Pet100 (PET100 cytochrome c oxidase chaperone) - Rat Genome Database

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Gene: Pet100 (PET100 cytochrome c oxidase chaperone) Rattus norvegicus
Analyze
Symbol: Pet100
Name: PET100 cytochrome c oxidase chaperone
RGD ID: 1585222
Description: Predicted to enable unfolded protein binding activity. Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be located in membrane and mitochondrion. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 12. Orthologous to human PET100 (PET100 cytochrome c oxidase chaperone); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC688786; LOC688786; PET100 homolog; PET100 homolog (S. cerevisiae); similar to CG14483-PA; uncharacterized protein LOC688786
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,477,703 - 6,480,435 (+)NCBIGRCr8
mRatBN7.2121,679,805 - 1,682,540 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,679,859 - 1,682,540 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx122,346,471 - 2,349,136 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0122,970,043 - 2,972,709 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0121,741,020 - 1,743,669 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,170,630 - 2,173,259 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,170,630 - 2,173,251 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,332,962 - 4,335,591 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,531,225 - 2,533,448 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera123,535,650 - 3,538,316 (+)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548  


Genomics

Comparative Map Data
Pet100
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,477,703 - 6,480,435 (+)NCBIGRCr8
mRatBN7.2121,679,805 - 1,682,540 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,679,859 - 1,682,540 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx122,346,471 - 2,349,136 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0122,970,043 - 2,972,709 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0121,741,020 - 1,743,669 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,170,630 - 2,173,259 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,170,630 - 2,173,251 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,332,962 - 4,335,591 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,531,225 - 2,533,448 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera123,535,650 - 3,538,316 (+)NCBICelera
Cytogenetic Map12p12NCBI
PET100
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,629,793 - 7,631,956 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl197,629,788 - 7,631,956 (+)EnsemblGRCh38hg38GRCh38
GRCh37197,694,679 - 7,696,842 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,600,677 - 7,602,961 (+)NCBINCBI36Build 36hg18NCBI36
Celera197,565,855 - 7,567,694 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef197,364,339 - 7,366,226 (+)NCBIHuRef
CHM1_1197,694,422 - 7,696,261 (+)NCBICHM1_1
T2T-CHM13v2.0197,630,676 - 7,632,839 (+)NCBIT2T-CHM13v2.0
Pet100
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3983,671,551 - 3,674,235 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl83,671,548 - 3,675,848 (+)EnsemblGRCm39 Ensembl
GRCm3883,621,551 - 3,624,235 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl83,621,548 - 3,625,848 (+)EnsemblGRCm38mm10GRCm38
MGSCv3783,621,554 - 3,625,606 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera83,851,883 - 3,855,935 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map81.92NCBI
Pet100
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,628,746 - 1,630,307 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555631,628,746 - 1,630,307 (-)NCBIChiLan1.0ChiLan1.0
LOC100983712
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22012,300,612 - 12,302,502 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11911,418,199 - 11,420,091 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0196,919,469 - 6,921,359 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1197,774,461 - 7,776,340 (+)NCBIpanpan1.1PanPan1.1panPan2
LOC611528
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,406,154 - 52,412,552 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2052,210,235 - 52,211,785 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02052,935,464 - 52,937,014 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2052,935,565 - 52,937,263 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12052,139,263 - 52,140,813 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02052,582,852 - 52,584,402 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02052,813,857 - 52,815,407 (+)NCBIUU_Cfam_GSD_1.0
LOC101966343
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,153,223 - 213,154,750 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365884,680,102 - 4,681,563 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365884,680,083 - 4,681,563 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PET100
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,519,392 - 71,520,886 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1271,519,395 - 71,520,820 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,911,816 - 71,913,241 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103233807
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,116,233 - 7,118,101 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl67,116,314 - 7,118,030 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666081743,504 - 745,391 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pet100
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624828712,171 - 713,801 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624828712,087 - 713,801 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pet100
19 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:88
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000071928
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)127977298525593Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat

Markers in Region
RH127969  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2121,682,314 - 1,682,530 (+)MAPPERmRatBN7.2
Rnor_6.0122,173,034 - 2,173,249NCBIRnor6.0
Rnor_5.0124,335,366 - 4,335,581UniSTSRnor5.0
RGSC_v3.4122,530,835 - 2,531,050UniSTSRGSC3.4
Celera123,538,091 - 3,538,306UniSTS
Cytogenetic Map12p12UniSTS
RH141147  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2121,680,757 - 1,681,621 (+)MAPPERmRatBN7.2
Rnor_6.0122,171,479 - 2,172,342NCBIRnor6.0
Rnor_5.0124,333,811 - 4,334,674UniSTSRnor5.0
RGSC_v3.4122,531,742 - 2,532,605UniSTSRGSC3.4
Celera123,536,499 - 3,537,362UniSTS
Cytogenetic Map12p12UniSTS
Pcp2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2121,681,755 - 1,682,967 (+)MAPPERmRatBN7.2
Rnor_6.0122,172,475 - 2,173,686NCBIRnor6.0
Rnor_5.0124,334,807 - 4,336,018UniSTSRnor5.0
RGSC_v3.4122,530,398 - 2,531,609UniSTSRGSC3.4
Celera123,537,532 - 3,538,743UniSTS
Cytogenetic Map12p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 37 57 41 19 41 7 10 74 35 41 11 7
Low 6 1 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000071928   ⟹   ENSRNOP00000067747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl121,679,859 - 1,682,540 (+)Ensembl
Rnor_6.0 Ensembl122,170,630 - 2,173,251 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107172   ⟹   ENSRNOP00000097605
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl121,679,984 - 1,682,531 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110166   ⟹   ENSRNOP00000086423
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl121,679,902 - 1,682,536 (+)Ensembl
RefSeq Acc Id: NM_001195245   ⟹   NP_001182174
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,477,806 - 6,480,435 (+)NCBI
mRatBN7.2121,679,909 - 1,682,540 (+)NCBI
Rnor_6.0122,170,630 - 2,173,259 (+)NCBI
Rnor_5.0124,332,962 - 4,335,591 (+)NCBI
Celera123,535,650 - 3,538,316 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089765   ⟹   XP_038945693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,477,703 - 6,479,552 (+)NCBI
mRatBN7.2121,679,805 - 1,682,540 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001182174 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945693 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL74941 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067747
  ENSRNOP00000067747.2
  ENSRNOP00000086423.1
  ENSRNOP00000097605.1
Reference Protein Sequences
RefSeq Acc Id: NP_001182174   ⟸   NM_001195245
- UniProtKB: A6KQ16 (UniProtKB/TrEMBL),   A6KQ18 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067747   ⟸   ENSRNOT00000071928
RefSeq Acc Id: XP_038945693   ⟸   XM_039089765
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000086423   ⟸   ENSRNOT00000110166
RefSeq Acc Id: ENSRNOP00000097605   ⟸   ENSRNOT00000107172

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZHD3-F1-model_v2 AlphaFold D3ZHD3 1-76 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698371
Promoter ID:EPDNEW_R8896
Type:multiple initiation site
Name:Pet100_1
Description:PET100 homolog
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0122,170,639 - 2,170,699EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1585222 AgrOrtholog
BioCyc Gene G2FUF-20392 BioCyc
Ensembl Genes ENSRNOG00000050169 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071928.2 UniProtKB/TrEMBL
  ENSRNOT00000107172.1 UniProtKB/TrEMBL
  ENSRNOT00000110166.1 UniProtKB/TrEMBL
InterPro DUF2346 UniProtKB/TrEMBL
KEGG Report rno:688786 UniProtKB/TrEMBL
NCBI Gene 688786 ENTREZGENE
PANTHER PROTEIN PET100 HOMOLOG, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR33968 UniProtKB/TrEMBL
Pfam DUF2346 UniProtKB/TrEMBL
PhenoGen Pet100 PhenoGen
RatGTEx ENSRNOG00000050169 RatGTEx
UniProt A0A8I6A169_RAT UniProtKB/TrEMBL
  A0A8I6B601_RAT UniProtKB/TrEMBL
  A6KQ16 ENTREZGENE, UniProtKB/TrEMBL
  A6KQ18 ENTREZGENE, UniProtKB/TrEMBL
  D3ZHD3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Pet100  PET100 cytochrome c oxidase chaperone  Pet100  PET100 homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-17 Pet100  PET100 homolog  Pet100  PET100 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-02 Pet100  PET100 homolog (S. cerevisiae)  LOC688786  similar to CG14483-PA  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC688786  similar to CG14483-PA      Symbol and Name status set to provisional 70820 PROVISIONAL