Mzt1 (mitotic spindle organizing protein 1) - Rat Genome Database

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Gene: Mzt1 (mitotic spindle organizing protein 1) Rattus norvegicus
Analyze
Symbol: Mzt1
Name: mitotic spindle organizing protein 1
RGD ID: 1592140
Description: Predicted to be involved in gamma-tubulin complex localization; microtubule nucleation by interphase microtubule organizing center; and mitotic spindle assembly. Predicted to be part of gamma-tubulin ring complex. Predicted to be active in centrosome; interphase microtubule organizing center; and spindle. Orthologous to human MZT1 (mitotic spindle organizing protein 1); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; oxaliplatin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC692032; LOC692032; mitotic-spindle organizing protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81582,195,128 - 82,205,436 (-)NCBIGRCr8
mRatBN7.21575,787,281 - 75,797,589 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1575,786,994 - 75,797,589 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1579,770,343 - 79,780,634 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01580,846,961 - 80,857,252 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01577,794,504 - 77,804,795 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01583,429,437 - 83,442,118 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1583,431,178 - 83,442,008 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01586,941,556 - 86,953,251 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41582,820,060 - 82,828,971 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map15q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20360068  


Genomics

Comparative Map Data
Mzt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81582,195,128 - 82,205,436 (-)NCBIGRCr8
mRatBN7.21575,787,281 - 75,797,589 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1575,786,994 - 75,797,589 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1579,770,343 - 79,780,634 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01580,846,961 - 80,857,252 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01577,794,504 - 77,804,795 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01583,429,437 - 83,442,118 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1583,431,178 - 83,442,008 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01586,941,556 - 86,953,251 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41582,820,060 - 82,828,971 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map15q21NCBI
MZT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381372,708,367 - 72,727,629 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1372,708,367 - 72,727,629 (-)EnsemblGRCh38hg38GRCh38
GRCh371373,282,505 - 73,301,767 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361372,180,496 - 72,199,826 (-)NCBINCBI36Build 36hg18NCBI36
Celera1354,180,988 - 54,200,426 (-)NCBICelera
Cytogenetic Map13q21.33NCBI
HuRef1353,980,057 - 53,999,481 (-)NCBIHuRef
CHM1_11373,250,244 - 73,269,658 (-)NCBICHM1_1
T2T-CHM13v2.01371,929,913 - 71,949,154 (-)NCBIT2T-CHM13v2.0
Mzt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391499,271,980 - 99,283,898 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1499,271,980 - 99,283,570 (-)EnsemblGRCm39 Ensembl
GRCm381499,034,544 - 99,046,453 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1499,034,544 - 99,046,134 (-)EnsemblGRCm38mm10GRCm38
MGSCv371499,433,763 - 99,445,355 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361497,917,684 - 97,929,214 (-)NCBIMGSCv36mm8
Celera1497,708,854 - 97,714,991 (-)NCBICelera
Cytogenetic Map14E2.2NCBI
cM Map1449.22NCBI
Mzt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540433,944,833 - 33,962,729 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540433,945,576 - 33,961,922 (+)NCBIChiLan1.0ChiLan1.0
MZT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21474,288,827 - 74,307,951 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11372,880,043 - 72,899,172 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01353,937,689 - 53,956,954 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11372,713,799 - 72,733,057 (-)NCBIpanpan1.1PanPan1.1panPan2
MZT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12226,862,454 - 26,880,213 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2226,863,674 - 26,880,126 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2226,718,302 - 26,736,061 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02227,193,817 - 27,211,586 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2227,192,928 - 27,211,465 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12226,855,994 - 26,873,687 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02226,895,506 - 26,913,143 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02226,966,775 - 26,984,527 (-)NCBIUU_Cfam_GSD_1.0
Mzt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945132,717,380 - 132,732,578 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365118,134,607 - 8,149,923 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MZT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1144,999,320 - 45,018,862 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11145,000,735 - 45,019,009 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21149,548,170 - 49,565,545 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MZT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1351,840,354 - 51,860,248 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl351,842,167 - 51,860,164 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660467,934,397 - 7,954,610 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mzt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475127,814,973 - 27,832,343 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475127,815,065 - 27,851,738 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mzt1
39 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:21
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000039400
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat
61477Aia4Adjuvant induced arthritis QTL 43joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)155559608991365858Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)155559608995018120Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1568327165100062518Rat
1331724Bp223Blood pressure QTL 2233.53715arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)157369051895018228Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)157369051899794247Rat
70182BpQTLcluster12Blood pressure QTL cluster 123.53arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)157369065795018120Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1575788062101769107Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1575788062101769107Rat

Markers in Region
RH127426  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21575,787,384 - 75,787,629 (+)MAPPERmRatBN7.2
Rnor_6.01583,429,541 - 83,429,785NCBIRnor6.0
Rnor_5.01586,941,660 - 86,941,904UniSTSRnor5.0
RGSC_v3.41582,818,982 - 82,819,226UniSTSRGSC3.4
Celera1575,025,513 - 75,025,757UniSTS
RH 3.4 Map15517.4UniSTS
Cytogenetic Map15q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 29 22 17 22 2 74 28 39 10
Low 8 28 19 2 19 8 9 7 2 1 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001399557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000039400   ⟹   ENSRNOP00000030357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1583,431,178 - 83,442,008 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095807   ⟹   ENSRNOP00000083391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1575,786,994 - 75,797,589 (-)Ensembl
RefSeq Acc Id: NM_001399557   ⟹   NP_001386486
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81582,195,128 - 82,205,436 (-)NCBI
mRatBN7.21575,787,281 - 75,797,589 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001386486 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000083391
  ENSRNOP00000083391.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000030357   ⟸   ENSRNOT00000039400
RefSeq Acc Id: ENSRNOP00000083391   ⟸   ENSRNOT00000095807
RefSeq Acc Id: NP_001386486   ⟸   NM_001399557
- UniProtKB: A0A8I5ZZ71 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A4N1-F1-model_v2 AlphaFold D4A4N1 1-78 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699861
Promoter ID:EPDNEW_R10382
Type:initiation region
Name:Mzt1_1
Description:mitotic spindle organizing protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01583,442,055 - 83,442,115EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592140 AgrOrtholog
BioCyc Gene G2FUF-12790 BioCyc
Ensembl Genes ENSRNOG00000024813 Ensembl
  ENSRNOG00000068487 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000095807 ENTREZGENE
  ENSRNOT00000095807.1 UniProtKB/TrEMBL
InterPro MZT1 UniProtKB/TrEMBL
KEGG Report rno:692032 UniProtKB/TrEMBL
NCBI Gene 692032 ENTREZGENE
PANTHER MITOTIC-SPINDLE ORGANIZING PROTEIN 1 UniProtKB/TrEMBL
  PTHR28520 UniProtKB/TrEMBL
Pfam MOZART1 UniProtKB/TrEMBL
PhenoGen Mzt1 PhenoGen
RatGTEx ENSRNOG00000024813 RatGTEx
  ENSRNOG00000068487 RatGTEx
UniProt A0A8I5ZZ71 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Mzt1  mitotic spindle organizing protein 1  Mzt1  mitotic spindle organizing protein 1  Data merged from RGD:149736527 737654 PROVISIONAL
2021-08-09 Mzt1  mitotic spindle organizing protein 1      Symbol and Name status set to provisional 45752 PROVISIONAL
2011-08-02 Mzt1  mitotic spindle organizing protein 1  LOC692032  hypothetical protein LOC692032  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC692032  hypothetical protein LOC692032      Symbol and Name status set to provisional 70820 PROVISIONAL