Aak1 (AP2 associated kinase 1) - Rat Genome Database

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Gene: Aak1 (AP2 associated kinase 1) Chinchilla lanigera
Analyze
Symbol: Aak1
Name: AP2 associated kinase 1
RGD ID: 8853612
Description: ENCODES a protein that exhibits AP-2 adaptor complex binding (ortholog); Notch binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN positive regulation of Notch signaling pathway (ortholog); presynaptic endocytosis (ortholog); protein stabilization (ortholog); ASSOCIATED WITH genetic disease (ortholog); tooth agenesis (ortholog); FOUND IN calyx of Held (ortholog); cell leading edge (ortholog); clathrin complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AP2-associated protein kinase 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542415,483,465 - 15,627,664 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542415,480,783 - 15,640,471 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Aak1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542415,483,465 - 15,627,664 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542415,480,783 - 15,640,471 (+)NCBIChiLan1.0ChiLan1.0
AAK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38269,457,997 - 69,643,739 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl269,457,997 - 69,674,349 (-)EnsemblGRCh38hg38GRCh38
GRCh37269,685,129 - 69,870,871 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36269,538,631 - 69,724,481 (-)NCBINCBI36Build 36hg18NCBI36
Celera269,535,200 - 69,722,074 (-)NCBICelera
Cytogenetic Map2p13.3NCBI
HuRef269,421,353 - 69,607,695 (-)NCBIHuRef
CHM1_1269,614,737 - 69,800,612 (-)NCBICHM1_1
T2T-CHM13v2.0269,470,304 - 69,656,050 (-)NCBIT2T-CHM13v2.0
Aak1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39686,826,252 - 86,980,209 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl686,826,499 - 86,980,205 (+)EnsemblGRCm39 Ensembl
GRCm38686,849,274 - 87,003,227 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl686,849,517 - 87,003,223 (+)EnsemblGRCm38mm10GRCm38
MGSCv37686,799,511 - 86,953,221 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36686,815,474 - 86,957,498 (+)NCBIMGSCv36mm8
Celera688,789,320 - 88,942,625 (+)NCBICelera
Cytogenetic Map6D1NCBI
cM Map637.75NCBI
Aak1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84120,845,012 - 121,009,170 (+)NCBIGRCr8
mRatBN7.24119,300,128 - 119,451,834 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4119,295,257 - 119,450,969 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4124,774,675 - 124,914,216 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04120,549,404 - 120,688,946 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04119,173,657 - 119,313,191 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04118,653,851 - 118,806,796 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4118,655,728 - 118,795,774 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04183,225,133 - 183,365,259 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44121,008,188 - 121,153,112 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14121,252,862 - 121,334,845 (+)NCBI
Celera4108,270,743 - 108,410,374 (+)NCBICelera
Cytogenetic Map4q34NCBI
AAK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21256,769,969 - 56,957,632 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A56,773,915 - 56,961,578 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A69,506,651 - 69,686,765 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A70,626,408 - 70,804,579 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A70,638,470 - 70,804,579 (-)Ensemblpanpan1.1panPan2
AAK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11068,181,584 - 68,336,266 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1068,134,902 - 68,335,988 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1068,071,405 - 68,227,419 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01069,203,126 - 69,359,380 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1069,199,727 - 69,359,723 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11068,888,872 - 69,077,460 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01069,184,012 - 69,340,378 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01069,481,396 - 69,637,824 (-)NCBIUU_Cfam_GSD_1.0
Aak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629214,673,456 - 14,855,467 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649113,729,727 - 13,897,923 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649113,720,687 - 13,897,899 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AAK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl372,794,158 - 72,968,194 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1372,793,977 - 72,960,315 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AAK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11437,492,885 - 37,669,953 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1437,576,872 - 37,658,050 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604574,325,972 - 74,505,290 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aak1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247623,723,113 - 3,866,417 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247623,722,429 - 3,873,105 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000009203   ⟹   ENSCLAP00000009074
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542415,483,465 - 15,627,664 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000009204   ⟹   ENSCLAP00000009075
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542415,483,465 - 15,627,664 (+)Ensembl
RefSeq Acc Id: XM_005385640   ⟹   XP_005385697
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542415,480,783 - 15,640,471 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005385641   ⟹   XP_005385698
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542415,480,783 - 15,640,471 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005385642   ⟹   XP_005385699
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542415,480,783 - 15,640,471 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005385643   ⟹   XP_005385700
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542415,550,553 - 15,640,471 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005385644   ⟹   XP_005385701
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542415,480,784 - 15,640,471 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005385645   ⟹   XP_005385702
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542415,480,784 - 15,640,471 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005385646   ⟹   XP_005385703
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542415,480,783 - 15,629,299 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005385647   ⟹   XP_005385704
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542415,480,784 - 15,629,299 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013514694   ⟹   XP_013370148
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542415,480,783 - 15,640,471 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013514695   ⟹   XP_013370149
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542415,480,783 - 15,640,471 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005385697   ⟸   XM_005385640
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005385699   ⟸   XM_005385642
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_005385701   ⟸   XM_005385644
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_005385702   ⟸   XM_005385645
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_005385698   ⟸   XM_005385641
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005385703   ⟸   XM_005385646
- Peptide Label: isoform X9
- UniProtKB: A0A8C2V2P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005385704   ⟸   XM_005385647
- Peptide Label: isoform X10
- UniProtKB: A0A8C2V2P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005385700   ⟸   XM_005385643
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_013370149   ⟸   XM_013514695
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_013370148   ⟸   XM_013514694
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSCLAP00000009074   ⟸   ENSCLAT00000009203
RefSeq Acc Id: ENSCLAP00000009075   ⟸   ENSCLAT00000009204
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000006331 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000009203 ENTREZGENE
  ENSCLAT00000009203.1 UniProtKB/TrEMBL
  ENSCLAT00000009204.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Aak1 ENTREZGENE
PANTHER AP2-ASSOCIATED PROTEIN KINASE 1 UniProtKB/TrEMBL
  PROTEIN KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2V2P0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2V8G4_CHILA UniProtKB/TrEMBL