Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,1-dichloroethene | decreases expression | ISO | Ppp1r16b (Mus musculus) | 6480464 | vinylidene chloride results in decreased expression of PPP1R16B mRNA | CTD | PMID:26682919 | 1,2-dimethylhydrazine | increases expression | ISO | Ppp1r16b (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of PPP1R16B mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | ISO | PPP1R16B (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of PPP1R16B mRNA and [Progesterone co-treated with Estradiol] results in decreased expression of PPP1R16B mRNA | CTD | PMID:17404688 and PMID:30165855 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of PPP1R16B mRNA | CTD | PMID:32145629 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of PPP1R16B mRNA | CTD | PMID:32741896 | 17beta-estradiol 3-benzoate | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of PPP1R16B mRNA | CTD | PMID:32741896 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PPP1R16B mRNA | CTD | PMID:33387578 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Ppp1r16b (Mus musculus) | 6480464 | bisphenol S affects the methylation of PPP1R16B gene | CTD | PMID:31683443 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of PPP1R16B mRNA | CTD | PMID:24780913 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of PPP1R16B mRNA | CTD | PMID:36843608 | aflatoxin B1 | increases methylation | ISO | PPP1R16B (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of PPP1R16B gene | CTD | PMID:27153756 | aflatoxin B1 | decreases methylation | ISO | PPP1R16B (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of PPP1R16B intron | CTD | PMID:30157460 | Aflatoxin B2 alpha | decreases methylation | ISO | PPP1R16B (Homo sapiens) | 6480464 | aflatoxin B2 results in decreased methylation of PPP1R16B intron | CTD | PMID:30157460 | all-trans-retinoic acid | increases expression | ISO | PPP1R16B (Homo sapiens) | 6480464 | Tretinoin results in increased expression of PPP1R16B mRNA | CTD | PMID:23724009 and PMID:33167477 | alpha-Zearalanol | increases expression | EXP | | 6480464 | Zeranol results in increased expression of PPP1R16B mRNA | CTD | PMID:35163327 | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of PPP1R16B mRNA | CTD | PMID:30779732 | arsane | affects methylation | ISO | PPP1R16B (Homo sapiens) | 6480464 | Arsenic affects the methylation of PPP1R16B gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | PPP1R16B (Homo sapiens) | 6480464 | Arsenic affects the methylation of PPP1R16B gene | CTD | PMID:25304211 | arsenite(3-) | increases expression | ISO | PPP1R16B (Homo sapiens) | 6480464 | arsenite results in increased expression of PPP1R16B mRNA | CTD | PMID:23974009 | atrazine | decreases expression | ISO | PPP1R16B (Homo sapiens) | 6480464 | Atrazine results in decreased expression of PPP1R16B mRNA | CTD | PMID:22378314 | benzene | increases expression | ISO | PPP1R16B (Homo sapiens) | 6480464 | Benzene results in increased expression of PPP1R16B mRNA | CTD | PMID:19162166 | benzo[a]pyrene | increases expression | ISO | Ppp1r16b (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of PPP1R16B mRNA | CTD | PMID:21569818 | benzo[a]pyrene | decreases expression | ISO | PPP1R16B (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of PPP1R16B mRNA | CTD | PMID:35870112 | benzo[a]pyrene | increases methylation | ISO | Ppp1r16b (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased methylation of PPP1R16B intron | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | PPP1R16B (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PPP1R16B 5' UTR more ... | CTD | PMID:27901495 and PMID:30157460 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PPP1R16B mRNA | CTD | PMID:25181051 | bisphenol A | decreases methylation | ISO | PPP1R16B (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of PPP1R16B gene | CTD | PMID:31601247 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PPP1R16B mRNA | CTD | PMID:30816183 | cadmium atom | decreases expression | ISO | PPP1R16B (Homo sapiens) | 6480464 | Cadmium results in decreased expression of PPP1R16B mRNA | CTD | PMID:24376830 | camptothecin | decreases response to substance | ISO | PPP1R16B (Homo sapiens) | 6480464 | PPP1R16B mRNA results in decreased susceptibility to Camptothecin | CTD | PMID:25269479 | chlordecone | decreases expression | ISO | Ppp1r16b (Mus musculus) | 6480464 | Chlordecone results in decreased expression of PPP1R16B mRNA | CTD | PMID:29980752 | chlorpyrifos | increases expression | ISO | Ppp1r16b (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of PPP1R16B mRNA | CTD | PMID:37019170 | choline | multiple interactions | ISO | Ppp1r16b (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PPP1R16B gene | CTD | PMID:20938992 | crocidolite asbestos | decreases expression | ISO | Ppp1r16b (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of PPP1R16B mRNA | CTD | PMID:29279043 | dimethylarsinic acid | multiple interactions | ISO | Ppp1r16b (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of PPP1R16B mRNA | CTD | PMID:34876320 | Erionite | decreases expression | ISO | Ppp1r16b (Mus musculus) | 6480464 | erionite results in decreased expression of PPP1R16B mRNA | CTD | PMID:29279043 | ethanol | multiple interactions | ISO | Ppp1r16b (Mus musculus) | 6480464 | Ethanol affects the expression of and affects the splicing of PPP1R16B mRNA | CTD | PMID:30319688 | ethanol | increases expression | ISO | Ppp1r16b (Mus musculus) | 6480464 | Ethanol results in increased expression of PPP1R16B mRNA | CTD | PMID:30319688 | folic acid | multiple interactions | ISO | Ppp1r16b (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PPP1R16B gene | CTD | PMID:20938992 | FR900359 | decreases phosphorylation | ISO | PPP1R16B (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of PPP1R16B protein | CTD | PMID:37730182 | genistein | increases expression | ISO | Ppp1r16b (Mus musculus) | 6480464 | Genistein results in increased expression of PPP1R16B mRNA | CTD | PMID:32186404 | iron atom | increases expression | ISO | PPP1R16B (Homo sapiens) | 6480464 | Iron deficiency results in increased expression of PPP1R16B mRNA | CTD | PMID:20368581 | iron(0) | increases expression | ISO | PPP1R16B (Homo sapiens) | 6480464 | Iron deficiency results in increased expression of PPP1R16B mRNA | CTD | PMID:20368581 | isotretinoin | increases expression | ISO | PPP1R16B (Homo sapiens) | 6480464 | Isotretinoin results in increased expression of PPP1R16B mRNA | CTD | PMID:20436886 | L-methionine | multiple interactions | ISO | Ppp1r16b (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PPP1R16B gene | CTD | PMID:20938992 | lead(0) | affects expression | ISO | PPP1R16B (Homo sapiens) | 6480464 | Lead affects the expression of PPP1R16B mRNA | CTD | PMID:28903495 | lipopolysaccharide | multiple interactions | ISO | PPP1R16B (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | lipopolysaccharide | decreases expression | ISO | PPP1R16B (Homo sapiens) | 6480464 | Lipopolysaccharides results in decreased expression of PPP1R16B mRNA | CTD | PMID:35811015 | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of PPP1R16B gene | CTD | PMID:35440735 | methylarsonic acid | multiple interactions | ISO | Ppp1r16b (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of PPP1R16B mRNA | CTD | PMID:34876320 | methylmercury chloride | increases expression | ISO | PPP1R16B (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of PPP1R16B mRNA | CTD | PMID:28001369 | nickel atom | increases expression | ISO | PPP1R16B (Homo sapiens) | 6480464 | Nickel results in increased expression of PPP1R16B mRNA | CTD | PMID:24768652 and PMID:25583101 | ozone | multiple interactions | ISO | Ppp1r16b (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of PPP1R16B mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of PPP1R16B mRNA | CTD | PMID:34911549 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of PPP1R16B mRNA | CTD | PMID:33387578 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Ppp1r16b (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of PPP1R16B mRNA | CTD | PMID:36331819 | phenobarbital | affects expression | ISO | Ppp1r16b (Mus musculus) | 6480464 | Phenobarbital affects the expression of PPP1R16B mRNA | CTD | PMID:23091169 | progesterone | multiple interactions | ISO | PPP1R16B (Homo sapiens) | 6480464 | [Progesterone co-treated with Estradiol] results in decreased expression of PPP1R16B mRNA | CTD | PMID:17404688 | propanal | decreases expression | ISO | PPP1R16B (Homo sapiens) | 6480464 | propionaldehyde results in decreased expression of PPP1R16B mRNA | CTD | PMID:26079696 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | PPP1R16B (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | serpentine asbestos | decreases expression | ISO | PPP1R16B (Homo sapiens) | 6480464 | Asbestos and Serpentine results in decreased expression of PPP1R16B mRNA | CTD | PMID:21148743 | sodium arsenate | multiple interactions | ISO | Ppp1r16b (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of PPP1R16B mRNA | CTD | PMID:34876320 | sodium arsenite | multiple interactions | ISO | Ppp1r16b (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of PPP1R16B mRNA | CTD | PMID:34876320 | sotorasib | multiple interactions | ISO | PPP1R16B (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PPP1R16B mRNA | CTD | PMID:36139627 | taurine | increases expression | ISO | PPP1R16B (Homo sapiens) | 6480464 | Taurine results in increased expression of PPP1R16B mRNA | CTD | PMID:16579726 | testosterone | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of PPP1R16B mRNA | CTD | PMID:32741896 | thapsigargin | decreases expression | ISO | PPP1R16B (Homo sapiens) | 6480464 | Thapsigargin results in decreased expression of PPP1R16B mRNA | CTD | PMID:22378314 | titanium dioxide | decreases expression | ISO | Ppp1r16b (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of PPP1R16B mRNA | CTD | PMID:23557971 and PMID:29264374 | trametinib | multiple interactions | ISO | PPP1R16B (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PPP1R16B mRNA | CTD | PMID:36139627 | tremolite asbestos | decreases expression | ISO | Ppp1r16b (Mus musculus) | 6480464 | tremolite results in decreased expression of PPP1R16B mRNA | CTD | PMID:29279043 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of PPP1R16B mRNA | CTD | PMID:33387578 | triclosan | decreases expression | ISO | PPP1R16B (Homo sapiens) | 6480464 | Triclosan results in decreased expression of PPP1R16B mRNA | CTD | PMID:30510588 | triptonide | increases expression | ISO | Ppp1r16b (Mus musculus) | 6480464 | triptonide results in increased expression of PPP1R16B mRNA | CTD | PMID:33045310 | tungsten | decreases expression | ISO | Ppp1r16b (Mus musculus) | 6480464 | Tungsten results in decreased expression of PPP1R16B mRNA | CTD | PMID:30912803 | tunicamycin | decreases expression | ISO | PPP1R16B (Homo sapiens) | 6480464 | Tunicamycin results in decreased expression of PPP1R16B mRNA | CTD | PMID:22378314 | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of PPP1R16B mRNA | CTD | PMID:29427782 | vancomycin | increases expression | ISO | Ppp1r16b (Mus musculus) | 6480464 | Vancomycin results in increased expression of PPP1R16B mRNA | CTD | PMID:18930951 | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of PPP1R16B gene | CTD | PMID:31682807 | |