Sla2 (Src-like-adaptor 2) - Rat Genome Database

Name: Sla2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Sla2 (Src-like-adaptor 2) Rattus norvegicus

Analyze

Symbol:

Sla2

Name:

Src-like-adaptor 2

RGD ID:

1562071

Description:

Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity and signaling adaptor activity. Predicted to be involved in negative regulation of signal transduction; negative regulation of transcription by RNA polymerase II; and phosphatidylinositol phosphate biosynthetic process. Predicted to be located in several cellular components, including Golgi apparatus; late endosome; and nucleoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex. Orthologous to human SLA2 (Src like adaptor 2); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC102554229; LOC499931; RGD1562071; similar to Src-like adaptor protein-2; src-like-adapter 2; uncharacterized LOC102554229

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLA2 (Src like adaptor 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Mus musculus (house mouse):	Sla2 (Src-like-adaptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sla2 (Src like adaptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLA2 (Src like adaptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLA2 (Src like adaptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sla2 (Src like adaptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLA2 (Src like adaptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLA2 (Src like adaptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sla2 (Src like adaptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RPRD1A (regulation of nuclear pre-mRNA domain containing 1A)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SLA2 (Src like adaptor 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sla2 (Src-like-adaptor 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sla2 (Src-like-adaptor 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Danio rerio (zebrafish):	si:ch211-25d12.7	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	sla2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	165,821,164 - 165,848,087 (-)	NCBI		GRCr8
mRatBN7.2	3	145,367,070 - 145,383,586 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	145,368,598 - 145,382,480 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	149,234,054 - 149,247,445 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	157,850,772 - 157,864,130 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	155,589,831 - 155,603,360 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	152,942,838 - 153,004,047 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	152,944,452 - 153,001,309 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	158,742,486 - 158,752,778 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	147,277,668 - 147,290,729 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	144,085,665 - 144,098,964 (-)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

focal epilepsy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

amphetamine (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

caffeine (ISO)

calcitriol (ISO)

cocaine (EXP)

diarsenic trioxide (ISO)

dorsomorphin (ISO)

indole-3-methanol (EXP)

mercury dichloride (ISO)

N-acetyl-L-cysteine (EXP)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

testosterone (EXP,ISO)

thioacetamide (EXP)

trichloroethene (EXP)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of calcium-mediated signaling (ISO)

negative regulation of T cell receptor signaling pathway (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

phosphatidylinositol phosphate biosynthetic process (IBA)

T cell activation (ISO)

Cellular Component

cytoplasmic vesicle (ISO)

Golgi apparatus (IEA,ISO)

intracellular membrane-bounded organelle (ISO)

late endosome (ISO)

nucleoplasm (IEA,ISO)

phosphatidylinositol 3-kinase complex (IBA)

plasma membrane (ISO)

Molecular Function

1-phosphatidylinositol-3-kinase regulator activity (IBA)

protein binding (ISO)

signaling adaptor activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11696592	PMID:11891219	PMID:12024036

Genomics

Comparative Map Data

Sla2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	165,821,164 - 165,848,087 (-)	NCBI		GRCr8
mRatBN7.2	3	145,367,070 - 145,383,586 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	145,368,598 - 145,382,480 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	149,234,054 - 149,247,445 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	157,850,772 - 157,864,130 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	155,589,831 - 155,603,360 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	152,942,838 - 153,004,047 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	152,944,452 - 153,001,309 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	158,742,486 - 158,752,778 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	147,277,668 - 147,290,729 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	144,085,665 - 144,098,964 (-)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

SLA2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	36,612,318 - 36,646,196 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	36,612,318 - 36,646,196 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	35,240,721 - 35,274,599 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	34,674,336 - 34,707,972 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	34,674,339 - 34,707,972	NCBI
Celera	20	31,947,996 - 31,982,111 (-)	NCBI		Celera
Cytogenetic Map	20	q11.23	NCBI
HuRef	20	31,976,969 - 32,010,653 (-)	NCBI		HuRef
CHM1_1	20	35,142,627 - 35,176,530 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	38,336,183 - 38,370,537 (-)	NCBI		T2T-CHM13v2.0

Sla2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	156,716,071 - 156,729,161 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	156,714,377 - 156,729,112 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	156,874,151 - 156,887,250 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	156,872,457 - 156,887,192 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	156,698,658 - 156,712,814 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	156,698,658 - 156,712,928 (-)	NCBI		MGSCv36	mm8
Celera	2	162,808,644 - 162,822,518 (-)	NCBI		Celera
Cytogenetic Map	2	H1	NCBI
cM Map	2	77.89	NCBI

Sla2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	24,986,028 - 25,003,732 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	24,978,447 - 25,003,732 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLA2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	42,350,879 - 42,387,763 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	42,343,837 - 42,381,788 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	32,945,409 - 32,978,966 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	34,065,385 - 34,098,581 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	34,065,385 - 34,098,581 (-)	Ensembl	panpan1.1		panPan2

SLA2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	25,396,187 - 25,426,789 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	25,396,900 - 25,422,467 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	25,039,425 - 25,072,052 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	26,091,095 - 26,123,942 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	26,094,518 - 26,120,342 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	25,369,896 - 25,402,347 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	25,468,792 - 25,501,560 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	25,959,331 - 25,992,034 (-)	NCBI		UU_Cfam_GSD_1.0

Sla2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	174,320,591 - 174,344,978 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936561	4,413,108 - 4,428,110 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936561	4,408,531 - 4,427,476 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLA2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	39,875,628 - 39,902,940 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	39,875,625 - 39,904,838 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

SLA2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666054	655,122 - 689,911 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sla2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624842	2,853,144 - 2,881,116 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624842	2,853,183 - 2,882,269 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sla2
70 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	53
Count of miRNA genes:	45
Interacting mature miRNAs:	50
Transcripts:	ENSRNOT00000027581
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	97551417	147415807	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	118839124	163839124	Rat
1598877	Bp285	Blood pressure QTL 285	1.5	0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	120538241	165538241	Rat
1300173	Rf11	Renal function QTL 11	3.38		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	121056165	145956249	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	121056165	157309487	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	122438700	167438700	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	124122556	169034231	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	127162703	168026850	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	130193298	161695983	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	130656562	169034231	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	130656562	169034231	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	131635904	169034231	Rat
2298477	Eau4	Experimental allergic uveoretinitis QTL 4		0.0011	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	3	137398739	169034231	Rat
8552952	Pigfal13	Plasma insulin-like growth factor 1 level QTL 13			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	138799500	169034231	Rat
5686842	Rf59	Renal function QTL 59			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	3	140069424	146976080	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141074471	169034231	Rat
1331726	Bp208	Blood pressure QTL 208	3.129		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141339013	162184794	Rat
61335	Bp20	Blood pressure QTL 20	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141339236	155617360	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			9	2	11	2
Low	3	13	32	23	8	23	7	10	54	7	23	11	7
Below cutoff		22	14	14		14	1	1	14	22	17		1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001172118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762374	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591992	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284391	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284392	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000027581 ⟹ ENSRNOP00000027581

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	145,368,598 - 145,382,480 (-)	Ensembl
Rnor_6.0 Ensembl	3	152,944,452 - 153,001,309 (-)	Ensembl

RefSeq Acc Id:

NM_001172118 ⟹ NP_001165589

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	165,828,657 - 165,842,048 (-)	NCBI
mRatBN7.2	3	145,368,598 - 145,381,994 (-)	NCBI
Rnor_6.0	3	152,944,366 - 152,998,234 (-)	NCBI
Rnor_5.0	3	158,742,486 - 158,752,778 (+)	NCBI
Celera	3	144,085,665 - 144,098,964 (-)	NCBI

Sequence:

show sequence

ATGATGGGAAGTTTGCCCAGCAGAGGGAAAAACTCCAGCCCAAGCTCCAGTTCCAGCTTCTCTG
GTCCAGGCCAGGAACCTGTGTCCATACAAGCAGAAAGACAGAAGGTCTCAGCTGTGGCCCTGGG
CAGTTTCCCAGCAGGTGAGCAGGCCAGACTATCTCTGAGAGTCGGGGAACCACTGACCATCATA
TCTGAGGATGGAGATTGGTGGACAGTCCAGTCGGAAGTCTCAGGCAGAGAGTATCATATCCCCA
GTGTGTATGTGGCTAAAGTCTCCCACGGGTGGCTGTATGAGGGCCTGAGTCGGGAGAAAGCTGA
GGAACTTCTCTTATTACCTGGGAACCCCGGAGGAGCCTTCCTCATCAGGGAGAGCCAGACCAGG
AGAGGCTGCTATTCCCTGTCCATCCGCCTCAGTCGCCCTGCTTCTTGGGACCGGATCAGACACT
ACAGGATACAGCGTCTTGACAATGGCTGGCTGTACATCTCACCTCGCCTCACCTTCCCCTCACT
CCACGCCCTGGTGGAACATTACTCTGAGCTAGCAGATGGCATCTGCTGTGCCCTCAGGGAGCCC
TGTGTCCTGCAGAAGCTTGGGCCACTACCTGGCAAAGATACACCTCTACCTGTGACTGTGCCAA
CGTCATCACTGAATTGGAAAAAGCTAGACAGGAGCCTCCTGTGTTTGGACGCACCTGCCAGTGG
GGAGGCGTCTCTTCTCAGTGAGGGCCTCCGGGAGTCCCTCAGCTCCTACATCAGCCTGACTGAG
GAGACCGCCTTGGACGATGCCTAGTCCTGAAGCTGGAAGCTAAAGGGAACCAAGGCAGTGGCAC
CTACAACTCTAACTTGGCTGACCCTGACAAAGCTCCCCAGAGGCAAGGCTGTGAAAGCAGACGG
TGGGGGTGGGGACACACATTCAGGGCCTCACCTGGACCTTCTGATAAGCCTGGATCTTCTTCCA
AGGCCTCATCCCTGCCTATAAGTTCTAGTCTGTGTGCAGCGCAGTTCAAAGCAGGGCCAGGCCT
GTACGGAGAGCAAGAGACTTCTGAGGTCTGGTAAGTCACTTCCTGAGAGGAA

hide sequence

RefSeq Acc Id:

XM_063284391 ⟹ XP_063140461

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	165,821,164 - 165,848,087 (-)	NCBI

RefSeq Acc Id:

XM_063284392 ⟹ XP_063140462

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	165,821,164 - 165,848,087 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001165589	(Get FASTA)	NCBI Sequence Viewer
	XP_063140461	(Get FASTA)	NCBI Sequence Viewer
	XP_063140462	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL85830	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000027581
	ENSRNOP00000027581.6

RefSeq Acc Id:

NP_001165589 ⟸ NM_001172118

- UniProtKB:

D3ZMV1 (UniProtKB/TrEMBL), A6KIC5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MMGSLPSRGKNSSPSSSSSFSGPGQEPVSIQAERQKVSAVALGSFPAGEQARLSLRVGEPLTII
SEDGDWWTVQSEVSGREYHIPSVYVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTR
RGCYSLSIRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCALREP
CVLQKLGPLPGKDTPLPVTVPTSSLNWKKLDRSLLCLDAPASGEASLLSEGLRESLSSYISLTE
ETALDDA

hide sequence

RefSeq Acc Id:

ENSRNOP00000027581 ⟸ ENSRNOT00000027581

RefSeq Acc Id:	XP_063140462 ⟸ XM_063284392
- Peptide Label:	isoform X1
- UniProtKB:	A6KIC5 (UniProtKB/TrEMBL), D3ZMV1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140461 ⟸ XM_063284391
- Peptide Label:	isoform X1
- UniProtKB:	A6KIC5 (UniProtKB/TrEMBL), D3ZMV1 (UniProtKB/TrEMBL)

Protein Domains

SH2 SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZMV1-F1-model_v2	AlphaFold	D3ZMV1	1-263	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692607

Promoter ID:

EPDNEW_R3130

Type:

single initiation site

Name:

Sla2_1

Description:

Src-like-adaptor 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	153,001,255 - 153,001,315	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1562071	AgrOrtholog
BioCyc Gene	G2FUF-47076	BioCyc
Ensembl Genes	ENSRNOG00000020337	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000027581	ENTREZGENE
	ENSRNOT00000027581.8	UniProtKB/TrEMBL
Gene3D-CATH	3.30.505.10	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
InterPro	Grb2-like	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/TrEMBL
	SH3-like_dom	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
	SLAP_SH2	UniProtKB/TrEMBL
KEGG Report	rno:499931	UniProtKB/TrEMBL
NCBI Gene	499931	ENTREZGENE
PANTHER	PROTEIN ENHANCER OF SEVENLESS 2B	UniProtKB/TrEMBL
	SRC-LIKE-ADAPTOR 2	UniProtKB/TrEMBL
Pfam	SH2	UniProtKB/TrEMBL
	SH3_1	UniProtKB/TrEMBL
PhenoGen	Sla2	PhenoGen
PRINTS	SH2DOMAIN	UniProtKB/TrEMBL
PROSITE	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000020337	RatGTEx
SMART	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
Superfamily-SCOP	SH3	UniProtKB/TrEMBL
	SSF55550	UniProtKB/TrEMBL
UniProt	A6KIC5	ENTREZGENE, UniProtKB/TrEMBL
	D3ZMV1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-29	Sla2	Src-like-adaptor 2	LOC102554229	uncharacterized LOC102554229	Data merged from RGD:7597994	737654	PROVISIONAL
2013-12-18	LOC102554229	uncharacterized LOC102554229			Symbol and Name status set to provisional	70820	PROVISIONAL
2010-05-05	Sla2	Src-like-adaptor 2	RGD1562071	similar to Src-like adaptor protein-2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1562071	similar to Src-like adaptor protein-2	RGD1562071_predicted	similar to Src-like adaptor protein-2 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1562071_predicted	similar to Src-like adaptor protein-2 (predicted)	LOC499931	similar to Src-like adaptor protein-2	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC499931	similar to Src-like adaptor protein-2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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