Mrps16 (mitochondrial ribosomal protein S16) - Rat Genome Database

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Gene: Mrps16 (mitochondrial ribosomal protein S16) Rattus norvegicus
Analyze
Symbol: Mrps16
Name: mitochondrial ribosomal protein S16
RGD ID: 1582995
Description: Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytosol and mitochondrion. Predicted to be part of mitochondrial small ribosomal subunit. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 2. Orthologous to human MRPS16 (mitochondrial ribosomal protein S16); INTERACTS WITH (-)-epigallocatechin 3-gallate; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 28S ribosomal protein S16, mitochondrial; LOC688912; similar to mitochondrial ribosomal protein S16; small ribosomal subunit protein bS16m
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8153,967,809 - 3,970,211 (+)NCBIGRCr8
mRatBN7.2153,918,621 - 3,921,024 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl153,918,615 - 3,921,656 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx153,928,728 - 3,931,130 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0155,315,153 - 5,317,551 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0153,927,549 - 3,929,947 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0154,351,292 - 4,353,694 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl154,351,292 - 4,353,694 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0158,452,790 - 8,455,192 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4154,147,260 - 4,149,662 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera15674,047 - 676,448 (-)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
translation  (IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11279123   PMID:14651853   PMID:18614015   PMID:25838379  


Genomics

Comparative Map Data
Mrps16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8153,967,809 - 3,970,211 (+)NCBIGRCr8
mRatBN7.2153,918,621 - 3,921,024 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl153,918,615 - 3,921,656 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx153,928,728 - 3,931,130 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0155,315,153 - 5,317,551 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0153,927,549 - 3,929,947 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0154,351,292 - 4,353,694 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl154,351,292 - 4,353,694 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0158,452,790 - 8,455,192 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4154,147,260 - 4,149,662 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera15674,047 - 676,448 (-)NCBICelera
Cytogenetic Map15p16NCBI
MRPS16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381073,248,849 - 73,252,644 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1073,248,843 - 73,252,693 (-)EnsemblGRCh38hg38GRCh38
GRCh371075,008,607 - 75,012,402 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361074,678,607 - 74,682,457 (-)NCBINCBI36Build 36hg18NCBI36
Build 341074,678,607 - 74,682,457NCBI
Celera1068,294,224 - 68,298,074 (-)NCBICelera
Cytogenetic Map10q22.2NCBI
HuRef1069,002,461 - 69,006,311 (-)NCBIHuRef
CHM1_11075,290,318 - 75,294,168 (-)NCBICHM1_1
T2T-CHM13v2.01074,120,230 - 74,124,025 (-)NCBIT2T-CHM13v2.0
Mrps16
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391420,441,290 - 20,443,702 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1420,439,372 - 20,443,702 (-)EnsemblGRCm39 Ensembl
GRCm381420,391,222 - 20,393,634 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1420,389,304 - 20,393,634 (-)EnsemblGRCm38mm10GRCm38
MGSCv371421,210,453 - 21,212,777 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361419,179,783 - 19,182,107 (-)NCBIMGSCv36mm8
Celera1416,772,069 - 16,774,394 (-)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1411.53NCBI
Mrps16
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543718,481,675 - 18,483,358 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543718,481,675 - 18,483,358 (+)NCBIChiLan1.0ChiLan1.0
MRPS16
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2885,423,330 - 85,428,536 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11085,430,098 - 85,433,859 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01069,796,505 - 69,800,304 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11072,255,326 - 72,259,172 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1072,255,326 - 72,259,172 (-)Ensemblpanpan1.1panPan2
MRPS16
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1423,827,690 - 23,829,319 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha423,965,843 - 23,967,471 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0424,109,078 - 24,110,705 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1424,006,656 - 24,008,287 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0424,205,950 - 24,207,578 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0424,561,947 - 24,563,578 (-)NCBIUU_Cfam_GSD_1.0
Mrps16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721357,293,090 - 57,295,175 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365215,785,830 - 5,787,588 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365215,785,819 - 5,787,402 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRPS16
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1476,048,868 - 76,074,618 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11476,071,017 - 76,074,639 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21482,195,903 - 82,199,525 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MRPS16
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1958,020,526 - 58,022,393 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604818,605,105 - 18,607,063 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mrps16
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247546,920,731 - 6,922,391 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247546,920,729 - 6,922,388 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mrps16
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:44
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000009207
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15105825014481294Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)colorectal tumor number (CMO:0001794)15226636822711984Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15226636822711984Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat

Markers in Region
RH143915  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2153,921,163 - 3,921,331 (+)MAPPERmRatBN7.2
Rnor_6.0154,353,834 - 4,354,001NCBIRnor6.0
Rnor_5.0158,455,332 - 8,455,499UniSTSRnor5.0
RGSC_v3.4154,149,802 - 4,149,969UniSTSRGSC3.4
Celera15673,740 - 673,907UniSTS
RH 3.4 Map1566.6UniSTS
Cytogenetic Map15p16UniSTS
RH143320  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2153,919,811 - 3,920,825 (+)MAPPERmRatBN7.2
Rnor_6.01520,937,854 - 20,938,083NCBIRnor6.0
Rnor_6.0154,352,482 - 4,353,495NCBIRnor6.0
Rnor_5.0158,453,980 - 8,454,993UniSTSRnor5.0
RGSC_v3.4154,148,450 - 4,149,463UniSTSRGSC3.4
Celera15674,246 - 675,258UniSTS
Celera1520,179,416 - 20,179,643UniSTS
RH 3.4 Map15189.0UniSTS
Cytogenetic Map15p16UniSTS
AA924605  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2153,920,813 - 3,920,972 (+)MAPPERmRatBN7.2
Rnor_6.0154,353,484 - 4,353,642NCBIRnor6.0
Rnor_5.0158,454,982 - 8,455,140UniSTSRnor5.0
RGSC_v3.4154,149,452 - 4,149,610UniSTSRGSC3.4
Celera15674,099 - 674,257UniSTS
RH 3.4 Map1568.7UniSTS
Cytogenetic Map15p16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009207   ⟹   ENSRNOP00000009207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl153,919,377 - 3,921,656 (+)Ensembl
Rnor_6.0 Ensembl154,351,292 - 4,353,694 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095199   ⟹   ENSRNOP00000083796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl153,918,615 - 3,921,656 (+)Ensembl
RefSeq Acc Id: NM_001109518   ⟹   NP_001102988
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8153,967,809 - 3,970,211 (+)NCBI
mRatBN7.2153,918,621 - 3,921,024 (+)NCBI
Rnor_6.0154,351,292 - 4,353,694 (+)NCBI
Rnor_5.0158,452,790 - 8,455,192 (+)NCBI
RGSC_v3.4154,147,260 - 4,149,662 (+)RGD
Celera15674,047 - 676,448 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102988 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL86221 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009207.5
  ENSRNOP00000083796.1
Reference Protein Sequences
RefSeq Acc Id: NP_001102988   ⟸   NM_001109518
- UniProtKB: D4A7X1 (UniProtKB/TrEMBL),   A6KKM7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009207   ⟸   ENSRNOT00000009207
RefSeq Acc Id: ENSRNOP00000083796   ⟸   ENSRNOT00000095199

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A7X1-F1-model_v2 AlphaFold D4A7X1 1-135 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699566
Promoter ID:EPDNEW_R10090
Type:initiation region
Name:Mrps16_1
Description:mitochondrial ribosomal protein S16
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0154,351,315 - 4,351,375EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1582995 AgrOrtholog
BioCyc Gene G2FUF-14536 BioCyc
Ensembl Genes ENSRNOG00000006898 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009207.6 UniProtKB/TrEMBL
  ENSRNOT00000095199.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1320.10 UniProtKB/TrEMBL
InterPro Ribosomal_S16 UniProtKB/TrEMBL
  Ribosomal_S16_dom UniProtKB/TrEMBL
KEGG Report rno:688912 UniProtKB/TrEMBL
NCBI Gene 688912 ENTREZGENE
PANTHER 28S RIBOSOMAL PROTEIN S16, MITOCHONDRIAL UniProtKB/TrEMBL
  Ribosomal_S16 UniProtKB/TrEMBL
Pfam Ribosomal_S16 UniProtKB/TrEMBL
PhenoGen Mrps16 PhenoGen
RatGTEx ENSRNOG00000006898 RatGTEx
Superfamily-SCOP Ribosomal_S16 UniProtKB/TrEMBL
UniProt A0A8I5ZXC8_RAT UniProtKB/TrEMBL
  A6KKM7 ENTREZGENE, UniProtKB/TrEMBL
  D4A7X1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Mrps16  mitochondrial ribosomal protein S16  LOC688912  similar to mitochondrial ribosomal protein S16  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC688912  similar to mitochondrial ribosomal protein S16  LOC683012  similar to mitochondrial ribosomal protein S16  Data merged from RGD:1591595 1643240 APPROVED
2006-11-20 LOC683012  similar to mitochondrial ribosomal protein S16      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC688912  similar to mitochondrial ribosomal protein S16      Symbol and Name status set to provisional 70820 PROVISIONAL