Acox2 (acyl-CoA oxidase 2) - Rat Genome Database

Name: Acox2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Acox2 (acyl-CoA oxidase 2) Rattus norvegicus

Analyze

Symbol:

Acox2

Name:

acyl-CoA oxidase 2

RGD ID:

628684

Description:

Enables 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity; fatty acid binding activity; and flavin adenine dinucleotide binding activity. Involved in fatty acid beta-oxidation. Located in peroxisome. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 6. Orthologous to human ACOX2 (acyl-CoA oxidase 2); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase; acyl-CoA oxidase 2, branched chain; acyl-Coenzyme A oxidase 2; acyl-Coenzyme A oxidase 2, branched chain; peroxisomal acyl-coenzyme A oxidase 2; THCA-CoA oxidase; THCCox; trihydroxycoprostanoyl-CoA oxidase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ACOX2 (acyl-CoA oxidase 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Acox2 (acyl-Coenzyme A oxidase 2, branched chain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Acox2 (acyl-CoA oxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ACOX2 (acyl-CoA oxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ACOX2 (acyl-CoA oxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Acox2 (acyl-CoA oxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ACOX2 (acyl-CoA oxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ACOX2 (acyl-CoA oxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Acox2 (acyl-CoA oxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Acox2 (acyl-Coenzyme A oxidase 2, branched chain)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ACOX2 (acyl-CoA oxidase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Acox57D-p	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	CG4586	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	POX1	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	acox2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	19,090,820 - 19,122,392 (+)	NCBI		GRCr8
mRatBN7.2	15	16,660,584 - 16,692,160 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	16,660,272 - 16,692,160 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	18,836,640 - 18,868,092 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	19,795,088 - 19,826,544 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	18,049,986 - 18,081,440 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	18,449,304 - 18,481,472 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	18,451,144 - 18,481,470 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	22,418,099 - 22,449,500 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	18,645,349 - 18,677,855 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	18,645,348 - 18,677,855 (+)	NCBI
Celera	15	16,620,632 - 16,652,578 (+)	NCBI		Celera
Cytogenetic Map	15	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital bile acid synthesis defect 6 (ISO)

Experimental Liver Cirrhosis (ISO)

Pyruvate Dehydrogenase E1-Beta Deficiency (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP)

2,3,4,7,8-Pentachlorodibenzofuran (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-amino-2-deoxy-D-glucopyranose (ISO)

3-methylcholanthrene (ISO)

4,4'-diaminodiphenylmethane (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (ISO)

acrylamide (EXP)

Actein (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucosamine (ISO)

aldehydo-D-glucose (ISO)

amiodarone (ISO)

ammonium chloride (EXP)

antimycin A (ISO)

antirheumatic drug (ISO)

arsenous acid (ISO)

benzamides (ISO)

benzo[a]pyrene (EXP,ISO)

Benzo[k]fluoranthene (ISO)

beta-D-glucosamine (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

calcitriol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroprene (ISO)

cisplatin (EXP,ISO)

clofibric acid (EXP)

cobalt dichloride (EXP)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

copper(II) sulfate (ISO)

cyclosporin A (EXP,ISO)

D-glucose (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (EXP)

dibenzo[a,l]pyrene (EXP)

difenoconazole (ISO)

diiodine (ISO)

dimethylarsinic acid (ISO)

diquat (ISO)

doxorubicin (EXP,ISO)

endosulfan (EXP)

epoxiconazole (ISO)

farnesol (ISO)

fenofibrate (ISO)

fludioxonil (ISO)

fluoranthene (EXP)

flutamide (EXP)

genistein (ISO)

glucose (ISO)

gold atom (ISO)

gold(0) (ISO)

GW 4064 (ISO)

GW 7647 (ISO)

indometacin (EXP)

isotretinoin (ISO)

methapyrilene (EXP)

methoxychlor (EXP)

methylarsonic acid (ISO)

N-methyl-N'-nitro-N-nitrosoguanidine (EXP)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (EXP)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

nickel sulfate (ISO)

nitrofen (EXP)

O-methyleugenol (ISO)

obeticholic acid (ISO)

okadaic acid (ISO)

oleic acid (ISO)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

phenobarbital (EXP)

phlorizin (ISO)

pirinixic acid (EXP,ISO)

pregnenolone 16alpha-carbonitrile (EXP)

propiconazole (ISO)

quercetin (ISO)

rotenone (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tamoxifen (EXP)

testosterone (ISO)

tetrachloromethane (EXP)

tetracycline (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP,ISO)

Triptolide (EXP,ISO)

valproic acid (EXP,ISO)

vancomycin (ISO)

zinc atom (EXP)

zinc(0) (EXP)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bile acid biosynthetic process (IEA,ISO,ISS)

fatty acid beta-oxidation (IDA)

fatty acid beta-oxidation using acyl-CoA oxidase (IBA,IEA,ISO)

fatty acid metabolic process (IEP)

lipid homeostasis (IBA)

very long-chain fatty acid metabolic process (IBA)

Cellular Component

cytosol (IEA,ISO)

intracellular membrane-bounded organelle (ISO)

peroxisome (IBA,IDA,IEA,ISO)

Molecular Function

3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity (IBA,IDA,IEA,ISO)

acyl-CoA oxidase activity (IEA)

FAD binding (IEA)

fatty acid binding (IBA,IDA,IEA)

flavin adenine dinucleotide binding (IBA,IDA)

palmitoyl-CoA oxidase activity (IBA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

bile acid biosynthetic pathway (IEA,ISO)

cerebrotendinous xanthomatosis pathway (ISO)

congenital bile acid synthesis defect pathway (ISO)

eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma (IEA)

familial hypercholanemia pathway (ISO)

primary bile acid biosynthetic pathway (IEA)

Zellweger syndrome pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Molecular cloning and further characterization of rat peroxisomal trihydroxycoprostanoyl-CoA oxidase.	Baumgart E, etal., Biochem J 1996 Nov 15;320 ( Pt 1):115-21.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease.	Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Peroxisomal beta-oxidation of 2-methyl-branched acyl-CoA esters: stereospecific recognition of the 2S-methyl compounds by trihydroxycoprostanoyl-CoA oxidase and pristanoyl-CoA oxidase.	Van Veldhoven PP, etal., FEBS Lett. 1996 Jun 10;388(1):80-4.
11.	Substrate specificities of rat liver peroxisomal acyl-CoA oxidases: palmitoyl-CoA oxidase (inducible acyl-CoA oxidase), pristanoyl-CoA oxidase (non-inducible acyl-CoA oxidase), and trihydroxycoprostanoyl-CoA oxidase.	Van Veldhoven PP, etal., J Biol Chem. 1992 Oct 5;267(28):20065-74.

Additional References at PubMed

PMID:2079609	PMID:8943006	PMID:16396499	PMID:16672280	PMID:20178365	PMID:27884763

Genomics

Comparative Map Data

Acox2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	19,090,820 - 19,122,392 (+)	NCBI		GRCr8
mRatBN7.2	15	16,660,584 - 16,692,160 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	16,660,272 - 16,692,160 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	18,836,640 - 18,868,092 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	19,795,088 - 19,826,544 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	18,049,986 - 18,081,440 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	18,449,304 - 18,481,472 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	18,451,144 - 18,481,470 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	22,418,099 - 22,449,500 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	18,645,349 - 18,677,855 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	18,645,348 - 18,677,855 (+)	NCBI
Celera	15	16,620,632 - 16,652,578 (+)	NCBI		Celera
Cytogenetic Map	15	p14	NCBI

ACOX2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	58,505,136 - 58,537,190 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	58,505,136 - 58,537,283 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	58,490,863 - 58,522,917 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	58,465,903 - 58,497,956 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	58,465,903 - 58,497,956	NCBI
Celera	3	58,504,526 - 58,536,479 (-)	NCBI		Celera
Cytogenetic Map	3	p14.3	NCBI
HuRef	3	58,587,451 - 58,619,350 (-)	NCBI		HuRef
CHM1_1	3	58,441,069 - 58,473,060 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	58,545,514 - 58,577,544 (-)	NCBI		T2T-CHM13v2.0

Acox2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	14,210,406 - 14,244,262 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	14,210,420 - 14,244,262 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	8,225,511 - 8,259,019 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	8,225,511 - 8,259,353 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	9,058,025 - 9,091,533 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	7,019,267 - 7,052,692 (-)	NCBI		MGSCv36	mm8
Celera	14	3,848,464 - 3,882,056 (-)	NCBI		Celera
Cytogenetic Map	14	A1	NCBI
cM Map	14	4.77	NCBI

Acox2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955430	1,638,431 - 1,665,141 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955430	1,638,931 - 1,665,308 (+)	NCBI	ChiLan1.0	ChiLan1.0

ACOX2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	58,476,727 - 58,508,835 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	58,479,316 - 58,519,840 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	58,442,532 - 58,474,601 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	59,852,771 - 59,884,548 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	59,852,771 - 59,884,548 (-)	Ensembl	panpan1.1		panPan2

ACOX2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	32,110,788 - 32,141,751 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	32,113,217 - 32,141,734 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	32,035,767 - 32,068,722 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	32,378,012 - 32,411,337 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	32,378,302 - 32,410,072 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	31,836,223 - 31,868,139 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	32,191,158 - 32,224,121 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	32,363,394 - 32,396,348 (+)	NCBI		UU_Cfam_GSD_1.0

Acox2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	169,355,964 - 169,386,915 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936473	2,494,554 - 2,526,787 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936473	2,494,568 - 2,525,956 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ACOX2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	40,223,010 - 40,255,967 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	40,220,952 - 40,255,967 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	44,232,258 - 44,264,976 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ACOX2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	19,805,736 - 19,838,399 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	19,804,440 - 19,838,374 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	146,983,928 - 147,016,629 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Acox2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624822	5,536,421 - 5,561,781 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624822	5,535,086 - 5,561,867 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Acox2
185 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	28
Count of miRNA genes:	23
Interacting mature miRNAs:	26
Transcripts:	ENSRNOT00000010260
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354657	Despr13	Despair related QTL 13		0.0022	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	15	1	29912054	Rat
8552920	Pigfal8	Plasma insulin-like growth factor 1 level QTL 8	3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	15	1	34723002	Rat
8694361	Abfw6	Abdominal fat weight QTL 6	10.2	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	15	1	34723002	Rat
9589149	Insul29	Insulin level QTL 29	9.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	15	1	34723002	Rat
731170	Pur3	Proteinuria QTL 3	2.3	0.0005	urine protein amount (VT:0005160)	urine protein excretion rate (CMO:0000759)	15	1	41686771	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	42356671	Rat
2298549	Neuinf12	Neuroinflammation QTL 12	3.5		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	15	1	55302115	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	306329	45306329	Rat
1641913	Colcr2	Colorectal carcinoma resistance QTL 2	6.57	0.0197	intestine integrity trait (VT:0010554)	colorectal tumor number (CMO:0001794)	15	2266368	22711984	Rat
1641913	Colcr2	Colorectal carcinoma resistance QTL 2	6.57	0.0197	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	15	2266368	22711984	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2266368	46921453	Rat
1582251	Gluco24	Glucose level QTL 24	3.2	0.0008	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	5530756	50530756	Rat
631273	Lecl2	Lens clarity QTL 2		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	15	10596089	55596089	Rat
2300167	Bmd63	Bone mineral density QTL 63	5.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
2300173	Bmd62	Bone mineral density QTL 62	12.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
2293688	Bss29	Bone structure and strength QTL 29	5.31	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	15	11111142	56111142	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	12496141	65205939	Rat
5685002	Bss103	Bone structure and strength QTL 103	2.8		tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	15	14481165	28469888	Rat

Markers in Region

AU048401

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	15	18,469,221 - 18,469,349	NCBI	Rnor6.0
RGSC_v3.4	15	18,666,231 - 18,666,357	UniSTS	RGSC3.4
Celera	15	16,640,956 - 16,641,082	UniSTS
Cytogenetic Map	15	p14	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			35	35		35				21	1
Low	1	5	19	6	14	6	8	11	14	14	11	10	8
Below cutoff	1	32	3		5				60		25	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_145770	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006251743	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006251744	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006251745	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB873097	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB882959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB894288	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC930506	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC940368	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC951697	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X95189	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000010260 ⟹ ENSRNOP00000010260

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	16,662,472 - 16,692,160 (+)	Ensembl
Rnor_6.0 Ensembl	15	18,451,144 - 18,481,470 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000101610 ⟹ ENSRNOP00000095724

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	16,660,272 - 16,692,160 (+)	Ensembl

RefSeq Acc Id:

NM_145770 ⟹ NP_665713

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	19,090,955 - 19,122,392 (+)	NCBI
mRatBN7.2	15	16,660,718 - 16,692,160 (+)	NCBI
Rnor_6.0	15	18,449,390 - 18,481,470 (+)	NCBI
Rnor_5.0	15	22,418,099 - 22,449,500 (+)	NCBI
RGSC_v3.4	15	18,645,349 - 18,677,855 (+)	RGD
Celera	15	16,620,632 - 16,652,578 (+)	RGD

Sequence:

show sequence

CCATAGCGAAGACTTCATGAAGACTGTCCCAGGCATGCTGTGACACAAACTACAGAAGGTGGGA
AAAGATCTTTGTGGTCAAACCATCCGGACCTTGGCTACCGCAGACAGAACAATACTGACCGCAT
TCACTCATACACAGTTCTCGGCACCTCCCAGTGCTCAGAGCAGACCCTCAAGGAGACGAGCAGA
TCCAGGATGGGGAGCCCAATGCACCGAGTGTCCCTGGGGGACACCTGGAGCTGGCAAGTGCACC
CGGACATAGACAGTGAAAGGCACTCACCGTCCTTCAGTGTGGAGCGACTCACCAACATCCTTGA
TGGAGGCCTCCCAAACACCGTGCTGCGAAGAAAAGTCGAAAGCATCATACAAAGTGACCCAGTG
TTTAATTTGAAGAAGCTTTACTTCATGACCCGAGAGGAGCTATATGAGGATGCGATTCAAAAGA
GATTCCATCTCGAGAAGCTAGCCTGGAGCCTGGGCTGGTCAGAAGATGGTCCTGAACGCATTTA
TGCTAACAGAGTCCTTGATGGAAACGTCAACTTAAGCTTACATGGTGTTGCCATGAATGCTATC
CGAAGCCTGGGCTCAGATGAACAGATTGCTAAATGGGGCCAACTCTGCAAAAACTTCCAAATCA
TCACAACATACGCCCAGACAGAGCTGGGACACGGGACATACCTACAGGGCCTGGAGACTGAAGC
CACCTATGATGAAGCCAGGCAGGAGTTTGTGATACACAGCCCTACGATGACTTCCACCAAGTGG
TGGCCTGGGGACTTGGGATGGTCGGTCACCCATGCTGTGGTCCTAGCCCAGTTGACCTGCTTAG
GAGTCCGGCACGGCATGCACGCCTTCATTGTGCCCATTCGGAGCCTAGAGGATCACACCCCACT
GCCAGGAATCACAGTTGGGGACATAGGCCCCAAGATGGGTTTGGAACACATAGACAATGGCTTC
CTGCAACTGAACCACGTGCGGGTTCCCAGAGAAAACATGCTCAGTCGCTTTGCAGAGGTCTTGC
CAGATGGTACCTACCAGAGGCTTGGGACGCCACAGAGCAATTATCTTGGCATGTTGGTGACCCG
GGTGCAGCTGCTGTGTAAAGGAATCCTACCCTCCCTCCAGAAGGCTTGCATCATTGCCACGCGC
TACTCAGTAATCCGCCATCAGTCTCGACTTCGGCCCAGTGACCCAGAGGCAAAAATCCTGGAAT
ACCAGACGCAGCAGCAGAAACTCCTTCCTCAGCTTGCTGTGAGCTATGCCTTCCACTTCACGGC
CACCAGCCTCTCAGAATTCTTCCACAGCTCCTACAGTGCTATTCTGAAGAGAGACTTCAGCCTC
CTGCCTGAGCTCCATGCATTGAGCACTGGTATGAAGGCCACGTTTGCAGACTTCTGTGCCCAGG
GGGCCGAGATCTGTCGCAGAGCTTGTGGGGGCCATGGCTACTCAAAGCTGAGCGGCCTGCCGAC
ACTGGTTGCTCGAGCAACAGCCTCTTGCACATATGAGGGTGAGAATACGGTGCTCTACCTGCAA
GTGGCCAGGTTTCTGATGAAGAGCTATCTGCAGGCTCAAGCGTCCCCAGGCGCCACACCACAGA
AGCCTCTCCCTCAGTCCGTCATGTATATTGCCACACAAAGGCCAGCCAGGTGCTCAGCCCAGAC
TGCAGCTGACTTCCGCTGCCCAGATGTCTATACCACAGCCTGGGCATATGTGTCTACCAGGCTC
ATAAGAGATGCAGCACACCGTACACAGACCCTCATGAAGTCCGGGGTTGACCAGCATGATGCCT
GGAATCAGACTACTGTCATCCACCTTCAGGCTGCTAAGGCTTACTGCTACTTCATCACTGTGAA
GAATTTCAAGGAAGCTGTGGAGAAACTAGACAAGGAACCAGAGATTCAGCGTGTGCTCCAACGC
CTCTGTGACCTCTATGCCTTACACGGTGTTCTGACTAACTCAGGGGACTTTCTGCATGATGGCT
TCCTGTCTGGGGCCCAGGTGGACATGGCCAGAGAAGCCTTCCTAGACCTGCTTCCCTTGATCCG
GAAGGATGCCATCTTGTTAACCGATGCTTTTGACTTCTCGGACCATTGTTTAAACTCGGCACTT
GGCTGTTATGATGGACACGTCTACGAACGCCTGTTTGAGTGGGCTCAGAAGTCCCCAGCCAATA
CTCAGGAGAACCCTGCCTATAAGAAGTATATCCGACCACTGATGCTCGGCTGGAGACACAAGAT
GTGAAAAGTCAAAGGATTTGGGACCGAGAAGCACCACGGCCTTACTATGGCACATATACATAGA
GAATTTAAAGCACGGGAGGGGGGGGGGGAGCGCTGCTCGGTTAAATCAGGTAGTAAATTGGTAC
ATGAATGGATGGTCATCCTATTAGTCTACTATTGAGCGTGTTTGAAACTTTCCCTTGTCCATCT
ATAGCATGTATTTGGCTAAATGCTAAAATTTTTGTTTTACATACAGGAAAAGCTAATAAACTTG
TCAGTTAC

hide sequence

RefSeq Acc Id:

XM_006251743 ⟹ XP_006251805

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	19,091,049 - 19,122,391 (+)	NCBI
mRatBN7.2	15	16,660,812 - 16,692,160 (+)	NCBI
Rnor_6.0	15	18,449,407 - 18,481,472 (+)	NCBI
Rnor_5.0	15	22,418,099 - 22,449,500 (+)	NCBI

Sequence:

show sequence

CCTGTGCAGCAGAGCCTGGGCATCCGAGATGGCTCTCAGTTGGTCCTCTTGCTGTTTTCCGTTT
GGTAGGGGGAAACTGACCGCAACAACGAAAATACTTCATGAAGACTGTCCCAGGCATGCTGTGA
CACAAACTACAGAAGGTGGGAAAAGATCTTTGTGGTCAAACCATCCGGACCTTGGCTACCGCAG
ACAGAACAATACTGACCGCATTCACTCATACACAGTTCTCGGCACCTCCCAGTGCTCAGAGCAG
ACCCTCAAGGAGACGAGCAGATCCAGGATGGGGAGCCCAATGCACCGAGTGTCCCTGGGGGACA
CCTGGAGCTGGCAAGTGCACCCGGACATAGACAGTGAAAGGCACTCACCGTCCTTCAGTGTGGA
GCGACTCACCAACATCCTTGATGGAGGCCTCCCAAACACCGTGCTGCGAAGAAAAGTCGAAAGC
ATCATACAAAGTGACCCAGTGTTTAATTTGAAGAAGCTTTACTTCATGACCCGAGAGGAGCTAT
ATGAGGATGCGATTCAAAAGAGATTCCATCTCGAGAAGCTAGCCTGGAGCCTGGGCTGGTCAGA
AGATGGTCCTGAACGCATTTATGCTAACAGAGTCCTTGATGGAAACGTCAACTTAAGCTTACAT
GGTGTTGCCATGAATGCTATCCGAAGCCTGGGCTCAGATGAACAGATTGCTAAATGGGGCCAAC
TCTGCAAAAACTTCCAAATCATCACAACATACGCCCAGACAGAGCTGGGACACGGGACATACCT
ACAGGGCCTGGAGACTGAAGCCACCTATGATGAAGCCAGGCAGGAGTTTGTGATACACAGCCCT
ACGATGACTTCCACCAAGTGGTGGCCTGGGGACTTGGGATGGTCGGTCACCCATGCTGTGGTCC
TAGCCCAGTTGACCTGCTTAGGAGTCCGGCACGGCATGCACGCCTTCATTGTGCCCATTCGGAG
CCTAGAGGATCACACCCCACTGCCAGGAATCACAGTTGGGGACATAGGCCCCAAGATGGGTTTG
GAACACATAGACAATGGCTTCCTGCAACTGAACCACGTGCGGGTTCCCAGAGAAAACATGCTCA
GTCGCTTTGCAGAGGTCTTGCCAGATGGTACCTACCAGAGGCTTGGGACGCCACAGAGCAATTA
TCTTGGCATGTTGGTGACCCGGGTGCAGCTGCTGTGTAAAGGAATCCTACCCTCCCTCCAGAAG
GCTTGCATCATTGCCACGCGCTACTCAGTAATCCGCCATCAGTCTCGACTTCGGCCCAGTGACC
CAGAGGCAAAAATCCTGGAATACCAGACGCAGCAGCAGAAACTCCTTCCTCAGCTTGCTGTGAG
CTATGCCTTCCACTTCACGGCCACCAGCCTCTCAGAATTCTTCCACAGCTCCTACAGTGCTATT
CTGAAGAGAGACTTCAGCCTCCTGCCTGAGCTCCATGCATTGAGCACTGGTATGAAGGCCACGT
TTGCAGACTTCTGTGCCCAGGGGGCCGAGATCTGTCGCAGAGCTTGTGGGGGCCATGGCTACTC
AAAGCTGAGCGGCCTGCCGACACTGGTTGCTCGAGCAACAGCCTCTTGCACATATGAGGGTGAG
AATACGGTGCTCTACCTGCAAGTGGCCAGGTTTCTGATGAAGAGCTATCTGCAGGCTCAAGCGT
CCCCAGGCGCCACACCACAGAAGCCTCTCCCTCAGTCCGTCATGTATATTGCCACACAAAGGCC
AGCCAGGTGCTCAGCCCAGACTGCAGCTGACTTCCGCTGCCCAGATGTCTATACCACAGCCTGG
GCATATGTGTCTACCAGGCTCATAAGAGATGCAGCACACCGTACACAGACCCTCATGAAGTCCG
GGGTTGACCAGCATGATGCCTGGAATCAGACTACTGTCATCCACCTTCAGGCTGCTAAGGCTTA
CTGCTACTTCATCACTGTGAAGAATTTCAAGGAAGCTGTGGAGAAACTAGACAAGGAACCAGAG
ATTCAGCGTGTGCTCCAACGCCTCTGTGACCTCTATGCCTTACACGGTGTTCTGACTAACTCAG
GGGACTTTCTGCATGATGGCTTCCTGTCTGGGGCCCAGGTGGACATGGCCAGAGAAGCCTTCCT
AGACCTGCTTCCCTTGATCCGGAAGGATGCCATCTTGTTAACCGATGCTTTTGACTTCTCGGAC
CATTGTTTAAACTCGGCACTTGGCTGTTATGATGGACACGTCTACGAACGCCTGTTTGAGTGGG
CTCAGAAGTCCCCAGCCAATACTCAGGAGAACCCTGCCTATAAGAAGTATATCCGACCACTGAT
GCTCGGCTGGAGACACAAGATGTGAAAAGTCAAAGGATTTGGGACCGAGAAGCACCACGGCCTT
ACTATGGCACATATACATAGAGAATTTAAAGCACGGGAGGGGGGGGGGGAGCGCTGCTCGGTTA
AATCAGGTAGTAAATTGGTACATGAATGGATGGTCATCCTATTAGTCTACTATTGAGCGTGTTT
GAAACTTTCCCTTGTCCATCTATAGCATGTATTTGGCTAAATGCTAAAATTTTTGTTTTACATA
CAGGAAAAGCTAATAAACTTGTCAGTTACTT

hide sequence

RefSeq Acc Id:

XM_006251744 ⟹ XP_006251806

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	19,090,820 - 19,122,391 (+)	NCBI
mRatBN7.2	15	16,660,584 - 16,692,160 (+)	NCBI
Rnor_6.0	15	18,449,304 - 18,481,472 (+)	NCBI
Rnor_5.0	15	22,418,099 - 22,449,500 (+)	NCBI

Sequence:

show sequence

AGGGAAAGGCCAGCCCCGCCTATGGAGCTGTCCCAGGACGGAACTAGTCAAGGGTTTAGTCCCA
GGCCAGCCAGAGAACTGACAGGCCATAGCGAAGGTTCTCGGCACCTCCCAGTGCTCAGAGCAGA
CCCTCAAGGAGACGAGCAGATCCAGGATGGGGAGCCCAATGCACCGAGTGTCCCTGGGGGACAC
CTGGAGCTGGCAAGTGCACCCGGACATAGACAGTGAAAGGCACTCACCGTCCTTCAGTGTGGAG
CGACTCACCAACATCCTTGATGGAGGCCTCCCAAACACCGTGCTGCGAAGAAAAGTCGAAAGCA
TCATACAAAGTGACCCAGTGTTTAATTTGAAGAAGCTTTACTTCATGACCCGAGAGGAGCTATA
TGAGGATGCGATTCAAAAGAGATTCCATCTCGAGAAGCTAGCCTGGAGCCTGGGCTGGTCAGAA
GATGGTCCTGAACGCATTTATGCTAACAGAGTCCTTGATGGAAACGTCAACTTAAGCTTACATG
GTGTTGCCATGAATGCTATCCGAAGCCTGGGCTCAGATGAACAGATTGCTAAATGGGGCCAACT
CTGCAAAAACTTCCAAATCATCACAACATACGCCCAGACAGAGCTGGGACACGGGACATACCTA
CAGGGCCTGGAGACTGAAGCCACCTATGATGAAGCCAGGCAGGAGTTTGTGATACACAGCCCTA
CGATGACTTCCACCAAGTGGTGGCCTGGGGACTTGGGATGGTCGGTCACCCATGCTGTGGTCCT
AGCCCAGTTGACCTGCTTAGGAGTCCGGCACGGCATGCACGCCTTCATTGTGCCCATTCGGAGC
CTAGAGGATCACACCCCACTGCCAGGAATCACAGTTGGGGACATAGGCCCCAAGATGGGTTTGG
AACACATAGACAATGGCTTCCTGCAACTGAACCACGTGCGGGTTCCCAGAGAAAACATGCTCAG
TCGCTTTGCAGAGGTCTTGCCAGATGGTACCTACCAGAGGCTTGGGACGCCACAGAGCAATTAT
CTTGGCATGTTGGTGACCCGGGTGCAGCTGCTGTGTAAAGGAATCCTACCCTCCCTCCAGAAGG
CTTGCATCATTGCCACGCGCTACTCAGTAATCCGCCATCAGTCTCGACTTCGGCCCAGTGACCC
AGAGGCAAAAATCCTGGAATACCAGACGCAGCAGCAGAAACTCCTTCCTCAGCTTGCTGTGAGC
TATGCCTTCCACTTCACGGCCACCAGCCTCTCAGAATTCTTCCACAGCTCCTACAGTGCTATTC
TGAAGAGAGACTTCAGCCTCCTGCCTGAGCTCCATGCATTGAGCACTGGTATGAAGGCCACGTT
TGCAGACTTCTGTGCCCAGGGGGCCGAGATCTGTCGCAGAGCTTGTGGGGGCCATGGCTACTCA
AAGCTGAGCGGCCTGCCGACACTGGTTGCTCGAGCAACAGCCTCTTGCACATATGAGGGTGAGA
ATACGGTGCTCTACCTGCAAGTGGCCAGGTTTCTGATGAAGAGCTATCTGCAGGCTCAAGCGTC
CCCAGGCGCCACACCACAGAAGCCTCTCCCTCAGTCCGTCATGTATATTGCCACACAAAGGCCA
GCCAGGTGCTCAGCCCAGACTGCAGCTGACTTCCGCTGCCCAGATGTCTATACCACAGCCTGGG
CATATGTGTCTACCAGGCTCATAAGAGATGCAGCACACCGTACACAGACCCTCATGAAGTCCGG
GGTTGACCAGCATGATGCCTGGAATCAGACTACTGTCATCCACCTTCAGGCTGCTAAGGCTTAC
TGCTACTTCATCACTGTGAAGAATTTCAAGGAAGCTGTGGAGAAACTAGACAAGGAACCAGAGA
TTCAGCGTGTGCTCCAACGCCTCTGTGACCTCTATGCCTTACACGGTGTTCTGACTAACTCAGG
GGACTTTCTGCATGATGGCTTCCTGTCTGGGGCCCAGGTGGACATGGCCAGAGAAGCCTTCCTA
GACCTGCTTCCCTTGATCCGGAAGGATGCCATCTTGTTAACCGATGCTTTTGACTTCTCGGACC
ATTGTTTAAACTCGGCACTTGGCTGTTATGATGGACACGTCTACGAACGCCTGTTTGAGTGGGC
TCAGAAGTCCCCAGCCAATACTCAGGAGAACCCTGCCTATAAGAAGTATATCCGACCACTGATG
CTCGGCTGGAGACACAAGATGTGAAAAGTCAAAGGATTTGGGACCGAGAAGCACCACGGCCTTA
CTATGGCACATATACATAGAGAATTTAAAGCACGGGAGGGGGGGGGGGAGCGCTGCTCGGTTAA
ATCAGGTAGTAAATTGGTACATGAATGGATGGTCATCCTATTAGTCTACTATTGAGCGTGTTTG
AAACTTTCCCTTGTCCATCTATAGCATGTATTTGGCTAAATGCTAAAATTTTTGTTTTACATAC
AGGAAAAGCTAATAAACTTGTCAGTTACTT

hide sequence

RefSeq Acc Id:

XM_039093004 ⟹ XP_038948932

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	19,091,332 - 19,122,391 (+)	NCBI
mRatBN7.2	15	16,661,097 - 16,692,160 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_665713	(Get FASTA)	NCBI Sequence Viewer
	XP_006251805	(Get FASTA)	NCBI Sequence Viewer
	XP_006251806	(Get FASTA)	NCBI Sequence Viewer
	XP_038948932	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAA64488	(Get FASTA)	NCBI Sequence Viewer
	CBF60596	(Get FASTA)	NCBI Sequence Viewer
	CBF65745	(Get FASTA)	NCBI Sequence Viewer
	CBF73146	(Get FASTA)	NCBI Sequence Viewer
	CBU85835	(Get FASTA)	NCBI Sequence Viewer
	CBU90616	(Get FASTA)	NCBI Sequence Viewer
	CBU96032	(Get FASTA)	NCBI Sequence Viewer
	EDL94160	(Get FASTA)	NCBI Sequence Viewer
	EDL94161	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000010260
	ENSRNOP00000010260.3
	ENSRNOP00000095724
	ENSRNOP00000095724.1
GenBank Protein	P97562	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_665713 ⟸ NM_145770

- UniProtKB:

P97562 (UniProtKB/Swiss-Prot), F1LNW3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGSPMHRVSLGDTWSWQVHPDIDSERHSPSFSVERLTNILDGGLPNTVLRRKVESIIQSDPVFN
LKKLYFMTREELYEDAIQKRFHLEKLAWSLGWSEDGPERIYANRVLDGNVNLSLHGVAMNAIRS
LGSDEQIAKWGQLCKNFQIITTYAQTELGHGTYLQGLETEATYDEARQEFVIHSPTMTSTKWWP
GDLGWSVTHAVVLAQLTCLGVRHGMHAFIVPIRSLEDHTPLPGITVGDIGPKMGLEHIDNGFLQ
LNHVRVPRENMLSRFAEVLPDGTYQRLGTPQSNYLGMLVTRVQLLCKGILPSLQKACIIATRYS
VIRHQSRLRPSDPEAKILEYQTQQQKLLPQLAVSYAFHFTATSLSEFFHSSYSAILKRDFSLLP
ELHALSTGMKATFADFCAQGAEICRRACGGHGYSKLSGLPTLVARATASCTYEGENTVLYLQVA
RFLMKSYLQAQASPGATPQKPLPQSVMYIATQRPARCSAQTAADFRCPDVYTTAWAYVSTRLIR
DAAHRTQTLMKSGVDQHDAWNQTTVIHLQAAKAYCYFITVKNFKEAVEKLDKEPEIQRVLQRLC
DLYALHGVLTNSGDFLHDGFLSGAQVDMAREAFLDLLPLIRKDAILLTDAFDFSDHCLNSALGC
YDGHVYERLFEWAQKSPANTQENPAYKKYIRPLMLGWRHKM

hide sequence

RefSeq Acc Id:	XP_006251806 ⟸ XM_006251744
- Peptide Label:	isoform X1
- UniProtKB:	P97562 (UniProtKB/Swiss-Prot), F1LNW3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGSPMHRVSLGDTWSWQVHPDIDSERHSPSFSVERLTNILDGGLPNTVLRRKVESIIQSDPVFN LKKLYFMTREELYEDAIQKRFHLEKLAWSLGWSEDGPERIYANRVLDGNVNLSLHGVAMNAIRS LGSDEQIAKWGQLCKNFQIITTYAQTELGHGTYLQGLETEATYDEARQEFVIHSPTMTSTKWWP GDLGWSVTHAVVLAQLTCLGVRHGMHAFIVPIRSLEDHTPLPGITVGDIGPKMGLEHIDNGFLQ LNHVRVPRENMLSRFAEVLPDGTYQRLGTPQSNYLGMLVTRVQLLCKGILPSLQKACIIATRYS VIRHQSRLRPSDPEAKILEYQTQQQKLLPQLAVSYAFHFTATSLSEFFHSSYSAILKRDFSLLP ELHALSTGMKATFADFCAQGAEICRRACGGHGYSKLSGLPTLVARATASCTYEGENTVLYLQVA RFLMKSYLQAQASPGATPQKPLPQSVMYIATQRPARCSAQTAADFRCPDVYTTAWAYVSTRLIR DAAHRTQTLMKSGVDQHDAWNQTTVIHLQAAKAYCYFITVKNFKEAVEKLDKEPEIQRVLQRLC DLYALHGVLTNSGDFLHDGFLSGAQVDMAREAFLDLLPLIRKDAILLTDAFDFSDHCLNSALGC YDGHVYERLFEWAQKSPANTQENPAYKKYIRPLMLGWRHKM hide sequence

RefSeq Acc Id:	XP_006251805 ⟸ XM_006251743
- Peptide Label:	isoform X1
- UniProtKB:	P97562 (UniProtKB/Swiss-Prot), F1LNW3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALSWSSCCFPFGRGKLTATTKILHEDCPRHAVTQTTEGGKRSLWSNHPDLGYRRQNNTDRIHS YTVLGTSQCSEQTLKETSRSRMGSPMHRVSLGDTWSWQVHPDIDSERHSPSFSVERLTNILDGG LPNTVLRRKVESIIQSDPVFNLKKLYFMTREELYEDAIQKRFHLEKLAWSLGWSEDGPERIYAN RVLDGNVNLSLHGVAMNAIRSLGSDEQIAKWGQLCKNFQIITTYAQTELGHGTYLQGLETEATY DEARQEFVIHSPTMTSTKWWPGDLGWSVTHAVVLAQLTCLGVRHGMHAFIVPIRSLEDHTPLPG ITVGDIGPKMGLEHIDNGFLQLNHVRVPRENMLSRFAEVLPDGTYQRLGTPQSNYLGMLVTRVQ LLCKGILPSLQKACIIATRYSVIRHQSRLRPSDPEAKILEYQTQQQKLLPQLAVSYAFHFTATS LSEFFHSSYSAILKRDFSLLPELHALSTGMKATFADFCAQGAEICRRACGGHGYSKLSGLPTLV ARATASCTYEGENTVLYLQVARFLMKSYLQAQASPGATPQKPLPQSVMYIATQRPARCSAQTAA DFRCPDVYTTAWAYVSTRLIRDAAHRTQTLMKSGVDQHDAWNQTTVIHLQAAKAYCYFITVKNF KEAVEKLDKEPEIQRVLQRLCDLYALHGVLTNSGDFLHDGFLSGAQVDMAREAFLDLLPLIRKD AILLTDAFDFSDHCLNSALGCYDGHVYERLFEWAQKSPANTQENPAYKKYIRPLMLGWRHKM hide sequence

RefSeq Acc Id:

ENSRNOP00000010260 ⟸ ENSRNOT00000010260

RefSeq Acc Id:	XP_038948932 ⟸ XM_039093004
- Peptide Label:	isoform X1
- UniProtKB:	P97562 (UniProtKB/Swiss-Prot), F1LNW3 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000095724 ⟸ ENSRNOT00000101610

Protein Domains

Acyl-CoA oxidase C-terminal Acyl-coenzyme A oxidase N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P97562-F1-model_v2	AlphaFold	P97562	1-681	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699586

Promoter ID:

EPDNEW_R10110

Type:

initiation region

Name:

Acox2_1

Description:

acyl-CoA oxidase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	15	18,451,142 - 18,451,202	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628684	AgrOrtholog
BioCyc Gene	G2FUF-14293	BioCyc
BioCyc Pathway	PWY-6061 [bile acid biosynthesis, neutral pathway]	BioCyc
BioCyc Pathway Image	PWY-6061	BioCyc
Ensembl Genes	ENSRNOG00000007378	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000010260	ENTREZGENE
	ENSRNOT00000010260.5	UniProtKB/TrEMBL
	ENSRNOT00000101610.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.540.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.40.110.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Butyryl-CoA Dehydrogenase, subunit A, domain 3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	ACO	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Acyl-CoA_ox_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Acyl-CoA_Oxase/DH_mid-dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Acyl-CoA_oxidase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Acyl-CoA_oxidase_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AcylCo_DH-like_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AcylCoA_DH/ox_N_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AcylCoA_DH/oxidase_NM_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:252898	UniProtKB/TrEMBL
NCBI Gene	252898	ENTREZGENE
PANTHER	PEROXISOMAL ACYL-COENZYME A OXIDASE 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10909	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	ACOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Acyl-CoA_ox_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Acox2	PhenoGen
PIRSF	Acyl-CoA_oxidase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000007378	RatGTEx
Superfamily-SCOP	SSF47203	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF56645	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6AM11_RAT	UniProtKB/TrEMBL
	A6K0B3_RAT	UniProtKB/TrEMBL
	A6K0B4_RAT	UniProtKB/TrEMBL
	ACOX2_RAT	UniProtKB/Swiss-Prot
	F1LNW3	ENTREZGENE, UniProtKB/TrEMBL
	P97562	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-08	Acox2	acyl-CoA oxidase 2	Acox2	acyl-CoA oxidase 2, branched chain	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-07-28	Acox2	acyl-CoA oxidase 2, branched chain	Acox2	acyl-Coenzyme A oxidase 2, branched chain	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-02-26	Acox2	acyl-Coenzyme A oxidase 2, branched chain			Symbol and Name status set to approved	625702	APPROVED
2003-02-27	Acox2	acyl-Coenzyme A oxidase 2, branched chain			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_function	oxidizes the CoA esters of the bile acid intermediates di- and tri-hyroxycoprostanic acids; does not act on 2-methyl-branched fatty acids	724707
gene_process	decreased in liver peroxisomes after treatment with bezafibrate	724759

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MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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