Mvk (mevalonate kinase) - Rat Genome Database

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Gene: Mvk (mevalonate kinase) Rattus norvegicus
Analyze
Symbol: Mvk
Name: mevalonate kinase
RGD ID: 621295
Description: Enables several functions, including ATP binding activity; magnesium ion binding activity; and mevalonate kinase activity. Involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway and negative regulation of translation. Located in peroxisome. Human ortholog(s) of this gene implicated in lipid metabolism disorder; mevalonic aciduria; and porokeratosis. Orthologous to human MVK (mevalonate kinase); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Lrbp; MK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81247,802,002 - 47,819,503 (-)NCBIGRCr8
mRatBN7.21242,141,391 - 42,158,893 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,141,384 - 42,158,882 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1243,308,698 - 43,326,126 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,922,277 - 43,939,707 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,982,791 - 43,000,222 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,904,266 - 47,920,457 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,904,719 - 47,919,400 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01249,695,252 - 49,711,443 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1243,753,220 - 43,770,539 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
22-Hydroxycholesterol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
Archazolid B  (ISO)
Aroclor 1254  (ISO)
ATP  (ISO)
Azaspiracid  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bromobenzene  (EXP)
caffeine  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clavulanic acid  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
dimethylarsinic acid  (ISO)
disodium selenite  (ISO)
dolichyl phosphate  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
farnesol  (ISO)
farnesyl diphosphate  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
fluoxetine  (ISO)
flusilazole  (ISO)
formaldehyde  (ISO)
Ganoderic acid A  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
geranyl diphosphate  (ISO)
geranylgeraniol  (ISO)
glafenine  (EXP)
isopentenyl diphosphate  (ISO)
isotretinoin  (ISO)
lipopolysaccharide  (ISO)
loperamide  (ISO)
methamphetamine  (ISO)
methylarsonic acid  (ISO)
mevalonic acid  (ISO)
monosodium L-glutamate  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylpropanolamine  (ISO)
picrotoxin  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
prenyl diphosphate  (ISO)
progesterone  (ISO)
rotenone  (EXP)
selenium atom  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
tipifarnib  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
triadimefon  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
undecane  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,IEA)
cytosol  (IBA,IEA,ISO)
intracellular membrane-bounded organelle  (IEA,ISO)
peroxisome  (IDA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mevalonate kinase is predominantly localized in peroxisomes and is defective in patients with peroxisome deficiency disorders. Biardi L, etal., J Biol Chem. 1994 Jan 14;269(2):1197-205.
2. Expression, purification, and characterization of His20 mutants of rat mevalonate kinase. Chu X and Li D, Protein Expr Purif. 2003 Nov;32(1):75-82.
3. The structure of a binary complex between a mammalian mevalonate kinase and ATP: insights into the reaction mechanism and human inherited disease. Fu Z, etal., J Biol Chem 2002 May 17;277(20):18134-42.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Differential binding of proteins to peroxisomes in rat hepatoma cells: unique association of enzymes involved in isoprenoid metabolism. Gupta SD, etal., J Lipid Res. 1999 Sep;40(9):1572-84.
7. Mevalonate kinase is a cytosolic enzyme in humans. Hogenboom S, etal., J Cell Sci. 2004 Feb 1;117(Pt 4):631-9.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes. Kovacs WJ, etal., Histochem Cell Biol. 2007 Mar;127(3):273-90. Epub 2006 Dec 19.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Isolation and characterization of a novel trans-factor for luteinizing hormone receptor mRNA from ovary. Nair AK and Menon KM, J Biol Chem. 2004 Apr 9;279(15):14937-44. Epub 2004 Jan 28.
12. Regulation of luteinizing hormone receptor expression: evidence of translational suppression in vitro by a hormonally regulated mRNA-binding protein and its endogenous association with luteinizing hormone receptor mRNA in the ovary. Nair AK and Menon KM, J Biol Chem. 2005 Dec 30;280(52):42809-16. Epub 2005 Nov 1.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. Studies on mevalonate kinase, phosphomevalonate kinase and pyrophosphomevalonate decarboxylase in developing rat brain. Ramachandran CK and Shah SN, J Neurochem. 1977 Apr;28(4):751-7.
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria. Schafer BL, etal., J Biol Chem. 1992 Jul 5;267(19):13229-38.
22. Mevalonate kinase is localized in rat liver peroxisomes. Stamellos KD, etal., J Biol Chem. 1992 Mar 15;267(8):5560-8.
23. Molecular cloning of mevalonate kinase and regulation of its mRNA levels in rat liver. Tanaka RD, etal., Proc Natl Acad Sci U S A 1990 Apr;87(8):2872-6.
24. Identification and characterization of proteins that selectively interact with the LHR mRNA binding protein (LRBP) in rat ovaries. Wang L, etal., Biochim Biophys Acta. 2010 May;1803(5):591-7. doi: 10.1016/j.bbamcr.2010.02.003. Epub 2010 Feb 16.
25. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
Additional References at PubMed
PMID:9325256   PMID:10369261   PMID:11792727   PMID:14680974   PMID:16189514   PMID:16732551   PMID:17055149   PMID:17964869   PMID:18302342   PMID:19716387   PMID:23376485   PMID:23376535  
PMID:24064360   PMID:25502805   PMID:26871637   PMID:30735219   PMID:31515488  


Genomics

Comparative Map Data
Mvk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81247,802,002 - 47,819,503 (-)NCBIGRCr8
mRatBN7.21242,141,391 - 42,158,893 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,141,384 - 42,158,882 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1243,308,698 - 43,326,126 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,922,277 - 43,939,707 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,982,791 - 43,000,222 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,904,266 - 47,920,457 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,904,719 - 47,919,400 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01249,695,252 - 49,711,443 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1243,753,220 - 43,770,539 (-)NCBICelera
Cytogenetic Map12q16NCBI
MVK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812109,573,272 - 109,598,125 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12109,573,255 - 109,598,125 (+)EnsemblGRCh38hg38GRCh38
GRCh3712110,011,599 - 110,035,930 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612108,496,000 - 108,519,450 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412108,474,336 - 108,497,787NCBI
Celera12109,635,867 - 109,659,439 (+)NCBICelera
Cytogenetic Map12q24.11NCBI
HuRef12107,029,480 - 107,053,054 (+)NCBIHuRef
CHM1_112109,979,352 - 110,002,922 (+)NCBICHM1_1
T2T-CHM13v2.012109,548,171 - 109,573,017 (+)NCBIT2T-CHM13v2.0
Mvk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395114,582,324 - 114,598,652 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5114,582,330 - 114,598,652 (+)EnsemblGRCm39 Ensembl
GRCm385114,444,264 - 114,460,591 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5114,444,269 - 114,460,591 (+)EnsemblGRCm38mm10GRCm38
MGSCv375114,894,315 - 114,910,600 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365114,705,305 - 114,721,590 (+)NCBIMGSCv36mm8
MGSCv365112,393,780 - 112,426,739 (+)NCBIMGSCv36mm8
Celera5111,543,727 - 111,559,933 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.99NCBI
Mvk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554558,930,125 - 8,953,894 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554558,933,250 - 8,953,883 (-)NCBIChiLan1.0ChiLan1.0
MVK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210117,640,740 - 117,664,230 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112117,637,164 - 117,660,637 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012107,150,477 - 107,173,978 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112110,544,991 - 110,568,524 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12110,544,991 - 110,568,524 (+)Ensemblpanpan1.1panPan2
MVK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12617,497,516 - 17,519,015 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2617,497,513 - 17,519,385 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2618,284,429 - 18,305,927 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02617,839,721 - 17,861,223 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2617,839,043 - 17,861,141 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12618,493,628 - 18,515,091 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02617,830,226 - 17,851,709 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02617,848,229 - 17,869,727 (-)NCBIUU_Cfam_GSD_1.0
Mvk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118144,180,507 - 144,201,367 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367691,274,540 - 1,298,178 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367691,274,595 - 1,295,186 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MVK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1441,281,673 - 41,357,368 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11441,320,790 - 41,357,437 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21443,838,243 - 43,874,068 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MVK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111104,812,882 - 104,837,089 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11104,813,846 - 104,835,517 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037140,282,725 - 140,306,924 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mvk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474710,834,306 - 10,857,595 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474710,837,743 - 10,858,758 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mvk
142 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:57
Count of miRNA genes:49
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000073774
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat

Markers in Region
RH138776   No map positions available.
RH139619  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21242,141,576 - 42,141,772 (+)MAPPERmRatBN7.2
Rnor_6.01247,904,452 - 47,904,647NCBIRnor6.0
Rnor_5.01249,695,438 - 49,695,633UniSTSRnor5.0
Celera1243,753,406 - 43,753,601UniSTS
RH136107  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21242,156,703 - 42,157,810 (+)MAPPERmRatBN7.2
Rnor_6.01247,918,297 - 47,919,409NCBIRnor6.0
Rnor_5.01249,709,283 - 49,710,395UniSTSRnor5.0
Celera1243,768,385 - 43,769,491UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 30 48 37 10 37 74 24 35 10
Low 13 9 4 9 4 8 11 11 6 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000073774   ⟹   ENSRNOP00000064795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1242,141,384 - 42,158,882 (-)Ensembl
Rnor_6.0 Ensembl1247,904,719 - 47,919,400 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097267   ⟹   ENSRNOP00000077122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1242,141,384 - 42,158,882 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113715   ⟹   ENSRNOP00000077434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1242,141,384 - 42,158,882 (-)Ensembl
RefSeq Acc Id: NM_001393702   ⟹   NP_001380631
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81247,802,002 - 47,819,503 (-)NCBI
mRatBN7.21242,141,391 - 42,158,893 (-)NCBI
RefSeq Acc Id: NM_031063   ⟹   NP_112325
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81247,802,002 - 47,819,503 (-)NCBI
mRatBN7.21242,141,391 - 42,158,893 (-)NCBI
Rnor_6.01247,904,266 - 47,920,457 (-)NCBI
Rnor_5.01249,695,252 - 49,711,443 (-)NCBI
Celera1243,753,220 - 43,770,539 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_112325   ⟸   NM_031063
- Peptide Label: isoform 1
- UniProtKB: P17256 (UniProtKB/Swiss-Prot),   A6J1Z8 (UniProtKB/TrEMBL),   A0A8I5Y175 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064795   ⟸   ENSRNOT00000073774
RefSeq Acc Id: ENSRNOP00000077434   ⟸   ENSRNOT00000113715
RefSeq Acc Id: ENSRNOP00000077122   ⟸   ENSRNOT00000097267
RefSeq Acc Id: NP_001380631   ⟸   NM_001393702
- Peptide Label: isoform 2
- UniProtKB: A0A8I5Y175 (UniProtKB/TrEMBL)
Protein Domains
GHMP kinase C-terminal   GHMP kinase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17256-F1-model_v2 AlphaFold P17256 1-395 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621295 AgrOrtholog
BioCyc Gene G2FUF-18947 BioCyc
BioCyc Pathway PWY-922 [mevalonate pathway I (eukaryotes and bacteria)] BioCyc
BioCyc Pathway Image PWY-922 BioCyc
Ensembl Genes ENSRNOG00000049604 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073774.3 UniProtKB/TrEMBL
  ENSRNOT00000097267 ENTREZGENE
  ENSRNOT00000097267.1 UniProtKB/TrEMBL
  ENSRNOT00000113715.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.230.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.890 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GHMP_kinase_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GHMP_kinase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GHMP_kinase_N_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GHMP_knse_ATP-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mev_gal_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold_subgr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81727 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 81727 ENTREZGENE
PANTHER MEVALONATE KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR43290 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GHMP_kinases_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GHMP_kinases_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mvk PhenoGen
PRINTS MEVGALKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GHMP_KINASES_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049604 RatGTEx
Superfamily-SCOP SSF54211 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55060 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5XW47_RAT UniProtKB/TrEMBL
  A0A8I5Y175 ENTREZGENE, UniProtKB/TrEMBL
  A6J1Z8 ENTREZGENE, UniProtKB/TrEMBL
  A6J1Z9_RAT UniProtKB/TrEMBL
  A6J200_RAT UniProtKB/TrEMBL
  KIME_RAT UniProtKB/Swiss-Prot
  M0R5W4_RAT UniProtKB/TrEMBL
  P17256 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Mvk  mevalonate kinase      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Mvk  mevalonate kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease mutation in gene is thought to cause the genetic disease mevalonic aciduria 728935