Gcgr (glucagon receptor) - Rat Genome Database

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Pathways
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Gene: Gcgr (glucagon receptor) Rattus norvegicus
Analyze
Symbol: Gcgr
Name: glucagon receptor
RGD ID: 2669
Description: Enables glucagon receptor activity and peptide hormone binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; exocytosis; and hormone-mediated signaling pathway. Located in endosome. Human ortholog(s) of this gene implicated in Mahvash Disease and type 2 diabetes mellitus. Orthologous to human GCGR (glucagon receptor); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; glucagon signaling pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GL-R; glucagon receptor perhaps same as Niddm3; MGC93090
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,306,803 - 106,314,970 (+)NCBIGRCr8
mRatBN7.210105,808,474 - 105,816,641 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,808,473 - 105,816,640 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10110,912,618 - 110,920,789 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,375,645 - 110,383,816 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,728,922 - 105,737,089 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,707,863 - 109,716,253 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,707,962 - 109,716,128 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,301,000 - 109,309,259 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,921,411 - 109,929,577 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110109,935,913 - 109,944,081 (+)NCBI
Celera10104,352,017 - 104,360,184 (+)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (EXP)
chlorpromazine  (ISO)
chrysene  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
disulfiram  (ISO)
endosulfan  (EXP)
fenthion  (ISO)
gatifloxacin  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glucagon  (ISO)
graphite  (EXP)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
naphthalene  (ISO)
O-methyleugenol  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenacetin  (EXP)
phenylhydrazine  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
tributylstannane  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
endosome  (IDA)
membrane  (IEA)
plasma membrane  (IBA,ISO,ISS)

Molecular Function
glucagon receptor activity  (IBA,IDA,IEA,IMP,ISO)
peptide hormone binding  (IBA,IDA,IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Alterations in hepatic glucagon receptor density and in Gsalpha and Gialpha2 protein content with diet-induced hepatic steatosis: effects of acute exercise. Charbonneau A, etal., Am J Physiol Endocrinol Metab. 2005 Jul;289(1):E8-14. Epub 2005 Feb 1.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Structural and functional characterizations of the 5'-flanking region of the mouse glucagon receptor gene: comparison with the rat gene. Geiger A, etal., Biochem Biophys Res Commun 2000 Jun 16;272(3):912-21.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus. Hager J, etal., Nat Genet. 1995 Mar;9(3):299-304.
6. Expression cloning and signaling properties of the rat glucagon receptor. Jelinek LJ, etal., Science 1993 Mar 12;259(5101):1614-6.
7. Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors. Ma X, etal., Mol Endocrinol. 2005 Jan;19(1):198-212. Epub 2004 Sep 30.
8. Glucagon-mediated internalization of serine-phosphorylated glucagon receptor and Gsalpha in rat liver. Merlen C, etal., FEBS Lett. 2006 Oct 16;580(24):5697-704. Epub 2006 Sep 20.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
13. Functional analysis of the glucose response element of the rat glucagon receptor gene in insulin-producing INS-1 cells. Portois L, etal., Biochim Biophys Acta 2002 Mar 19;1574(2):175-86.
14. Identification of a glucose response element in the promoter of the rat glucagon receptor gene. Portois L, etal., J Biol Chem 1999 Mar 19;274(12):8181-90.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19. A cDNA construct allowing the expression of rat hepatic glucagon receptors. Svoboda M, etal., Biochem Biophys Res Commun 1993 Apr 15;192(1):135-42.
20. Small introns in a hepatic cDNA encoding a new glucagon-like peptide 1-type receptor. Svoboda M, etal., Biochem Biophys Res Commun 1993 Mar 15;191(2):479-86.
21. Localization of the rat genes encoding glucagon, glucagon receptor, and insulin receptor, candidates for diabetes mellitus susceptibility loci. Szpirer C, etal., Mamm Genome 1997 Aug;8(8):586-8
22. Roles of specific extracellular domains of the glucagon receptor in ligand binding and signaling. Unson CG, etal., Biochemistry 2002 Oct 1;41(39):11795-803.
23. Antibodies against specific extracellular epitopes of the glucagon receptor block glucagon binding. Unson CG, etal., Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):310-5.
Additional References at PubMed
PMID:8082779   PMID:9287038   PMID:11853547   PMID:12552113   PMID:17053032   PMID:17462598   PMID:18787074   PMID:19046568   PMID:23209793   PMID:23918690   PMID:26975347   PMID:28514451  


Genomics

Comparative Map Data
Gcgr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,306,803 - 106,314,970 (+)NCBIGRCr8
mRatBN7.210105,808,474 - 105,816,641 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,808,473 - 105,816,640 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10110,912,618 - 110,920,789 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,375,645 - 110,383,816 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,728,922 - 105,737,089 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,707,863 - 109,716,253 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,707,962 - 109,716,128 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,301,000 - 109,309,259 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,921,411 - 109,929,577 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110109,935,913 - 109,944,081 (+)NCBI
Celera10104,352,017 - 104,360,184 (+)NCBICelera
Cytogenetic Map10q32.3NCBI
GCGR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381781,804,150 - 81,814,008 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1781,804,132 - 81,814,008 (+)EnsemblGRCh38hg38GRCh38
GRCh371779,762,026 - 79,771,884 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 34171,860,193 - 1,870,113NCBI
Celera1776,365,499 - 76,375,377 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,168,495 - 75,173,668 (+)NCBIHuRef
CHM1_11779,848,214 - 79,858,084 (+)NCBICHM1_1
T2T-CHM13v2.01782,671,316 - 82,681,173 (+)NCBIT2T-CHM13v2.0
Gcgr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,420,011 - 120,429,815 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,421,525 - 120,429,812 (+)EnsemblGRCm39 Ensembl
GRCm3811120,529,185 - 120,538,989 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,530,699 - 120,538,986 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711120,392,041 - 120,400,298 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611120,345,362 - 120,355,178 (+)NCBIMGSCv36mm8
Celera11132,266,137 - 132,274,394 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.24NCBI
Gcgr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,340,689 - 1,344,260 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555061,340,410 - 1,348,028 (-)NCBIChiLan1.0ChiLan1.0
GCGR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,339,489 - 98,350,188 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,240,205 - 103,250,716 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,205,023 - 76,220,171 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11781,911,915 - 81,922,906 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1781,912,135 - 81,922,906 (+)Ensemblpanpan1.1panPan2
GCGR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19455,744 - 463,070 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9344,438 - 459,925 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha91,057,897 - 1,065,209 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.091,048,891 - 1,056,220 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.191,074,261 - 1,081,570 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,200,838 - 1,208,113 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,279,553 - 1,286,873 (-)NCBIUU_Cfam_GSD_1.0
Gcgr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056021,060,107 - 1,068,224 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365945,343,740 - 5,351,923 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365945,347,789 - 5,351,852 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GCGR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,146,069 - 1,157,234 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1121,149,589 - 1,157,234 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GCGR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,672,490 - 73,693,297 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1673,681,571 - 73,693,299 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607745,089,536 - 45,141,103 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gcgr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,678,944 - 10,682,362 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480110,674,854 - 10,682,619 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gcgr
27 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:51
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000054962
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat

Markers in Region
D10Mcw1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210105,813,290 - 105,813,458 (+)MAPPERmRatBN7.2
Rnor_6.010109,712,779 - 109,712,946NCBIRnor6.0
Rnor_5.010109,305,909 - 109,306,076UniSTSRnor5.0
RGSC_v3.410109,926,227 - 109,926,395RGDRGSC3.4
RGSC_v3.410109,926,228 - 109,926,395UniSTSRGSC3.4
RGSC_v3.110109,940,731 - 109,940,899RGD
Celera10104,356,834 - 104,357,001UniSTS
Cytogenetic Map10q32.3UniSTS
RH142644  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210105,807,925 - 105,808,092 (+)MAPPERmRatBN7.2
Rnor_6.010109,707,414 - 109,707,580NCBIRnor6.0
Rnor_5.010109,300,544 - 109,300,710UniSTSRnor5.0
RGSC_v3.410109,920,896 - 109,921,062UniSTSRGSC3.4
Celera10104,351,294 - 104,351,460UniSTS
Cytogenetic Map10q32.3UniSTS
RH142648  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210105,807,953 - 105,808,117 (+)MAPPERmRatBN7.2
Rnor_6.010109,707,442 - 109,707,605NCBIRnor6.0
Rnor_5.010109,300,572 - 109,300,735UniSTSRnor5.0
RGSC_v3.410109,920,924 - 109,921,087UniSTSRGSC3.4
Celera10104,351,322 - 104,351,485UniSTS
Cytogenetic Map10q32.3UniSTS
RH141343  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210105,816,456 - 105,816,636 (+)MAPPERmRatBN7.2
Rnor_6.010109,715,945 - 109,716,124NCBIRnor6.0
Rnor_5.010109,309,075 - 109,309,254UniSTSRnor5.0
RGSC_v3.410109,929,394 - 109,929,573UniSTSRGSC3.4
Celera10104,360,000 - 104,360,179UniSTS
Cytogenetic Map10q32.3UniSTS
Gcgr  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210105,815,396 - 105,816,285 (+)MAPPERmRatBN7.2
Rnor_6.010109,714,885 - 109,715,773NCBIRnor6.0
Rnor_5.010109,308,015 - 109,308,903UniSTSRnor5.0
RGSC_v3.410109,928,334 - 109,929,222UniSTSRGSC3.4
Celera10104,358,940 - 104,359,828UniSTS
Cytogenetic Map10q32.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7 37 35 6 35 16
Low 3 18 20 6 13 6 7 9 11 13 30 11 7
Below cutoff 18 1 2 45 6 11 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001430043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001430044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001430045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_172091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_172092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_073147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_190841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC131537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF229080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH003671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB735411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV117246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L04796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M96674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X68692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000054962   ⟹   ENSRNOP00000051845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10105,808,473 - 105,816,640 (+)Ensembl
Rnor_6.0 Ensembl10109,707,962 - 109,716,128 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083601   ⟹   ENSRNOP00000074929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl10109,708,755 - 109,716,128 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088898   ⟹   ENSRNOP00000074632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10105,808,510 - 105,816,640 (+)Ensembl
Rnor_6.0 Ensembl10109,707,998 - 109,716,128 (+)Ensembl
RefSeq Acc Id: NM_172091   ⟹   NP_742088
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,307,596 - 106,314,970 (+)NCBI
mRatBN7.210105,809,267 - 105,816,641 (+)NCBI
Rnor_6.010109,708,755 - 109,716,129 (+)NCBI
Rnor_5.010109,301,000 - 109,309,259 (+)NCBI
RGSC_v3.410109,921,411 - 109,929,577 (+)RGD
Celera10104,352,810 - 104,360,184 (+)NCBI
Sequence:
RefSeq Acc Id: NM_172092   ⟹   NP_742089
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,306,803 - 106,314,970 (+)NCBI
mRatBN7.210105,808,474 - 105,816,641 (+)NCBI
Rnor_6.010109,707,962 - 109,716,129 (+)NCBI
Rnor_5.010109,301,000 - 109,309,259 (+)NCBI
RGSC_v3.410109,921,411 - 109,929,577 (+)RGD
Celera10104,352,017 - 104,360,184 (+)NCBI
Sequence:
RefSeq Acc Id: NR_073147
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,306,803 - 106,314,970 (+)NCBI
mRatBN7.210105,808,474 - 105,816,641 (+)NCBI
Rnor_6.010109,707,962 - 109,716,129 (+)NCBI
Rnor_5.010109,301,000 - 109,309,259 (+)NCBI
Celera10104,352,017 - 104,360,184 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247877   ⟹   XP_006247939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,310,748 - 106,314,970 (+)NCBI
mRatBN7.210105,812,419 - 105,816,641 (+)NCBI
Rnor_6.010109,708,719 - 109,716,129 (+)NCBI
Rnor_5.010109,301,000 - 109,309,259 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008768468   ⟹   XP_008766690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,310,213 - 106,314,970 (+)NCBI
mRatBN7.210105,811,849 - 105,816,641 (+)NCBI
Rnor_6.010109,711,347 - 109,716,253 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008768469   ⟹   XP_008766691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,310,213 - 106,314,819 (+)NCBI
mRatBN7.210105,811,849 - 105,816,641 (+)NCBI
Rnor_6.010109,711,344 - 109,716,253 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085243   ⟹   XP_038941171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,310,271 - 106,314,970 (+)NCBI
mRatBN7.210105,811,938 - 105,816,641 (+)NCBI
RefSeq Acc Id: XM_039085245   ⟹   XP_038941173
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,311,058 - 106,314,970 (+)NCBI
mRatBN7.210105,812,737 - 105,816,641 (+)NCBI
RefSeq Acc Id: XM_039085247   ⟹   XP_038941175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,310,213 - 106,313,401 (+)NCBI
mRatBN7.210105,811,849 - 105,815,075 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_742089   ⟸   NM_172092
- Peptide Label: precursor
- UniProtKB: P30082 (UniProtKB/Swiss-Prot),   A6HLE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_742088   ⟸   NM_172091
- Peptide Label: precursor
- UniProtKB: P30082 (UniProtKB/Swiss-Prot),   A6HLE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247939   ⟸   XM_006247877
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008766691   ⟸   XM_008768469
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008766690   ⟸   XM_008768468
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000074929   ⟸   ENSRNOT00000083601
RefSeq Acc Id: ENSRNOP00000074632   ⟸   ENSRNOT00000088898
RefSeq Acc Id: ENSRNOP00000051845   ⟸   ENSRNOT00000054962
RefSeq Acc Id: XP_038941175   ⟸   XM_039085247
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038941171   ⟸   XM_039085243
- Peptide Label: isoform X2
- UniProtKB: P30082 (UniProtKB/Swiss-Prot),   A6HLE4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941173   ⟸   XM_039085245
- Peptide Label: isoform X5
- UniProtKB: Q66HT0 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 2 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30082-F1-model_v2 AlphaFold P30082 1-485 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697961
Promoter ID:EPDNEW_R8485
Type:initiation region
Name:Gcgr_1
Description:glucagon receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010109,707,882 - 109,707,942EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2669 AgrOrtholog
BioCyc Gene G2FUF-22413 BioCyc
Ensembl Genes ENSRNOG00000036692 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00065003924 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000054962 ENTREZGENE
  ENSRNOT00000054962.3 UniProtKB/Swiss-Prot
  ENSRNOT00000088898.2 UniProtKB/TrEMBL
  ENSRNOT00065005752 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.1240.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7192550 IMAGE-MGC_LOAD
InterPro GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracell_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracellular_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_GLP1/glucagon_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_glucagon_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24953 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93090 IMAGE-MGC_LOAD
NCBI Gene 24953 ENTREZGENE
PANTHER GLUCAGON RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDF RECEPTOR-LIKE PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gcgr PhenoGen
PRINTS GLUCAGNFAMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUCAGONR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRSECRETIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000036692 RatGTEx
  ENSRNOG00065003924 RatGTEx
SMART HormR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hormone receptor domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6HLE4 ENTREZGENE, UniProtKB/TrEMBL
  A6HLE5_RAT UniProtKB/TrEMBL
  GLR_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q66HT0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gcgr  glucagon receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function transduces signals leading to the accumulation of cAMP and calcium 61488
gene_other may be a candidate gene for Niddm3 61488
gene_process participates in glucose stimulation 625576
gene_process controls blood glucose concentrations 61488
gene_transcript non-coding domain from -545 and -527 nucleotides has a 19 nucleotide centered 2 G boxes 625576