Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | SIPA1L1 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SIPA1L1 mRNA | CTD | PMID:22079256 | (-)-epigallocatechin 3-gallate | increases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | epigallocatechin gallate results in increased expression of SIPA1L1 mRNA | CTD | PMID:22079256 | 1,1-dichloroethene | decreases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | vinylidene chloride results in decreased expression of SIPA1L1 mRNA | CTD | PMID:26682919 | 1,2-dichloroethane | increases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | ethylene dichloride results in increased expression of SIPA1L1 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | multiple interactions | ISO | Sipa1l1 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of SIPA1L1 mRNA] | CTD | PMID:22206623 | 1,2-dimethylhydrazine | decreases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of SIPA1L1 mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | ISO | SIPA1L1 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of SIPA1L1 mRNA | CTD | PMID:30165855 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SIPA1L1 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SIPA1L1 mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Sipa1l1 (Mus musculus) | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of SIPA1L1 mRNA | CTD | PMID:25975270 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of SIPA1L1 mRNA | CTD | PMID:21346803 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of SIPA1L1 mRNA | CTD | PMID:26251327 | 3,4-methylenedioxymethamphetamine | affects expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine affects the expression of SIPA1L1 mRNA | CTD | PMID:30071829 | acrolein | multiple interactions | ISO | SIPA1L1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of SIPA1L1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of SIPA1L1 mRNA | CTD | PMID:32699268 | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of SIPA1L1 mRNA | CTD | PMID:28959563 | aflatoxin B1 | increases methylation | ISO | SIPA1L1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of SIPA1L1 gene | CTD | PMID:27153756 | aflatoxin B1 | decreases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of SIPA1L1 mRNA | CTD | PMID:27153756 | all-trans-retinoic acid | increases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of SIPA1L1 mRNA | CTD | PMID:33167477 | alpha-pinene | multiple interactions | ISO | SIPA1L1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of SIPA1L1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of SIPA1L1 mRNA | CTD | PMID:32699268 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SIPA1L1 mRNA | CTD | PMID:16483693 | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of SIPA1L1 mRNA | CTD | PMID:30779732 | aristolochic acid A | decreases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of SIPA1L1 mRNA | CTD | PMID:33212167 | arsenite(3-) | multiple interactions | ISO | SIPA1L1 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to SIPA1L1 mRNA] | CTD | PMID:32406909 | atrazine | decreases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of SIPA1L1 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | decreases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of SIPA1L1 mRNA | CTD | PMID:19770486 and PMID:21715664 | benzo[a]pyrene | affects methylation | ISO | SIPA1L1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SIPA1L1 intron | CTD | PMID:30157460 | benzo[a]pyrene | decreases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of SIPA1L1 mRNA | CTD | PMID:20106945 and PMID:21632981 | benzo[a]pyrene | increases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SIPA1L1 mRNA | CTD | PMID:22228805 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:26238291 | bisphenol A | decreases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of SIPA1L1 mRNA | CTD | PMID:25047013 | bisphenol A | increases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | bisphenol A results in increased expression of SIPA1L1 mRNA | CTD | PMID:32156529 | bisphenol A | decreases methylation | ISO | SIPA1L1 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of SIPA1L1 gene | CTD | PMID:31601247 | bisphenol A | increases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | bisphenol A analog results in increased expression of SIPA1L1 mRNA | CTD | PMID:32387340 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SIPA1L1 mRNA | CTD | PMID:25181051 and PMID:30816183 | bisphenol A | decreases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of SIPA1L1 mRNA | CTD | PMID:26063408 | caffeine | affects phosphorylation | ISO | SIPA1L1 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of SIPA1L1 protein | CTD | PMID:35688186 | carbon nanotube | decreases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | chlorpyrifos | decreases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of SIPA1L1 mRNA | CTD | PMID:37019170 | cisplatin | decreases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of SIPA1L1 mRNA | CTD | PMID:19561079 and PMID:27392435 | cisplatin | multiple interactions | ISO | SIPA1L1 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of SIPA1L1 mRNA | CTD | PMID:27392435 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of SIPA1L1 mRNA | CTD | PMID:20187946 | cyclosporin A | increases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of SIPA1L1 mRNA | CTD | PMID:25562108 | dexamethasone | increases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | Dexamethasone results in increased expression of SIPA1L1 mRNA | CTD | PMID:22733784 | dicrotophos | increases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of SIPA1L1 mRNA | CTD | PMID:28302478 | Diisodecyl phthalate | decreases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | diisodecyl phthalate results in decreased expression of SIPA1L1 mRNA | CTD | PMID:25270620 | dioxygen | multiple interactions | ISO | Sipa1l1 (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of SIPA1L1 mRNA | CTD | PMID:30529165 | disodium selenite | increases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | Sodium Selenite results in increased expression of SIPA1L1 mRNA | CTD | PMID:18175754 | diuron | decreases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | Diuron results in decreased expression of SIPA1L1 mRNA | CTD | PMID:35967413 | dorsomorphin | multiple interactions | ISO | SIPA1L1 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of SIPA1L1 mRNA | CTD | PMID:29391264 | entinostat | decreases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | entinostat results in decreased expression of SIPA1L1 mRNA | CTD | PMID:26272509 | entinostat | multiple interactions | ISO | SIPA1L1 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SIPA1L1 mRNA | CTD | PMID:27188386 | ethanol | increases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | Ethanol results in increased expression of SIPA1L1 mRNA | CTD | PMID:30319688 | ethanol | multiple interactions | ISO | Sipa1l1 (Mus musculus) | 6480464 | Ethanol affects the expression of and affects the splicing of SIPA1L1 mRNA | CTD | PMID:30319688 | fenthion | decreases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | Fenthion results in decreased expression of SIPA1L1 mRNA | CTD | PMID:34813904 | flavonoids | increases expression | EXP | | 6480464 | Flavonoids results in increased expression of SIPA1L1 mRNA | CTD | PMID:18035473 | folic acid | multiple interactions | ISO | Sipa1l1 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of SIPA1L1 mRNA] | CTD | PMID:22206623 | FR900359 | affects phosphorylation | ISO | SIPA1L1 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of SIPA1L1 protein | CTD | PMID:37730182 | hydralazine | multiple interactions | ISO | SIPA1L1 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of SIPA1L1 mRNA | CTD | PMID:17183730 | hypochlorous acid | decreases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | Hypochlorous Acid results in decreased expression of SIPA1L1 mRNA | CTD | PMID:19376150 | methidathion | decreases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | methidathion results in decreased expression of SIPA1L1 mRNA | CTD | PMID:34813904 | nickel atom | increases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | Nickel results in increased expression of SIPA1L1 mRNA | CTD | PMID:24768652 | ozone | multiple interactions | ISO | SIPA1L1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of SIPA1L1 mRNA more ... | CTD | PMID:32699268 and PMID:35430440 | ozone | multiple interactions | ISO | Sipa1l1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of SIPA1L1 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of SIPA1L1 mRNA | CTD | PMID:34911549 | phenytoin | increases expression | EXP | | 6480464 | Phenytoin results in increased expression of SIPA1L1 mRNA | CTD | PMID:20345932 | pirinixic acid | multiple interactions | ISO | SIPA1L1 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SIPA1L1 mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of SIPA1L1 mRNA | CTD | PMID:18301758 and PMID:23811191 | potassium chromate | decreases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of SIPA1L1 mRNA | CTD | PMID:22079256 | potassium chromate | multiple interactions | ISO | SIPA1L1 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SIPA1L1 mRNA | CTD | PMID:22079256 | progesterone | increases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | Progesterone results in increased expression of SIPA1L1 mRNA | CTD | PMID:18037150 | quercetin | decreases phosphorylation | ISO | SIPA1L1 (Homo sapiens) | 6480464 | Quercetin results in decreased phosphorylation of SIPA1L1 protein | CTD | PMID:35688186 | rimonabant | multiple interactions | ISO | Sipa1l1 (Mus musculus) | 6480464 | Rimonabant inhibits the reaction [Dietary Fats results in increased expression of SIPA1L1 mRNA] | CTD | PMID:19030233 | rimonabant | affects expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | Rimonabant affects the expression of SIPA1L1 mRNA | CTD | PMID:19030233 | SB 431542 | multiple interactions | ISO | SIPA1L1 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sodium arsenite | affects expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | sodium arsenite affects the expression of SIPA1L1 mRNA | CTD | PMID:29319823 | sulforaphane | increases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | sulforaphane results in increased expression of SIPA1L1 mRNA | CTD | PMID:26833863 | tamoxifen | increases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | Tamoxifen results in increased expression of SIPA1L1 mRNA | CTD | PMID:25123088 | tert-butyl hydroperoxide | increases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in increased expression of SIPA1L1 mRNA | CTD | PMID:15336504 | testosterone | multiple interactions | ISO | Sipa1l1 (Mus musculus) | 6480464 | 1 more ... | CTD | PMID:33848595 | testosterone | increases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | Testosterone deficiency results in increased expression of SIPA1L1 mRNA | CTD | PMID:33848595 | tetrachloromethane | affects expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of SIPA1L1 mRNA | CTD | PMID:17484886 | titanium dioxide | decreases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of SIPA1L1 mRNA | CTD | PMID:27760801 and PMID:29264374 | Tributyltin oxide | decreases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | bis(tri-n-butyltin)oxide results in decreased expression of SIPA1L1 mRNA | CTD | PMID:25270620 | troglitazone | decreases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | troglitazone results in decreased expression of SIPA1L1 mRNA | CTD | PMID:28973697 | tungsten | decreases expression | ISO | Sipa1l1 (Mus musculus) | 6480464 | Tungsten results in decreased expression of SIPA1L1 mRNA | CTD | PMID:30912803 | urethane | increases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | Urethane results in increased expression of SIPA1L1 mRNA | CTD | PMID:28818685 | valproic acid | multiple interactions | ISO | SIPA1L1 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of SIPA1L1 mRNA more ... | CTD | PMID:17183730 and PMID:27188386 | valproic acid | increases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of SIPA1L1 mRNA | CTD | PMID:23179753 and PMID:27188386 | valproic acid | decreases expression | ISO | SIPA1L1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of SIPA1L1 mRNA | CTD | PMID:23179753 more ... | venlafaxine hydrochloride | increases expression | EXP | | 6480464 | Venlafaxine Hydrochloride results in increased expression of SIPA1L1 mRNA | CTD | PMID:25423262 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of SIPA1L1 mRNA | CTD | PMID:19015723 | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of SIPA1L1 mRNA | CTD | PMID:23555832 | |