Slc7a2 (solute carrier family 7 member 2) - Rat Genome Database

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Gene: Slc7a2 (solute carrier family 7 member 2) Rattus norvegicus
Analyze
Symbol: Slc7a2
Name: solute carrier family 7 member 2
RGD ID: 68387
Description: Enables L-arginine transmembrane transporter activity. Involved in L-arginine transmembrane transport. Predicted to be located in cell junction and membrane. Predicted to be active in plasma membrane. Orthologous to human SLC7A2 (solute carrier family 7 member 2); PARTICIPATES IN 2-aminoadipic 2-oxoadipic aciduria pathway; glutaric aciduria type I pathway; hyperlysinemia pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: solute carrier family 7, member 3; CAT-2; Cat2; Cat2a; Cat2b; cationic amino acid transporter 2; cationic amino acid transporter-2A; low affinity cationic amino acid transporter 2; RCAT2; solute carrier family 7 (cationic amino acid transporter y+ system) member 2; solute carrier family 7 (cationic amino acid transporter, y+ system), member 2; solute carrier family 7 (cationic amino acid transporter, y+system), member 2; solute carrier family 7, member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81658,115,991 - 58,174,256 (-)NCBIGRCr8
mRatBN7.21651,417,478 - 51,470,784 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1651,417,493 - 51,470,784 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1656,736,689 - 56,789,896 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01660,136,544 - 60,189,834 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01655,370,642 - 55,423,851 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01654,459,409 - 54,513,349 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1654,460,067 - 54,513,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01654,171,102 - 54,224,384 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41654,752,119 - 54,805,406 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1649,310,502 - 49,363,790 (-)NCBICelera
Cytogenetic Map16q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-Iodothyronamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
diallyl trisulfide  (ISO)
dieldrin  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
gentamycin  (EXP)
heptachlor  (EXP)
inulin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
mirex  (EXP)
N-nitrosodiethylamine  (EXP)
nickel dichloride  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
picene  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell junction  (IEA,ISO)
membrane  (ISO)
plasma membrane  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Interleukin-1 beta and tumor necrosis factor-alpha stimulate the cat-2 gene of the L-arginine transporter in cultured vascular smooth muscle cells. Gill DJ, etal., J Biol Chem. 1996 May 10;271(19):11280-3.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Nuclear factor-kappaB mediates simultaneous induction of inducible nitric-oxide synthase and Up-regulation of the cationic amino acid transporter CAT-2B in rat alveolar macrophages. Hammermann R, etal., Mol Pharmacol 2000 Dec;58(6):1294-302.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Differential regulation of glomerular arginine transporters (CAT-1 and CAT-2) in lipopolysaccharide-treated rats. Schwartz D, etal., Am J Physiol Renal Physiol 2003 Apr;284(4):F788-95.
12. Tetrahydrobiopterin augments arginine transport in rat cardiac myocytes through modulation of CAT-2 mRNA. Schwartz IF, etal., J Lab Clin Med. 2001 May;137(5):356-62.
13. L-Arginine transport is augmented through up-regulation of tubular CAT-2 mRNA in ischemic acute renal failure in rats. Schwartz IF, etal., Kidney Int 2002 Nov;62(5):1700-6.
14. Differential regulation of L-arginine transporters (cationic amino acid transporter-1 and -2) by peroxynitrite in rat mesangial cells. Schwartz IF, etal., Nephrol Dial Transplant. 2006 Dec;21(12):3409-14. Epub 2006 Sep 23.
15. Induced nitric oxide synthesis is dependent on induced alternatively spliced CAT-2 encoding L-arginine transport in brain astrocytes. Stevens BR, etal., J Biol Chem 1996 Sep 27;271(39):24017-22.
Additional References at PubMed
PMID:8187816   PMID:8195186   PMID:8385111   PMID:11278602   PMID:11665818   PMID:12675924   PMID:12716655   PMID:16670299   PMID:16703566   PMID:17003120   PMID:18028947   PMID:19386725  
PMID:29476059  


Genomics

Comparative Map Data
Slc7a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81658,115,991 - 58,174,256 (-)NCBIGRCr8
mRatBN7.21651,417,478 - 51,470,784 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1651,417,493 - 51,470,784 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1656,736,689 - 56,789,896 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01660,136,544 - 60,189,834 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01655,370,642 - 55,423,851 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01654,459,409 - 54,513,349 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1654,460,067 - 54,513,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01654,171,102 - 54,224,384 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41654,752,119 - 54,805,406 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1649,310,502 - 49,363,790 (-)NCBICelera
Cytogenetic Map16q12.1NCBI
SLC7A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38817,494,069 - 17,570,566 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl817,497,088 - 17,570,573 (+)EnsemblGRCh38hg38GRCh38
GRCh37817,354,597 - 17,428,075 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36817,440,665 - 17,472,352 (+)NCBINCBI36Build 36hg18NCBI36
Build 34817,440,684 - 17,472,296NCBI
Celera816,320,372 - 16,393,730 (+)NCBICelera
Cytogenetic Map8p22NCBI
HuRef815,899,173 - 15,972,649 (+)NCBIHuRef
CHM1_1817,556,088 - 17,629,545 (+)NCBICHM1_1
T2T-CHM13v2.0817,761,599 - 17,837,697 (+)NCBIT2T-CHM13v2.0
Slc7a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39841,315,404 - 41,375,107 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl841,315,433 - 41,375,345 (+)EnsemblGRCm39 Ensembl
GRCm38840,862,341 - 40,922,070 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl840,862,396 - 40,922,308 (+)EnsemblGRCm38mm10GRCm38
MGSCv37841,947,721 - 42,007,424 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36842,361,229 - 42,421,125 (+)NCBIMGSCv36mm8
Celera843,496,255 - 43,555,499 (+)NCBICelera
Cytogenetic Map8A4NCBI
cM Map823.89NCBI
Slc7a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555522,117,755 - 2,141,231 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555522,117,972 - 2,141,144 (-)NCBIChiLan1.0ChiLan1.0
SLC7A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2735,969,973 - 36,043,781 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1811,704,679 - 11,770,243 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0816,723,227 - 16,788,745 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1813,671,571 - 13,741,007 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl813,671,571 - 13,735,645 (+)Ensemblpanpan1.1panPan2
SLC7A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11640,855,270 - 40,879,956 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1640,745,458 - 40,875,106 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1641,312,676 - 41,387,063 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01642,867,670 - 42,935,808 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1642,867,675 - 42,935,804 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11640,961,049 - 41,029,086 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01641,504,575 - 41,572,831 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01641,699,102 - 41,767,417 (+)NCBIUU_Cfam_GSD_1.0
Slc7a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494338,425,216 - 38,494,926 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936614157,828 - 184,583 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936614111,625 - 184,571 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC7A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl175,192,022 - 5,271,849 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1175,191,973 - 5,271,849 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2175,704,846 - 5,725,732 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC7A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1815,591,795 - 15,665,837 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl815,638,113 - 15,660,487 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605226,611,997 - 26,686,779 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc7a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476921,681,709 - 21,757,213 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476921,678,084 - 21,757,168 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc7a2
190 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:497
Count of miRNA genes:165
Interacting mature miRNAs:190
Transcripts:ENSRNOT00000014809, ENSRNOT00000015127, ENSRNOT00000059032
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 33 31 2 31 4 4 4 2 16 10 4
Low 1 41 24 10 17 10 4 7 70 33 24 1 4
Below cutoff 2 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014809   ⟹   ENSRNOP00000014809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1651,417,493 - 51,470,784 (-)Ensembl
Rnor_6.0 Ensembl1654,460,067 - 54,513,349 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000015127   ⟹   ENSRNOP00000015127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1651,417,493 - 51,470,784 (-)Ensembl
Rnor_6.0 Ensembl1654,460,067 - 54,513,349 (-)Ensembl
RefSeq Acc Id: NM_001134686   ⟹   NP_001128158
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81658,120,968 - 58,174,256 (-)NCBI
mRatBN7.21651,417,493 - 51,470,784 (-)NCBI
Rnor_6.01654,460,067 - 54,513,349 (-)NCBI
Rnor_5.01654,171,102 - 54,224,384 (-)NCBI
RGSC_v3.41654,752,119 - 54,805,406 (-)RGD
Celera1649,310,502 - 49,363,790 (-)RGD
Sequence:
RefSeq Acc Id: NM_022619   ⟹   NP_072141
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81658,120,968 - 58,174,256 (-)NCBI
mRatBN7.21651,417,493 - 51,470,784 (-)NCBI
Rnor_6.01654,460,067 - 54,513,349 (-)NCBI
Rnor_5.01654,171,102 - 54,224,384 (-)NCBI
RGSC_v3.41654,752,119 - 54,805,406 (-)RGD
Celera1649,310,502 - 49,363,790 (-)RGD
Sequence:
RefSeq Acc Id: XM_039094810   ⟹   XP_038950738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81658,115,991 - 58,174,047 (-)NCBI
mRatBN7.21651,417,478 - 51,470,566 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_072141   ⟸   NM_022619
- Peptide Label: isoform a
- UniProtKB: B5D5P0 (UniProtKB/Swiss-Prot),   B5D5N9 (UniProtKB/Swiss-Prot),   Q925V9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001128158   ⟸   NM_001134686
- Peptide Label: isoform b
- UniProtKB: Q925V9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014809   ⟸   ENSRNOT00000014809
RefSeq Acc Id: ENSRNOP00000015127   ⟸   ENSRNOT00000015127
RefSeq Acc Id: XP_038950738   ⟸   XM_039094810
- Peptide Label: isoform X1
- UniProtKB: Q925V9 (UniProtKB/TrEMBL)
Protein Domains
Cationic amino acid transporter C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5D5N9-F1-model_v2 AlphaFold B5D5N9 1-657 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700121
Promoter ID:EPDNEW_R10645
Type:initiation region
Name:Slc7a2_1
Description:solute carrier family 7 member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01654,513,338 - 54,513,398EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68387 AgrOrtholog
BioCyc Gene G2FUF-11248 BioCyc
Ensembl Genes ENSRNOG00000011016 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055011496 UniProtKB/Swiss-Prot
  ENSRNOG00060007110 UniProtKB/Swiss-Prot
  ENSRNOG00065002922 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014809 ENTREZGENE
  ENSRNOT00000014809.6 UniProtKB/Swiss-Prot
  ENSRNOT00000015127 ENTREZGENE
  ENSRNOT00000015127.6 UniProtKB/Swiss-Prot
  ENSRNOT00055019542 UniProtKB/Swiss-Prot
  ENSRNOT00060011714 UniProtKB/Swiss-Prot
  ENSRNOT00065004074 UniProtKB/Swiss-Prot
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AA/rel_permease1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cat_AA_permease UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAT_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64554 UniProtKB/Swiss-Prot
NCBI Gene 64554 ENTREZGENE
PANTHER CATIONIC AMINO ACID TRANSPORTER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INNER MEMBRANE TRANSPORTER YGJI-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AA_permease_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AA_permease_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc7a2 PhenoGen
RatGTEx ENSRNOG00000011016 RatGTEx
  ENSRNOG00055011496 RatGTEx
  ENSRNOG00060007110 RatGTEx
  ENSRNOG00065002922 RatGTEx
UniProt B5D5N9 ENTREZGENE
  B5D5P0 ENTREZGENE
  CTR2_RAT UniProtKB/Swiss-Prot
  Q925V9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B5D5P0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc7a2  solute carrier family 7 member 2  Slc7a2  solute carrier family 7 (cationic amino acid transporter, y+ system), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc7a2  solute carrier family 7 (cationic amino acid transporter, y+ system), member 2    solute carrier family 7, member 3  Name updated 1299863 APPROVED
2002-06-10 Slc7a2  solute carrier family 7, member 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA expression is upregulated by ischemic acute renal failure leading to increased NO production and increase L-arginine transport