Fbl (fibrillarin rRNA 2'-O-methyltransferase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Fbl (fibrillarin rRNA 2'-O-methyltransferase) Rattus norvegicus
Analyze
Symbol: Fbl
Name: fibrillarin rRNA 2'-O-methyltransferase (Ensembl:fibrillarin)
RGD ID: 1305542
Description: Predicted to enable several functions, including ATPase binding activity; S-adenosylmethionine-dependent methyltransferase activity; and TFIID-class transcription factor complex binding activity. Predicted to be involved in box C/D sno(s)RNA 3'-end processing; ribosome biogenesis; and snoRNA localization. Predicted to act upstream of or within sno(s)RNA metabolic process. Located in Cajal body; chromosome; and dense fibrillar component. Orthologous to human FBL (fibrillarin); PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH (+)-schisandrin B; (R,R,R)-alpha-tocopherol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: fibrillarin; histone-glutamine methyltransferase; LOC292747; MGC116371; nucleolar protein 1; rRNA 2'-O-methyltransferase fibrillarin; U6 snRNA 2'-O-methyltransferase fibrillarin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,597,407 - 92,606,507 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl192,597,258 - 92,606,506 (+)EnsemblGRCr8
mRatBN7.2183,469,832 - 83,478,932 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,469,832 - 83,478,932 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx188,880,071 - 88,889,164 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,338,304 - 97,347,397 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,635,930 - 90,645,023 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0185,103,519 - 85,112,619 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,103,519 - 85,112,619 (+)Ensemblrn6Rnor6.0
Rnor_5.0186,319,815 - 86,328,915 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4183,271,967 - 83,281,069 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera177,869,745 - 77,878,845 (+)NCBICelera
RGSC_v3.1183,350,077 - 83,359,180 (+)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,6-dimethoxyphenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (EXP)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
biochanin A  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dibutyl phthalate  (ISO)
Didecyldimethylammonium  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
etoposide  (ISO)
fenpyroximate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
ivermectin  (ISO)
ketamine  (EXP)
lead diacetate  (ISO)
mercury dichloride  (ISO)
methimazole  (EXP)
methylisothiazolinone  (ISO)
miconazole  (ISO)
mitomycin C  (ISO)
Monobutylphthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
nitrates  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
picoxystrobin  (ISO)
Potassium hexachloropalladate(IV)  (ISO)
pyrimidifen  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
tebufenpyrad  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Nucleologenesis: use of non-isotopic in situ hybridization and immunocytochemistry to compare the localization of rDNA and nucleolar proteins during mitosis. Jimenez-Garcia LF, etal., Biol Cell. 1989;65(3):239-46.
4. Purification and partial characterization of a nucleolar scleroderma antigen (Mr = 34,000; pI, 8.5) rich in NG,NG-dimethylarginine. Lischwe MA, etal., J Biol Chem. 1985 Nov 15;260(26):14304-10.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Neuronal body size correlates with the number of nucleoli and Cajal bodies, and with the organization of the splicing machinery in rat trigeminal ganglion neurons. Pena E, etal., J Comp Neurol. 2001 Feb 5;430(2):250-63.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Immunopurified small nucleolar ribonucleoprotein particles pseudouridylate rRNA independently of their association with phosphorylated Nopp140. Wang C, etal., Mol Cell Biol 2002 Dec;22(24):8457-66.
12. The box C/D and H/ACA snoRNPs: key players in the modification, processing and the dynamic folding of ribosomal RNA. Watkins NJ and Bohnsack MT, Wiley Interdiscip Rev RNA. 2012 May-Jun;3(3):397-414. doi: 10.1002/wrna.117. Epub 2011 Nov 7.
13. Conserved composition of mammalian box H/ACA and box C/D small nucleolar ribonucleoprotein particles and their interaction with the common factor Nopp140. Yang Y, etal., Mol Biol Cell 2000 Feb;11(2):567-77.
Additional References at PubMed
PMID:7768196   PMID:7772340   PMID:11092755   PMID:11237729   PMID:12477932   PMID:12714744   PMID:14612397   PMID:15485902   PMID:15489334   PMID:15494374   PMID:16129783   PMID:16210410  
PMID:16687569   PMID:16855206   PMID:17158916   PMID:17636026   PMID:18625840   PMID:19056867   PMID:19208757   PMID:20168299   PMID:22658674   PMID:22681889   PMID:22720776   PMID:23203802  
PMID:23500592   PMID:24174535   PMID:24352239   PMID:24625528   PMID:30361391   PMID:30540930  


Genomics

Comparative Map Data
Fbl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,597,407 - 92,606,507 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl192,597,258 - 92,606,506 (+)EnsemblGRCr8
mRatBN7.2183,469,832 - 83,478,932 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,469,832 - 83,478,932 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx188,880,071 - 88,889,164 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,338,304 - 97,347,397 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,635,930 - 90,645,023 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0185,103,519 - 85,112,619 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,103,519 - 85,112,619 (+)Ensemblrn6Rnor6.0
Rnor_5.0186,319,815 - 86,328,915 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4183,271,967 - 83,281,069 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera177,869,745 - 77,878,845 (+)NCBICelera
RGSC_v3.1183,350,077 - 83,359,180 (+)NCBI
Cytogenetic Map1q21NCBI
FBL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381939,834,458 - 39,846,379 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1939,834,453 - 39,846,440 (-)Ensemblhg38GRCh38
GRCh371940,325,098 - 40,337,019 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,016,938 - 45,028,813 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341945,016,937 - 45,028,813NCBI
Celera1937,127,387 - 37,139,349 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1936,772,106 - 36,784,069 (-)NCBIHuRef
CHM1_11940,326,441 - 40,338,404 (-)NCBICHM1_1
T2T-CHM13v2.01942,639,380 - 42,651,301 (-)NCBIT2T-CHM13v2.0
Fbl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,868,293 - 27,878,701 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl727,869,135 - 27,878,694 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38728,168,893 - 28,179,269 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,169,710 - 28,179,269 (+)Ensemblmm10GRCm38
MGSCv37728,954,767 - 28,964,288 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36727,878,508 - 27,888,029 (+)NCBIMGSCv36mm8
Celera722,730,966 - 22,740,488 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map716.67NCBI
Fbl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555781,176,713 - 1,186,873 (+)Ensembl
ChiLan1.0NW_0049555781,176,713 - 1,186,873 (+)NCBIChiLan1.0ChiLan1.0
FBL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22046,063,417 - 46,075,395 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11947,934,073 - 47,946,047 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01936,866,329 - 36,878,293 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11945,413,978 - 45,425,930 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1945,413,978 - 45,425,930 (-)EnsemblpanPan2panpan1.1
FBL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,632,899 - 113,643,805 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1113,632,929 - 113,643,748 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1113,036,931 - 113,047,842 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01114,233,485 - 114,244,396 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,233,538 - 114,244,391 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,791,323 - 113,802,229 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,424,985 - 113,435,889 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,419,243 - 114,430,150 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fbl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934914,016,916 - 14,027,394 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366612,444,866 - 2,455,528 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366612,444,985 - 2,455,423 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,314,783 - 48,326,436 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1648,314,782 - 48,326,433 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,160,315 - 44,171,969 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FBL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,370,558 - 34,382,909 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl634,370,558 - 34,376,836 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607312,444,667 - 12,457,740 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462492556,421 - 67,082 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462492556,421 - 67,102 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fbl
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12167,802,409 - 167,811,525 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fbl
52 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:20
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000026021
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat

Markers in Region
MARC_26184-26185:1030717529:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2183,476,828 - 83,477,961 (+)MAPPERmRatBN7.2
Rnor_6.0185,110,516 - 85,111,648NCBIRnor6.0
Rnor_5.0186,326,812 - 86,327,944UniSTSRnor5.0
RGSC_v3.4183,278,966 - 83,280,098UniSTSRGSC3.4
Celera177,876,741 - 77,877,873UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000026021   ⟹   ENSRNOP00000026021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl192,597,390 - 92,606,506 (+)Ensembl
mRatBN7.2 Ensembl183,469,832 - 83,478,932 (+)Ensembl
Rnor_6.0 Ensembl185,103,519 - 85,112,619 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000135690   ⟹   ENSRNOP00000106100
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl192,597,390 - 92,606,506 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000162776   ⟹   ENSRNOP00000105587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl192,597,258 - 92,606,283 (+)Ensembl
RefSeq Acc Id: NM_001025643   ⟹   NP_001020814
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,597,407 - 92,606,507 (+)NCBI
mRatBN7.2183,469,832 - 83,478,932 (+)NCBI
Rnor_6.0185,103,519 - 85,112,619 (+)NCBI
Rnor_5.0186,319,815 - 86,328,915 (+)NCBI
RGSC_v3.4183,271,967 - 83,281,069 (+)RGD
Celera177,869,745 - 77,878,845 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001020814 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH99198 (Get FASTA)   NCBI Sequence Viewer  
  EDM07914 (Get FASTA)   NCBI Sequence Viewer  
  EDM07915 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026021
GenBank Protein P22509 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001020814   ⟸   NM_001025643
- UniProtKB: Q4KLH8 (UniProtKB/Swiss-Prot),   P22509 (UniProtKB/Swiss-Prot),   A6J9G9 (UniProtKB/TrEMBL),   A6J9H0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026021   ⟸   ENSRNOT00000026021
Ensembl Acc Id: ENSRNOP00000106100   ⟸   ENSRNOT00000135690
Ensembl Acc Id: ENSRNOP00000105587   ⟸   ENSRNOT00000162776

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22509-F1-model_v2 AlphaFold P22509 1-327 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689863
Promoter ID:EPDNEW_R388
Type:initiation region
Name:Fbl_1
Description:fibrillarin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0185,103,540 - 85,103,600EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305542 AgrOrtholog
BioCyc Gene G2FUF-60262 BioCyc
Ensembl Genes ENSRNOG00000019229 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000026021 ENTREZGENE
Gene3D-CATH 3.40.50.150 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7383920 IMAGE-MGC_LOAD
InterPro Fibrillarin UniProtKB/Swiss-Prot
  Fibrillarin_CS UniProtKB/Swiss-Prot
  SAM-dependent_MTases UniProtKB/Swiss-Prot
KEGG Report rno:292747 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116371 IMAGE-MGC_LOAD
NCBI Gene 292747 ENTREZGENE
PANTHER RRNA 2'-O-METHYLTRANSFERASE FIBRILLARIN UniProtKB/Swiss-Prot
  RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN UniProtKB/Swiss-Prot
Pfam Fibrillarin UniProtKB/Swiss-Prot
PhenoGen Fbl PhenoGen
PRINTS FIBRILLARIN UniProtKB/Swiss-Prot
PROSITE FIBRILLARIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019229 RatGTEx
SMART Fibrillarin UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot
UniProt A0A8L2UK98_RAT UniProtKB/TrEMBL
  A0ABK0LQY1_RAT UniProtKB/TrEMBL
  A0ABK0LTL6_RAT UniProtKB/TrEMBL
  A6J9G9 ENTREZGENE, UniProtKB/TrEMBL
  A6J9H0 ENTREZGENE, UniProtKB/TrEMBL
  FBRL_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4KLH8 ENTREZGENE
UniProt Secondary Q4KLH8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-11-13 Fbl  fibrillarin rRNA 2'-O-methyltransferase  Fbl  fibrillarin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Fbl  fibrillarin  Fbl_predicted  fibrillarin (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Fbl_predicted  fibrillarin (predicted)      Symbol and Name status set to approved 70820 APPROVED