Arhgap4 (Rho GTPase activating protein 4) - Rat Genome Database

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Gene: Arhgap4 (Rho GTPase activating protein 4) Rattus norvegicus
Analyze
Symbol: Arhgap4
Name: Rho GTPase activating protein 4
RGD ID: 628901
Description: Enables GTPase activator activity. Involved in negative regulation of axon extension; negative regulation of fibroblast migration; and nervous system development. Located in growth cone and microtubule. Orthologous to human ARHGAP4 (Rho GTPase activating protein 4); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: rho GTPase-activating protein 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X156,787,566 - 156,802,841 (-)NCBIGRCr8
mRatBN7.2X151,636,071 - 151,651,528 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,632,454 - 151,651,128 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,777,408 - 153,792,281 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,340,624 - 157,355,497 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X155,012,457 - 155,027,330 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,873,094 - 156,888,762 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,873,849 - 156,888,761 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,621,929 - 152,636,830 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,824,136 - 159,839,008 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X159,895,781 - 159,914,456 (-)NCBI
Celera1136,240,986 - 136,255,858 (+)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IEA,ISO)
growth cone  (IDA)
microtubule  (IDA)
nucleoplasm  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cloning of rat ARHGAP4/C1, a RhoGAP family member expressed in the nervous system that colocalizes with the Golgi complex and microtubules. Foletta VC, etal., Brain Res Mol Brain Res 2002 Oct 30;107(1):65-79.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. RefSeq and LocusLink: NCBI gene-centered resources Pruitt KD and Maglott DR, Nucleic Acids Res. 2001 Jan 1;29(1):137-40.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. ARHGAP4 is a novel RhoGAP that mediates inhibition of cell motility and axon outgrowth. Vogt DL, etal., Mol Cell Neurosci. 2007 Nov;36(3):332-42. Epub 2007 Jul 24.
Additional References at PubMed
PMID:26365803  


Genomics

Comparative Map Data
Arhgap4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X156,787,566 - 156,802,841 (-)NCBIGRCr8
mRatBN7.2X151,636,071 - 151,651,528 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,632,454 - 151,651,128 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,777,408 - 153,792,281 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,340,624 - 157,355,497 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X155,012,457 - 155,027,330 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,873,094 - 156,888,762 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,873,849 - 156,888,761 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,621,929 - 152,636,830 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,824,136 - 159,839,008 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X159,895,781 - 159,914,456 (-)NCBI
Celera1136,240,986 - 136,255,858 (+)NCBICelera
Cytogenetic MapXq37NCBI
ARHGAP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X153,907,378 - 153,926,264 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX153,907,367 - 153,934,999 (-)EnsemblGRCh38hg38GRCh38
GRCh37X153,172,832 - 153,191,718 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,826,025 - 152,844,892 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X152,693,677 - 152,712,545NCBI
CeleraX153,406,543 - 153,425,434 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX141,824,230 - 141,844,372 (-)NCBIHuRef
CHM1_1X153,047,278 - 153,066,168 (-)NCBICHM1_1
T2T-CHM13v2.0X152,181,090 - 152,199,981 (-)NCBIT2T-CHM13v2.0
Arhgap4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X72,937,958 - 72,954,945 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX72,935,048 - 72,965,476 (-)EnsemblGRCm39 Ensembl
GRCm38X73,894,352 - 73,911,345 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX73,891,442 - 73,921,870 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X71,139,691 - 71,156,637 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X70,147,078 - 70,163,949 (-)NCBIMGSCv36mm8
CeleraX65,146,782 - 65,163,733 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.45NCBI
Arhgap4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955580586,986 - 600,299 (-)NCBIChiLan1.0ChiLan1.0
ARHGAP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X153,952,137 - 153,971,360 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X153,955,743 - 153,975,083 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X143,462,157 - 143,481,496 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X153,349,050 - 153,367,709 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,349,050 - 153,367,709 (-)Ensemblpanpan1.1panPan2
ARHGAP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,754,965 - 121,772,209 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,755,221 - 121,772,541 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX107,083,712 - 107,100,978 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X124,896,249 - 124,913,499 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX124,896,263 - 124,913,532 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X120,665,512 - 120,682,776 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X123,180,944 - 123,198,176 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X122,942,263 - 122,959,510 (-)NCBIUU_Cfam_GSD_1.0
Arhgap4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,053,506 - 119,069,677 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936809791,274 - 807,450 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936809791,275 - 807,448 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,641,226 - 124,655,279 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,641,222 - 124,655,312 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,205,952 - 142,220,121 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103232807
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,331,693 - 128,351,169 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,330,060 - 128,350,324 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666473133 - 21,510 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgap4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624946543,542 - 556,865 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arhgap4
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:51
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000056344
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat

Markers in Region
RH127646  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,635,683 - 151,635,868 (-)MAPPERmRatBN7.2
Rnor_6.0X156,889,138 - 156,889,322NCBIRnor6.0
Rnor_5.01152,637,206 - 152,637,390UniSTSRnor5.0
RGSC_v3.4X159,823,576 - 159,823,760UniSTSRGSC3.4
Celera1136,256,234 - 136,256,418UniSTS
Cytogenetic MapXq37UniSTS
AI028822  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,636,270 - 151,636,471 (-)MAPPERmRatBN7.2
Rnor_6.0X156,888,535 - 156,888,735NCBIRnor6.0
Rnor_5.01152,636,603 - 152,636,803UniSTSRnor5.0
RGSC_v3.4X159,824,163 - 159,824,363UniSTSRGSC3.4
Celera1136,255,631 - 136,255,831UniSTS
Cytogenetic MapXq37UniSTS
REN88106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,634,689 - 151,634,951 (-)MAPPERmRatBN7.2
Rnor_6.0X156,890,055 - 156,890,316NCBIRnor6.0
Rnor_5.01152,638,123 - 152,638,384UniSTSRnor5.0
RGSC_v3.4X159,822,582 - 159,822,843UniSTSRGSC3.4
Celera1136,257,151 - 136,257,412UniSTS
Cytogenetic MapXq37UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8 19 41 4 3 10
Low 1 43 49 41 41 8 11 33 31 36 1 8
Below cutoff 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_144740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005497911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF401635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY742900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO572120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000085410   ⟹   ENSRNOP00000069460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,632,454 - 151,651,128 (-)Ensembl
Rnor_6.0 EnsemblX156,873,849 - 156,888,761 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104884   ⟹   ENSRNOP00000091062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,632,454 - 151,651,128 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109725   ⟹   ENSRNOP00000094863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,632,454 - 151,651,128 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109822   ⟹   ENSRNOP00000083983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,632,454 - 151,651,128 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117215   ⟹   ENSRNOP00000095360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,632,454 - 151,651,128 (-)Ensembl
RefSeq Acc Id: NM_144740   ⟹   NP_653341
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,787,566 - 156,802,438 (-)NCBI
mRatBN7.2X151,636,244 - 151,651,116 (-)NCBI
Rnor_6.0X156,873,890 - 156,888,762 (+)NCBI
Rnor_5.01152,621,929 - 152,636,830 (+)NCBI
RGSC_v3.4X159,824,136 - 159,839,008 (-)RGD
Celera1136,240,986 - 136,255,858 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229545   ⟹   XP_006229607
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,787,566 - 156,802,479 (-)NCBI
mRatBN7.2X151,636,244 - 151,651,158 (-)NCBI
Rnor_6.0X156,873,094 - 156,888,762 (+)NCBI
Rnor_5.01152,621,929 - 152,636,830 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229546   ⟹   XP_006229608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,787,566 - 156,802,480 (-)NCBI
mRatBN7.2X151,636,244 - 151,651,160 (-)NCBI
Rnor_6.0X156,873,094 - 156,888,762 (+)NCBI
Rnor_5.01152,621,929 - 152,636,830 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099451   ⟹   XP_038955379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,787,566 - 156,802,486 (-)NCBI
mRatBN7.2X151,636,071 - 151,651,166 (-)NCBI
RefSeq Acc Id: XM_039099452   ⟹   XP_038955380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,787,566 - 156,802,483 (-)NCBI
mRatBN7.2X151,636,244 - 151,651,163 (-)NCBI
RefSeq Acc Id: XM_039099453   ⟹   XP_038955381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,787,566 - 156,802,485 (-)NCBI
mRatBN7.2X151,636,244 - 151,651,165 (-)NCBI
RefSeq Acc Id: XM_039099454   ⟹   XP_038955382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,787,566 - 156,802,488 (-)NCBI
mRatBN7.2X151,636,244 - 151,651,168 (-)NCBI
RefSeq Acc Id: XM_039099456   ⟹   XP_038955384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,787,566 - 156,802,488 (-)NCBI
mRatBN7.2X151,636,244 - 151,651,169 (-)NCBI
RefSeq Acc Id: XM_039099457   ⟹   XP_038955385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,787,566 - 156,802,484 (-)NCBI
mRatBN7.2X151,636,244 - 151,651,164 (-)NCBI
RefSeq Acc Id: XM_063279778   ⟹   XP_063135848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,787,566 - 156,802,480 (-)NCBI
RefSeq Acc Id: XM_063279779   ⟹   XP_063135849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,787,566 - 156,802,481 (-)NCBI
RefSeq Acc Id: XR_005497911
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,790,541 - 156,802,841 (-)NCBI
mRatBN7.2X151,639,219 - 151,651,528 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_653341   ⟸   NM_144740
- UniProtKB: Q8K4G7 (UniProtKB/TrEMBL),   A0A0G2JVF0 (UniProtKB/TrEMBL),   A6KRT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229607   ⟸   XM_006229545
- Peptide Label: isoform X3
- UniProtKB: A6KRU0 (UniProtKB/TrEMBL),   Q8K4G7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229608   ⟸   XM_006229546
- Peptide Label: isoform X6
- UniProtKB: A0A8I6AIK5 (UniProtKB/TrEMBL),   A6KRU1 (UniProtKB/TrEMBL),   Q8K4G7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069460   ⟸   ENSRNOT00000085410
RefSeq Acc Id: XP_038955379   ⟸   XM_039099451
- Peptide Label: isoform X1
- UniProtKB: Q8K4G7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955384   ⟸   XM_039099456
- Peptide Label: isoform X8
- UniProtKB: Q8K4G7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955382   ⟸   XM_039099454
- Peptide Label: isoform X5
- UniProtKB: Q8K4G7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955381   ⟸   XM_039099453
- Peptide Label: isoform X4
- UniProtKB: Q8K4G7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955385   ⟸   XM_039099457
- Peptide Label: isoform X9
- UniProtKB: Q8K4G7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955380   ⟸   XM_039099452
- Peptide Label: isoform X2
- UniProtKB: Q8K4G7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000094863   ⟸   ENSRNOT00000109725
RefSeq Acc Id: ENSRNOP00000083983   ⟸   ENSRNOT00000109822
RefSeq Acc Id: ENSRNOP00000091062   ⟸   ENSRNOT00000104884
RefSeq Acc Id: ENSRNOP00000095360   ⟸   ENSRNOT00000117215
RefSeq Acc Id: XP_063135849   ⟸   XM_063279779
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063135848   ⟸   XM_063279778
- Peptide Label: isoform X7
- UniProtKB: A0A8I5ZY52 (UniProtKB/TrEMBL)
Protein Domains
F-BAR   Rho-GAP   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JVF0-F1-model_v2 AlphaFold A0A0G2JVF0 1-955 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702053
Promoter ID:EPDNEW_R12577
Type:initiation region
Name:Arhgap4_1
Description:Rho GTPase activating protein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X156,873,904 - 156,873,964EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628901 AgrOrtholog
BioCyc Gene G2FUF-656 BioCyc
Ensembl Genes ENSRNOG00000058545 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000085410 ENTREZGENE
  ENSRNOT00000085410.2 UniProtKB/TrEMBL
  ENSRNOT00000104884.1 UniProtKB/TrEMBL
  ENSRNOT00000109725.1 UniProtKB/TrEMBL
  ENSRNOT00000109822.1 UniProtKB/TrEMBL
  ENSRNOT00000117215.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
  1.20.1270.60 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro AH/BAR-dom UniProtKB/TrEMBL
  F_BAR UniProtKB/TrEMBL
  FCH UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report rno:246249 UniProtKB/TrEMBL
NCBI Gene 246249 ENTREZGENE
PANTHER RHO GTPASE-ACTIVATING PROTEIN 4 UniProtKB/TrEMBL
  SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN UniProtKB/TrEMBL
Pfam FCH UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PhenoGen Arhgap4 PhenoGen
PROSITE F_BAR UniProtKB/TrEMBL
  RHOGAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000058545 RatGTEx
SMART FCH UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP Rho_GAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SSF103657 UniProtKB/TrEMBL
UniProt A0A0G2JVF0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZY52 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AIK5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AN89_RAT UniProtKB/TrEMBL
  A0A8I6GIQ7_RAT UniProtKB/TrEMBL
  A6KRT9 ENTREZGENE, UniProtKB/TrEMBL
  A6KRU0 ENTREZGENE, UniProtKB/TrEMBL
  A6KRU1 ENTREZGENE, UniProtKB/TrEMBL
  A6KRU2_RAT UniProtKB/TrEMBL
  A6KRU3_RAT UniProtKB/TrEMBL
  Q8K4G7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Arhgap4  Rho GTPase activating protein 4      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Arhgap4  Rho GTPase activating protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the Rho GTPase activating protein family 632235