Adamtsl4 (ADAMTS-like 4) - Rat Genome Database

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Gene: Adamtsl4 (ADAMTS-like 4) Rattus norvegicus
Analyze
Symbol: Adamtsl4
Name: ADAMTS-like 4
RGD ID: 1561012
Description: Predicted to enable identical protein binding activity and protease binding activity. Predicted to be involved in extracellular matrix organization and positive regulation of apoptotic process. Predicted to act upstream of or within epithelial cell development and pigment cell development. Predicted to be located in interstitial matrix. Human ortholog(s) of this gene implicated in autosomal recessive isolated ectopia lentis 2 and ectopia lentis with ectopia of pupil. Orthologous to human ADAMTSL4 (ADAMTS like 4); INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ADAMTS-like protein 4; ADAMTSL-4; MGC116260; thrombospondin repeat protein 1; Tsrc1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82185,924,582 - 185,936,039 (-)NCBIGRCr8
mRatBN7.22183,235,634 - 183,247,091 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,235,646 - 183,246,848 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2190,900,493 - 190,911,711 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02188,695,980 - 188,707,197 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02183,533,021 - 183,544,239 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02197,803,572 - 197,815,058 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2197,803,584 - 197,814,808 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02217,293,446 - 217,305,288 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2175,766,222 - 175,776,877 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:16364318   PMID:18757743   PMID:24006456   PMID:26405179  


Genomics

Comparative Map Data
Adamtsl4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82185,924,582 - 185,936,039 (-)NCBIGRCr8
mRatBN7.22183,235,634 - 183,247,091 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,235,646 - 183,246,848 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2190,900,493 - 190,911,711 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02188,695,980 - 188,707,197 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02183,533,021 - 183,544,239 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02197,803,572 - 197,815,058 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2197,803,584 - 197,814,808 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02217,293,446 - 217,305,288 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2175,766,222 - 175,776,877 (-)NCBICelera
Cytogenetic Map2q34NCBI
ADAMTSL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381150,549,408 - 150,560,937 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1150,549,369 - 150,560,937 (+)EnsemblGRCh38hg38GRCh38
GRCh371150,521,884 - 150,533,413 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361148,788,522 - 148,800,037 (+)NCBINCBI36Build 36hg18NCBI36
Celera1123,637,660 - 123,649,179 (+)NCBICelera
Cytogenetic Map1q21.2NCBI
HuRef1121,900,033 - 121,911,558 (+)NCBIHuRef
CHM1_11151,917,677 - 151,929,196 (+)NCBICHM1_1
T2T-CHM13v2.01149,673,436 - 149,684,971 (+)NCBIT2T-CHM13v2.0
Adamtsl4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,583,511 - 95,595,232 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl395,583,511 - 95,595,228 (-)EnsemblGRCm39 Ensembl
GRCm38395,676,201 - 95,687,927 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,676,201 - 95,687,917 (-)EnsemblGRCm38mm10GRCm38
MGSCv37395,480,127 - 95,491,781 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36395,761,609 - 95,773,263 (-)NCBIMGSCv36mm8
Celera397,107,777 - 97,119,933 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.74NCBI
Adamtsl4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955413257,915 - 269,325 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955413258,078 - 269,324 (-)NCBIChiLan1.0ChiLan1.0
ADAMTSL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2199,278,285 - 99,289,872 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1199,032,057 - 99,043,800 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01125,893,739 - 125,905,337 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11129,541,795 - 129,553,376 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1129,541,795 - 129,553,376 (+)Ensemblpanpan1.1panPan2
ADAMTSL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11759,736,628 - 59,747,689 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1759,736,534 - 59,746,980 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1759,182,917 - 59,193,988 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01760,752,115 - 60,763,186 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1760,752,163 - 60,764,125 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11759,582,451 - 59,593,512 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01759,666,385 - 59,677,455 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01760,393,999 - 60,405,069 (+)NCBIUU_Cfam_GSD_1.0
Adamtsl4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505821,735,970 - 21,760,887 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936580782,112 - 791,605 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936580782,146 - 791,388 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAMTSL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl498,577,823 - 98,589,180 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1498,577,813 - 98,589,255 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24107,824,843 - 107,836,265 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAMTSL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603812,726,761 - 12,738,295 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adamtsl4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477218,267,719 - 18,275,597 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477218,264,521 - 18,275,497 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adamtsl4
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:64
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000074156
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat

Markers in Region
RH127870  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,235,693 - 183,235,893 (+)MAPPERmRatBN7.2
Rnor_6.02197,803,632 - 197,803,831NCBIRnor6.0
Rnor_5.02217,293,506 - 217,293,705UniSTSRnor5.0
Celera2175,766,278 - 175,766,477UniSTS
RH 3.4 Map21215.9UniSTS
Cytogenetic Map2q34UniSTS
BF412563  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,238,829 - 183,238,977 (+)MAPPERmRatBN7.2
Rnor_6.02197,806,766 - 197,806,913NCBIRnor6.0
Rnor_5.02217,296,640 - 217,296,787UniSTSRnor5.0
Celera2175,769,412 - 175,769,559UniSTS
RH 3.4 Map21215.8UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 16 15 15 7 15 8 11 4 15 11 8
Low 27 42 26 12 26 50 31 26
Below cutoff 24

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001034012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001836465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC085819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000074156   ⟹   ENSRNOP00000063998
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2183,235,646 - 183,246,848 (-)Ensembl
Rnor_6.0 Ensembl2197,803,584 - 197,814,808 (-)Ensembl
RefSeq Acc Id: NM_001034012   ⟹   NP_001029184
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,924,586 - 185,935,796 (-)NCBI
mRatBN7.22183,235,638 - 183,246,848 (-)NCBI
Rnor_6.02197,803,576 - 197,814,808 (-)NCBI
Rnor_5.02217,293,446 - 217,305,288 (-)NCBI
Celera2175,766,222 - 175,776,877 (-)RGD
Sequence:
RefSeq Acc Id: XM_017590903   ⟹   XP_017446392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,924,582 - 185,936,039 (-)NCBI
mRatBN7.22183,235,634 - 183,247,091 (-)NCBI
Rnor_6.02197,803,572 - 197,815,058 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017590906   ⟹   XP_017446395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,924,582 - 185,935,908 (-)NCBI
mRatBN7.22183,235,634 - 183,246,947 (-)NCBI
Rnor_6.02197,803,572 - 197,814,859 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017590907   ⟹   XP_017446396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,924,582 - 185,934,903 (-)NCBI
mRatBN7.22183,235,634 - 183,245,937 (-)NCBI
Rnor_6.02197,803,572 - 197,813,941 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039102358   ⟹   XP_038958286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,924,582 - 185,936,039 (-)NCBI
mRatBN7.22183,235,634 - 183,247,091 (-)NCBI
RefSeq Acc Id: XM_039102359   ⟹   XP_038958287
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,924,582 - 185,934,912 (-)NCBI
mRatBN7.22183,235,634 - 183,245,965 (-)NCBI
RefSeq Acc Id: XM_039102360   ⟹   XP_038958288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,924,582 - 185,936,039 (-)NCBI
mRatBN7.22183,235,634 - 183,247,091 (-)NCBI
RefSeq Acc Id: XM_039102361   ⟹   XP_038958289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,924,582 - 185,935,849 (-)NCBI
mRatBN7.22183,235,634 - 183,246,901 (-)NCBI
RefSeq Acc Id: XM_039102362   ⟹   XP_038958290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,924,582 - 185,935,908 (-)NCBI
mRatBN7.22183,235,634 - 183,246,947 (-)NCBI
RefSeq Acc Id: XM_039102363   ⟹   XP_038958291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,924,582 - 185,936,039 (-)NCBI
mRatBN7.22183,235,634 - 183,247,091 (-)NCBI
RefSeq Acc Id: XM_039102364   ⟹   XP_038958292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,924,582 - 185,934,905 (-)NCBI
mRatBN7.22183,235,634 - 183,245,918 (-)NCBI
RefSeq Acc Id: XM_039102366   ⟹   XP_038958294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,927,701 - 185,936,039 (-)NCBI
mRatBN7.22183,238,769 - 183,247,091 (-)NCBI
RefSeq Acc Id: XM_039102367   ⟹   XP_038958295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,927,701 - 185,936,039 (-)NCBI
mRatBN7.22183,238,771 - 183,247,091 (-)NCBI
RefSeq Acc Id: XM_063281874   ⟹   XP_063137944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,924,582 - 185,935,849 (-)NCBI
RefSeq Acc Id: XM_063281875   ⟹   XP_063137945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,924,582 - 185,934,910 (-)NCBI
RefSeq Acc Id: XM_063281876   ⟹   XP_063137946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,924,582 - 185,936,039 (-)NCBI
RefSeq Acc Id: XM_063281877   ⟹   XP_063137947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,924,582 - 185,934,706 (-)NCBI
RefSeq Acc Id: XM_063281878   ⟹   XP_063137948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,924,582 - 185,935,820 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001029184   ⟸   NM_001034012
- Peptide Label: precursor
- UniProtKB: Q4FZU4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017446392   ⟸   XM_017590903
- Peptide Label: isoform X2
- UniProtKB: Q4FZU4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017446395   ⟸   XM_017590906
- Peptide Label: isoform X2
- UniProtKB: Q4FZU4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017446396   ⟸   XM_017590907
- Peptide Label: isoform X2
- UniProtKB: Q4FZU4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000063998   ⟸   ENSRNOT00000074156
RefSeq Acc Id: XP_038958288   ⟸   XM_039102360
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038958286   ⟸   XM_039102358
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038958291   ⟸   XM_039102363
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038958290   ⟸   XM_039102362
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038958289   ⟸   XM_039102361
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038958287   ⟸   XM_039102359
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038958292   ⟸   XM_039102364
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038958294   ⟸   XM_039102366
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038958295   ⟸   XM_039102367
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063137946   ⟸   XM_063281876
- Peptide Label: isoform X2
- UniProtKB: Q4FZU4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063137944   ⟸   XM_063281874
- Peptide Label: isoform X2
- UniProtKB: Q4FZU4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063137948   ⟸   XM_063281878
- Peptide Label: isoform X2
- UniProtKB: Q4FZU4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063137945   ⟸   XM_063281875
- Peptide Label: isoform X2
- UniProtKB: Q4FZU4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063137947   ⟸   XM_063281877
- Peptide Label: isoform X2
- UniProtKB: Q4FZU4 (UniProtKB/Swiss-Prot)
Protein Domains
PLAC   TSP type-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4FZU4-F1-model_v2 AlphaFold Q4FZU4 1-1030 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691554
Promoter ID:EPDNEW_R2078
Type:initiation region
Name:Adamtsl4_1
Description:ADAMTS-like 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02197,814,816 - 197,814,876EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561012 AgrOrtholog
BioCyc Gene G2FUF-52082 BioCyc
Ensembl Genes ENSRNOG00000049385 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055031628 UniProtKB/Swiss-Prot
  ENSRNOG00060013233 UniProtKB/Swiss-Prot
  ENSRNOG00065023504 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000074156 ENTREZGENE
  ENSRNOT00000074156.2 UniProtKB/Swiss-Prot
  ENSRNOT00055054782 UniProtKB/Swiss-Prot
  ENSRNOT00060022557 UniProtKB/Swiss-Prot
  ENSRNOT00065040198 UniProtKB/Swiss-Prot
Gene3D-CATH 2.20.100.10 UniProtKB/Swiss-Prot
  2.60.120.830 UniProtKB/Swiss-Prot
  Thrombospondin type-1 (TSP1) repeat UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7124600 IMAGE-MGC_LOAD
  IMAGE:7462597 IMAGE-MGC_LOAD
InterPro ADAM_spacer1 UniProtKB/Swiss-Prot
  ADAMTS_CR_3 UniProtKB/Swiss-Prot
  PLAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:310670 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116260 IMAGE-MGC_LOAD
  MGC:94085 IMAGE-MGC_LOAD
NCBI Gene 310670 ENTREZGENE
PANTHER ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAMTS-LIKE PROTEIN 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADAM_CR_3 UniProtKB/Swiss-Prot
  ADAM_spacer1 UniProtKB/Swiss-Prot
  PLAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_ADAMTS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP_1 UniProtKB/Swiss-Prot
PhenoGen Adamtsl4 PhenoGen
PROSITE PLAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049385 RatGTEx
  ENSRNOG00055031628 RatGTEx
  ENSRNOG00060013233 RatGTEx
  ENSRNOG00065023504 RatGTEx
SMART TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF82895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6K305_RAT UniProtKB/TrEMBL
  ATL4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Adamtsl4  ADAMTS-like 4  Tsrc1  thrombospondin repeat protein 1  Symbol and Name updated 1299863 APPROVED
2006-02-09 Tsrc1  thrombospondin repeat protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL