Gprasp1 (G protein-coupled receptor associated sorting protein 1) - Rat Genome Database

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Gene: Gprasp1 (G protein-coupled receptor associated sorting protein 1) Rattus norvegicus
Analyze
Symbol: Gprasp1
Name: G protein-coupled receptor associated sorting protein 1
RGD ID: 621343
Description: Predicted to be involved in G protein-coupled receptor catabolic process and endosome to lysosome transport. Predicted to be active in cytosol and nucleus. Orthologous to human GPRASP1 (G protein-coupled receptor associated sorting protein 1); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G-protein coupled receptor-associated sorting protein 1; GASP-1; Per1 interacting protein; per1-interacting protein; pips
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X103,556,493 - 103,564,275 (+)NCBIGRCr8
mRatBN7.2X98,764,853 - 98,772,685 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX98,709,841 - 98,772,851 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX100,897,429 - 100,905,214 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X104,408,031 - 104,415,816 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X101,961,938 - 101,969,720 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X106,306,795 - 106,313,904 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX106,306,795 - 106,313,853 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X106,806,369 - 106,867,373 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX100,372,227 - 100,379,281 (-)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IEA,ISO)
nucleus  (IBA)

Molecular Function
protein binding  (IPI,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A novel protein interacts with a clock-related protein, rPer1. Matsuki T, etal., Brain Res 2001 Oct 19;916(1-2):1-10.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. The circadian rhythm of Per1 gene product in the rat suprachiasmatic nucleus and its modulation by seasonal changes in daylength. Sumova A, etal., Brain Res 2002 Aug 30;947(2):260-70.
8. Ca2+/cAMP response element-binding protein (CREB)-dependent activation of Per1 is required for light-induced signaling in the suprachiasmatic nucleus circadian clock. Tischkau SA, etal., J Biol Chem 2003 Jan 10;278(2):718-23.
Additional References at PubMed
PMID:16049099   PMID:16298334   PMID:23954414  


Genomics

Comparative Map Data
Gprasp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X103,556,493 - 103,564,275 (+)NCBIGRCr8
mRatBN7.2X98,764,853 - 98,772,685 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX98,709,841 - 98,772,851 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX100,897,429 - 100,905,214 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X104,408,031 - 104,415,816 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X101,961,938 - 101,969,720 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X106,306,795 - 106,313,904 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX106,306,795 - 106,313,853 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X106,806,369 - 106,867,373 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX100,372,227 - 100,379,281 (-)NCBICelera
Cytogenetic MapXq32NCBI
GPRASP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X102,651,483 - 102,659,083 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX102,651,092 - 102,659,083 (+)EnsemblGRCh38hg38GRCh38
GRCh37X101,906,411 - 101,914,011 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X101,792,950 - 101,800,667 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X101,712,586 - 101,719,523NCBI
CeleraX102,344,925 - 102,352,642 (+)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX91,571,439 - 91,579,193 (+)NCBIHuRef
CHM1_1X101,798,965 - 101,806,682 (+)NCBICHM1_1
T2T-CHM13v2.0X101,096,438 - 101,104,038 (+)NCBIT2T-CHM13v2.0
Gprasp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X134,643,441 - 134,704,217 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX134,643,482 - 134,704,223 (+)EnsemblGRCm39 Ensembl
GRCm38X135,742,692 - 135,803,468 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX135,742,733 - 135,803,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X132,277,231 - 132,338,007 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X131,089,056 - 131,149,832 (+)NCBIMGSCv36mm8
CeleraX119,059,474 - 119,120,009 (+)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX57.26NCBI
Gprasp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955548133,425 - 137,468 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955548132,373 - 137,817 (+)NCBIChiLan1.0ChiLan1.0
GPRASP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X102,200,309 - 102,263,893 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X102,209,907 - 102,267,491 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X91,823,855 - 91,881,439 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X102,254,518 - 102,262,345 (+)NCBIpanpan1.1PanPan1.1panPan2
GPRASP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X76,274,196 - 76,318,204 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX76,313,740 - 76,318,607 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX76,313,740 - 76,318,607 (+)NCBICanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X77,695,302 - 77,743,851 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X75,245,415 - 75,293,946 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X76,908,573 - 76,956,891 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X76,618,574 - 76,666,911 (+)NCBIUU_Cfam_GSD_1.0
Gprasp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X62,261,477 - 62,267,088 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368131,208,373 - 1,212,548 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368131,208,018 - 1,213,224 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPRASP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX83,765,303 - 83,810,085 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X83,765,210 - 83,810,090 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X97,711,430 - 97,750,334 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPRASP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X90,582,364 - 90,645,882 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606515,426,228 - 15,484,120 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gprasp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462503497,575 - 101,729 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462503497,240 - 102,427 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gprasp1
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:57
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000073661
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat

Markers in Region
RH137646  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X98,772,407 - 98,772,527 (+)MAPPERmRatBN7.2
Rnor_6.0X106,313,627 - 106,313,746NCBIRnor6.0
Rnor_5.0X106,806,477 - 106,806,596UniSTSRnor5.0
CeleraX100,372,335 - 100,372,454UniSTS
Cytogenetic MapXq22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 26 20 6 11 6 1 1 74 23 37 11 1
Low 3 17 37 35 8 35 7 10 12 4 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000073661   ⟹   ENSRNOP00000066239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX98,765,581 - 98,772,634 (+)Ensembl
Rnor_6.0 EnsemblX106,306,795 - 106,313,853 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101596   ⟹   ENSRNOP00000090886
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX98,764,770 - 98,772,851 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102627   ⟹   ENSRNOP00000091518
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX98,709,874 - 98,772,685 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102872   ⟹   ENSRNOP00000097511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX98,709,841 - 98,772,851 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109064   ⟹   ENSRNOP00000079015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX98,709,907 - 98,772,702 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112205   ⟹   ENSRNOP00000082826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX98,709,874 - 98,772,851 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116397   ⟹   ENSRNOP00000091617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX98,709,907 - 98,772,851 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119255   ⟹   ENSRNOP00000092743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX98,709,841 - 98,772,851 (+)Ensembl
RefSeq Acc Id: NM_134386   ⟹   NP_599213
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X103,556,493 - 103,564,275 (+)NCBI
mRatBN7.2X98,764,853 - 98,772,635 (+)NCBI
Rnor_6.0X106,306,795 - 106,313,854 (+)NCBI
Rnor_5.0X106,806,369 - 106,867,373 (-)NCBI
CeleraX100,372,227 - 100,379,281 (-)RGD
Sequence:
RefSeq Acc Id: XM_063279769   ⟹   XP_063135839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X103,557,146 - 103,564,275 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_599213   ⟸   NM_134386
- UniProtKB: Q920R4 (UniProtKB/Swiss-Prot),   M0R9R0 (UniProtKB/TrEMBL),   A6KT36 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066239   ⟸   ENSRNOT00000073661
RefSeq Acc Id: ENSRNOP00000091518   ⟸   ENSRNOT00000102627
RefSeq Acc Id: ENSRNOP00000091617   ⟸   ENSRNOT00000116397
RefSeq Acc Id: ENSRNOP00000079015   ⟸   ENSRNOT00000109064
RefSeq Acc Id: ENSRNOP00000092743   ⟸   ENSRNOT00000119255
RefSeq Acc Id: ENSRNOP00000097511   ⟸   ENSRNOT00000102872
RefSeq Acc Id: ENSRNOP00000082826   ⟸   ENSRNOT00000112205
RefSeq Acc Id: ENSRNOP00000090886   ⟸   ENSRNOT00000101596
RefSeq Acc Id: XP_063135839   ⟸   XM_063279769
- Peptide Label: isoform X1
- UniProtKB: A6KT36 (UniProtKB/TrEMBL),   M0R9R0 (UniProtKB/TrEMBL)
Protein Domains
Armadillo repeat-containing

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q920R4-F1-model_v2 AlphaFold Q920R4 1-1346 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621343 AgrOrtholog
BioCyc Gene G2FUF-1647 BioCyc
Ensembl Genes ENSRNOG00000049985 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073661.3 UniProtKB/TrEMBL
  ENSRNOT00000101596 ENTREZGENE
  ENSRNOT00000101596.1 UniProtKB/TrEMBL
  ENSRNOT00000102627.1 UniProtKB/TrEMBL
  ENSRNOT00000102872.1 UniProtKB/TrEMBL
  ENSRNOT00000109064.1 UniProtKB/TrEMBL
  ENSRNOT00000112205.1 UniProtKB/TrEMBL
  ENSRNOT00000116397.1 UniProtKB/TrEMBL
  ENSRNOT00000119255.1 UniProtKB/TrEMBL
InterPro ARM-rpt_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BHLHb9/GASP-1/GASP-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171407 UniProtKB/Swiss-Prot
NCBI Gene 171407 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR-ASSOCIATED SORTING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46414 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arm_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gprasp1 PhenoGen
RatGTEx ENSRNOG00000049985 RatGTEx
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KT36 ENTREZGENE, UniProtKB/TrEMBL
  GASP1_RAT UniProtKB/Swiss-Prot
  M0R9R0 ENTREZGENE, UniProtKB/TrEMBL
  Q920R4 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Gprasp1  G protein-coupled receptor associated sorting protein 1  pips  Per1 interacting protein  Symbol and Name updated 1299863 APPROVED
2002-08-07 pips  Per1 interacting protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the hypothalamus including the suprachiasmatic nuclei (SCN) of the brain 633668
gene_physical_interaction binds to Per1 in vivo 633668