Snai1 (snail family transcriptional repressor 1) - Rat Genome Database

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Gene: Snai1 (snail family transcriptional repressor 1) Rattus norvegicus
Analyze
Symbol: Snai1
Name: snail family transcriptional repressor 1
RGD ID: 620758
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding activity; and kinase binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of intracellular signal transduction; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including hair follicle morphogenesis; negative regulation of cell differentiation involved in embryonic placenta development; and trophoblast giant cell differentiation. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be part of pericentric heterochromatin. Biomarker of rheumatic heart disease. Orthologous to human SNAI1 (snail family transcriptional repressor 1); INTERACTS WITH (+)-schisandrin B; (R)-carnitine; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Sna; snail family zinc finger 1; snail homolog; snail homolog 1; snail homolog 1 (Drosophila); snail homolog, (Drosophila); zinc finger protein SNAI1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83176,667,476 - 176,671,965 (+)NCBIGRCr8
mRatBN7.23156,248,479 - 156,252,969 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3156,248,485 - 156,252,969 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3160,043,780 - 160,048,265 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03168,542,842 - 168,547,327 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03166,284,546 - 166,289,031 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03164,274,710 - 164,279,199 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3164,274,710 - 164,279,378 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03170,425,898 - 170,430,387 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43158,676,980 - 158,681,471 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13158,583,924 - 158,586,727 (+)NCBI
Celera3154,827,543 - 154,832,032 (+)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP,ISO)
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-carnitine  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-Dihydroxybenzophenone  (ISO)
2-ethylhexan-1-ol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
acteoside  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (ISO)
allyl isothiocyanate  (ISO)
alpha-pinene  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
AM-251  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
antroquinonol  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aucubin  (ISO)
bafilomycin A1  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
carboxy-PTIO  (ISO)
celecoxib  (ISO)
CHIR 99021  (ISO)
chloroquine  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cytochalasin D  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
delphinidin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
embelin  (ISO)
endosulfan  (EXP,ISO)
eplerenone  (ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
fludioxonil  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
galaxolide  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gingerol  (ISO)
glucose  (ISO)
Honokiol  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
Iodine aqueous  (ISO)
jaspamide  (ISO)
ketamine  (ISO)
L-1,4-dithiothreitol  (ISO)
L-methionine  (ISO)
lapatinib  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
loliolide  (ISO)
losartan  (ISO)
luteolin  (ISO)
LY294002  (ISO)
mangiferin  (ISO)
menadione  (ISO)
methimazole  (EXP)
methoxyacetic acid  (ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
MK-2206  (ISO)
monocrotaline  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N-nitrosourea  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (EXP,ISO)
nicotine  (EXP,ISO)
nisin  (ISO)
Nonylphenol  (ISO)
oridonin  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
Pachymic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
patulin  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenol red  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pifithrin-?  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
pterostilbene  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
reparixin  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
ridaforolimus  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
Salinomycin  (ISO)
sanguinarine  (ISO)
SB 203580  (ISO)
SB 431542  (EXP,ISO)
sclareol  (ISO)
serpentine asbestos  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
stattic  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetraethylenepentamine  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
titanium dioxide  (ISO)
tolfenamic acid  (ISO)
topotecan  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Snail blocks the cell cycle and confers resistance to cell death. Vega S, etal., Genes Dev 2004 May 15;18(10):1131-43.
7. Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial‑mesenchymal transition in the valvular damage due to rheumatic heart disease. Xian S, etal., Mol Med Rep. 2021 Jan;23(1):10. doi: 10.3892/mmr.2020.11648. Epub 2020 Nov 12.
8. Snail and Axin2 expression predict the malignant transformation of oral leukoplakia. Zhang X, etal., Oral Oncol. 2017 Oct;73:48-55. doi: 10.1016/j.oraloncology.2017.08.004. Epub 2017 Aug 12.
Additional References at PubMed
PMID:1302246   PMID:9676199   PMID:10655586   PMID:11689706   PMID:11912130   PMID:12477932   PMID:12832491   PMID:12917416   PMID:15314165   PMID:15448698   PMID:15630473   PMID:16096638  
PMID:16801545   PMID:17093497   PMID:17376812   PMID:17692821   PMID:18663143   PMID:18832382   PMID:19502595   PMID:19955572   PMID:20018240   PMID:20128911   PMID:20890042   PMID:20930141  
PMID:23288509   PMID:23460471   PMID:23707238   PMID:23831330   PMID:24209753   PMID:24239292   PMID:24379627   PMID:25303734   PMID:25893292   PMID:26781174   PMID:26884822   PMID:31115509  
PMID:31668740   PMID:32187849  


Genomics

Comparative Map Data
Snai1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83176,667,476 - 176,671,965 (+)NCBIGRCr8
mRatBN7.23156,248,479 - 156,252,969 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3156,248,485 - 156,252,969 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3160,043,780 - 160,048,265 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03168,542,842 - 168,547,327 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03166,284,546 - 166,289,031 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03164,274,710 - 164,279,199 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3164,274,710 - 164,279,378 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03170,425,898 - 170,430,387 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43158,676,980 - 158,681,471 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13158,583,924 - 158,586,727 (+)NCBI
Celera3154,827,543 - 154,832,032 (+)NCBICelera
Cytogenetic Map3q42NCBI
SNAI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382049,982,980 - 49,988,886 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2049,982,980 - 49,988,886 (+)EnsemblGRCh38hg38GRCh38
GRCh372048,599,517 - 48,605,423 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362048,032,934 - 48,038,830 (+)NCBINCBI36Build 36hg18NCBI36
Build 342048,032,933 - 48,038,825NCBI
Celera2045,304,074 - 45,309,984 (+)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2045,348,282 - 45,354,192 (+)NCBIHuRef
CHM1_12048,504,120 - 48,510,030 (+)NCBICHM1_1
T2T-CHM13v2.02051,752,473 - 51,758,373 (+)NCBIT2T-CHM13v2.0
Snai1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392167,380,115 - 167,384,734 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2167,380,115 - 167,384,734 (+)EnsemblGRCm39 Ensembl
GRCm382167,538,195 - 167,542,814 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,538,195 - 167,542,814 (+)EnsemblGRCm38mm10GRCm38
MGSCv372167,363,727 - 167,368,314 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362167,229,432 - 167,234,019 (+)NCBIMGSCv36mm8
Celera2173,478,489 - 173,483,072 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.33NCBI
Snai1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554458,231,924 - 8,237,996 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554458,232,084 - 8,237,893 (-)NCBIChiLan1.0ChiLan1.0
SNAI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22155,722,221 - 55,732,559 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12055,715,326 - 55,725,666 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02046,321,075 - 46,328,865 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12047,384,818 - 47,390,738 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2047,384,818 - 47,390,733 (+)Ensemblpanpan1.1panPan2
SNAI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12436,498,343 - 36,503,623 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2436,498,062 - 36,503,628 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2435,741,546 - 35,747,503 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02437,204,007 - 37,209,960 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2437,204,036 - 37,209,945 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12436,445,442 - 36,451,401 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02436,578,693 - 36,584,651 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02437,122,272 - 37,128,230 (+)NCBIUU_Cfam_GSD_1.0
Snai1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640189,002,837 - 189,012,567 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365144,456,484 - 4,462,987 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365144,456,498 - 4,462,436 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SNAI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1751,546,477 - 51,552,499 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11751,546,446 - 51,552,498 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SNAI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1213,988,059 - 13,993,780 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl213,988,024 - 13,993,746 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605062,416,997 - 62,422,718 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Snai1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247905,509,311 - 5,515,266 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247905,509,541 - 5,515,240 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Snai1
16 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:375
Count of miRNA genes:200
Interacting mature miRNAs:251
Transcripts:ENSRNOT00000012939
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145956084157309487Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3145956084161299569Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 26 4 4 2 4 6 20 27 3
Low 3 16 44 29 16 29 4 7 60 15 14 8 4
Below cutoff 1 9 8 1 8 4 4 8 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012939   ⟹   ENSRNOP00000012939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3156,248,485 - 156,252,969 (+)Ensembl
Rnor_6.0 Ensembl3164,274,710 - 164,279,194 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077581   ⟹   ENSRNOP00000071187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3164,275,095 - 164,279,378 (+)Ensembl
RefSeq Acc Id: NM_053805   ⟹   NP_446257
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83176,667,476 - 176,671,965 (+)NCBI
mRatBN7.23156,248,479 - 156,252,969 (+)NCBI
Rnor_6.03164,274,710 - 164,279,199 (+)NCBI
Rnor_5.03170,425,898 - 170,430,387 (+)NCBI
RGSC_v3.43158,676,980 - 158,681,471 (+)RGD
Celera3154,827,543 - 154,832,032 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446257 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG31598 (Get FASTA)   NCBI Sequence Viewer  
  AAH79210 (Get FASTA)   NCBI Sequence Viewer  
  EDL96401 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012939.5
Reference Protein Sequences
RefSeq Acc Id: NP_446257   ⟸   NM_053805
- UniProtKB: Q6AY35 (UniProtKB/TrEMBL),   E9PU82 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071187   ⟸   ENSRNOT00000077581
RefSeq Acc Id: ENSRNOP00000012939   ⟸   ENSRNOT00000012939
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AY35-F1-model_v2 AlphaFold Q6AY35 1-264 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692692
Promoter ID:EPDNEW_R3217
Type:single initiation site
Name:Snai1_1
Description:snail family transcriptional repressor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03164,274,701 - 164,274,761EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620758 AgrOrtholog
BioCyc Gene G2FUF-46731 BioCyc
Ensembl Genes ENSRNOG00000009594 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012939.6 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7131806 IMAGE-MGC_LOAD
InterPro Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:116490 UniProtKB/TrEMBL
MGC_CLONE MGC:94272 IMAGE-MGC_LOAD
NCBI Gene 116490 ENTREZGENE
PANTHER FINGER PROTEIN, PUTATIVE-RELATED UniProtKB/TrEMBL
  KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN SNAI1 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
  zf-C2H2_6 UniProtKB/TrEMBL
PhenoGen Snai1 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009594 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A8J8YBT6_RAT UniProtKB/TrEMBL
  E9PU82 ENTREZGENE
  Q6AY35 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary E9PU82 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Snai1  snail family transcriptional repressor 1  Snai1  snail family zinc finger 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-06-05 Snai1  snail family zinc finger 1  Snai1  snail homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Snai1  snail homolog 1 (Drosophila)    snail homolog, (Drosophila)  Name updated 1299863 APPROVED
2004-09-10 Snai1  snail homolog, (Drosophila)  Sna    Symbol and Name updated 1299863 APPROVED
2002-08-07 Sna  snail homolog, (Drosophila)      Symbol and Name status set to provisional 70820 PROVISIONAL