Aak1 (AP2 associated kinase 1) - Rat Genome Database

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Gene: Aak1 (AP2 associated kinase 1) Rattus norvegicus
Analyze
Symbol: Aak1
Name: AP2 associated kinase 1
RGD ID: 1305520
Description: Enables AP-2 adaptor complex binding activity and protein serine/threonine kinase activity. Involved in presynaptic endocytosis and regulation of clathrin-dependent endocytosis. Located in cell leading edge and terminal bouton. Part of clathrin complex. Is active in calyx of Held. Orthologous to human AAK1 (AP2 associated kinase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Aak1_predicted; adaptor-associated kinase 1; AP2 associated kinase 1 (predicted); AP2-associated protein kinase 1; LOC312519; LOC500244; RGD1563580; similar to AP2 associated kinase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84120,845,012 - 121,009,170 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4120,858,557 - 121,004,236 (+)EnsemblGRCr8
mRatBN7.24119,300,128 - 119,451,834 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4119,295,257 - 119,450,969 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4124,774,675 - 124,914,216 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04120,549,404 - 120,688,946 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04119,173,657 - 119,313,191 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04118,653,851 - 118,806,796 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4118,655,728 - 118,795,774 (+)Ensemblrn6Rnor6.0
Rnor_5.04183,225,133 - 183,365,259 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44121,008,188 - 121,153,112 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4108,270,743 - 108,410,374 (+)NCBICelera
RGSC_v3.14121,252,862 - 121,334,845 (+)NCBI
Cytogenetic Map4q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
6-propyl-2-thiouracil  (EXP)
aconitine  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
baricitinib  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dicrotophos  (ISO)
dimethylselenide  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
fluoxetine  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methyl methanesulfonate  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
reactive oxygen species  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
thiram  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis. Conner SD and Schmid SL, J Cell Biol. 2002 Mar 4;156(5):921-9. Epub 2002 Mar 4.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Hidden proteome of synaptic vesicles in the mammalian brain. Taoufiq Z, etal., Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33586-33596. doi: 10.1073/pnas.2011870117. Epub 2020 Dec 21.
Additional References at PubMed
PMID:14617351   PMID:15057822   PMID:17494869   PMID:18657069   PMID:21464124   PMID:21802010   PMID:22445341   PMID:29476059   PMID:35726359  


Genomics

Comparative Map Data
Aak1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84120,845,012 - 121,009,170 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4120,858,557 - 121,004,236 (+)EnsemblGRCr8
mRatBN7.24119,300,128 - 119,451,834 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4119,295,257 - 119,450,969 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4124,774,675 - 124,914,216 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04120,549,404 - 120,688,946 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04119,173,657 - 119,313,191 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04118,653,851 - 118,806,796 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4118,655,728 - 118,795,774 (+)Ensemblrn6Rnor6.0
Rnor_5.04183,225,133 - 183,365,259 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44121,008,188 - 121,153,112 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4108,270,743 - 108,410,374 (+)NCBICelera
RGSC_v3.14121,252,862 - 121,334,845 (+)NCBI
Cytogenetic Map4q34NCBI
AAK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38269,457,997 - 69,643,739 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl269,457,997 - 69,674,349 (-)Ensemblhg38GRCh38
GRCh37269,685,129 - 69,870,871 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36269,538,631 - 69,724,481 (-)NCBIBuild 36Build 36hg18NCBI36
Celera269,535,200 - 69,722,074 (-)NCBICelera
Cytogenetic Map2p13.3NCBI
HuRef269,421,353 - 69,607,695 (-)NCBIHuRef
CHM1_1269,614,737 - 69,800,612 (-)NCBICHM1_1
T2T-CHM13v2.0269,470,304 - 69,656,050 (-)NCBIT2T-CHM13v2.0
Aak1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39686,826,252 - 86,980,209 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl686,826,499 - 86,980,205 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38686,849,274 - 87,003,227 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl686,849,517 - 87,003,223 (+)Ensemblmm10GRCm38
MGSCv37686,799,511 - 86,953,221 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36686,815,474 - 86,957,498 (+)NCBIMGSCv36mm8
Celera688,789,320 - 88,942,625 (+)NCBICelera
Cytogenetic Map6D1NCBI
cM Map637.75NCBI
Aak1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542415,483,465 - 15,627,664 (+)Ensembl
ChiLan1.0NW_00495542415,480,783 - 15,640,471 (+)NCBIChiLan1.0ChiLan1.0
AAK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21256,769,969 - 56,957,632 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A56,773,915 - 56,961,578 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A69,506,651 - 69,686,765 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A70,626,408 - 70,804,579 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A70,638,470 - 70,804,579 (-)EnsemblpanPan2panpan1.1
AAK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11068,181,584 - 68,336,266 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1068,134,902 - 68,335,988 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1068,071,405 - 68,227,419 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01069,203,126 - 69,359,380 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1069,199,727 - 69,359,723 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11068,888,872 - 69,077,460 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01069,184,012 - 69,340,378 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01069,481,396 - 69,637,824 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629214,673,456 - 14,855,467 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649113,729,727 - 13,897,923 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649113,720,687 - 13,897,899 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AAK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl372,794,158 - 72,968,194 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1372,793,977 - 72,960,315 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AAK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11437,492,885 - 37,669,953 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1437,576,872 - 37,658,050 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604574,325,972 - 74,505,290 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aak1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247623,723,113 - 3,866,417 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247623,722,429 - 3,873,105 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Aak1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1659,322,128 - 59,400,703 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Aak1
475 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:738
Count of miRNA genes:306
Interacting mature miRNAs:426
Transcripts:ENSRNOT00000043082
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)496731383141731383Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4117737142152833657Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat

Markers in Region
RH132363  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24119,433,433 - 119,433,647 (+)MAPPERmRatBN7.2
Rnor_6.04118,788,331 - 118,788,544NCBIRnor6.0
Rnor_5.04183,357,816 - 183,358,029UniSTSRnor5.0
RGSC_v3.44121,140,486 - 121,140,699UniSTSRGSC3.4
Celera4108,402,931 - 108,403,144UniSTS
RH 3.4 Map4698.6UniSTS
Cytogenetic Map4q34UniSTS
RH132368  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24119,440,487 - 119,440,671 (+)MAPPERmRatBN7.2
Rnor_6.04118,795,385 - 118,795,568NCBIRnor6.0
Rnor_5.04183,364,870 - 183,365,053UniSTSRnor5.0
RGSC_v3.44121,147,540 - 121,147,723UniSTSRGSC3.4
Celera4108,409,985 - 108,410,168UniSTS
RH 3.4 Map4698.4UniSTS
Cytogenetic Map4q34UniSTS
RH143910  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24119,300,181 - 119,300,375 (+)MAPPERmRatBN7.2
Rnor_6.04118,654,682 - 118,654,875NCBIRnor6.0
Rnor_5.04183,224,106 - 183,224,299UniSTSRnor5.0
RGSC_v3.44121,007,018 - 121,007,211UniSTSRGSC3.4
Celera4108,269,697 - 108,269,890UniSTS
RH 3.4 Map4696.0UniSTS
Cytogenetic Map4q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001173450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC112554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000043082   ⟹   ENSRNOP00000044665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4120,858,567 - 120,998,214 (+)Ensembl
mRatBN7.2 Ensembl4119,301,228 - 119,440,877 (+)Ensembl
Rnor_6.0 Ensembl4118,655,728 - 118,795,774 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096717   ⟹   ENSRNOP00000094963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4120,858,561 - 121,004,164 (+)Ensembl
mRatBN7.2 Ensembl4119,301,228 - 119,448,597 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100088   ⟹   ENSRNOP00000086691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4119,295,257 - 119,450,969 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100839   ⟹   ENSRNOP00000087662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4120,858,559 - 121,004,164 (+)Ensembl
mRatBN7.2 Ensembl4119,301,228 - 119,440,877 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102896   ⟹   ENSRNOP00000088529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4120,858,557 - 121,004,236 (+)Ensembl
mRatBN7.2 Ensembl4119,301,228 - 119,448,597 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104791   ⟹   ENSRNOP00000078415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4120,858,557 - 121,004,164 (+)Ensembl
mRatBN7.2 Ensembl4119,301,228 - 119,445,850 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116423   ⟹   ENSRNOP00000087063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4120,987,401 - 121,004,236 (+)Ensembl
mRatBN7.2 Ensembl4119,429,746 - 119,448,597 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118607   ⟹   ENSRNOP00000084865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4120,858,559 - 121,004,164 (+)Ensembl
mRatBN7.2 Ensembl4119,301,228 - 119,450,969 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000136866   ⟹   ENSRNOP00000111555
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4120,987,474 - 121,004,164 (+)Ensembl
RefSeq Acc Id: NM_001173450   ⟹   NP_001166921
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,567 - 120,998,214 (+)NCBI
mRatBN7.24119,301,228 - 119,440,877 (+)NCBI
Rnor_6.04118,655,728 - 118,795,774 (+)NCBI
Rnor_5.04183,225,133 - 183,365,259 (+)NCBI
Celera4108,270,743 - 108,410,374 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236833   ⟹   XP_006236895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,529 - 120,998,208 (+)NCBI
mRatBN7.24119,301,210 - 119,440,871 (+)NCBI
Rnor_6.04118,655,703 - 118,795,768 (+)NCBI
Rnor_5.04183,225,133 - 183,365,259 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236834   ⟹   XP_006236896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,556 - 120,998,208 (+)NCBI
mRatBN7.24119,301,210 - 119,440,871 (+)NCBI
Rnor_6.04118,655,703 - 118,795,768 (+)NCBI
Rnor_5.04183,225,133 - 183,365,259 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592817   ⟹   XP_017448306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,555 - 121,009,170 (+)NCBI
mRatBN7.24119,301,209 - 119,451,834 (+)NCBI
Rnor_6.04118,655,702 - 118,806,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592818   ⟹   XP_017448307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,845,012 - 121,009,170 (+)NCBI
mRatBN7.24119,300,128 - 119,451,834 (+)NCBI
Rnor_6.04118,653,851 - 118,806,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592819   ⟹   XP_017448308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,555 - 121,009,170 (+)NCBI
mRatBN7.24119,301,209 - 119,451,834 (+)NCBI
Rnor_6.04118,655,702 - 118,806,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592820   ⟹   XP_017448309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,555 - 121,009,170 (+)NCBI
mRatBN7.24119,301,209 - 119,451,834 (+)NCBI
Rnor_6.04118,655,703 - 118,806,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592821   ⟹   XP_017448310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,556 - 121,009,170 (+)NCBI
mRatBN7.24119,301,209 - 119,451,834 (+)NCBI
Rnor_6.04118,655,703 - 118,806,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592822   ⟹   XP_017448311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,502 - 121,009,170 (+)NCBI
mRatBN7.24119,301,209 - 119,451,834 (+)NCBI
Rnor_6.04118,655,703 - 118,806,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039108159   ⟹   XP_038964087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,555 - 121,009,170 (+)NCBI
mRatBN7.24119,301,209 - 119,451,834 (+)NCBI
RefSeq Acc Id: XM_039108160   ⟹   XP_038964088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,555 - 121,009,170 (+)NCBI
mRatBN7.24119,301,209 - 119,451,834 (+)NCBI
RefSeq Acc Id: XM_039108161   ⟹   XP_038964089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,555 - 121,009,170 (+)NCBI
mRatBN7.24119,301,209 - 119,451,834 (+)NCBI
RefSeq Acc Id: XM_039108162   ⟹   XP_038964090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,556 - 121,009,170 (+)NCBI
mRatBN7.24119,301,209 - 119,451,834 (+)NCBI
RefSeq Acc Id: XM_063286530   ⟹   XP_063142600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,555 - 121,009,170 (+)NCBI
RefSeq Acc Id: XM_063286531   ⟹   XP_063142601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,556 - 121,009,170 (+)NCBI
RefSeq Acc Id: XM_063286532   ⟹   XP_063142602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,556 - 120,998,208 (+)NCBI
RefSeq Acc Id: NP_001166921   ⟸   NM_001173450
- UniProtKB: P0C1X8 (UniProtKB/Swiss-Prot),   F1LRI7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236895   ⟸   XM_006236833
- Peptide Label: isoform X12
- UniProtKB: P0C1X8 (UniProtKB/Swiss-Prot),   F1LRI7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236896   ⟸   XM_006236834
- Peptide Label: isoform X13
- UniProtKB: P0C1X8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017448307   ⟸   XM_017592818
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017448306   ⟸   XM_017592817
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017448308   ⟸   XM_017592819
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017448309   ⟸   XM_017592820
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017448310   ⟸   XM_017592821
- Peptide Label: isoform X8
- UniProtKB: A0A8I6ALS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448311   ⟸   XM_017592822
- Peptide Label: isoform X10
- UniProtKB: A0A8I6A256 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044665   ⟸   ENSRNOT00000043082
RefSeq Acc Id: XP_038964088   ⟸   XM_039108160
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038964087   ⟸   XM_039108159
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038964089   ⟸   XM_039108161
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038964090   ⟸   XM_039108162
- Peptide Label: isoform X11
Ensembl Acc Id: ENSRNOP00000087063   ⟸   ENSRNOT00000116423
Ensembl Acc Id: ENSRNOP00000088529   ⟸   ENSRNOT00000102896
Ensembl Acc Id: ENSRNOP00000094963   ⟸   ENSRNOT00000096717
Ensembl Acc Id: ENSRNOP00000086691   ⟸   ENSRNOT00000100088
Ensembl Acc Id: ENSRNOP00000078415   ⟸   ENSRNOT00000104791
Ensembl Acc Id: ENSRNOP00000087662   ⟸   ENSRNOT00000100839
Ensembl Acc Id: ENSRNOP00000084865   ⟸   ENSRNOT00000118607
RefSeq Acc Id: XP_063142600   ⟸   XM_063286530
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063142601   ⟸   XM_063286531
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063142602   ⟸   XM_063286532
- Peptide Label: isoform X14
- UniProtKB: P0C1X8 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000111555   ⟸   ENSRNOT00000136866
Protein Domains
BMP-2-inducible protein kinase C-terminal   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C1X8-F1-model_v2 AlphaFold P0C1X8 1-962 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693215
Promoter ID:EPDNEW_R3740
Type:multiple initiation site
Name:Aak1_1
Description:AP2 associated kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04118,655,718 - 118,655,778EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305520 AgrOrtholog
BioCyc Gene G2FUF-43880 BioCyc
Ensembl Genes ENSRNOG00000018317 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000043082 ENTREZGENE
  ENSRNOT00000096717 ENTREZGENE
  ENSRNOT00000102896 ENTREZGENE
  ENSRNOT00000104791 ENTREZGENE
  ENSRNOT00000118607 ENTREZGENE
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro AP2_assoc_SerThr_kinase UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
NCBI Gene Aak1 ENTREZGENE
PANTHER AP2-ASSOCIATED PROTEIN KINASE 1 UniProtKB/Swiss-Prot
  PROTEIN KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Aak1 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018317 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I5ZKV0_RAT UniProtKB/TrEMBL
  A0A8I6A256 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A3P1_RAT UniProtKB/TrEMBL
  A0A8I6A6D5_RAT UniProtKB/TrEMBL
  A0A8I6ALS6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GFC9_RAT UniProtKB/TrEMBL
  A0ABK0M9I1_RAT UniProtKB/TrEMBL
  AAK1_RAT UniProtKB/Swiss-Prot
  F1LRI7 ENTREZGENE, UniProtKB/TrEMBL
  P0C1X8 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-08 Aak1  AP2 associated kinase 1  Aak1_predicted  AP2 associated kinase 1 (predicted)  Symbol and Name updated 1299863 APPROVED
2008-05-08 Aak1_predicted  AP2 associated kinase 1 (predicted)  Aak1  AP2 associated kinase 1  Data merged from RGD:1563580 737654 APPROVED
2008-03-07 Aak1  AP2 associated kinase 1  RGD1563580_predicted  similar to AP2 associated kinase 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Aak1  AP2 associated kinase 1  Aak1  AP2 associated kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1563580_predicted  similar to AP2 associated kinase 1 (predicted)  LOC500244  similar to AP2 associated kinase 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500244  similar to AP2 associated kinase 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Aak1_predicted  AP2 associated kinase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED