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Gene: Aif1l (allograft inflammatory factor 1-like) Rattus norvegicus

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Symbol:

Aif1l

Name:

allograft inflammatory factor 1-like

RGD ID:

1305081

Description:

Predicted to enable actin filament binding activity and calcium ion binding activity. Predicted to be involved in actin filament bundle assembly and ruffle assembly. Part of protein-containing complex. Orthologous to human AIF1L (allograft inflammatory factor 1 like); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC362107; RGD1305081; similar to ionized calcium binding adapter molecule 2 (Iba2)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	35,627,239 - 35,651,793 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	35,627,239 - 35,651,793 (+)	Ensembl				GRCr8
mRatBN7.2	3	15,229,476 - 15,254,033 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	15,229,524 - 15,254,023 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	18,302,434 - 18,326,985 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	26,887,419 - 26,911,975 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	25,134,603 - 25,159,186 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	9,237,944 - 9,262,628 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	9,237,944 - 9,262,628 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	14,598,261 - 14,622,945 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	11,053,196 - 11,078,079 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	9,976,750 - 10,001,583 (+)	NCBI		Celera
RGSC_v3.1	3	10,945,778 - 10,972,062 (+)	NCBI
Cytogenetic Map	3	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

breast cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetylsalicylic acid (ISO)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

aldrin (ISO)

all-trans-retinoic acid (EXP,ISO)

alpha-Zearalanol (EXP)

amitrole (EXP)

antirheumatic drug (ISO)

avobenzone (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

butan-1-ol (ISO)

butanal (ISO)

cadmium atom (EXP)

cadmium dichloride (EXP,ISO)

caffeine (ISO)

carbon nanotube (ISO)

cisplatin (EXP,ISO)

cocaine (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

Cuprizon (EXP)

cyclosporin A (EXP,ISO)

cytarabine (ISO)

DDE (ISO)

dexamethasone (ISO)

diethylstilbestrol (EXP)

dioxygen (ISO)

disodium selenite (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

enzyme inhibitor (ISO)

ethanol (ISO)

fenvalerate (EXP)

FR900359 (ISO)

fulvestrant (ISO)

gentamycin (EXP)

hexadecanoic acid (ISO)

inulin (ISO)

lead diacetate (ISO)

N-methyl-4-phenylpyridinium (ISO)

paracetamol (EXP)

pentanal (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

potassium dichromate (ISO)

propanal (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

succimer (ISO)

sulindac (ISO)

sunitinib (ISO)

temozolomide (ISO)

testosterone (ISO)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament bundle assembly (IBA)

ruffle assembly (IBA)

Cellular Component

actin cytoskeleton (ISO)

actin filament (IBA,ISO)

focal adhesion (ISO)

protein-containing complex (IDA)

ruffle membrane (IBA,IEA)

Molecular Function

actin filament binding (IBA,ISO)

calcium ion binding (IBA,IEA)

metal ion binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Absence of AIF1L contributes to cell migration and a poor prognosis of breast cancer.	Liu P, etal., Onco Targets Ther. 2018 Sep 5;11:5485-5498. doi: 10.2147/OTT.S165874. eCollection 2018.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Identification of a multiprotein "motor" complex binding to water channel aquaporin-2.	Noda Y, etal., Biochem Biophys Res Commun. 2005 May 20;330(4):1041-7.
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:18699778	PMID:19056867	PMID:23376485

Genomics

Comparative Map Data

Aif1l
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	35,627,239 - 35,651,793 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	35,627,239 - 35,651,793 (+)	Ensembl				GRCr8
mRatBN7.2	3	15,229,476 - 15,254,033 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	15,229,524 - 15,254,023 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	18,302,434 - 18,326,985 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	26,887,419 - 26,911,975 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	25,134,603 - 25,159,186 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	9,237,944 - 9,262,628 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	9,237,944 - 9,262,628 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	14,598,261 - 14,622,945 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	11,053,196 - 11,078,079 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	9,976,750 - 10,001,583 (+)	NCBI		Celera
RGSC_v3.1	3	10,945,778 - 10,972,062 (+)	NCBI
Cytogenetic Map	3	p12	NCBI

AIF1L
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	131,096,531 - 131,123,144 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	131,096,476 - 131,123,152 (+)	Ensembl			hg38	GRCh38
GRCh37	9	133,971,918 - 133,998,531 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	132,961,733 - 132,988,360 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	9	131,001,465 - 131,028,093	NCBI
Celera	9	104,510,955 - 104,537,611 (+)	NCBI		Celera
Cytogenetic Map	9	q34.12-q34.13	NCBI
HuRef	9	103,462,597 - 103,489,133 (+)	NCBI		HuRef
CHM1_1	9	134,121,047 - 134,147,670 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	143,304,798 - 143,331,382 (+)	NCBI		T2T-CHM13v2.0

Aif1l
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	31,840,315 - 31,863,454 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	31,840,151 - 31,863,454 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	31,950,303 - 31,973,442 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	31,950,139 - 31,973,442 (+)	Ensembl			mm10	GRCm38
MGSCv37	2	31,805,823 - 31,828,962 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	31,772,312 - 31,795,451 (+)	NCBI		MGSCv36	mm8
Celera	2	31,653,266 - 31,676,512 (+)	NCBI		Celera
Cytogenetic Map	2	B	NCBI
cM Map	2	21.95	NCBI

Aif1l
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955513	936,889 - 954,667 (+)	Ensembl
ChiLan1.0	NW_004955513	936,889 - 954,667 (+)	NCBI	ChiLan1.0	ChiLan1.0

AIF1L
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	8,228,896 - 8,255,509 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	8,231,238 - 8,257,851 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	102,218,242 - 102,244,846 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	130,865,394 - 130,891,744 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	130,863,031 - 130,891,744 (+)	Ensembl			panPan2	panpan1.1

AIF1L
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	52,944,925 - 52,966,953 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	52,947,570 - 52,966,894 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	52,145,653 - 52,167,685 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	53,846,023 - 53,868,058 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	53,846,023 - 53,868,071 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	52,623,528 - 52,645,555 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	52,944,014 - 52,966,040 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	53,037,079 - 53,059,133 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Aif1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	198,193,397 - 198,211,193 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936487	17,961,854 - 17,979,749 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936487	17,961,922 - 17,979,721 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AIF1L
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	271,075,316 - 271,102,807 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	271,075,376 - 271,099,984 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	305,102,354 - 305,127,760 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AIF1L
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	7,016,619 - 7,043,663 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	7,016,398 - 7,043,575 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666079	8,457,744 - 8,484,869 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aif1l
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	4,739,793 - 4,757,280 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624760	4,739,886 - 4,757,291 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Aif1l
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	3,667,291 - 3,691,200 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Aif1l
182 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	356
Count of miRNA genes:	217
Interacting mature miRNAs:	249
Transcripts:	ENSRNOT00000013286
Prediction methods:	Microtar, Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1558647	Cm46	Cardiac mass QTL 46	5.4	0.0000055	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	22677150	50766390	Rat
1358357	Srcrtb1	Stress Responsive Cort Basal QTL 1	6.36	0.002	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	29056275	47904329	Rat
6893355	Bw101	Body weight QTL 101	0.4	0.38	body mass (VT:0001259)	body weight (CMO:0000012)	3	5766390	50766390	Rat
10450811	Scl73	Serum cholesterol level QTL 73	4.7	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	2904329	47904329	Rat
2292615	Ept17	Estrogen-induced pituitary tumorigenesis QTL 17	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6556347	51556347	Rat
10450808	Scl72	Serum cholesterol level QTL 72	4.4	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	2904329	47904329	Rat
10450806	Scl71	Serum cholesterol level QTL 71	5.8	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	2904329	47904329	Rat
1558654	Bw56	Body weight QTL 56	4.5	0.0000171	body mass (VT:0001259)	body weight (CMO:0000012)	3	5766390	50766390	Rat
10401810	Kidm53	Kidney mass QTL 53			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	28625339	67641995	Rat
1298526	Arunc3	Aerobic running capacity QTL 3	2.2		exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	3	6125437	51125437	Rat
8693641	Alc30	Alcohol consumption QTL 30	2	0.739	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	3	30832384	44921701	Rat
2298542	Neuinf11	Neuroinflammation QTL 11	3.9		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	3	35403199	97383526	Rat
631545	Bp85	Blood pressure QTL 85	3.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	36721849	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	1	141509147	Rat
631679	Cm10	Cardiac mass QTL 10	7.34	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	6556347	51556347	Rat
1558657	Cm43	Cardiac mass QTL 43	6.6	3e-08	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	22677150	50766390	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	15272348	60272348	Rat
6893363	Bw105	Body weight QTL 105	2.6	0.0036	body mass (VT:0001259)	body weight (CMO:0000012)	3	5766390	50766390	Rat
70203	Gcr2	Gastric cancer resistance QTL 2	2.6		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	3	29056275	47904329	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	5675975	141509147	Rat
1358185	Ept6	Estrogen-induced pituitary tumorigenesis QTL 6	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6556347	51556347	Rat

Markers in Region

D3Kyo2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	3	35,644,555 - 35,644,700 (+)	Marker Load Pipeline
mRatBN7.2	3	15,246,796 - 15,246,941 (-)	MAPPER	mRatBN7.2
Rnor_6.0	3	9,245,037 - 9,245,181	NCBI	Rnor6.0
Rnor_5.0	3	14,605,354 - 14,605,498	UniSTS	Rnor5.0
RGSC_v3.4	3	11,070,842 - 11,070,986	UniSTS	RGSC3.4
RGSC_v3.4	3	11,070,841 - 11,070,986	RGD	RGSC3.4
Celera	3	9,994,339 - 9,994,490	UniSTS
RH 3.4 Map	3	58.9	RGD
RH 3.4 Map	3	58.9	UniSTS
Cytogenetic Map	3	p11	UniSTS

AI013738

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	15,253,581 - 15,253,676 (-)	MAPPER	mRatBN7.2
Rnor_6.0	3	9,238,301 - 9,238,395	NCBI	Rnor6.0
Rnor_5.0	3	14,598,618 - 14,598,712	UniSTS	Rnor5.0
RGSC_v3.4	3	11,077,628 - 11,077,722	UniSTS	RGSC3.4
Celera	3	10,001,132 - 10,001,226	UniSTS
RH 3.4 Map	3	59.0	UniSTS
Cytogenetic Map	3	p11	UniSTS

BE119659

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	15,240,446 - 15,240,596 (-)	MAPPER	mRatBN7.2
Rnor_6.0	3	9,251,382 - 9,251,531	NCBI	Rnor6.0
Rnor_5.0	3	14,611,699 - 14,611,848	UniSTS	Rnor5.0
RGSC_v3.4	3	11,064,480 - 11,064,629	UniSTS	RGSC3.4
Celera	3	9,987,983 - 9,988,132	UniSTS
RH 3.4 Map	3	58.5	UniSTS
Cytogenetic Map	3	p11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	86	59	6	350	186	11	141	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108578	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000013286 ⟹ ENSRNOP00000013286

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	35,627,239 - 35,651,793 (+)	Ensembl
mRatBN7.2 Ensembl	3	15,229,524 - 15,254,023 (+)	Ensembl
Rnor_6.0 Ensembl	3	9,237,944 - 9,262,628 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000138716 ⟹ ENSRNOP00000103971

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	35,627,239 - 35,651,793 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000158362 ⟹ ENSRNOP00000105517

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	35,627,239 - 35,651,793 (+)	Ensembl

RefSeq Acc Id:

NM_001108578 ⟹ NP_001102048

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	35,627,239 - 35,651,793 (+)	NCBI
mRatBN7.2	3	15,229,476 - 15,254,033 (+)	NCBI
Rnor_6.0	3	9,237,944 - 9,262,628 (-)	NCBI
Rnor_5.0	3	14,598,261 - 14,622,945 (-)	NCBI
RGSC_v3.4	3	11,053,196 - 11,078,079 (+)	RGD
Celera	3	9,976,750 - 10,001,583 (+)	RGD

Sequence:

show sequence

GGGCGGGGTGTGTCGGGCCGCGAGGTCCCTCCGCCCCTGGGTCCCGTCGCCACACGCCGCCGAA
GGTCTGGACCAGACGCCTTTTCCTCCCTCTTGTCCATCGCCTTGTCCGGAGTCGGGCGCATACC
ATGTCCGTCGCACTCAGCAACAGGTTCCAAGGAGGGAAGGCGTTCGGCTTGCTCAAAGCCCGGC
AGGAGAAGAGACTGGAGGAGATCAACCGGGAGTTCCTCTGTGACCAGAAGTACAGTGATGAAGA
GAACCTGCCGGAAAAGCTTGCGGCCTTTAAAGAGAAATATATGGAGTTTGACCTGAACAATGAA
GGCGAGATTGATCTGATGTCTTTAAAGAGGATGATGGAGAAGCTGGGGGTCCCCAAGACCCACC
TGGAGATGAAGAAGATGATCTCGGAAGTGACAGGGGGTGTCAGTGACACCATCTCCTACCGAGA
CTTTGTGAACATGATGCTGGGCAAGCGATCAGCTGTCCTCAAGCTGGTCATGATGTTTGAAGGA
AAAGCCAACGAGAGCAGCCCAAAGCCAGCTGGCCCACCTCCAGAAAGAGACATTGCCAGCCTGC
CTTGAAGACCCACCCAGACCTTCTGGGCTGCCATCCCTGCCCCTGCCTCTCCCTCCTGCTCTCT
GCTATCGTGACTCAGTGTGATATGTCTCATGCGTTATGTCCCAGAGGACTCACTTTCTTTTTCT
TTTTCATTTCTTTATGTAAGCACTTGTTACCTGACTTAATGAGGCTGGGAATCCTGAGCCTCAG
GCCCCTTCACTCCCTGCAGCCCTGCCCTCTCTATACAAAAGGGCTGACATCAAACCAAAAACTG
GAGAGGGCAGGGAGGCTGCAAACCTCATTCCCCATGTTTGAAGAGGGTCCTGTCCAAGTCTGTT
CATCTTTCAAGGTTTCTAAACTAAATTCAGGCTGCAGATTTGGTTCTGGTGGGCCCCTCCCCTT
CTCCAACTCTCAGAAGATCCAGGGCTTCTTAGTGTCCTAGGGGCGTGCTTCCAGTGCTGCCAGG
GCTTCTAGCAATGGCCACCCAGTGCCTAGAGACACAACTAATTCTTGGTTCTTGCCCCTGTCCA
TTCTCAGAGACGTGGCACAAGTTGGGGAGGAAAGAACAACCTTTGGGGTCCTTCAGAGGAACCA
GAAGGAACCACAGCTTTACCGACAGCTCAGAGGGACATTGGAAGTGCACTGTCCCTTGCTAGGG
CAGTAAGGGGTTTGAAGGCAGAGATGAGGACAGAGGTGAGGGGGAGTCCTACTTTCAGGGTGGA
TGCTGAGGGCGCGAGGGGAGAAAAGGAGACAAGTGTTAAACCTCAAACAGAGAAATAGGTTGTC
TGATTGCACAGTGCCCCAAATCCAGCTATTTACATTCCCGCCCCACTCGCTCCTCCCTCCTCTC
CCTCAGTATGTATTACAAGCTTTAAGTCCTCCTGCTTTTTCTTCATGTGTGCTATGTCCAACTC
CTAGATCCCTTTTCAAATCCTTCAAGACCTGGAGCTTGGGGATTAGATGAAGGTCACCTAGCTG
ATTTTGGCTGGGTCAGTCCTTCCATTTCACTCCTGGCCTCCAGGGGTTAAGTGCCTTGCTGAAG
ATCAGTGGGGGCTATCAGAGAGTGTGGACTGAATGAAGCCCTGCTCTAGGCTACACTGGTCAAA
GGAAAGGGTAGGGAGCAGTATCTCCCTGCGTGATACTTGAGGAAGGTTTGATCTCCACTGAACA
CCTTGGGTCAGGATTCACCCTCCTGAGGGCCTCCAAGTTGGCAGTGAGATTTCTTGCAGCAAAG
TATCAAACATGACCCATCTTTTTTTTTTTTTTTTTTTCTTTTTCGGAGCTGGGGACCGAACCCA
GGGCCTTGTGCTTCCTAGGCAAGCACTCTACCACTAAGCTAAATCCCCAACCCCTAAACGTGAC
CCATCTTACCGGAGTGGGAGTTTTAGCCTTGATCCTAACTGTTCTGGGCACTCAGGACAAGATA
CAGTCACTCATCTTTACCAAGCACCTGCTCTATGCCACAAGTCCAGAACCCAGCAGTGAAATGG
ACTGAGGCATGAAATTTGTGTCTACTGGGAAGCCACACCCAGCTAATGACAGTGTGATGTTAGG
AAATGGGGGGAGGAGCAAGAGGTGAGTGCCGCCGAGTAGTCCCAGGAATTCCAGCTGGGCTCAT
GACTTGGCAAGTGTCAGAAGAGCTTCTGTGAAACTCTTAAGTGGAGAAAGACAGGGAAGCATTG
AGCTAGTGTGGTTTTCCTGTGGCTCCTTAGAGTTCCACAGTCCAGTACCCAGGGTGCTGTTCCC
ACAGCATCGAGGAAGAGTGAAGCAAGCAGCATCGAATGGTTAGCTCCACTTCATCCTCTGGTCT
CAACCAGTTCAGTTCAGGAGAGATTGTTTAGCTATGACTGGTTGATTTTTCAGCCTAAGGAGTT
GCTTCAAATGCTCAGTCTAGTTGAAGTTTAAACCCCAACATTCCTCCCTATAAATATAAAACCC
TGTCTACCCTCACCCCACCTTTGACTTTTTTTTTTTTTTTTAAGATTACCATCTCTGCCTCCAT
TCCTTCTGCCTTCCTTCTCTGACTGGACTGGGACCTTGGACTGCATTGTGTCCCTATTCTCTGT
GATAGAGGACGGCAGAATCAGCCAGGCTCAATGGGTCTACACTCATGAGCTTACACACCGCCTC
CATAAAGGAGTGTGCCTCTGTCCTCTGCAAAGTACAGAAAGACCATCTTCAGTGGTTTTAGCTC
AACCCATGGGAAGATAGTCTTAAGAATAACCTTTTAATGAAGGAGTTGGCAAATATTTCAAGTT
GTGCCTGCTGGTTCCAGGGTTCTTAACCTCTCTAGTTAAGGGCTTAGCTTTCTTGGGACATCAA
CTGTCTTATTTCTGAAAAAGACCAAATGTAACTGGTGTCACCAGCAGTGTGGGAATGACCAAGT
ATGACTTTGTCCCTGTGATTCAAAAGATGTTTGTCAGGTAGAGTTGGGTGAATGCCATTATTGT
GTGCATGGGTATGTATGGGTGGGATATGGTCTCCTGCAGACTGAAATAAATCAGAGCAATTT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102048	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL93259	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000013286
	ENSRNOP00000013286.6
	ENSRNOP00000103971.1
	ENSRNOP00000105517.1

RefSeq Acc Id:	NP_001102048 ⟸ NM_001108578
- UniProtKB:	A6JU37 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSVALSNRFQGGKAFGLLKARQEKRLEEINREFLCDQKYSDEENLPEKLAAFKEKYMEFDLNNE GEIDLMSLKRMMEKLGVPKTHLEMKKMISEVTGGVSDTISYRDFVNMMLGKRSAVLKLVMMFEG KANESSPKPAGPPPERDIASLP hide sequence

Ensembl Acc Id:

ENSRNOP00000013286 ⟸ ENSRNOT00000013286

Ensembl Acc Id:

ENSRNOP00000105517 ⟸ ENSRNOT00000158362

Ensembl Acc Id:

ENSRNOP00000103971 ⟸ ENSRNOT00000138716

Protein Domains

EF-hand

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZRD9-F1-model_v2	AlphaFold	D3ZRD9	1-150	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691962

Promoter ID:

EPDNEW_R2487

Type:

initiation region

Name:

Aif1l_1

Description:

allograft inflammatory factor 1-like

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	9,262,577 - 9,262,637	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305081	AgrOrtholog
BioCyc Gene	G2FUF-50166	BioCyc
Ensembl Genes	ENSRNOG00000009951	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000013286	ENTREZGENE
	ENSRNOT00000013286.7	UniProtKB/TrEMBL
	ENSRNOT00000138716.1	UniProtKB/TrEMBL
	ENSRNOT00000158362.1	UniProtKB/TrEMBL
Gene3D-CATH	EF-hand	UniProtKB/TrEMBL
InterPro	AIF-1_EF_pair	UniProtKB/TrEMBL
	AIF1/AIF1L	UniProtKB/TrEMBL
	EF-hand-like_dom	UniProtKB/TrEMBL
	EF_hand_Ca-bd	UniProtKB/TrEMBL
KEGG Report	rno:362107	UniProtKB/TrEMBL
NCBI Gene	362107	ENTREZGENE
PANTHER	PTHR10356	UniProtKB/TrEMBL
	PTHR10356:SF5	UniProtKB/TrEMBL
Pfam	AIF-1	UniProtKB/TrEMBL
PhenoGen	Aif1l	PhenoGen
PROSITE	EF_HAND_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000009951	RatGTEx
Superfamily-SCOP	SSF47473	UniProtKB/TrEMBL
UniProt	A0ABK0LGL3_RAT	UniProtKB/TrEMBL
	A0ABK0LLV2_RAT	UniProtKB/TrEMBL
	A6JU37	ENTREZGENE, UniProtKB/TrEMBL
	D3ZRD9_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2009-06-12	Aif1l	allograft inflammatory factor 1-like	RGD1305081	similar to ionized calcium binding adapter molecule 2 (Iba2)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1305081	similar to ionized calcium binding adapter molecule 2 (Iba2)	RGD1305081_predicted	similar to ionized calcium binding adapter molecule 2 (Iba2) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-20	RGD1305081_predicted	similar to ionized calcium binding adapter molecule 2 (Iba2) (predicted)	LOC362107_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC362107_predicted	similar to ionized calcium binding adapter molecule 2 (Iba2) (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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