Adad2 (adenosine deaminase domain containing 2) - Rat Genome Database

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Gene: Adad2 (adenosine deaminase domain containing 2) Rattus norvegicus
Analyze
Symbol: Adad2
Name: adenosine deaminase domain containing 2
RGD ID: 1586236
Description: Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Predicted to be involved in RNA processing; adenosine to inosine editing; and spermatid development. Predicted to be located in nucleus. Predicted to be active in cytoplasm and nucleolus. Orthologous to human ADAD2 (adenosine deaminase domain containing 2); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adenosine deaminase domain-containing protein 2; LOC292057; RGD1560949; similar to testis nuclear RNA-binding protein; similar to testis nuclear RNA-binding protein-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81964,573,915 - 64,578,194 (+)NCBIGRCr8
mRatBN7.21947,665,288 - 47,669,433 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1947,665,309 - 47,669,436 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01952,258,908 - 52,263,031 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1952,258,947 - 52,262,959 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01963,007,120 - 63,011,235 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41949,855,251 - 49,872,666 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1946,924,353 - 46,927,424 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO)
nucleolus  (IBA)
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Adad2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81964,573,915 - 64,578,194 (+)NCBIGRCr8
mRatBN7.21947,665,288 - 47,669,433 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1947,665,309 - 47,669,436 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01952,258,908 - 52,263,031 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1952,258,947 - 52,262,959 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01963,007,120 - 63,011,235 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41949,855,251 - 49,872,666 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1946,924,353 - 46,927,424 (+)NCBICelera
Cytogenetic Map19q12NCBI
ADAD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381684,191,157 - 84,197,166 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1684,191,138 - 84,197,168 (+)EnsemblGRCh38hg38GRCh38
GRCh371684,224,763 - 84,230,772 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361682,782,245 - 82,788,273 (+)NCBINCBI36Build 36hg18NCBI36
Celera1668,526,534 - 68,532,570 (+)NCBICelera
Cytogenetic Map16q24.1NCBI
HuRef1669,978,501 - 69,984,546 (+)NCBIHuRef
CHM1_11685,636,112 - 85,642,160 (+)NCBICHM1_1
T2T-CHM13v2.01690,257,231 - 90,263,239 (+)NCBIT2T-CHM13v2.0
Adad2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398120,339,449 - 120,343,665 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8120,339,486 - 120,343,663 (+)EnsemblGRCm39 Ensembl
GRCm388119,612,710 - 119,616,926 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8119,612,747 - 119,616,924 (+)EnsemblGRCm38mm10GRCm38
MGSCv378122,136,647 - 122,140,826 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368122,498,724 - 122,502,903 (+)NCBIMGSCv36mm8
Celera8123,830,225 - 123,834,750 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map868.05NCBI
Adad2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955564112,531 - 119,283 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955564113,943 - 120,083 (-)NCBIChiLan1.0ChiLan1.0
ADAD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21893,937,089 - 93,944,127 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11699,854,254 - 99,861,291 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01664,856,014 - 64,862,493 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11684,198,190 - 84,204,243 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1684,198,190 - 84,204,243 (+)Ensemblpanpan1.1panPan2
ADAD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1568,163,216 - 68,170,044 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl568,163,170 - 68,170,019 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha568,177,469 - 68,179,752 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0568,396,440 - 68,403,056 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1568,408,978 - 68,415,576 (-)NCBIUMICH_Zoey_3.1
Adad2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934927,887,567 - 27,892,129 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366413,641,215 - 3,645,742 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366413,641,123 - 3,645,624 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl64,437,798 - 4,443,898 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.164,437,797 - 4,444,068 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.264,862,053 - 4,868,711 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1569,599,376 - 69,605,956 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl569,600,012 - 69,605,762 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660476,149,312 - 6,155,417 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adad2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247463,391,742 - 3,399,452 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247463,393,426 - 3,399,388 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adad2
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:67
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000021072
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 17
Low 2 10 6 6 6 31 2 18
Below cutoff 16 15 13 2 13 1 1 33 16 3 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021072   ⟹   ENSRNOP00000021072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1947,665,309 - 47,669,436 (+)Ensembl
Rnor_6.0 Ensembl1952,258,947 - 52,262,959 (+)Ensembl
RefSeq Acc Id: XM_039098198   ⟹   XP_038954126
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81964,573,915 - 64,578,194 (+)NCBI
mRatBN7.21947,665,288 - 47,669,433 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038954126 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021072
  ENSRNOP00000021072.7
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000021072   ⟸   ENSRNOT00000021072
RefSeq Acc Id: XP_038954126   ⟸   XM_039098198
- UniProtKB: F1M8B2 (UniProtKB/TrEMBL)
Protein Domains
A to I editase   DRBM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M8B2-F1-model_v2 AlphaFold F1M8B2 1-559 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586236 AgrOrtholog
BioCyc Gene G2FUF-5510 BioCyc
BioCyc Pathway PWY-6609 [adenine and adenosine salvage III] BioCyc
  PWY-7179 [purine deoxyribonucleosides degradation I] BioCyc
  PWY-7179-1 [purine deoxyribonucleosides degradation II] BioCyc
  PWY0-1296 [purine ribonucleosides degradation] BioCyc
  SALVADEHYPOX-PWY [adenosine nucleotides degradation II] BioCyc
BioCyc Pathway Image PWY-6609 BioCyc
  PWY-7179 BioCyc
  PWY-7179-1 BioCyc
  PWY0-1296 BioCyc
  SALVADEHYPOX-PWY BioCyc
Ensembl Genes ENSRNOG00000015690 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021072.7 UniProtKB/TrEMBL
Gene3D-CATH 3.30.160.20 UniProtKB/TrEMBL
InterPro A_deamin UniProtKB/TrEMBL
  dsRNA-bd-like UniProtKB/TrEMBL
NCBI Gene 691275 ENTREZGENE
PANTHER ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
  EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN UniProtKB/TrEMBL
Pfam A_deamin UniProtKB/TrEMBL
  dsrm UniProtKB/TrEMBL
PhenoGen Adad2 PhenoGen
PROSITE A_DEAMIN_EDITASE UniProtKB/TrEMBL
  DS_RBD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015690 RatGTEx
SMART ADEAMc UniProtKB/TrEMBL
  DSRM UniProtKB/TrEMBL
Superfamily-SCOP dsRNA-binding domain-like UniProtKB/TrEMBL
UniProt F1M8B2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-28 Adad2  adenosine deaminase domain containing 2  RGD1560949  similar to testis nuclear RNA-binding protein-like  Data merged from RGD:1560949 737654 APPROVED
2008-04-30 RGD1560949  similar to testis nuclear RNA-binding protein-like   RGD1560949_predicted  similar to testis nuclear RNA-binding protein-like (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-19 LOC691275  similar to testis nuclear RNA-binding protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1560949_predicted  similar to testis nuclear RNA-binding protein-like (predicted)  LOC292057  similar to testis nuclear RNA-binding protein-like  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC292057  similar to testis nuclear RNA-binding protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL