Slc25a12 (solute carrier family 25 member 12) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Slc25a12 (solute carrier family 25 member 12) Rattus norvegicus
Analyze
Symbol: Slc25a12
Name: solute carrier family 25 member 12
RGD ID: 1305181
Description: Predicted to enable amino acid:monoatomic cation antiporter activity; calcium ion binding activity; and identical protein binding activity. Involved in several processes, including malate-aspartate shuttle; positive regulation of ATP biosynthetic process; and regulation of glucose metabolic process. Predicted to be located in mitochondrial inner membrane. Biomarker of fetal alcohol spectrum disorder. Human ortholog(s) of this gene implicated in Asperger syndrome; autistic disorder; and developmental and epileptic encephalopathy 39. Orthologous to human SLC25A12 (solute carrier family 25 member 12); PARTICIPATES IN argininosuccinic aciduria pathway; carbamoyl phosphate synthetase I deficiency pathway; citrullinemia pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Aralar1; calcium-binding mitochondrial carrier protein Aralar1; electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial; LOC362145; RGD1561141; solute carrier family 25 (aspartate/glutamate carrier), member 12; solute carrier family 25 (mitochondrial carrier, Aralar), member 12; solute carrier family 25, member 12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8376,504,868 - 76,599,536 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl376,504,868 - 76,599,536 (-)EnsemblGRCr8
mRatBN7.2356,097,166 - 56,191,841 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl356,097,269 - 56,192,100 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx359,494,953 - 59,589,864 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0368,078,560 - 68,173,464 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0365,840,596 - 65,935,265 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0357,881,951 - 57,998,214 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl357,882,370 - 57,957,346 (-)Ensemblrn6Rnor6.0
Rnor_5.0364,377,674 - 64,416,725 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0364,425,236 - 64,487,369 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4353,620,160 - 53,680,498NCBIRGSC_v3.4RGSC_v3.4rn4
Celera355,645,527 - 55,739,772 (-)NCBICelera
Cytogenetic Map3q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (EXP)
aldehydo-D-glucose  (EXP)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Brodifacoum  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
glucose  (EXP)
hypochlorous acid  (ISO)
inulin  (ISO)
ivermectin  (ISO)
lamivudine  (ISO)
methapyrilene  (ISO)
monosodium L-glutamate  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(I:C)  (EXP)
potassium chromate  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
mitochondrial inner membrane  (IEA,ISO,ISS)
mitochondrion  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Silencing of the mitochondrial NADH shuttle component aspartate-glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets. Casimir M, etal., Biochem J. 2009 Dec 10;424(3):459-66. doi: 10.1042/BJ20090729.
2. Brief report: High frequency of biochemical markers for mitochondrial dysfunction in autism: no association with the mitochondrial aspartate/glutamate carrier SLC25A12 gene. Correia C, etal., J Autism Dev Disord. 2006 Nov;36(8):1137-40. doi: 10.1007/s10803-006-0138-6.
3. Single nucleotide polymorphism rs6716901 in SLC25A12 gene is associated with Asperger syndrome. Durdiaková J, etal., Mol Autism. 2014 Mar 31;5(1):25. doi: 10.1186/2040-2392-5-25.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects. Lepagnol-Bestel AM, etal., Mol Psychiatry. 2008 Apr;13(4):385-97. doi: 10.1038/sj.mp.4002120. Epub 2008 Jan 8.
7. Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools. McKenna MC, etal., Biochem Pharmacol. 2006 Feb 14;71(4):399-407. Epub 2005 Dec 20.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism. Ramoz N, etal., Am J Psychiatry 2004 Apr;161(4):662-9.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Slc25a12 disruption alters myelination and neurofilaments: a model for a hypomyelination syndrome and childhood neurodevelopmental disorders. Sakurai T, etal., Biol Psychiatry. 2010 May 1;67(9):887-94. doi: 10.1016/j.biopsych.2009.08.042. Epub 2009 Dec 16.
16. Low-dose thyroxine attenuates autism-associated adverse effects of fetal alcohol in male offspring's social behavior and hippocampal gene expression. Tunc-Ozcan E, etal., Alcohol Clin Exp Res. 2013 Nov;37(11):1986-95. doi: 10.1111/acer.12183. Epub 2013 Jun 13.
17. NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Ying W Antioxid Redox Signal. 2008 Feb;10(2):179-206.
Additional References at PubMed
PMID:9722566   PMID:11566871   PMID:12084073   PMID:12865426   PMID:14701727   PMID:15494407   PMID:16269409   PMID:17213189   PMID:17634366   PMID:18614015   PMID:20833797   PMID:25410934  


Genomics

Comparative Map Data
Slc25a12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8376,504,868 - 76,599,536 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl376,504,868 - 76,599,536 (-)EnsemblGRCr8
mRatBN7.2356,097,166 - 56,191,841 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl356,097,269 - 56,192,100 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx359,494,953 - 59,589,864 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0368,078,560 - 68,173,464 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0365,840,596 - 65,935,265 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0357,881,951 - 57,998,214 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl357,882,370 - 57,957,346 (-)Ensemblrn6Rnor6.0
Rnor_5.0364,377,674 - 64,416,725 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0364,425,236 - 64,487,369 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4353,620,160 - 53,680,498NCBIRGSC_v3.4RGSC_v3.4rn4
Celera355,645,527 - 55,739,772 (-)NCBICelera
Cytogenetic Map3q22NCBI
SLC25A12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382171,783,405 - 171,894,244 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2171,781,400 - 171,999,859 (-)Ensemblhg38GRCh38
GRCh372172,639,915 - 172,750,754 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362172,349,126 - 172,458,979 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342172,466,387 - 172,576,240NCBI
Celera2166,256,502 - 166,367,904 (-)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2164,525,268 - 164,635,693 (-)NCBIHuRef
CHM1_12172,646,763 - 172,757,956 (-)NCBICHM1_1
T2T-CHM13v2.02172,260,855 - 172,372,092 (-)NCBIT2T-CHM13v2.0
Slc25a12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39271,104,614 - 71,198,125 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl271,101,407 - 71,198,093 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38271,274,270 - 71,367,781 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl271,271,063 - 71,367,749 (-)Ensemblmm10GRCm38
MGSCv37271,112,352 - 71,205,611 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36271,075,134 - 71,168,393 (-)NCBIMGSCv36mm8
Celera272,934,243 - 73,030,549 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map242.38NCBI
Slc25a12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554493,093,603 - 3,186,737 (+)Ensembl
ChiLan1.0NW_0049554493,093,603 - 3,182,513 (+)NCBIChiLan1.0ChiLan1.0
SLC25A12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21374,460,821 - 74,684,204 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B74,475,794 - 74,699,177 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B59,071,123 - 59,297,327 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B176,532,940 - 176,755,193 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B176,532,940 - 176,641,894 (-)EnsemblpanPan2panpan1.1
SLC25A12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13616,185,011 - 16,391,080 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3616,185,649 - 16,483,016 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3616,195,022 - 16,399,770 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03616,305,983 - 16,511,922 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3616,305,986 - 16,511,932 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13616,393,768 - 16,599,876 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03616,393,468 - 16,600,256 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03616,496,286 - 16,703,375 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc25a12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303133,440,179 - 133,608,738 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365091,990,116 - 2,077,938 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365091,994,082 - 2,077,731 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC25A12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1577,895,938 - 78,098,383 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11577,895,935 - 78,021,930 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21587,284,119 - 87,308,544 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC25A12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11057,268,948 - 57,387,958 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1057,265,550 - 57,387,910 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040142,052,296 - 142,277,404 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc25a12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247879,184,514 - 9,320,060 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247879,187,450 - 9,319,684 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc25a12
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1548,568,713 - 48,660,029 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc25a12
645 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:56
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000036728
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)35986366387321459Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)35986366387321459Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)35986366383358329Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)37359251285062403Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
RH135310  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8376,557,080 - 76,557,296 (+)Marker Load Pipeline
mRatBN7.2356,149,389 - 56,149,604 (+)MAPPERmRatBN7.2
Rnor_6.0357,940,302 - 57,940,516NCBIRnor6.0
Rnor_5.0364,428,614 - 64,428,828UniSTSRnor5.0
RGSC_v3.4353,623,508 - 53,623,722UniSTSRGSC3.4
Celera355,696,750 - 55,696,964UniSTS
Cytogenetic Map3q21UniSTS
RH138988  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2356,148,628 - 56,148,754 (+)MAPPERmRatBN7.2
Rnor_6.0357,939,541 - 57,939,666NCBIRnor6.0
Rnor_5.0364,427,853 - 64,427,978UniSTSRnor5.0
RGSC_v3.4353,622,747 - 53,622,872UniSTSRGSC3.4
Celera355,695,989 - 55,696,114UniSTS
RH 3.4 Map4402.55UniSTS
Cytogenetic Map3q21UniSTS
RH139242  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2356,151,840 - 56,152,089 (+)MAPPERmRatBN7.2
Rnor_6.0357,942,753 - 57,943,001NCBIRnor6.0
Rnor_5.0364,431,065 - 64,431,313UniSTSRnor5.0
RGSC_v3.4353,625,960 - 53,626,208UniSTSRGSC3.4
Celera355,699,201 - 55,699,449UniSTS
Cytogenetic Map3q21UniSTS
M2SSR54B  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2356,144,119 - 56,145,121 (+)MAPPERmRatBN7.2
mRatBN7.2356,144,119 - 56,145,131 (+)MAPPERmRatBN7.2
Rnor_6.0357,935,032 - 57,936,043NCBIRnor6.0
Rnor_6.0357,935,032 - 57,936,033NCBIRnor6.0
Rnor_5.0364,423,344 - 64,424,355UniSTSRnor5.0
Rnor_5.0364,423,344 - 64,424,345UniSTSRnor5.0
RGSC_v3.4353,618,238 - 53,619,249UniSTSRGSC3.4
RGSC_v3.4353,618,238 - 53,619,239UniSTSRGSC3.4
Celera355,691,478 - 55,692,479UniSTS
Celera355,691,478 - 55,692,491UniSTS
Cytogenetic Map3q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000036728   ⟹   ENSRNOP00000032909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl376,504,868 - 76,599,536 (-)Ensembl
mRatBN7.2 Ensembl356,097,269 - 56,166,424 (-)Ensembl
Rnor_6.0 Ensembl357,882,370 - 57,957,346 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090426   ⟹   ENSRNOP00000072270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl376,506,486 - 76,538,470 (-)Ensembl
mRatBN7.2 Ensembl356,098,786 - 56,130,772 (-)Ensembl
Rnor_6.0 Ensembl357,882,421 - 57,913,999 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118666   ⟹   ENSRNOP00000093623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl376,504,868 - 76,563,102 (-)Ensembl
mRatBN7.2 Ensembl356,097,269 - 56,192,100 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000156572   ⟹   ENSRNOP00000111139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl376,504,868 - 76,558,293 (-)Ensembl
RefSeq Acc Id: NM_001399269   ⟹   NP_001386198
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,504,868 - 76,599,536 (-)NCBI
mRatBN7.2356,097,166 - 56,191,841 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001386198 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000032909
GenBank Protein F1LX07 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000032909   ⟸   ENSRNOT00000036728
Ensembl Acc Id: ENSRNOP00000072270   ⟸   ENSRNOT00000090426
Ensembl Acc Id: ENSRNOP00000093623   ⟸   ENSRNOT00000118666
RefSeq Acc Id: NP_001386198   ⟸   NM_001399269
- UniProtKB: F1LX07 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000111139   ⟸   ENSRNOT00000156572
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LX07-F1-model_v2 AlphaFold F1LX07 1-655 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305181 AgrOrtholog
BioCyc Gene G2FUF-49472 BioCyc
Ensembl Genes ENSRNOG00000022922 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000036728 ENTREZGENE
Gene3D-CATH 1.50.40.10 UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
  Mit_carrier UniProtKB/Swiss-Prot
  Mito_Solute_Carrier UniProtKB/Swiss-Prot
  Mitochondrial_sb/sol_carrier UniProtKB/Swiss-Prot
  Mt_carrier_dom_sf UniProtKB/Swiss-Prot
NCBI Gene 362145 ENTREZGENE
PANTHER CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1 UniProtKB/Swiss-Prot
  MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED UniProtKB/Swiss-Prot
Pfam Mito_carr UniProtKB/Swiss-Prot
PhenoGen Slc25a12 PhenoGen
PRINTS MITOCARRIER UniProtKB/Swiss-Prot
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
  SOLCAR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000022922 RatGTEx
SMART EFh UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103506 UniProtKB/Swiss-Prot
  SSF47473 UniProtKB/Swiss-Prot
UniProt A0A0G2K2J7_RAT UniProtKB/TrEMBL
  A0A8I6AM68_RAT UniProtKB/TrEMBL
  A0A8W1B2M1_RAT UniProtKB/TrEMBL
  A0ABK0M2J3_RAT UniProtKB/TrEMBL
  F1LX07 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc25a12  solute carrier family 25 member 12  Slc25a12  solute carrier family 25 (aspartate/glutamate carrier), member 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc25a12  solute carrier family 25 (aspartate/glutamate carrier), member 12  Slc25a12  solute carrier family 25 (mitochondrial carrier, Aralar), member 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Slc25a12  solute carrier family 25 (mitochondrial carrier, Aralar), member 12  LOC100360985  solute carrier family 25, member 12  Data merged from RGD:2321075 1643240 APPROVED
2010-05-05 LOC100360985  solute carrier family 25, member 12      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Slc25a12  solute carrier family 25 (mitochondrial carrier, Aralar), member 12   Slc25a12_predicted  solute carrier family 25 (mitochondrial carrier, Aralar), member 12 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Slc25a12_predicted  solute carrier family 25 (mitochondrial carrier, Aralar), member 12 (predicted)      Symbol and Name status set to approved 70820 APPROVED