,596,947 - 7,599,981 (+)EnsemblpanPan2panpan1.1
CD68
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,500,899 - 32,503,355 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,501,380 - 32,503,183 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha532,640,582 - 32,642,831 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0532,606,269 - 32,608,583 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,606,541 - 32,608,348 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,573,887 - 32,576,133 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,530,349 - 32,532,594 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,709,456 - 32,711,701 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cd68
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,384,190 - 47,386,943 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936595858,289 - 861,131 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD68
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,874,785 - 52,877,695 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11252,874,754 - 52,877,256 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,296,987 - 55,299,491 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD68
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,956,633 - 6,959,645 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,957,212 - 6,959,042 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605914,448,764 - 14,451,756 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd68
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478610,195,337 - 10,197,963 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cd68
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1949,275,365 - 49,277,810 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cd68
15 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:61
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000056918
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105269900459876693Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105429622767476781Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105429622758944345Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
PMC136595P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,382,057 - 54,382,917 (+)MAPPERmRatBN7.2
Rnor_6.01056,268,970 - 56,269,829NCBIRnor6.0
Rnor_5.01056,014,608 - 56,015,467UniSTSRnor5.0
RGSC_v3.41056,481,945 - 56,482,804UniSTSRGSC3.4
Celera1053,536,595 - 53,537,454UniSTS
Cytogenetic Map10q24UniSTS
PMC27130P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,382,616 - 54,382,852 (+)MAPPERmRatBN7.2
Rnor_6.01056,269,529 - 56,269,764NCBIRnor6.0
Rnor_5.01056,015,167 - 56,015,402UniSTSRnor5.0
RGSC_v3.41056,482,504 - 56,482,739UniSTSRGSC3.4
Celera1053,537,154 - 53,537,389UniSTS
Cytogenetic Map10q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 355 192 11 140 80 92 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000056918   ⟹   ENSRNOP00000053756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1054,880,563 - 54,882,441 (-)Ensembl
mRatBN7.2 Ensembl1054,381,815 - 54,383,693 (-)Ensembl
Rnor_6.0 Ensembl1056,268,720 - 56,270,640 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111511   ⟹   ENSRNOP00000080098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1054,880,563 - 54,882,540 (-)Ensembl
mRatBN7.2 Ensembl1054,381,815 - 54,383,697 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000135981   ⟹   ENSRNOP00000106912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1054,880,563 - 54,882,540 (-)Ensembl
RefSeq Acc Id: NM_001031638   ⟹   NP_001026808
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,880,562 - 54,882,441 (-)NCBI
mRatBN7.21054,381,814 - 54,383,693 (-)NCBI
Rnor_6.01056,268,726 - 56,270,605 (-)NCBI
Rnor_5.01056,014,364 - 56,016,243 (-)NCBI
RGSC_v3.41056,481,701 - 56,483,580 (-)RGD
Celera1053,536,351 - 53,538,212 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001026808 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98931 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000053756.3
  ENSRNOP00000080098
  ENSRNOP00000080098.1
  ENSRNOP00000106912.1
RefSeq Acc Id: NP_001026808   ⟸   NM_001031638
- Peptide Label: precursor
- UniProtKB: Q4FZY1 (UniProtKB/TrEMBL),   A0A8I5ZPU9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000053756   ⟸   ENSRNOT00000056918
Ensembl Acc Id: ENSRNOP00000080098   ⟸   ENSRNOT00000111511
Ensembl Acc Id: ENSRNOP00000106912   ⟸   ENSRNOT00000135981
Protein Domains
Lysosome-associated membrane glycoprotein 2-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4FZY1-F1-model_v2 AlphaFold Q4FZY1 1-330 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697320
Promoter ID:EPDNEW_R7845
Type:multiple initiation site
Name:Cd68_1
Description:Cd68 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01056,270,586 - 56,270,646EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305970 AgrOrtholog
BioCyc Gene G2FUF-24533 BioCyc
Ensembl Genes ENSRNOG00000037563 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000056918.5 UniProtKB/TrEMBL
  ENSRNOT00000111511 ENTREZGENE
  ENSRNOT00000111511.2 UniProtKB/TrEMBL
  ENSRNOT00000135981.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.160.110 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7368498 IMAGE-MGC_LOAD
InterPro Lamp UniProtKB/TrEMBL
  Lamp2-like_luminal UniProtKB/TrEMBL
  LAMP_CS UniProtKB/TrEMBL
KEGG Report rno:287435 UniProtKB/TrEMBL
MGC_CLONE MGC:114377 IMAGE-MGC_LOAD
NCBI Gene 287435 ENTREZGENE
PANTHER Lamp UniProtKB/TrEMBL
  MACROSIALIN UniProtKB/TrEMBL
Pfam Lamp UniProtKB/TrEMBL
PhenoGen Cd68 PhenoGen
PRINTS LYSASSOCTDMP UniProtKB/TrEMBL
PROSITE LAMP_2 UniProtKB/TrEMBL
  LAMP_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000037563 RatGTEx
UniProt A0A8I5ZPU9 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LYC8_RAT UniProtKB/TrEMBL
  F7F2B3_RAT UniProtKB/TrEMBL
  Q4FZY1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-29 Cd68  Cd68 molecule  Cd68  CD68 antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Cd68  CD68 antigen  Cd68_predicted  CD68 antigen (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Cd68_predicted  CD68 antigen (predicted)      Symbol and Name status set to approved 70820 APPROVED