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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-pilocarpine | increases expression | ISO | RGD:61924 | 6480464 | Pilocarpine results in increased expression of AIF1 protein | CTD | PMID:18226170 | (S)-colchicine | decreases expression | ISO | RGD:61924 | 6480464 | Colchicine results in decreased expression of AIF1 mRNA | CTD | PMID:20624997 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:62217 | 6480464 | Ethinyl Estradiol results in increased expression of AIF1 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:62217 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AIF1 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:61924 | 6480464 | Ethinyl Estradiol results in increased expression of AIF1 mRNA | CTD | PMID:17351261 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:62217 | 6480464 | Ethinyl Estradiol affects the expression of AIF1 mRNA | CTD | PMID:17555576 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of AIF1 mRNA | CTD | PMID:19684285 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:62217 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AIF1 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of AIF1 mRNA | CTD | PMID:19684285 | 2-nitrofluorene | increases expression | ISO | RGD:61924 | 6480464 | 2-nitrofluorene results in increased expression of AIF1 mRNA | CTD | PMID:14600272 | 3H-1,2-dithiole-3-thione | decreases expression | ISO | RGD:61924 | 6480464 | 1,2-dithiol-3-thione results in decreased expression of AIF1 mRNA | CTD | PMID:19162173 | 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one | increases expression | ISO | RGD:61924 | 6480464 | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of AIF1 mRNA | CTD | PMID:14600272 | aflatoxin B1 | decreases expression | EXP | | 6480464 | Aflatoxin B1 results in decreased expression of AIF1 mRNA | CTD | PMID:22100608 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of AIF1 mRNA | CTD | PMID:15498508 | ammonium chloride | affects expression | ISO | RGD:61924 | 6480464 | Ammonium Chloride affects the expression of AIF1 mRNA | CTD | PMID:16483693 | benzene | affects expression | ISO | RGD:61924 | 6480464 | Benzene affects the expression of AIF1 mRNA | CTD | PMID:15878777 | benzo[a]pyrene | multiple interactions | ISO | RGD:62217 | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to AIF1 promoter] | CTD | PMID:19654925 | benzo[a]pyrene | increases expression | ISO | RGD:62217 | 6480464 | Benzo(a)pyrene results in increased expression of AIF1 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | multiple interactions | ISO | RGD:62217 | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of AIF1 mRNA] | CTD | PMID:22228805 | cadmium dichloride | decreases methylation | ISO | RGD:61924 | 6480464 | Cadmium Chloride results in decreased methylation of AIF1 promoter | CTD | PMID:22457795 | chloroprene | decreases expression | ISO | RGD:62217 | 6480464 | Chloroprene results in decreased expression of AIF1 mRNA | CTD | PMID:23125180 | cisplatin | decreases expression | ISO | RGD:61924 | 6480464 | Cisplatin results in decreased expression of AIF1 mRNA | CTD | PMID:22023808 | copper(2+) sulfate | decreases expression | EXP | | 6480464 | Copper Sulfate results in decreased expression of AIF1 mRNA | CTD | PMID:19549813 | diarsenic trioxide | decreases expression | EXP | | 6480464 | arsenic trioxide results in decreased expression of AIF1 mRNA | CTD | PMID:19128835 | diazoxide | decreases expression | ISO | RGD:62217 | 6480464 | Isoproterenol results in decreased expression of AIF1 mRNA | CTD | PMID:20003209 | hexachlorobenzene | affects expression | ISO | RGD:61924 | 6480464 | Hexachlorobenzene affects the expression of AIF1 mRNA | CTD | PMID:15159207 | isoprenaline | decreases expression | ISO | RGD:62217 | 6480464 | Isoproterenol results in decreased expression of AIF1 mRNA | CTD | PMID:20003209 | lead diacetate | increases expression | ISO | RGD:62217 | 6480464 | lead acetate results in increased expression of AIF1 mRNA | CTD | PMID:21829687 | mycophenolic acid | decreases expression | ISO | RGD:61924 | 6480464 | Mycophenolic Acid results in decreased expression of AIF1 mRNA | CTD | PMID:10688038 | mycophenolic acid | multiple interactions | ISO | RGD:61924 | 6480464 | [Quercetin co-treated with Mycophenolic Acid] results in decreased expression of AIF1 mRNA | CTD | PMID:10688038 | N-nitrosodimethylamine | increases expression | ISO | RGD:61924 | 6480464 | Dimethylnitrosamine results in increased expression of AIF1 mRNA | CTD | PMID:14600272 | pirinixic acid | decreases expression | ISO | RGD:61924 | 6480464 | pirinixic acid results in decreased expression of AIF1 mRNA | CTD | PMID:19162173 | pregnenolone 16alpha-carbonitrile | decreases expression | ISO | RGD:61924 | 6480464 | Pregnenolone Carbonitrile results in decreased expression of AIF1 mRNA | CTD | PMID:19162173 | quercetin | multiple interactions | ISO | RGD:61924 | 6480464 | [Quercetin co-treated with Mycophenolic Acid] results in decreased expression of AIF1 mRNA | CTD | PMID:10688038 | quercetin | decreases expression | ISO | RGD:61924 | 6480464 | Quercetin results in decreased expression of AIF1 mRNA | CTD | PMID:10688038 | quinoline | increases activity | EXP | | 6480464 | quinoline analog results in increased activity of AIF1 protein | CTD | PMID:18645022 | rosiglitazone | decreases expression | ISO | RGD:61924 | 6480464 | rosiglitazone results in decreased expression of AIF1 mRNA | CTD | PMID:21515302 | tamibarotene | increases expression | EXP | | 6480464 | Am 80 results in increased expression of AIF1 mRNA; more ... | CTD | PMID:15498508 | valproic acid | affects expression | ISO | RGD:62217 | 6480464 | Valproic Acid affects the expression of AIF1 mRNA | CTD | PMID:17292431 | vincaleukoblastine | decreases expression | ISO | RGD:61924 | 6480464 | Vinblastine results in decreased expression of AIF1 mRNA | CTD | PMID:20624997 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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References - curated| 1. |
Almolda B, etal., J Neuroimmunol. 2009 Apr 30;209(1-2):65-80. Epub 2009 Feb 26. |
| 2. |
Beiter T, etal., J Neuroimmunol. 2005 Mar;160(1-2):25-31. Epub 2004 Dec 15. |
| 3. |
Chen ZW, etal., Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13879-84. |
| 4. |
Eike MC, etal., Genes Immun. 2009 Mar;10(2):141-50. Epub 2008 Nov 6. |
| 5. |
Girard S, etal., Neuroscience. 2009 Jan 23;158(2):673-82. Epub 2008 Oct 30. |
| 6. |
GOA_HUMAN data from the GO Consortium |
| 7. |
Herden C, etal., Neuropathol Appl Neurobiol. 2005 Oct;31(5):512-21. |
| 8. |
Hirsch J, etal., Mol Cell Proteomics. 2006 Jun;5(6):979-86. Epub 2006 Feb 24. |
| 9. |
Jakubs K, etal., J Neurosci. 2008 Nov 19;28(47):12477-88. |
| 10. |
Jakubs K, etal., Neuron. 2006 Dec 21;52(6):1047-59. |
| 11. |
Kalm M, etal., J Neuroimmunol. 2009 Jan 3;206(1-2):70-5. Epub 2008 Dec 13. |
| 12. |
Lee JK, etal., Neurosci Lett. 2009 Jan 30;450(2):136-41. Epub 2008 Dec 6. |
| 13. |
Lepore AC, etal., Nat Neurosci. 2008 Nov;11(11):1294-301. Epub 2008 Oct 19. |
| 14. |
Mishima T, etal., Int J Mol Med. 2008 Feb;21(2):181-7. |
| 15. |
Nakano T, etal., Neurosci Lett. 2009 Sep 18;461(2):110-5. Epub 2009 Jun 9. |
| 16. |
Narita M, etal., Neurosci Lett. 2007 Feb 27;414(1):21-5. Epub 2006 Dec 15. |
| 17. |
Nixon K, etal., Neurobiol Dis. 2008 Aug;31(2):218-29. Epub 2008 May 3. |
| 18. |
Postler E, etal., J Neuroimmunol. 2000 Apr 3;104(1):85-91. |
| 19. |
Rappold PM, etal., Brain Res. 2006 May 17;1089(1):171-8. Epub 2006 Apr 25. |
| 20. |
RGD automated import pipeline for gene-chemical interactions |
| 21. |
Rivera EJ, etal., J Alzheimers Dis. 2005 Dec;8(3):247-68. |
| 22. |
Sakuma M, etal., J Neural Transm. 2008;115(3):413-22. Epub 2008 Feb 26. |
| 23. |
Thored P, etal., Glia. 2009 Jun;57(8):835-49. |
| 24. |
Tsubata Y, etal., Kidney Int. 2006 Dec;70(11):1948-54. Epub 2006 Oct 11. |
| 25. |
Tsuda M, etal., Glia. 2008 Mar;56(4):378-86. |
| 26. |
Vega-Avelaira D, etal., Brain Behav Immun. 2007 Jul;21(5):617-23. Epub 2006 Dec 8. |
| 27. |
Wixey JA, etal., J Neuroimmunol. 2009 Jul 25;212(1-2):35-43. Epub 2009 May 17. |
References - uncurated| PubMed | 10202016 |
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| 22505724 | |
| 22560794 | |
| 7769138 | |
| 8499947 | |
| 8629302 | |
| 8912632 | |
| 9614071 |
RGD Disease Portals| AIF1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| AIF1 (Homo sapiens) |
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| Aif1 (Mus musculus) |
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| Aif1 (Rattus norvegicus) |
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Position Markers| SHGC-132025 |
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| AIF1_696.2 |
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| D6S1864 |
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QTLs in Region (Human Genome Assembly GRCh37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001623 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_004847 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_032955 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | ABBA01038082 | (Get FASTA) | Search GEO for Microarray Profiles |
| ABBA01038083 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF088038 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF129756 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF299327 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF299329 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK290771 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AL662801 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AL662847 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AL805934 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AMYH01016217 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BA000025 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC009474 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BX248305 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CB215777 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CD521003 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH471081 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CR542153 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CR753892 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CR759761 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D86438 | (Get FASTA) | Search GEO for Microarray Profiles | |
| DB502939 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EF070981 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EF070982 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EF070983 | (Get FASTA) | Search GEO for Microarray Profiles | |
| JQ782414 | (Get FASTA) | Search GEO for Microarray Profiles | |
| JQ782415 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U19713 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U49392 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U95213 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Y14768 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_004847 | ||||||||||||||||||||
| RefSeq Status: | REVIEWED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_004838 | ||||||||||||||||||||
| Peptide Label: | isoform 2 | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001623 | |||||||||||||||||||||||||
| RefSeq Status: | REVIEWED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_001614 | |||||||||||||||||||||||||
| Peptide Label: | isoform 3 | |||||||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_032955 | |||||||||||||||||||||||||
| RefSeq Status: | REVIEWED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_116573 | |||||||||||||||||||||||||
| Peptide Label: | isoform 1 | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001614 | (Get FASTA) |
| NP_004838 | (Get FASTA) | |
| NP_116573 | (Get FASTA) | |
| GenBank Protein | AAA92457 | (Get FASTA) |
| AAB05003 | (Get FASTA) | |
| AAC24422 | (Get FASTA) | |
| AAD18087 | (Get FASTA) | |
| AAG39110 | (Get FASTA) | |
| AAG39112 | (Get FASTA) | |
| AAH09474 | (Get FASTA) | |
| ABK35646 | (Get FASTA) | |
| ABK35647 | (Get FASTA) | |
| ACE87076 | (Get FASTA) | |
| ACE87756 | (Get FASTA) | |
| AFL46387 | (Get FASTA) | |
| AFL46388 | (Get FASTA) | |
| BAA13088 | (Get FASTA) | |
| BAB63392 | (Get FASTA) | |
| BAF83460 | (Get FASTA) | |
| CAA75060 | (Get FASTA) | |
| CAA75061 | (Get FASTA) | |
| CAA75062 | (Get FASTA) | |
| CAG46950 | (Get FASTA) | |
| EAX03442 | (Get FASTA) | |
| EAX03443 | (Get FASTA) | |
| EAX03444 | (Get FASTA) | |
| EAX03445 | (Get FASTA) | |
| EAX03446 | (Get FASTA) | |
| EAX03447 | (Get FASTA) | |
| P55008 | (Get FASTA) |
Promoters| RGD ID: | 6804157 | ||||||||||
| Promoter ID: | HG_KWN:52942 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Jurkat, K562, Lymphoblastoid, NB4 | ||||||||||
| Transcripts: | ENST00000337917, ENST00000376049, NM_004847, OTTHUMT00000076512, OTTHUMT00000076517, OTTHUMT00000076518, OTTHUMT00000259316, UC010JSY.1 | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| COSMIC | AIF1 | COSMIC |
| Ensembl Genes | ENSG00000204472 | ENTREZGENE |
| Ensembl Protein | ENSP00000365217 | ENTREZGENE |
| ENSP00000365227 | ENTREZGENE | |
| Ensembl Transcript | ENST00000376049 | ENTREZGENE |
| ENST00000376059 | ENTREZGENE | |
| Entrez Gene | 199 | ENTREZGENE |
| Gene3D-CATH | EF-Hand_type | UniProtKB/Swiss-Prot |
| Germonline | ENSG00000204472 | |
| HGNC ID | 352 | ENTREZGENE |
| HomoloGene Group ID | 1226 | ENTREZGENE |
| HPRD ID | 03496 | ENTREZGENE |
| InterPro | EF-hand-like_dom | UniProtKB/Swiss-Prot |
| EF_hand_Ca-bd | UniProtKB/Swiss-Prot | |
| IPI | IPI00022630 | UniProtKB/Swiss-Prot |
| KEGG Report | hsa:199 | ENTREZGENE, UniProtKB/Swiss-Prot |
| OMIM | 601833 | OMIM |
| PharmGKB | PA24646 | PharmGKB |
| PROSITE | EF_HAND_1; FALSE_NEG | UniProtKB/Swiss-Prot |
| EF_HAND_2 | UniProtKB/Swiss-Prot | |
| UniGene | Hs.76364 | ENTREZGENE |
| UniProt | AIF1_HUMAN | UniProtKB/Swiss-Prot |
| I3WTX1_HUMAN | UniProtKB/TrEMBL | |
| Q4V347_HUMAN | UniProtKB/TrEMBL | |
| Q5STX8_HUMAN | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2011-08-16 | AIF1 | allograft inflammatory factor 1 | AIF1 | allograft inflammatory factor 1 | Symbol and/or name change | 39860 | APPROVED |
| More on AIF1 | |||
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Entrez Gene | ||
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Ensembl Gene | ||
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HGNC Report | ||
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NCBI Map Viewer | ||
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Vista | ||
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Vista + UCSC | ||
| RGD Object Information | |
| RGD ID: | 735562 |
| Created: | 2004-02-06 |
| Species: | Homo sapiens |
| Last Modified: | 2013-03-05 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




