Dsp (desmoplakin) - Rat Genome Database

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Gene: Dsp (desmoplakin) Rattus norvegicus
Analyze
Symbol: Dsp
Name: desmoplakin
RGD ID: 1305794
Description: Predicted to enable protein kinase C binding activity; scaffold protein binding activity; and structural molecule activity. Predicted to be involved in several processes, including intermediate filament organization; regulation of heart contraction; and ventricular compact myocardium morphogenesis. Predicted to act upstream of or within adherens junction organization; desmosome organization; and epithelial cell-cell adhesion. Located in desmosome and fascia adherens. Human ortholog(s) of this gene implicated in Carvajal syndrome; arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 8; dilated cardiomyopathy; and keratosis palmoplantaris striata 2. Orthologous to human DSP (desmoplakin); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DP; LOC306871
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81726,829,153 - 26,877,419 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1726,829,153 - 26,877,121 (-)EnsemblGRCr8
mRatBN7.21726,623,602 - 26,671,692 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1726,623,588 - 26,671,800 (-)EnsemblmRatBN7.2
Rnor_6.01727,286,811 - 27,334,453 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1727,286,796 - 27,334,379 (-)Ensemblrn6Rnor6.0
Rnor_5.01729,201,872 - 29,249,490 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41732,848,313 - 32,896,044 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1726,257,726 - 26,305,766 (-)NCBICelera
RGSC_v3.11732,851,800 - 32,898,885 (-)NCBI
Cytogenetic Map17p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
amyloidosis  (ISO)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
arrhythmogenic right ventricular dysplasia 1  (ISO)
arrhythmogenic right ventricular dysplasia 8  (ISO,ISS)
arrhythmogenic right ventricular dysplasia 9  (ISO)
autistic disorder  (ISO)
autosomal recessive intellectual developmental disorder 13  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2J  (ISO)
Brugada syndrome  (ISO)
Brugada syndrome 1  (ISO)
cardiac arrest  (ISO)
Cardiac Arrhythmias  (ISO)
cardiomyopathy  (ISO)
Carvajal syndrome  (ISO,ISS)
catecholaminergic polymorphic ventricular tachycardia 1  (ISO)
chronic obstructive pulmonary disease  (ISO)
Congenital Erythroderma with Palmoplantar Keratoderma, Hypotrichosis, and Hyper-IgE  (ISO)
COVID-19  (ISO)
Developmental Disabilities  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1A  (ISO)
dilated cardiomyopathy 1B  (ISO)
dilated cardiomyopathy 1G  (ISO)
dilated cardiomyopathy 1S  (ISO)
Dilated Cardiomyopathy with Left Ventricular Noncompaction  (ISO)
Dilated Cardiomyopathy with Woolly Hair, Keratoderma, and Tooth Agenesis  (ISO)
Ectodermal Dysplasia-Skin Fragility Syndrome  (ISO)
Epidermolysis Bullosa, Lethal Acantholytic  (ISO)
familial hypertrophic cardiomyopathy  (ISO)
hemiplegia  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
hypertrophic cardiomyopathy 2  (ISO)
idiopathic pulmonary fibrosis  (ISO)
interstitial lung disease 2  (ISO)
keratosis palmoplantaris striata 2  (ISO)
Left Ventricular Hypertrophy  (ISO)
left ventricular noncompaction  (ISO)
long QT syndrome  (ISO)
long QT syndrome 1  (ISO)
Marfanoid Mental Retardation Syndrome, Autosomal  (ISO)
migraine  (ISO)
myocarditis  (ISO)
palmoplantar keratoderma and woolly hair  (ISO)
palmoplantar keratosis  (ISO)
Paroxysmal Ventricular Fibrillation  (ISO)
progressive familial heart block  (ISO)
pulmonary fibrosis  (ISO)
restrictive cardiomyopathy  (ISO)
subvalvular aortic stenosis  (ISO)
Subvalvular Aortic Stenosis, Eisenberg Type  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Death  (ISO)
Sudden Unexpected Nocturnal Death Syndrome  (ISO)
systolic heart failure  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Fibrillation, Paroxysmal Familial, 1  (ISO)
Ventricular Tachycardia  (ISO)
Wolff-Parkinson-White syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amphetamine  (EXP)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bisphenol F  (ISO)
butanal  (ISO)
butane-2,3-dione  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cocaine  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dihydroartemisinin  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
fipronil  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
glafenine  (EXP)
GSK-J4  (ISO)
indometacin  (ISO)
lasalocid  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
malathion  (ISO)
mercury dibromide  (ISO)
methamphetamine  (ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (EXP)
nitrofen  (EXP)
Nonylphenol  (EXP)
okadaic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
adherens junction  (IDA,ISO)
axon  (IEA)
basolateral plasma membrane  (IEA,ISO)
cell junction  (IEA,ISO)
cell-cell junction  (IEA,ISO)
cornified envelope  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO,ISS)
cytoskeleton  (IEA)
desmosome  (IDA,IEA,ISO)
fascia adherens  (IDA)
intercalated disc  (IBA,IEA,ISO)
intermediate filament  (IBA,IEA,ISO)
nucleus  (IEA)
plasma membrane  (IBA,IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A recessive mutation in desmoplakin causes arrhythmogenic right ventricular dysplasia, skin disorder, and woolly hair. Alcalai R, etal., J Am Coll Cardiol. 2003 Jul 16;42(2):319-27.
2. Dissociated spatial patterning of gap junctions and cell adhesion junctions during postnatal differentiation of ventricular myocardium. Angst BD, etal., Circ Res. 1997 Jan;80(1):88-94.
3. Assembly and remodelling of myofibrils and intercalated discs in cultured neonatal rat heart cells. Atherton BT, etal., J Cell Sci. 1986 Dec;86:233-48.
4. Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes. Ben-Ze'ev A, etal., Proc Natl Acad Sci U S A. 1988 Apr;85(7):2161-5.
5. The area composita of adhering junctions connecting heart muscle cells of vertebrates. II. Colocalizations of desmosomal and fascia adhaerens molecules in the intercalated disk. Borrmann CM, etal., Eur J Cell Biol. 2006 Jun;85(6):469-85. Epub 2006 Apr 4.
6. The complement of desmosomal plaque proteins in different cell types. Cowin P, etal., J Cell Biol. 1985 Oct;101(4):1442-54.
7. Lumen formation and redistribution of inframembranous proteins during differentiation of ducts in the rat mammary gland. Dulbecco R, etal., Proc Natl Acad Sci U S A. 1984 Sep;81(18):5763-6.
8. The area composita of adhering junctions connecting heart muscle cells of vertebrates. I. Molecular definition in intercalated disks of cardiomyocytes by immunoelectron microscopy of desmosomal proteins. Franke WW, etal., Eur J Cell Biol. 2006 Feb;85(2):69-82. Epub 2006 Jan 9.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Desmoplakin expression and distribution in cultured rat bladder epithelial cells of varying tumorigenic potential. Green KJ, etal., Exp Cell Res. 1991 Mar;193(1):134-43.
12. Contact-inhibitory factor induces alterations in the distribution and content of specific cytoskeletal elements in an established line of rat hepatic tumor cells. Higgins PJ, etal., Int J Cancer. 1987 Dec 15;40(6):792-801.
13. Intermediate filament-co-localized molecules with myosin heavy chain epitopes define distinct cellular domains in hair follicles and epidermis. Jazwinska A, etal., BMC Cell Biol. 2003 Aug 4;4:10.
14. Specific attachment of desmin filaments to desmosomal plaques in cardiac myocytes. Kartenbeck J, etal., EMBO J. 1983;2(5):735-42.
15. Changes in cytokeratin, vimentin and desmoplakin distribution during the repair of irradiation-induced lung injury in adult rats. Kasper M, etal., Virchows Arch B Cell Pathol Incl Mol Pathol. 1993;64(5):271-9.
16. Spatiotemporal development and distribution of intercellular junctions in adult rat cardiomyocytes in culture. Kostin S, etal., Circ Res. 1999 Jul 23;85(2):154-67.
17. Remodeling of cell-cell and cell-extracellular matrix interactions at the border zone of rat myocardial infarcts. Matsushita T, etal., Circ Res. 1999 Nov 26;85(11):1046-55.
18. Formation of cell junctions between grafted and host cardiomyocytes at the border zone of rat myocardial infarction. Matsushita T, etal., Circulation. 1999 Nov 9;100(19 Suppl):II262-8.
19. Expression of desmosomal proteins in rat keratinocytes during in vitro differentiation. Mochizuki R, etal., J Vet Med Sci. 2002 Feb;64(2):123-7.
20. Formation of the tooth enamel rod pattern and the cytoskeletal organization in secretory ameloblasts of the rat incisor. Nishikawa S, etal., Eur J Cell Biol. 1988 Dec;47(2):222-32.
21. Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma. Norgett EE, etal., Hum Mol Genet. 2000 Nov 1;9(18):2761-6.
22. Disappearance of desmosomal components in rat corneal epithelium during wound healing. Okada Y, etal., Ophthalmologica. 2001 Jan-Feb;215(1):61-5.
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Cytoskeletons of retinal pigment epithelial cells: interspecies differences of expression patterns indicate independence of cell function from the specific complement of cytoskeletal proteins. Owaribe K, etal., Cell Tissue Res. 1988 Nov;254(2):301-15.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. Progesterone treatment and the progress of early pregnancy reduce desmoglein 1&2 staining along the lateral plasma membrane in rat uterine epithelial cells. Preston AM, etal., Acta Histochem. 2004;106(5):345-51.
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. Savagner P, etal., J Cell Biol 1997 Jun 16;137(6):1403-19.
30. A novel type of adhering junction in an epithelioid tumorigenic rat cell culture line. Schmelz M, etal., Cell Tissue Res. 1998 Oct;294(1):11-25.
31. Complexus adhaerentes, a new group of desmoplakin-containing junctions in endothelial cells: II. Different types of lymphatic vessels. Schmelz M, etal., Differentiation. 1994 Aug;57(2):97-117.
32. Altered patterns of cardiac intercellular junction distribution in hypertrophic cardiomyopathy. Sepp R, etal., Heart. 1996 Nov;76(5):412-7.
33. Cytoplasmic desmosomes and intermediate filament disturbance following acrylamide treatment in cultured rat keratinocytes. Shabana AH, etal., Tissue Cell. 1994 Feb;26(1):43-55.
34. The cytoplasmic domain of CEACAM1-L controls its lateral localization and the organization of desmosomes in polarized epithelial cells. Sundberg U, etal., J Cell Sci. 2004 Mar 1;117(Pt 7):1091-104. Epub 2004 Feb 17.
35. Protein phosphatases maintain the organization and structural interactions of hepatic keratin intermediate filaments. Toivola DM, etal., J Cell Sci. 1997 Jan;110 ( Pt 1):23-33.
36. Contributions of cytoplasmic domains of desmosomal cadherins to desmosome assembly and intermediate filament anchorage. Troyanovsky SM, etal., Cell. 1993 Feb 26;72(4):561-74.
37. Isolation of cell-to-cell adherens junctions from rat liver. Tsukita S and Tsukita S, J Cell Biol. 1989 Jan;108(1):31-41.
38. Remodeling of gap junctional coupling in hypertrophied right ventricles of rats with monocrotaline-induced pulmonary hypertension. Uzzaman M, etal., Circ Res. 2000 Apr 28;86(8):871-8.
39. Blood-testis barrier dynamics are regulated by an engagement/disengagement mechanism between tight and adherens junctions via peripheral adaptors. Yan HH and Cheng CY, Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11722-7. Epub 2005 Aug 5.
40. Localization of Na+ channel isoforms at the atrioventricular junction and atrioventricular node in the rat. Yoo S, etal., Circulation. 2006 Sep 26;114(13):1360-71. Epub 2006 Sep 11.
Additional References at PubMed
PMID:9864371   PMID:10852826   PMID:10908733   PMID:11781569   PMID:12373648   PMID:12477932   PMID:12951053   PMID:14673151   PMID:16418220   PMID:16917092   PMID:17535849   PMID:18474624  
PMID:18496566   PMID:19001636   PMID:19056867   PMID:19199708   PMID:19723622   PMID:20458337   PMID:20859650   PMID:21630459   PMID:21700703   PMID:22152112   PMID:22658674   PMID:22781308  
PMID:22889254   PMID:23376485   PMID:23381804   PMID:23979707   PMID:25617501   PMID:26296893   PMID:26403541   PMID:27892606   PMID:29959233   PMID:35352799  


Genomics

Comparative Map Data
Dsp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81726,829,153 - 26,877,419 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1726,829,153 - 26,877,121 (-)EnsemblGRCr8
mRatBN7.21726,623,602 - 26,671,692 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1726,623,588 - 26,671,800 (-)EnsemblmRatBN7.2
Rnor_6.01727,286,811 - 27,334,453 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1727,286,796 - 27,334,379 (-)Ensemblrn6Rnor6.0
Rnor_5.01729,201,872 - 29,249,490 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41732,848,313 - 32,896,044 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1726,257,726 - 26,305,766 (-)NCBICelera
RGSC_v3.11732,851,800 - 32,898,885 (-)NCBI
Cytogenetic Map17p12NCBI
DSP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3867,541,671 - 7,586,714 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl67,541,326 - 7,586,717 (+)Ensemblhg38GRCh38
GRCh3767,541,904 - 7,586,947 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3667,486,869 - 7,531,945 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3467,486,868 - 7,531,945NCBI
Celera68,771,623 - 8,816,711 (+)NCBICelera
Cytogenetic Map6p24.3NCBI
HuRef67,419,476 - 7,464,417 (+)NCBIHuRef
CHM1_167,544,023 - 7,589,106 (+)NCBICHM1_1
T2T-CHM13v2.067,410,711 - 7,455,759 (+)NCBIT2T-CHM13v2.0
Dsp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391338,335,357 - 38,382,553 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1338,335,270 - 38,382,553 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381338,151,294 - 38,198,577 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1338,151,294 - 38,198,577 (+)Ensemblmm10GRCm38
MGSCv371338,243,163 - 38,290,446 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361338,158,760 - 38,206,043 (+)NCBIMGSCv36mm8
Celera1339,265,897 - 39,313,259 (+)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1318.0NCBI
Dsp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554656,356,863 - 6,392,207 (-)Ensembl
ChiLan1.0NW_0049554656,356,970 - 6,391,206 (-)NCBIChiLan1.0ChiLan1.0
DSP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2522,183,206 - 22,228,587 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1618,180,000 - 18,225,467 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v067,381,046 - 7,426,408 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.167,664,399 - 7,709,391 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl67,664,211 - 7,709,391 (+)EnsemblpanPan2panpan1.1
DSP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1357,479,628 - 7,524,732 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl357,479,643 - 7,524,044 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha357,483,107 - 7,528,345 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0357,562,265 - 7,607,463 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl357,562,020 - 7,607,463 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1357,415,316 - 7,460,024 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0357,441,523 - 7,486,395 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0358,773,585 - 8,819,012 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dsp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494616,760,022 - 16,807,481 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365345,028,911 - 5,077,199 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365345,029,008 - 5,076,467 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DSP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl74,862,649 - 4,915,623 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.174,862,649 - 4,915,626 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.274,968,344 - 5,021,222 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DSP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11764,611,243 - 64,656,297 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1764,611,103 - 64,656,366 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660447,495,774 - 7,541,054 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dsp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475618,035,892 - 18,083,336 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475618,036,103 - 18,083,379 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dsp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11457,196,761 - 57,244,459 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dsp
187 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:16
Count of miRNA genes:16
Interacting mature miRNAs:16
Transcripts:ENSRNOT00000018649
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17436005727233623Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
1331720Rf43Renal function QTL 432.881kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)171553702528637951Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17436005727233623Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat

Markers in Region
RH130644  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21726,623,710 - 26,623,906 (+)MAPPERmRatBN7.2
Rnor_6.01727,286,920 - 27,287,115NCBIRnor6.0
Rnor_5.01729,201,981 - 29,202,176UniSTSRnor5.0
RGSC_v3.41732,848,422 - 32,848,617UniSTSRGSC3.4
Celera1726,257,835 - 26,258,030UniSTS
RH 3.4 Map17341.4UniSTS
Cytogenetic Map17p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 155 91 90 59 68 59 6 332 168 11 133 81 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000018649   ⟹   ENSRNOP00000018649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1726,829,153 - 26,877,121 (-)Ensembl
mRatBN7.2 Ensembl1726,623,588 - 26,671,800 (-)Ensembl
Rnor_6.0 Ensembl1727,286,796 - 27,334,379 (-)Ensembl
RefSeq Acc Id: NM_001419598   ⟹   NP_001406527
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81726,829,153 - 26,877,121 (-)NCBI
mRatBN7.21726,623,602 - 26,671,566 (-)NCBI
RefSeq Acc Id: XM_017600713   ⟹   XP_017456202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81726,829,153 - 26,877,419 (-)NCBI
mRatBN7.21726,623,602 - 26,671,692 (-)NCBI
Rnor_6.01727,286,811 - 27,334,452 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001406527 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456202 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98071 (Get FASTA)   NCBI Sequence Viewer  
  EDL98260 (Get FASTA)   NCBI Sequence Viewer  
  EDL98261 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018649
  ENSRNOP00000018649.5
GenBank Protein F1LMV6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_017456202   ⟸   XM_017600713
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000018649   ⟸   ENSRNOT00000018649
RefSeq Acc Id: NP_001406527   ⟸   NM_001419598
- UniProtKB: F1LMV6 (UniProtKB/Swiss-Prot),   Q4QQR7 (UniProtKB/Swiss-Prot),   A6J7B0 (UniProtKB/TrEMBL)
Protein Domains
SH3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700401
Promoter ID:EPDNEW_R10917
Type:initiation region
Name:Dsp_1
Description:desmoplakin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01727,334,318 - 27,334,378EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305794 AgrOrtholog
BioCyc Gene G2FUF-9681 BioCyc
Ensembl Genes ENSRNOG00000013928 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018649 ENTREZGENE
  ENSRNOT00000018649.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.1060 UniProtKB/Swiss-Prot
  1.20.58.60 UniProtKB/Swiss-Prot
  3.30.160.780 UniProtKB/Swiss-Prot
  3.90.1290.10 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7459514 IMAGE-MGC_LOAD
InterPro Desmoplakin_SH3 UniProtKB/Swiss-Prot
  Desmoplakin_Spectrin-like UniProtKB/Swiss-Prot
  Plakin UniProtKB/Swiss-Prot
  Plakin_repeat_sf UniProtKB/Swiss-Prot
  Plectin_repeat UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  Spectrin/alpha-actinin UniProtKB/Swiss-Prot
MGC_CLONE MGC:116287 IMAGE-MGC_LOAD
NCBI Gene 306871 ENTREZGENE
PANTHER DESMOPLAKIN UniProtKB/Swiss-Prot
  ENVOPLAKIN UniProtKB/Swiss-Prot
Pfam Plectin UniProtKB/Swiss-Prot
  SH3_10 UniProtKB/Swiss-Prot
  Spectrin_3 UniProtKB/Swiss-Prot
  Spectrin_like UniProtKB/Swiss-Prot
PharmGKB DSP RGD
PhenoGen Dsp PhenoGen
PROSITE SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013928 RatGTEx
SMART PLEC UniProtKB/Swiss-Prot
  SPEC UniProtKB/Swiss-Prot
Superfamily-SCOP Plakin repeat UniProtKB/Swiss-Prot
  Spectrin repeat UniProtKB/Swiss-Prot
UniProt A6J7B0 ENTREZGENE, UniProtKB/TrEMBL
  A6J7B1_RAT UniProtKB/TrEMBL
  DESP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4QQR7 ENTREZGENE
UniProt Secondary Q4QQR7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Dsp  desmoplakin  Dsp_predicted  desmoplakin (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Dsp_predicted  desmoplakin (predicted)      Symbol and Name status set to approved 70820 APPROVED